{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:08:18Z","timestamp":1792872498408,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado from Instituto Polit\u00e9cnico Nacional","award":["SIP-20201870"],"award-info":[{"award-number":["SIP-20201870"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado from Instituto Polit\u00e9cnico Nacional","award":["CBF2023-2024-2199"],"award-info":[{"award-number":["CBF2023-2024-2199"]}]},{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00edas (CONAHCyT)","award":["SIP-20201870"],"award-info":[{"award-number":["SIP-20201870"]}]},{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00edas (CONAHCyT)","award":["CBF2023-2024-2199"],"award-info":[{"award-number":["CBF2023-2024-2199"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue (DENV) and Chikungunya (CHIKV) viruses can be transmitted simultaneously by Aedes mosquitoes, and there may be co-infections in humans. However, how the adaptive immune response is modified in the host has yet to be known entirely. In this study, we analyzed the cross-reactivity and neutralizing activity of IgG antibodies against DENV and CHIKV in sera of patients from the Mexican Institute of Social Security in Veracruz, Mexico, collected in 2013 and 2015 and using IgG antibodies of BALB\/c mice inoculated with DENV and\/or CHIKV. Mice first inoculated with DENV and then with CHIKV produced IgG antibodies that neutralized both viruses. Mice were inoculated with CHIKV, and then with DENV; they had IgG antibodies with more significant anti-CHIKV IgG antibody neutralizing activity. However, the inoculation only with CHIKV resulted in better neutralization of DENV2. In sera obtained from patients in 2013, significant cross-reactivity and low anti-CHIKV IgG antibody neutralizing activity were observed. In CHIKV-positive 2015 sera, the anti-DENV IgG antibody neutralizing activity was high. These results suggest that CHIKV stimulates DENV2-induced memory responses and vice versa. Furthermore, cross-reactivity between the two viruses generated neutralizing antibodies, but exchanging CHIKV for DENV2 generated a better anti-CHIKV neutralizing response.<\/jats:p>","DOI":"10.3390\/v16071098","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T11:30:02Z","timestamp":1720438202000},"page":"1098","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cross-Neutralizing Anti-Chikungunya and Anti-Dengue 2 IgG Antibodies from Patients and BALB\/c Mice against Dengue and Chikungunya Viruses"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-3257","authenticated-orcid":false,"given":"Araceli","family":"Posadas-Mondrag\u00f3n","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4148-4008","authenticated-orcid":false,"given":"Jos\u00e9 Angel","family":"Santiago-Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"},{"name":"Laboratorio de Ecolog\u00eda Microbiana, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-9222","authenticated-orcid":false,"given":"Ang\u00e9lica","family":"P\u00e9rez-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0646-6955","authenticated-orcid":false,"given":"Norma Estela","family":"Herrera-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-6194","authenticated-orcid":false,"given":"Sara M.","family":"Sosa-Delgado","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Elena","family":"Wong-Ar\u00e1mbula","sequence":"additional","affiliation":[{"name":"Laboratorio de Genoma de Pat\u00f3genos, Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos (InDRE) \u201cDr. Manuel Mart\u00ednez B\u00e1ez\u201d, Secretar\u00eda de Salud, Mexico City 01480, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abril Paulina","family":"Rodr\u00edguez-Maldonado","sequence":"additional","affiliation":[{"name":"Laboratorio de Genoma de Pat\u00f3genos, Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos (InDRE) \u201cDr. Manuel Mart\u00ednez B\u00e1ez\u201d, Secretar\u00eda de Salud, Mexico City 01480, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"V\u00e1zquez-Pichardo","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirus, Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos (InDRE) \u201cDr. Manuel Mart\u00ednez B\u00e1ez\u201d, Secretar\u00eda de Salud, Mexico City 01480, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Duran-Ayala","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirus, Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos (InDRE) \u201cDr. Manuel Mart\u00ednez B\u00e1ez\u201d, Secretar\u00eda de Salud, Mexico City 01480, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0519-3254","authenticated-orcid":false,"given":"Jos\u00e9 Leopoldo","family":"Aguilar-Faisal","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0140-6736(23)02576-X","article-title":"Dengue","volume":"403","author":"Adams","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"de Lima Cavalcanti, T.Y.V., Pereira, M.R., de Paula, S.O., and Franca, R.F.O. 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