{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:58:16Z","timestamp":1791655096484,"version":"4.3.4"},"reference-count":73,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"INCT\/CNPq","doi-asserted-by":"publisher","award":["150093\/2024-1"],"award-info":[{"award-number":["150093\/2024-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"INCT\/CNPq","doi-asserted-by":"publisher","award":["406757\/2022"],"award-info":[{"award-number":["406757\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"INCT\/CNPq","doi-asserted-by":"publisher","award":["441187\/2023-4"],"award-info":[{"award-number":["441187\/2023-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PPBio\/CNPq","award":["150093\/2024-1"],"award-info":[{"award-number":["150093\/2024-1"]}]},{"name":"PPBio\/CNPq","award":["406757\/2022"],"award-info":[{"award-number":["406757\/2022"]}]},{"name":"PPBio\/CNPq","award":["441187\/2023-4"],"award-info":[{"award-number":["441187\/2023-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hantaviruses are zoonotic agents responsible for causing Hantavirus Cardiopulmonary Syndrome (HCPS) in the Americas, with Brazil ranking first in number of confirmed HCPS cases in South America. In this study, we simulate the monthly spread of highly lethal hantavirus in natural hosts by conjugating a Kermack\u2013McCormick SIR model with a cellular automata model (CA), therefore simultaneously evaluating both in-cell and between-cell infection dynamics in host populations, using recently compiled data on main host species abundances and confirmed deaths by hantavirus infection. For both host species, our models predict an increase in the area of infection, with 22 municipalities where no cases have been confirmed to date expected to have at least one case in the next decade, and a reduction in infection in 11 municipalities. Our findings support existing research and reveal new areas where hantavirus is likely to spread within recognized epicenters. Highlighting spatial-temporal trends and potential expansion, we emphasize the increased risk due to pervasive habitat fragmentation and agricultural expansion. Consistent prevention efforts and One Health actions are crucial, especially in newly identified high-risk municipalities.<\/jats:p>","DOI":"10.3390\/v16071154","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T16:35:58Z","timestamp":1721234158000},"page":"1154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hantavirus Expansion Trends in Natural Host Populations in Brazil"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-9689","authenticated-orcid":false,"given":"Jos\u00e9 Henrique Fortes","family":"Mello","sequence":"first","affiliation":[{"name":"Department of Ecology, Institute of Biology, Rio de Janeiro Federal University (UFRJ), Rio de Janeiro 21941-902, Brazil"},{"name":"Knowledge Center for Biodiversity, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6466-6210","authenticated-orcid":false,"given":"Renata L.","family":"Muylaert","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology and Public Health Laboratory, School of Veterinary Science\u2014T\u0101wharau Ora, Massey University, Private Bag 11-222, Palmerston North 4474, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-8655","authenticated-orcid":false,"given":"Carlos Eduardo Viveiros","family":"Grelle","sequence":"additional","affiliation":[{"name":"Department of Ecology, Institute of Biology, Rio de Janeiro Federal University (UFRJ), Rio de Janeiro 21941-902, Brazil"},{"name":"Knowledge Center for Biodiversity, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"003","DOI":"10.3855\/jidc.317","article-title":"Hantavirus Infection: A Review and Global Update","volume":"2","author":"Bi","year":"2008","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1111\/1469-0691.12291","article-title":"Hantavirus Infections","volume":"21","author":"Saksida","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"D\u2019Souza, M.H., and Patel, T.R. (2020). Biodefense Implications of New-World Hantaviruses. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00925"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/vbz.2010.0001","article-title":"Genetic Characterization of Hantaviruses Associated with Sigmodontine Rodents in an Endemic Area for Hantavirus Pulmonary Syndrome in Southern Brazil","volume":"11","author":"Padula","year":"2011","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12982-015-0036-5","article-title":"Vulnerability of Brazilian Municipalities to Hantavirus Infections Based on Multi-Criteria Decision Analysis","volume":"12","author":"Fonseca","year":"2015","journal-title":"Emerg. Themes Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Muylaert, R.L., Bovendorp, R.S., Sabino-Santos, G., Prist, P.R., Melo, G.L., Priante, C.D.F., Wilkinson, D.A., Ribeiro, M.C., and Hayman, D.T.S. (2019). Hantavirus Host Assemblages and Human Disease in the Atlantic Forest. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007655"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1590\/S0036-46651997000400010","article-title":"Hantavirus Pulmonary Syndrome. Report of the First Three Cases in S\u00e3o Paulo, Brazil","volume":"39","author":"Vasconcelos","year":"1997","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1590\/0037-8682-0254-2015","article-title":"Ten Years of a Hantavirus Disease Emergency in the Federal District, Brazil","volume":"49","author":"Dusi","year":"2016","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"120479","DOI":"10.34117\/bjdv7n12-695","article-title":"Environmental Influence on the Hantavirosis Incidence in the Federal District, Brazil\/Influ\u00eancia Ambiental Na Incid\u00eancia da Hantavirose No Distrito Federal, Brasil","volume":"7","author":"Barbosa","year":"2021","journal-title":"Braz. J. Dev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jcv.2014.08.033","article-title":"Hantaviruses\u2014Globally Emerging Pathogens","volume":"64","author":"Kruger","year":"2015","journal-title":"J. Clin. Virol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Sabino-Santos, G., Maia, F.G.M., Martins, R.B., Gagliardi, T.B., Souza, W.M.D., Muylaert, R.L., Luna, L.K.D.S., Melo, D.M., Cardoso, R.D.S., and Barbosa, N.D.S. (2018). Natural Infection of Neotropical Bats with Hantavirus in Brazil. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-27442-w"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.3201\/eid1012.040295","article-title":"Identifying Rodent Hantavirus Reservoirs, Brazil","volume":"10","author":"Suzuki","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.actatropica.2008.05.018","article-title":"A Serosurvey for Hantavirus Infection in Wild Rodents from the States of Rio de Janeiro and Pernambuco, Brazil","volume":"107","author":"Sobreira","year":"2008","journal-title":"Acta Trop."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.virusres.2015.07.022","article-title":"Detection of Different South American Hantaviruses","volume":"210","author":"Guterres","year":"2015","journal-title":"Virus Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/tbed.13442","article-title":"Hantavirus Antibodies among Phyllostomid Bats from the Arc of Deforestation in Southern Amazonia, Brazil","volume":"67","author":"Ferreira","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4269\/ajtmh.15-0032","article-title":"Evidence of Hantavirus Infection Among Bats in Brazil","volume":"93","author":"Maia","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"De Araujo, J., Thomazelli, L.M., Henriques, D.A., Lautenschalager, D., Ometto, T., Dutra, L.M., Aires, C.C., Favorito, S., and Durigon, E.L. (2012). Detection of Hantavirus in Bats from Remaining Rain Forest in S\u00e3o Paulo, Brazil. BMC Res. Notes, 5.","DOI":"10.1186\/1756-0500-5-690"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10211-016-0238-z","article-title":"Personality and Behavioural Syndrome in Necromys lasiurus (Rodentia: Cricetidae): Notes on Dispersal and Invasion Processes","volume":"19","author":"Malange","year":"2016","journal-title":"Acta Ethologica"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"234","DOI":"10.31687\/saremMN.20.27.2.0.09","article-title":"Cornfield Effects on Breeding and Abundance of Oligoryzomys nigripes (Rodentia: Sigmodontinae)","volume":"27","author":"Braga","year":"2020","journal-title":"Mastozool. Neotrop."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Muylaert, R., Sabino-Santos, G., Prist, P., Oshima, J., Niebuhr, B., Sobral-Souza, T., Oliveira, S., Bovendorp, R., Marshall, J., and Hayman, D. (2019). Spatiotemporal Dynamics of Hantavirus Cardiopulmonary Syndrome Transmission Risk in Brazil. Viruses, 11.","DOI":"10.3390\/v11111008"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1590\/S0037-86822011000100013","article-title":"Uso e ocupa\u00e7\u00e3o do solo e a dissemina\u00e7\u00e3o da hantavirose na regi\u00e3o de S\u00e3o Sebasti\u00e3o, Distrito Federal: 2004\u20132008","volume":"44","author":"Santos","year":"2011","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Anyamba, A., Chretien, J.-P., Britch, S.C., Soebiyanto, R.P., Small, J.L., Jepsen, R., Forshey, B.M., Sanchez, J.L., Smith, R.D., and Harris, R. (2019). Global Disease Outbreaks Associated with the 2015\u20132016 El Ni\u00f1o Event. Sci. Rep., 9.","DOI":"10.1038\/s41598-018-38034-z"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1086\/315467","article-title":"Outbreak of Hantavirus Infection in the Four Corners Region of the United States in the Wake of the 1997\u20131998 El Ni\u00f1o\u2013Southern Oscillation","volume":"181","author":"Hjelle","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Prist, P.R., Uriarte, M., Tambosi, L.R., Prado, A., Pardini, R., D\u2019Andrea, P.S., and Metzger, J.P. (2016). Landscape, Environmental and Social Predictors of Hantavirus Risk in S\u00e3o Paulo, Brazil. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163459"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Prist, P.R., Uriarte, M., Fernandes, K., and Metzger, J.P. (2017). Climate Change and Sugarcane Expansion Increase Hantavirus Infection Risk. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005705"},{"key":"ref_26","unstructured":"MapBiomas (2024). Relat\u00f3rio Anual do Desmatamento no Brasil\u20142024, MapBiomas."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1002\/ecy.1893","article-title":"Atlantic Small-mammal: A Dataset of Communities of Rodents and Marsupials of the Atlantic Forests of South America","volume":"98","author":"Bovendorp","year":"2017","journal-title":"Ecology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/ecy.2367","article-title":"Cerrado Small Mammals: Abundance and Distribution of Marsupials, Lagomorphs, and Rodents in a Neotropical Savanna","volume":"99","author":"Percequillo","year":"2018","journal-title":"Ecology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2155-6180.1000354","article-title":"Quantile Regression Models and Their Applications: A Review","volume":"8","author":"Huang","year":"2017","journal-title":"J. Biom. Biostat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1890\/1540-9295(2003)001[0412:AGITQR]2.0.CO;2","article-title":"A Gentle Introduction to Quantile Regression for Ecologists","volume":"1","author":"Cade","year":"2003","journal-title":"Front. Ecol. Environ."},{"key":"ref_31","first-page":"639","article-title":"Moving Beyond Linear Regression: Implementing and Interpreting Quantile Regression Models with Fixed Effects","volume":"53","author":"Maroto","year":"2022","journal-title":"Sociol. Methods Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s10980-012-9757-9","article-title":"What Size Is a Biologically Relevant Landscape?","volume":"27","author":"Jackson","year":"2012","journal-title":"Landsc. Ecol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/geb.12233","article-title":"Are Ecologists Conducting Research at the Optimal Scale?","volume":"24","author":"Jackson","year":"2015","journal-title":"Glob. Ecol. Biogeogr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1086\/600087","article-title":"Abundance and the Environmental Niche: Environmental Suitability Estimated from Niche Models Predicts the Upper Limit of Local Abundance","volume":"174","author":"VanDerWal","year":"2009","journal-title":"Am. Nat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/ecog.02125","article-title":"Is There a Correlation between Abundance and Environmental Suitability Derived from Ecological Niche Modelling? A Meta-analysis","volume":"40","author":"Weber","year":"2017","journal-title":"Ecography"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4322\/natcon.2012.035","article-title":"Does Environmental Suitability Explain the Relative Abundance of the Tailed Tailless Bat, Anoura Caudifer?","volume":"10","author":"Weber","year":"2012","journal-title":"Nat. Conserv."},{"key":"ref_37","unstructured":"R Core Team, R. (2024). A Language and Environment for Statistical Computing, R Core Team R."},{"key":"ref_38","unstructured":"Koenker, R. (2024, March 15). Quantreg: Quantile Regression. 2023. R Package Version 5.97. Available online: https:\/\/cran.r-project.org\/package=quantreg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1467-9868.2010.00749.x","article-title":"Fast Stable Restricted Maximum Likelihood and Marginal Likelihood Estimation of Semiparametric Generalized Linear Models","volume":"73","author":"Wood","year":"2011","journal-title":"J. R. Stat. Soc. Ser. B Stat. Methodol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1080\/01621459.2016.1180986","article-title":"Smoothing Parameter and Model Selection for General Smooth Models","volume":"111","author":"Wood","year":"2016","journal-title":"J. Am. Stat. Assoc."},{"key":"ref_41","unstructured":"(2024, June 23). Minist\u00e9rio da Sa\u00fade DATASUS\u2014Minist\u00e9rio Da Sa\u00fade, Available online: https:\/\/datasus.saude.gov.br\/."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fonseca, L.X., Oliveira, S.V.D., and Duarte, E.C. (2018). Magnitude e Distribui\u00e7\u00e3o Dos \u00d3bitos Por Hantavirose No Brasil, 2007\u20132015*. Epidemiol. Servi\u00e7os Sa\u00fade, 27.","DOI":"10.5123\/S1679-49742018000200011"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global Burden of 369 Diseases and Injuries in 204 Countries and Territories, 1990\u20132019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Vos","year":"2020","journal-title":"Lancet"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Malta, D.C., Felisbino-Mendes, M.S., Machado, \u00cd.E., Veloso, G.A., Gomes, C.S., Brant, L.C.C., Ribeiro, A.L.P., Oliveira, P.P.V.D., Flor, L.S., and Gakidou, E. (2022). Burden of Disease Attributable to Risk Factors in Brazil: An Analysis of National and Subnational Estimates from the 2019 Global Burden of Disease Study. Rev. Soc. Bras. Med. Trop., 55.","DOI":"10.1590\/0037-8682-0262-2021"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41586-024-07380-6","article-title":"A Meta-Analysis on Global Change Drivers and the Risk of Infectious Disease","volume":"629","author":"Mahon","year":"2024","journal-title":"Nature"},{"key":"ref_46","unstructured":"QGIS.org (2024, February 28). QGIS Geographic Information System. Open Source Geospatial Found. Proj., Available online: https:\/\/qgis.org."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Schiff, J.L. (2008). Cellular Automata: A Discrete View of the World, Wiley-Interscience.","DOI":"10.1002\/9781118032381"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/wics.1301","article-title":"Scientific Modeling with Cellular Automata","volume":"6","author":"Schiff","year":"2014","journal-title":"WIREs Comput. Stats"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hawkins, J. (2024). The Mathematics of Cellular Automata, The Student Mathematical Library; American Mathematical Society.","DOI":"10.1090\/stml\/108"},{"key":"ref_50","first-page":"193","article-title":"Modeling Epidemics Using Cellular Automata","volume":"186","author":"White","year":"2007","journal-title":"Appl. Math. Comput."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.simpat.2008.05.015","article-title":"Modelling SIR-Type Epidemics by ODEs, PDEs, Difference Equations and Cellular Automata\u2014A Comparative Study","volume":"16","author":"Schneckenreither","year":"2008","journal-title":"Simul. Model. Pract. Theory"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mbs.2005.07.006","article-title":"The Kermack\u2013McKendrick Epidemic Model Revisited","volume":"198","author":"Brauer","year":"2005","journal-title":"Math. Biosci."},{"key":"ref_53","first-page":"33","article-title":"Contributions to the Mathematical Theory of Epidemics\u2014I","volume":"53","author":"Kermack","year":"1991","journal-title":"Bull. Math. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1590\/S0037-86822010000400002","article-title":"Diagnosis of Hantavirus Infection in Humans and Rodents in Ribeir\u00e3o Preto, State of S\u00e3o Paulo, Brazil","volume":"43","author":"Figueiredo","year":"2010","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/jmammal\/gyaa140","article-title":"Local Effects of Global Climate on a Small Rodent Necromys Lasiurus","volume":"102","author":"Magnusson","year":"2021","journal-title":"J. Mammal."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Da Rosa, C.A., Ganan\u00e7a, P.H.S., Lima, A.P., and Magnusson, W.E. (2021). Necromys Lasiurus: Lessons From a 38-Year Study in an Amazonian Savanna. Front. Ecol. Evol., 9.","DOI":"10.3389\/fevo.2021.716384"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i09","article-title":"Solving Differential Equations in R: Package deSolve","volume":"33","author":"Soetaert","year":"2010","journal-title":"J. Stat. Softw."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v021.i12","article-title":"Reshaping Data with the Reshape Package","volume":"21","author":"Wickham","year":"2007","journal-title":"J. Stat. Softw."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.3201\/eid1112.050501","article-title":"Person-to-Person Transmission of Andes Virus","volume":"11","author":"Martinez","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/viro.1997.8976","article-title":"Hantavirus Pulmonary Syndrome Outbrake in Argentina: Molecular Evidence for Person-to-Person Transmission of Andes Virus","volume":"241","author":"Padula","year":"1998","journal-title":"Virology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11056-020-09777-3","article-title":"An Overview of Forest Loss and Restoration in the Brazilian Amazon","volume":"52","author":"Benayas","year":"2021","journal-title":"New For."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Lovejoy, T.E., and Nobre, C. (2018). Amazon Tipping Point. Sci. Adv., 4.","DOI":"10.1126\/sciadv.aat2340"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Bochow, N., and Boers, N. (2023). The South American Monsoon Approaches a Critical Transition in Response to Deforestation. Sci. Adv., 9.","DOI":"10.1126\/sciadv.add9973"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11646\/zootaxa.3220.1.1","article-title":"The Taxonomic Status of the Castelo Dos Sonhos Hantavirus Reservoir, Oligoryzomys Utiaritensis Allen 1916 (Rodentia: Cricetidae: Sigmodontinae)","volume":"3220","author":"Agrellos","year":"2012","journal-title":"Zootaxa"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.3201\/eid1708.101547","article-title":"Pygmy Rice Rat as Potential Host of Castelo Dos Sonhos Hantavirus","volume":"17","author":"Medeiros","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_66","unstructured":"Brazil\u2013Minist\u00e9rio da Sa\u00fade (2024, April 09). \u00d3bitos Confirmados de Hantavirose Segundo Unidade Federada Do Local Prov\u00e1vel de Infec\u00e7\u00e3o. Brasil\u20142012 a 2024*, Available online: https:\/\/www.gov.br\/saude\/pt-br\/assuntos\/saude-de-a-a-z\/h\/hantavirose\/arquivos\/obitos-por-hantavirose-2012-a-2024\/view."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Oliveira, S.V.D., Escobar, L.E., Peterson, A.T., and Gurgel-Gon\u00e7alves, R. (2013). Potential Geographic Distribution of Hantavirus Reservoirs in Brazil. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0085137"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Amuah, E.E.Y., Tetteh, I.K., Boadu, J.A., and Nandomah, S. (2023). Environmental Impact Assessment Practices of the Federative Republic of Brazil: A Comprehensive Review. Environ. Chall., 13.","DOI":"10.1016\/j.envc.2023.100746"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Queiroz-Stein, G.D., Seifert, C.A., and Luiz, A.M.M.T. (2023). Climate Change, Denialism, and Participatory Institutions in Brazil: Effects of the Bolsonaro Government\u2019s Environmental Strategy (2019\u20132022). Braz. Political Sci. Rev., 17.","DOI":"10.1590\/1981-3821202300030005"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40823-024-00096-3","article-title":"Landscape Ecology Meets Disease Ecology in the Tropical America: Patterns, Trends, and Future Directions","volume":"9","author":"Mancini","year":"2024","journal-title":"Curr. Landsc. Ecol. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/trstmh\/traa117","article-title":"One Health for Neglected Tropical Diseases","volume":"115","author":"Laing","year":"2021","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Mackenzie, J.S., and Jeggo, M. (2019). The One Health Approach\u2014Why Is It So Important?. Trop. Med. Infect. Dis., 4.","DOI":"10.3390\/tropicalmed4020088"},{"key":"ref_73","unstructured":"Brasil\u2013Minist\u00e9rio da Sa\u00fade (2017). Guia de Vigil\u00e2ncia em Sa\u00fade: Volume 1, Brasil\u2013Minist\u00e9rio da Sa\u00fade."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/7\/1154\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:18:37Z","timestamp":1760109517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/7\/1154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":73,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["v16071154"],"URL":"https:\/\/doi.org\/10.3390\/v16071154","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]}}}