{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:22:11Z","timestamp":1782404531152,"version":"3.54.5"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiyuan Municipal Health Commission and Taiyuan Municipal Bureau of Science and Technology","award":["ZC2024003"],"award-info":[{"award-number":["ZC2024003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The HIV-1 pandemic, spanning four decades, presents a significant challenge to global public health. This study aimed to understand the molecular transmission characteristics of newly reported HIV infections in Taiyuan, Shanxi Province, China, to analyze the characteristics of subtypes and the risk factors of the transmission network, providing a scientific basis for precise prevention and intervention measures. A total of 720 samples were collected from newly diagnosed HIV-1 patients residing in Taiyuan between 2021 and 2023. Sequencing of partial genes of the HIV-1 pol gene resulted in multiple sequence acquisitions and was conducted to analyze their subtypes and molecular transmission networks. Out of the samples, 584 pol sequences were obtained, revealing 17 HIV-1 subtypes, with CRF07_BC (48.29%), CRF01_AE (31.34%), and CRF79_0107 (7.19%) being the dominant subtypes. Using a genetic distance threshold of 1.5%, 49 molecular transmission clusters were generated from the 313 pol gene sequences. Univariate analysis showed significant differences in the HIV transmission molecular network in terms of HIV subtype and household registration (p &lt; 0.05). Multivariate logistic regression analysis showed that CRF79_0107 subtype and its migrants were associated with higher proportions of sequences in the HIV transmission network. These findings provide a scientific foundation for the development of localized HIV-specific intervention strategies.<\/jats:p>","DOI":"10.3390\/v16071174","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:20:38Z","timestamp":1721650838000},"page":"1174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characteristics of Subtype and Molecular Transmission Networks among Newly Diagnosed HIV-1 Infections in Patients Residing in Taiyuan City, Shanxi Province, China, from 2021 to 2023"],"prefix":"10.3390","volume":"16","author":[{"given":"Ruihong","family":"Gao","sequence":"first","affiliation":[{"name":"Academy of Medical Sciences, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, Shanxi, China"},{"name":"School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, Shanxi, China"},{"name":"Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentong","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Medical Sciences, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, Shanxi, China"},{"name":"School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, Shanxi, China"},{"name":"Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Xu","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiane","family":"Guo","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6645-0755","authenticated-orcid":false,"given":"Jitao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, Shanxi, China"},{"name":"Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/COH.0000000000000534","article-title":"HIV subtype diversity worldwide","volume":"14","author":"Bbosa","year":"2019","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.molmed.2011.12.001","article-title":"The origin and diversity of the HIV-1 pandemic","volume":"18","author":"Hemelaar","year":"2012","journal-title":"Trends Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2014733","DOI":"10.1080\/21645515.2021.2014733","article-title":"HIV-1 genetic diversity a challenge for AIDS vaccine development: A retrospective bibliometric analysis","volume":"18","author":"Rashid","year":"2022","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sivay, M.V., Totmenin, A.V., Zyryanova, D.P., Osipova, I.P., Nalimova, T.M., Gashnikova, M.P., Ivlev, V.V., Meshkov, I.O., Chokmorova, U.Z., and Narmatova, E. (2021). Characterization of HIV-1 Epidemic in Kyrgyzstan. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.753675"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1039\/C8MD00124C","article-title":"Generation of a long-acting fusion inhibitor against HIV-1","volume":"9","author":"Guo","year":"2018","journal-title":"Medchemcomm"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/17130","article-title":"Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes","volume":"397","author":"Gao","year":"1999","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.287.5453.607","article-title":"AIDS as a zoonosis: Scientific and public health implications","volume":"287","author":"Hahn","year":"2000","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Li, X., Guo, Y., Li, H., Huang, X., Pei, Z., Wang, X., Liu, Y., Jia, L., Li, T., and Bao, Z. (2021). Infection by Diverse HIV-1 Subtypes Leads to Different Elevations in HERV-K Transcriptional Levels in Human T Cell Lines. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.662573"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.2019.1343","article-title":"Ending the HIV Epidemic: A Plan for the United States","volume":"321","author":"Fauci","year":"2019","journal-title":"Jama"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/S2352-3018(14)70017-7","article-title":"90-90-90: How do we get there?","volume":"1","author":"McMahon","year":"2014","journal-title":"Lancet HIV"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1080\/22221751.2022.2119167","article-title":"Molecular genetics and epidemiological characteristics of HIV-1 epidemic strains in various sexual risk behaviour groups in developed Eastern China, 2017-2020","volume":"11","author":"Fan","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"ref_12","first-page":"S147","article-title":"Detection of antibody to LAV\/HTLV-III in sera from hemophiliacs in China","volume":"2","author":"Zeng","year":"1986","journal-title":"AIDS Res."},{"key":"ref_13","unstructured":"(2024). National AIDS STD epidemic in December 2023. Chin. J. AIDS STD, 30, 225."},{"key":"ref_14","first-page":"137","article-title":"Progress in research and practice of molecular epidemiology of HIV-1","volume":"4","author":"Ping","year":"2019","journal-title":"Electron. J. Emerg. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e00683-20","DOI":"10.1128\/JVI.00683-20","article-title":"Comparative Circulation Dynamics of the Five Main HIV Types in China","volume":"94","author":"Vrancken","year":"2020","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chen, Y., Chen, S., Kang, J., Fang, H., Dao, H., Guo, W., Lai, C., Lai, M., Fan, J., and Fu, L. (2014). Evolving molecular epidemiological profile of human immunodeficiency virus 1 in the southwest border of China. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107578"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/QAD.0b013e328360db2d","article-title":"The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s","volume":"27","author":"Feng","year":"2013","journal-title":"Aids"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1099\/vir.0.009290-0","article-title":"Genetic and temporal dynamics of human immunodeficiency virus type 1 CRF07_BC in Xinjiang, China","volume":"90","author":"Xin","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.meegid.2015.01.022","article-title":"Epidemiological and molecular characteristics of HIV infection among money boys and general men who have sex with men in Shanghai, China","volume":"31","author":"Yan","year":"2015","journal-title":"Infect. Genet. Evol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/aid.2016.0117","article-title":"Trends of HIV-1 Subtypes Among Young People in Hangzhou, China","volume":"33","author":"Zhang","year":"2017","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zheng, S., Wu, J., Hu, Z., Gan, M., Liu, L., Song, C., Lei, Y., Wang, H., Liao, L., and Feng, Y. (2021). Epidemiology and Molecular Transmission Characteristics of HIV in the Capital City of Anhui Province in China. Pathogens, 10.","DOI":"10.3390\/pathogens10121554"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1080\/22221751.2021.1888659","article-title":"Epidemiological profile and molecular genetic characterization of HIV-1 among female sex workers and elderly male clients in Guangxi, China","volume":"10","author":"Chen","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"ref_23","first-page":"409","article-title":"Characteristic analysis of molecular subtypes and recombinant structure of HIV-1 infection in Zhejiang Province, 2015","volume":"52","author":"Fan","year":"2018","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Su, L., Feng, Y., Liang, S., Zeng, Y., Li, Y., Yang, H., Ye, L., Wang, Q., Wei, D., and Yuan, D. (2020). The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, China. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-05488-4"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1038\/s41598-020-61870-x","article-title":"Tracing the transmission dynamics of HIV-1 CRF55_01B","volume":"10","author":"Zai","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11684-020-0756-y","article-title":"Molecular network-based intervention brings us closer to ending the HIV pandemic","volume":"14","author":"Han","year":"2020","journal-title":"Front. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1016\/S2352-3018(18)30359-X","article-title":"HIV transmission networks among transgender women in Los Angeles County, CA, USA: A phylogenetic analysis of surveillance data","volume":"6","author":"Hu","year":"2019","journal-title":"Lancet HIV"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"ofaa154","DOI":"10.1093\/ofid\/ofaa154","article-title":"The Central Role of Nondisclosed Men Who Have Sex With Men in Human Immunodeficiency Virus-1 Transmission Networks in Guangzhou, China","volume":"7","author":"Yan","year":"2020","journal-title":"Open Forum Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijid.2022.12.033","article-title":"Combining molecular network analysis and field epidemiology to quantify local HIV transmission and highlight ongoing epidemics","volume":"128","author":"Zhang","year":"2023","journal-title":"Int. J. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"ofac042","DOI":"10.1093\/ofid\/ofac042","article-title":"Nonstudent Young Men Put Students at High Risk of HIV Acquisition in Guangxi, China: A Phylogenetic Analysis of Surveillance Data","volume":"9","author":"Jiang","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_31","first-page":"157","article-title":"Characteristics of the molecular transmission network in newly confirmed human immunodeficiency virus type 1 infected cases from 2018 to 2019 in Shaoxing City, Zhejiang Province","volume":"39","author":"Cao","year":"2021","journal-title":"Chin. J. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ijid.2021.05.066","article-title":"Phylodynamic analysis reveals changing transmission dynamics of HIV-1 CRF01_AE in Japan from heterosexuals to men who have sex with men","volume":"108","author":"Otani","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/QAD.0000000000002783","article-title":"Combining traditional and molecular epidemiology methods to quantify local HIV transmission among foreign-born residents","volume":"35","author":"Tordoff","year":"2021","journal-title":"Aids"},{"key":"ref_34","unstructured":"China Centers for Disease Control and Prevention (2013). Guideline for HIV-1 Genotyping Drug Resistance Testing and Quality Assurance, Chinese Center for Disease Control and Prevention."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: Molecular Evolutionary Genetics Analysis Version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1093\/molbev\/msy016","article-title":"HIV-TRACE (TRAnsmission Cluster Engine): A Tool for Large Scale Molecular Epidemiology of HIV-1 and Other Rapidly Evolving Pathogens","volume":"35","author":"Weaver","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Lu, Z., Ji, W., Yin, Y., Jin, X., Wang, L., Li, Z., Wang, N., Wang, K., and Peng, Z. (2021). Analysis on the trend of AIDS incidence in Zhejiang, China based on the age-period-cohort model (2004-2018). BMC Public Health, 21.","DOI":"10.1186\/s12889-021-11050-x"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yan, Y., Wu, S., Chen, L., Yan, P., Qiu, Y., Xie, M., Wang, Z., and Lin, X. (2016). Shift in HIV\/AIDS Epidemic in Southeastern China: A Longitudinal Study from 1987 to 2015. Int. J. Environ. Res. Public Health, 13.","DOI":"10.3390\/ijerph13080794"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"ofab051","DOI":"10.1093\/ofid\/ofab051","article-title":"Analysis of the Driving Factors of Active and Rapid Growth Clusters Among CRF07_BC-Infected Patients in a Developed Area in Eastern China","volume":"8","author":"Fan","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1007\/s00705-017-3485-z","article-title":"Transmission network characteristics based on env and gag sequences from MSM during acute HIV-1 infection in Beijing, China","volume":"162","author":"Zhang","year":"2017","journal-title":"Arch. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhou, P.P., Yu, G., Kuang, Y.Q., Huang, X.H., Li, Y., Fu, X., Lin, P., Yan, J., and He, X. (2019). Rapid and complicated HIV genotype expansion among high-risk groups in Guangdong Province, China. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-3788-7"},{"key":"ref_42","first-page":"140","article-title":"Genetic characteristics and drug resistance of HIV strains isolated in Taiyuan, Shanxi, 2016\u20132017","volume":"35","author":"Mei","year":"2020","journal-title":"Dis. Survellance"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/cid\/ciaa380","article-title":"CRF01_AE and CRF01_AE Cluster 4 Are Associated With Poor Immune Recovery in Chinese Patients Under Combination Antiretroviral Therapy","volume":"72","author":"Ge","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_44","first-page":"1438","article-title":"Survey on extramarital sexual behaviors and HIV infection in middle-aged and elderly people aged 50 and above in selected areas of Chongqing","volume":"39","author":"Jiang","year":"2018","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li, L., Sun, G., Liang, S., Li, J., Li, T., Wang, Z., Liu, W., Yang, S., Liu, Y., and Wang, X. (2013). Different distribution of HIV-1 subtype and drug resistance were found among treatment na\u00efve individuals in Henan, Guangxi, and Yunnan province of China. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075777"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e26640","DOI":"10.1097\/MD.0000000000026640","article-title":"HIV-1 molecular transmission network among sexually transmitted populations in Liaoning Province, China","volume":"100","author":"Ma","year":"2021","journal-title":"Medicine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12985-020-1281-y","article-title":"Genetic characterization of HIV-1 epidemic in Anhui Province, China","volume":"17","author":"Zhang","year":"2020","journal-title":"Virol. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1080\/22221751.2021.1978822","article-title":"HIV-1 CRF07_BC transmission dynamics in China: Two decades of national molecular surveillance","volume":"10","author":"Ge","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"ref_49","first-page":"56","article-title":"Transmission and drug resistance characteristics of HIV-1 strain among MSM in Taiyuan city, Shanxi province","volume":"30","author":"Lin","year":"2023","journal-title":"Int. J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Eshraghian, E.A., Ferdos, S.N., and Mehta, S.R. (2020). The Impact of Human Mobility on Regional and Global Efforts to Control HIV Transmission. Viruses, 12.","DOI":"10.3390\/v12010067"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1089\/aid.2015.0212","article-title":"The Epidemic Dynamics of Four Major Lineages of HIV-1 CRF01_AE Strains After Their Introduction into China","volume":"32","author":"Zeng","year":"2016","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1089\/aid.2017.0066","article-title":"Genome Sequence of a Novel HIV-1 Circulating Recombinant Form (CRF79_0107) Identified from Shanxi, China","volume":"33","author":"Li","year":"2017","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhou, C., Liang, S., Li, Y., Zhang, Y., Li, L., Ye, L., Yuan, D., and Su, L. (2022). Characterization of HIV-1 molecular epidemiology and transmitted drug-resistance in newly diagnosed HIV-infected patients in Sichuan, China. BMC Infect. Dis., 22.","DOI":"10.1186\/s12879-022-07576-z"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/aid.2020.0159","article-title":"Near Full-Length Genomic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF107_01B) Identified Among Men Who Have Sex with Men in Heilongjiang Province of China","volume":"37","author":"Song","year":"2021","journal-title":"AIDS Res. Hum. Retroviruses"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/7\/1174\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:21:01Z","timestamp":1760109661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/7\/1174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":54,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["v16071174"],"URL":"https:\/\/doi.org\/10.3390\/v16071174","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,22]]}}}