{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:05:09Z","timestamp":1765487109478,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The QuantiFERON CMV (QCMV) test evaluates specific adaptive immune system activity against CMV by measuring IFN-\u03b3 released by activated CD8+ T lymphocytes. We aimed to evaluate the QCMV test as a predictive tool for CMV manifestations and acute or chronic lung allograft rejection (AR and CLAD) in lung transplant (LTx) patients. A total of 73 patients were divided into four groups based on donor and recipient (D\/R) serology for CMV and QCMV assay: group A low-risk for CMV infection and disease (D\u2212\/R\u2212); group B and C at intermediate-risk (R+), group B with non-reactive QCMV and group C with reactive QCMV; group D at high-risk (D+\/R\u2212). Group D patients experienced higher viral replication; no differences were observed among R+ patients of groups B and C. D+\/R\u2212 patients had a higher number of AR events and group C presented a lower incidence of AR. Prevalence of CLAD at 24 months was higher in group B with a higher risk of CLAD development (OR 6.33). The QCMV test allows us to identify R+ non-reactive QCMV population as the most exposed to onset of CLAD. This population had a higher, although non-significant, susceptibility to AR compared to the R+ population with reactive QCMV.<\/jats:p>","DOI":"10.3390\/v16081251","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:37:30Z","timestamp":1722843450000},"page":"1251","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["QuantiFERON CMV Test and CMV Serostatus in Lung Transplant: Stratification Risk for Infection, Chronic and Acute Allograft Rejection"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-2871","authenticated-orcid":false,"given":"Paolo","family":"Solidoro","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Cardiovascular and Thoracic Department, AOU Citt\u00e0 della Salute e della Scienza di Torino, 10126 Torino, Italy"},{"name":"Medical Sciences Department, University of Turin, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Sciarrone","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Cardiovascular and Thoracic Department, AOU Citt\u00e0 della Salute e della Scienza di Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Sidoti","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Public Health and Pediatrics, AOU Citt\u00e0 della Salute e della Scienza di Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-8734","authenticated-orcid":false,"given":"Filippo","family":"Patrucco","sequence":"additional","affiliation":[{"name":"Respiratory Diseases Unit, Medical Department, AOU Maggiore della Carit\u00e0 di Novara, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Zanotto","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Public Health and Pediatrics, AOU Citt\u00e0 della Salute e della Scienza di Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Boffini","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Division, Surgical Sciences Department, AOU Citt\u00e0 della Salute e della Scienza di Torino, University of Turin, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco Francesco","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Cardiovascular and Thoracic Department, AOU Citt\u00e0 della Salute e della Scienza di Torino, 10126 Torino, Italy"},{"name":"Medical Sciences Department, University of Turin, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1979-3229","authenticated-orcid":false,"given":"Alessandro","family":"Bondi","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Public Health and Pediatrics, AOU Citt\u00e0 della Salute e della Scienza di Torino, University of Turin, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0334-869X","authenticated-orcid":false,"given":"Carlo","family":"Albera","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Cardiovascular and Thoracic Department, AOU Citt\u00e0 della Salute e della Scienza di Torino, 10126 Torino, Italy"},{"name":"Medical Sciences Department, University of Turin, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-4196","authenticated-orcid":false,"given":"Antonio","family":"Curtoni","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Public Health and Pediatrics, AOU Citt\u00e0 della Salute e della Scienza di Torino, University of Turin, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6549-4553","authenticated-orcid":false,"given":"Cristina","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Public Health and Pediatrics, AOU Citt\u00e0 della Salute e della Scienza di Torino, University of Turin, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1164\/rccm.200911-1786OC","article-title":"Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation","volume":"181","author":"Snyder","year":"2010","journal-title":"Am J Respir Crit Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1111\/j.1600-6143.2011.03663.x","article-title":"Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome","volume":"11","author":"Paraskeva","year":"2011","journal-title":"Am. 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