{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:56:47Z","timestamp":1785326207586,"version":"3.55.0"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas\u2014FAPEAM\u2014RESOLU\u00c7\u00c3O","award":["002\/2023"],"award-info":[{"award-number":["002\/2023"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas\u2014FAPEAM\u2014RESOLU\u00c7\u00c3O","award":["006\/2020"],"award-info":[{"award-number":["006\/2020"]}]},{"name":"FAPEAM\/POSGRAD","award":["002\/2023"],"award-info":[{"award-number":["002\/2023"]}]},{"name":"FAPEAM\/POSGRAD","award":["006\/2020"],"award-info":[{"award-number":["006\/2020"]}]},{"name":"CAPES\/CNPq\/POSGRAD","award":["002\/2023"],"award-info":[{"award-number":["002\/2023"]}]},{"name":"CAPES\/CNPq\/POSGRAD","award":["006\/2020"],"award-info":[{"award-number":["006\/2020"]}]},{"name":"FAPEAM\/PAIC","award":["002\/2023"],"award-info":[{"award-number":["002\/2023"]}]},{"name":"FAPEAM\/PAIC","award":["006\/2020"],"award-info":[{"award-number":["006\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Human Herpesviruses (HHVs) play a significant role in neurological diseases such as encephalitis and meningitis, adding significant morbidity. This study aims to retrospectively analyze the effect of HHVs on patients with neurological symptoms, focusing on the Herpesviridae family\u2019s contributions to central nervous system (CNS) infections. Methods: This retrospective cohort study included 895 patients suspected of viral CNS infections, utilizing molecular diagnosis via qPCR to identify HHVs in cerebrospinal fluid (CSF) samples. This was conducted at a reference tertiary care hospital for infectious diseases in the western Brazilian Amazon from January 2015 to December 2022, focusing on the Herpesviridae family\u2019s clinical repercussions and of Cytomegalovirus in CNS infections. Results: The findings revealed that 7.5% of the analyzed samples tested positive for HHVs, with Human Cytomegalovirus (HCMV) and Epstein\u2013Barr Virus (EBV) being the most prevalent. A significant association was found between HHVs and neurological diseases such as encephalitis and meningitis, especially among people living with HIV\/AIDS (PLWHA), highlighting the opportunistic nature of these viruses. The study underscores the critical role of CSF analysis in diagnosing CNS infections and the complexity of managing these infections in HIV patients due to their immunocompromised status. Conclusions: The results emphasize the need for comprehensive diagnostic approaches and tailored treatment strategies for CNS infections in immunocompromised individuals. The study calls for ongoing research and advancements in clinical practice to improve patient outcomes facing CNS infections, particularly those caused by HHVs.<\/jats:p>","DOI":"10.3390\/v16091437","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T05:06:06Z","timestamp":1725858366000},"page":"1437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unveiling the Impact of Human Herpesviruses-Associated on CNS Infections: An Observational Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Caio Cesar L. B.","family":"Barrionuevo","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro P. A.","family":"Baptista","sequence":"additional","affiliation":[{"name":"Faculdade de Educa\u00e7\u00e3o F\u00edsica e Fisioterapia, Universidade Federal do Amazonas, Manaus 69060-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewerton F.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Ger\u00eancia de Bacteriologia, Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo M.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssia da L.","family":"Goulart","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina A.","family":"de Melo","sequence":"additional","affiliation":[{"name":"Ger\u00eancia de Bacteriologia, Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valderjane A.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (PPGCIS), Manaus 69020-180, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Laycia A.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2881-8205","authenticated-orcid":false,"given":"Rossicleia L.","family":"Monte","sequence":"additional","affiliation":[{"name":"Ger\u00eancia de Bacteriologia, Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9995-0249","authenticated-orcid":false,"given":"Fernando F.","family":"Almeida-Val","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-451X","authenticated-orcid":false,"given":"Pablo Vin\u00edcius S.","family":"Feitoza","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica Cir\u00fargica, Faculdade de Medicina, Universidade Federal do Amazonas, Manaus 69020-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-666X","authenticated-orcid":false,"given":"Michele de S.","family":"Bastos","sequence":"additional","affiliation":[{"name":"Ger\u00eancia de Bacteriologia, Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (PPGCIS), Manaus 69020-180, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"001673","DOI":"10.1099\/jgv.0.001673","article-title":"ICTV Virus Taxonomy Profile: Herpesviridae 2021","volume":"102","author":"Gatherer","year":"2021","journal-title":"J. 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