{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:02:07Z","timestamp":1792807327957,"version":"4.5.0"},"reference-count":151,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Unit of Bezmialem Vakif University","award":["4.2022\/02"],"award-info":[{"award-number":["4.2022\/02"]}],"id":[{"id":"https:\/\/ror.org\/04z60tq39","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Scientific Research Unit of Bezmialem Vakif University","award":["4.2019\/12"],"award-info":[{"award-number":["4.2019\/12"]}],"id":[{"id":"https:\/\/ror.org\/04z60tq39","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Scientific Research Unit of Bezmialem Vakif University","award":["6.2017\/27"],"award-info":[{"award-number":["6.2017\/27"]}],"id":[{"id":"https:\/\/ror.org\/04z60tq39","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Crimean\u2013Congo hemorrhagic fever virus (CCHFV) is an orthonairovirus from the Bunyavirales order that is widely distributed geographically and causes severe or fatal infections in humans. The viral genome consists of three segmented negative-sense RNA molecules. The CCHFV nucleocapsid protein (CCHFV NP) is encoded by the smallest segment of the virus. CCHFV NP, the primary function of which is the encapsidation of viral RNA molecules, plays a critical role in various mechanisms important for viral replication and pathogenesis. This review is an attempt to revisit the literature available on the highly immunogenic and highly conserved CCHFV NP, summarizing the multifunctional roles of this protein in the immunology of CCHFV. Specifically, the review addresses the impact of CCHFV NP on innate, humoral, and cellular immune responses, epitopes recognized by B and T cells that limit viral spread, and its role as a target for diagnostic tests and for vaccine design. Based on the extensive information generated by many research groups, it could be stated that NP constitutes a significant and critical player in the immunology of CCHFV.<\/jats:p>","DOI":"10.3390\/v16101547","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:45:27Z","timestamp":1727675127000},"page":"1547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean\u2013Congo Hemorrhagic Fever Virus (CCHFV)"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1260-5736","authenticated-orcid":false,"given":"Aysegul","family":"Pirincal","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine and Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vak\u0131f University, Istanbul 34093, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Z.","family":"Doymaz","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine and Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vak\u0131f University, Istanbul 34093, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1007\/s00705-017-3358-5","article-title":"Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017)","volume":"162","author":"Adams","year":"2017","journal-title":"Arch. 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