{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:32:53Z","timestamp":1760146373254,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)","award":["006\/2020","006\/2019-UNIVERSAL AMAZONAS","002\/2008","007\/2018","002\/2023\u2014POSGRAD 2023","005\/2019-PR\u00d3-ESTADO","003\/2022-PRODOC\/FAPEAM"],"award-info":[{"award-number":["006\/2020","006\/2019-UNIVERSAL AMAZONAS","002\/2008","007\/2018","002\/2023\u2014POSGRAD 2023","005\/2019-PR\u00d3-ESTADO","003\/2022-PRODOC\/FAPEAM"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","award":["006\/2020","006\/2019-UNIVERSAL AMAZONAS","002\/2008","007\/2018","002\/2023\u2014POSGRAD 2023","005\/2019-PR\u00d3-ESTADO","003\/2022-PRODOC\/FAPEAM"],"award-info":[{"award-number":["006\/2020","006\/2019-UNIVERSAL AMAZONAS","002\/2008","007\/2018","002\/2023\u2014POSGRAD 2023","005\/2019-PR\u00d3-ESTADO","003\/2022-PRODOC\/FAPEAM"]}]},{"name":"CNPq","award":["006\/2020","006\/2019-UNIVERSAL AMAZONAS","002\/2008","007\/2018","002\/2023\u2014POSGRAD 2023","005\/2019-PR\u00d3-ESTADO","003\/2022-PRODOC\/FAPEAM"],"award-info":[{"award-number":["006\/2020","006\/2019-UNIVERSAL AMAZONAS","002\/2008","007\/2018","002\/2023\u2014POSGRAD 2023","005\/2019-PR\u00d3-ESTADO","003\/2022-PRODOC\/FAPEAM"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>A 9-year-old male with autism and a history of well-controlled epilepsy presented with acute headache, fever, and generalized tonic-clonic seizures. Initial diagnostics, including imaging and cerebrospinal fluid analysis, were inconclusive. However, further serological testing suggested the presence of the chikungunya virus, establishing a diagnosis of chikungunya-associated neurological manifestation. The patient was treated with anticonvulsants, antibiotics for secondary bacterial pneumonia, and supportive care, leading to a gradual recovery. This case highlights the importance of considering systemic viral infections in pediatric patients with neurological symptoms and underscores the potential for arboviruses like chikungunya to cause neurological manifestation.<\/jats:p>","DOI":"10.3390\/v16111658","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T04:11:38Z","timestamp":1729743098000},"page":"1658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurological Manifestation Associated with Chikungunya Infection in a Pediatric Patient from Itacoatiara, Brazilian Amazon: A Case Report"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4821-8100","authenticated-orcid":false,"given":"Samuel Benjamin Aguiar de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil"},{"name":"Tropical Medicine Post Graduation Program, School of Health Sciences, Amazonas State University, Manaus 69040-000, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-6096","authenticated-orcid":false,"given":"Barbara Aparecida","family":"Chaves","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0830-3909","authenticated-orcid":false,"given":"Maur\u00edcio Teixeira","family":"Lima","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-3868","authenticated-orcid":false,"given":"Alexandre Vilhena","family":"Silva-Neto","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil"},{"name":"Tropical Medicine Post Graduation Program, School of Health Sciences, Amazonas State University, Manaus 69040-000, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-9708","authenticated-orcid":false,"given":"Jady Shayenne Mota","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil"},{"name":"Tropical Medicine Post Graduation Program, School of Health Sciences, Amazonas State University, Manaus 69040-000, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-1940","authenticated-orcid":false,"given":"Wuelton Marcelo","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil"},{"name":"Tropical Medicine Post Graduation Program, School of Health Sciences, Amazonas State University, Manaus 69040-000, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-666X","authenticated-orcid":false,"given":"Michele de Souza","family":"Bastos","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil"},{"name":"Basic and Applied Immunology Post Graduation Program, Federal University of Amazonas, Manaus 69067-005, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7307-8851","authenticated-orcid":false,"given":"Vanderson de Souza","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil"},{"name":"Tropical Medicine Post Graduation Program, School of Health Sciences, Amazonas State University, Manaus 69040-000, Amazonas, Brazil"},{"name":"Instituto Todos Pela Sa\u00fade, S\u00e3o Paulo 01310-200, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.4269\/ajtmh.21-0189","article-title":"Clinical Features of Acute Chikungunya Virus Infection in Children and Adults during an Outbreak in the Maldives","volume":"105","author":"Imad","year":"2021","journal-title":"Am. 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