{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:27:22Z","timestamp":1792848442701,"version":"4.5.0"},"reference-count":86,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for genetic Engineering and Biotechnology of Havana, Cuba","award":["COC-1-2023-UNIPV\u2013ID S1.P0002"],"award-info":[{"award-number":["COC-1-2023-UNIPV\u2013ID S1.P0002"]}]},{"name":"Arturo Falaschi ICGEB Fellowship Programme of the International Center for Genetic Engineering and Biotechnology, Trieste, Italy","award":["COC-1-2023-UNIPV\u2013ID S1.P0002"],"award-info":[{"award-number":["COC-1-2023-UNIPV\u2013ID S1.P0002"]}]},{"name":"PNRR \u201cGENESIS\u201d","award":["COC-1-2023-UNIPV\u2013ID S1.P0002"],"award-info":[{"award-number":["COC-1-2023-UNIPV\u2013ID S1.P0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue virus (DENV) causes the most prevalent and rapidly spreading arboviral disease of humans. It enters human cells by receptor-mediated endocytosis. Numerous cell-surface proteins were proposed as DENV entry factors. Among these, the phosphatidylserine receptor TIM-1 is the only one known to mediate virus internalization. However, several cellular models lacking TIM-1 are permissive to DENV infection, suggesting that other receptors exist. Here, we show that the low-density lipoprotein receptor-related protein-1 (LRP1) binds DENV virions by interacting with the DIII of the viral envelope glycoprotein. DENV infection is effectively inhibited by the purified receptor at 5 \u00d7 10\u22128 mol\/L, and the interaction of the envelope protein with LRP1 is also blocked by a natural ligand of LRP1. The depletion of LRP1 causes 100-fold lower production of infectious virus than controls. Our results indicate that LRP1 is another DENV receptor, thus becoming an attractive target to evaluate for the development of effective antiviral drugs against DENV.<\/jats:p>","DOI":"10.3390\/v16111692","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T12:25:39Z","timestamp":1730291139000},"page":"1692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Low-Density Lipoprotein Receptor-Related Protein-1 Is Essential for Dengue Virus Infection"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-1757","authenticated-orcid":false,"given":"Vivian","family":"Huerta","sequence":"first","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7291-2274","authenticated-orcid":false,"given":"Alejandro M.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Sarr\u00eda","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-3394","authenticated-orcid":false,"given":"Osmany","family":"Guirola","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7406-8740","authenticated-orcid":false,"given":"Alexis","family":"Yero","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-3830","authenticated-orcid":false,"given":"Yassel","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Pupo","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayron","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-2399","authenticated-orcid":false,"given":"Tea","family":"Carletti","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-4342","authenticated-orcid":false,"given":"Luis G.","family":"Gonz\u00e1lez-Lodeiro","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-8202","authenticated-orcid":false,"given":"Alessandro","family":"Marcello","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glay","family":"Chinea","sequence":"additional","affiliation":[{"name":"Department of System Biology, Direction of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16055","DOI":"10.1038\/nrdp.2016.55","article-title":"Dengue infection","volume":"2","author":"Guzman","year":"2016","journal-title":"Nat. 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