{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:33:09Z","timestamp":1760146389989,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["101003673"],"award-info":[{"award-number":["101003673"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>In the frame of the I-MOVE-COVID-19 project, a cohort of 2050 patients admitted in two Spanish reference hospitals between March 2020 and December 2021 was selected and a range of clinical factor data were collected at admission to assess their impact on the risk COVID-19 severity outcomes through a multivariate adjusted analysis and nomograms. The need for ventilation and intensive care unit (ICU) admission were found to be directly associated with a higher death risk (OR 6.9 and 3.2, respectively). The clinical predictors of death were the need for ventilation and ICU, advanced age, neuromuscular disorders, thrombocytopenia, hypoalbuminemia, dementia, cancer, elevated creatin phosphokinase (CPK), and neutrophilia (OR between 1.8 and 3.5), whilst the presence of vomiting, sore throat, and cough diminished the risk of death (OR 0.5, 0.2, and 0.1, respectively). Admission to ICU was predicted by the need for ventilation, abdominal pain, and elevated lactate dehydrogenase (LDH) (OR 371.0, 3.6, and 2.2, respectively) as risk factors; otherwise, it was prevented by advanced age (OR 0.5). In turn, the need for ventilation was predicted by low oxygen saturation, elevated LDH and CPK, diabetes, neutrophilia, obesity, and elevated GGT (OR between 1.7 and 5.2), whilst it was prevented by hypertension (OR 0.5). These findings could enhance patient management and strategic interventions to combat COVID-19.<\/jats:p>","DOI":"10.3390\/v16111705","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T06:55:37Z","timestamp":1730357737000},"page":"1705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-0124","authenticated-orcid":false,"given":"Miriam","family":"Latorre-Mill\u00e1n","sequence":"first","affiliation":[{"name":"Research Group on Infections Difficult to Diagnose and Treat, Miguel Servet University Hospital, Institute for Health Research Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6933-1102","authenticated-orcid":false,"given":"Mar\u00eda Mar","family":"Rodr\u00edguez del \u00c1guila","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Preventiva, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-2331","authenticated-orcid":false,"given":"Laura","family":"Clusa","sequence":"additional","affiliation":[{"name":"Research Group on Infections Difficult to Diagnose and Treat, Miguel Servet University Hospital, Institute for Health Research Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6909-6923","authenticated-orcid":false,"given":"Clara","family":"Mazagatos","sequence":"additional","affiliation":[{"name":"National Centre of Epidemiology, Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-2245","authenticated-orcid":false,"given":"Amparo","family":"Larrauri","sequence":"additional","affiliation":[{"name":"National Centre of Epidemiology, Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Amelia","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Preventiva, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7294-245X","authenticated-orcid":false,"given":"Antonio","family":"Rezusta","sequence":"additional","affiliation":[{"name":"Research Group on Infections Difficult to Diagnose and Treat, Miguel Servet University Hospital, Institute for Health Research Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-8952","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Milagro","sequence":"additional","affiliation":[{"name":"Research Group on Infections Difficult to Diagnose and Treat, Miguel Servet University Hospital, Institute for Health Research Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"ref_1","unstructured":"(2024, July 25). 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