{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:46:14Z","timestamp":1772502374376,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA-ARS","doi-asserted-by":"publisher","award":["G-202302-69885"],"award-info":[{"award-number":["G-202302-69885"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"USDA-ARS","doi-asserted-by":"publisher","award":["PICT 2021-0953"],"award-info":[{"award-number":["PICT 2021-0953"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"USDA-ARS","doi-asserted-by":"publisher","award":["PD-I 113"],"award-info":[{"award-number":["PD-I 113"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["G-202302-69885"],"award-info":[{"award-number":["G-202302-69885"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2021-0953"],"award-info":[{"award-number":["PICT 2021-0953"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PD-I 113"],"award-info":[{"award-number":["PD-I 113"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INTA","award":["G-202302-69885"],"award-info":[{"award-number":["G-202302-69885"]}]},{"name":"INTA","award":["PICT 2021-0953"],"award-info":[{"award-number":["PICT 2021-0953"]}]},{"name":"INTA","award":["PD-I 113"],"award-info":[{"award-number":["PD-I 113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vaccine schemes against serotype O strains was studied, evaluating the impact of revaccination, antigen dose, and incorporation of additional FMDV serotypes. Na\u00efve cattle were immunized with seven distinct FMDV vaccines, receiving three doses of the same formulation at 0, 28, and 56 days post-primary vaccination (dpv). Serum samples were collected up to 70 dpv and tested by a virus-neutralizing test against serotype O strains from a South American lineage and two strains representative of two Asian lineages. Our results showed that vaccines containing the ME-SA topotype O1\/Campos strain developed cross-neutralizing responses against the two Asian viruses after the first vaccination. In contrast, significant heterotypic neutralizing antibody titers against the homologous topotype strain were only found after the second vaccination, indicating that the phylogenic relationship may differ from the antigenic profiles for these two viruses. The amount of the O1\/Campos strain and the revaccination were essential factors for neutralization against the homologous- and heterologous-type O FMDV viruses. The strain composition of the vaccine was only relevant for cross-neutralization against one of the Asian strains, suggesting potential intra-serotypic divergences for this pattern.<\/jats:p>","DOI":"10.3390\/v16111732","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T03:57:34Z","timestamp":1730692654000},"page":"1732","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Different Foot and Mouth Disease Vaccine Schemes in Cross-Neutralization Against Heterologous Serotype O Strains in Cattle"],"prefix":"10.3390","volume":"16","author":[{"given":"Mar\u00eda Cruz","family":"Miraglia","sequence":"first","affiliation":[{"name":"Instituto de Virolog\u00eda e Innovaciones Tecnol\u00f3gicas, CICVyA, INTA-CONICET, Buenos Aires 1686, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Barrios-Benito","sequence":"additional","affiliation":[{"name":"WOAH FMD Reference Laboratory, SENASA, Buenos Aires 1640, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Galdo-Novo","sequence":"additional","affiliation":[{"name":"WOAH FMD Reference Laboratory, SENASA, Buenos Aires 1640, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-7475","authenticated-orcid":false,"given":"Danilo","family":"Bucafusco","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Virolog\u00eda, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires (UBA), Buenos Aires 1427, Argentina"},{"name":"Instituto de Investigaciones en Producci\u00f3n Animal, UBA-CONICET, Buenos Aires 1427, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Taffarel","sequence":"additional","affiliation":[{"name":"Instituto de Virolog\u00eda e Innovaciones Tecnol\u00f3gicas, CICVyA, INTA-CONICET, Buenos Aires 1686, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra Victoria","family":"Capozzo","sequence":"additional","affiliation":[{"name":"Centro de Altos Estudios en Ciencias Humanas y de la Salud, CONICET-Universidad Abierta Interamericana, Av. Montes de Oca 745, Buenos Aires 1270, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Victor","family":"Borca","sequence":"additional","affiliation":[{"name":"Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0111-5358","authenticated-orcid":false,"given":"Daniel Mariano","family":"P\u00e9rez-Filgueira","sequence":"additional","affiliation":[{"name":"Instituto de Virolog\u00eda e Innovaciones Tecnol\u00f3gicas, CICVyA, INTA-CONICET, Buenos Aires 1686, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"ref_1","unstructured":"WOAH (2022). WOAH Chapter 3.1.8 Foot and Mouth Disease. 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