{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:13:28Z","timestamp":1789416808276,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Introduction: The development of chronic kidney disease (CKD) is a common and significant complication, contributing to morbidity after liver transplantation (LT). Cytomegalovirus (CMV) infection is common in the overall population, and relevant reinfection after LT may occur. CMV-associated kidney damage has been discussed, but the clinical significance on CKD development after LT remains unclear. Methods: A total of 745 patients who underwent LT between 2006 and 2017 were included in this retrospective analysis. Clinical data, as well as laboratory parameters, were analyzed. Univariate and multivariate analysis were performed. Results: The univariate analysis revealed significantly impaired estimated glomerular filtration rates (eGFRs) in patients with histories of CMV infection (81.4 (8\u2013137) mL\/min vs. 90.0 (5\u2013147) mL\/min; p = 0.004). This effect was confirmed in the multivariate analysis. Post-LT, eGFR was impaired in patients with CMV (re)infection at 6, 12, 36, and 60 months, 10 years, and 15 years after LT. Immunosuppressive levels were comparable between groups. Overall survival was negatively affected by CMV infection (p = 0.001). Discussion: A clinically significant detrimental impact of CMV infection on renal function was observed, that could individualize clinical risk evaluation prior and after LT further. However, the pathophysiological mechanisms behind this observation are not yet understood.<\/jats:p>","DOI":"10.3390\/v16121830","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T04:02:18Z","timestamp":1732593738000},"page":"1830","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-3560","authenticated-orcid":false,"given":"Ramin Raul","family":"Ossami Saidy","sequence":"first","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Eurich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1482-6255","authenticated-orcid":false,"given":"Brigitta","family":"Globke","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Academy, Clinician Scientist Program, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzel","family":"Sch\u00f6ning","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-1673","authenticated-orcid":false,"given":"Robert","family":"\u00d6llinger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-7063","authenticated-orcid":false,"given":"Nathanael","family":"Raschzok","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Academy, Clinician Scientist Program, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Pratschke","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Eurich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1616-9826","authenticated-orcid":false,"given":"Eva Maria","family":"Dobrindt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus Virchow Klinikum and Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11901-020-00527-9","article-title":"Selection for Liver Transplantation: Indications and Evaluation","volume":"19","author":"Mahmud","year":"2020","journal-title":"Curr. Hepatol. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Vohra, V., Gupta, N., Jolly, A.S., and Bhalotra, S. (2023). Indication and Contraindications for Liver Transplantation. Peri-Operative Anesthetic Management in Liver Transplantation, Springer Nature.","DOI":"10.1007\/978-981-19-6045-1"},{"key":"ref_3","first-page":"101681","article-title":"Immunosuppression in liver transplant","volume":"46\u201347","author":"Little","year":"2020","journal-title":"Best. Pr. Res. Clin. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s12072-020-10091-5","article-title":"Immunosuppressive regimens for adult liver transplant recipients in real-life practice: Consensus recommendations from an Italian Working Group","volume":"14","author":"Cillo","year":"2020","journal-title":"Hepatol. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.12659\/AOT.889299","article-title":"Mycophenolate mofetil in liver transplantation: A review","volume":"18","author":"Kaltenborn","year":"2013","journal-title":"Ann. Transpl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21037\/tgh.2020.02.07","article-title":"Metabolic syndrome following liver transplantation in nonalcoholic steatohepatitis","volume":"6","author":"Spiritos","year":"2020","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.21037\/jtd.2018.04.79","article-title":"New frontiers in immunosuppression","volume":"10","author":"Benvenuto","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.transproceed.2013.02.033","article-title":"New Perspectives of Immunosuppression","volume":"45","author":"Halleck","year":"2013","journal-title":"Transplant. Proc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/tri.12553","article-title":"The need for minimization strategies: Current problems of immunosuppression","volume":"28","author":"Bamoulid","year":"2015","journal-title":"Transpl. Int."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Safdar, A. (2019). Infections in Liver Transplantation. Principles and Practice of Transplant Infectious Diseases, Springer.","DOI":"10.1007\/978-1-4939-9034-4"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100317","DOI":"10.1016\/j.aohep.2021.100317","article-title":"The changing impact of pre-liver transplant renal dysfunction on post-transplant survival: Results of 2 decades from a single center","volume":"24","author":"Wadei","year":"2021","journal-title":"Ann. Hepatol."},{"key":"ref_12","first-page":"1","article-title":"Renal Dysfunction in Liver Transplant Candidates: Evaluation, Classification and Management in Contemporary Practice","volume":"6","author":"Gleisner","year":"2012","journal-title":"J. Nephrol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.transproceed.2007.04.025","article-title":"Overview of the MELD score and the UNOS adult liver allocation system","volume":"39","author":"Martin","year":"2007","journal-title":"Transpl. Proc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101306","DOI":"10.1016\/j.jceh.2023.101306","article-title":"Post Liver Transplant Renal Dysfunction-Evaluation, Management and Immunosuppressive Practice","volume":"14","author":"Raja","year":"2024","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4254\/wjh.v14.i1.45","article-title":"Current aspects of renal dysfunction after liver transplantation","volume":"14","author":"Pacheco","year":"2022","journal-title":"World J. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1111\/tri.14154","article-title":"Post-liver transplantation chronic kidney disease is associated with increased cardiovascular disease risk and poor survival","volume":"34","author":"Bhanji","year":"2021","journal-title":"Transpl. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/2050640617707089","article-title":"Outcome and natural course of renal dysfunction in liver transplant recipients with severely impaired kidney function prior to transplantation","volume":"6","author":"Horvatits","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1002\/lt.21900","article-title":"Outcomes after liver transplantation: Chronic kidney disease","volume":"15","author":"Bahirwani","year":"2009","journal-title":"Liver Transpl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13643-022-02004-4","article-title":"Prevalence, incidence, and risk factors associated with cytomegalovirus infection in healthcare and childcare worker: A systematic review and meta-analysis","volume":"11","author":"Balegamire","year":"2022","journal-title":"Syst. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e13512","DOI":"10.1111\/ctr.13512","article-title":"Cytomegalovirus in solid organ transplant recipients\u2014Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Razonable","year":"2019","journal-title":"Clin. Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3947\/ic.2013.45.3.260","article-title":"Cytomegalovirus infections in solid organ transplantation: A review","volume":"45","author":"Ramanan","year":"2013","journal-title":"Infect. Chemother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e13553","DOI":"10.1111\/tid.13553","article-title":"Primary sclerosing cholangitis as an independent risk factor for cytomegalovirus infection after liver transplant","volume":"23","author":"Sauter","year":"2021","journal-title":"Transpl. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1086\/379711","article-title":"Cytomegalovirus Infection in Immunocompetent Patients","volume":"37","author":"Wreghitt","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1743-422X-5-47","article-title":"Severe cytomegalovirus infection in apparently immunocompetent patients: A systematic review","volume":"5","author":"Rafailidis","year":"2008","journal-title":"Virol. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13613-016-0207-8","article-title":"Cytomegalovirus infection in immunocompetent critically ill adults: Literature review","volume":"6","author":"Aljamaan","year":"2016","journal-title":"Ann. Intensive Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.5694\/mja14.00183","article-title":"Cytomegalovirus disease in immunocompetent adults","volume":"201","author":"Lancini","year":"2014","journal-title":"Med. J. Aust."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1590\/S1679-45082015RW3175","article-title":"Cytomegalovirus infection in renal transplantation: Clinical aspects, management and the perspectives","volume":"13","year":"2015","journal-title":"Einstein (Sao Paulo)"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wall, N.A., Chue, C.D., Edwards, N.C., Pankhurst, T., Harper, L., Steeds, R.P., Lauder, S., Townend, J.N., Moss, P., and Ferro, C.J. (2013). Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055686"},{"key":"ref_29","first-page":"239","article-title":"Cytomegalovirus and kidney","volume":"30","author":"Battegay","year":"1988","journal-title":"Clin. Nephrol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ckj\/sft002","article-title":"Viruses and collapsing glomerulopathy: A brief critical review","volume":"6","author":"Chandra","year":"2012","journal-title":"Clin. Kidney J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/ndt\/18.1.187","article-title":"Acute cytomegalovirus infection complicated by collapsing glomerulopathy","volume":"18","author":"Tomlinson","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/ckj\/sft156","article-title":"The significance of tubuloreticular inclusions as a marker of systemic stimulation by interferons in a case of focal and segmental glomerulosclerosis associated with cytomegalovirus (CMV) infection","volume":"7","author":"Bromfield","year":"2014","journal-title":"Clin. Kidney J."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Masset, C., Le Turnier, P., Bressollette-Bodin, C., Renaudin, K., Raffi, F., and Dantal, J. (2022). Virus-Associated Nephropathies: A Narrative Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231912014"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","article-title":"Evaluation and management of chronic kidney disease: Synopsis of the kidney disease: Improving global outcomes 2012 clinical practice guideline","volume":"158","author":"Stevens","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Engelmann, C., Sterneck, M., Weiss, K.H., Templin, S., Zopf, S., Denk, G., Eurich, D., Pratschke, J., Weiss, J., and Braun, F. (2020). Prevention and Management of CMV Infections after Liver Transplantation: Current Practice in German Transplant Centers. J. Clin. Med., 9.","DOI":"10.3390\/jcm9082352"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/lt.20721","article-title":"MELD and prediction of post-liver transplantation survival","volume":"12","author":"Habib","year":"2006","journal-title":"Liver Transpl."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ling, Q., Dai, H., Zhuang, R., Shen, T., Wang, W., Xu, X., and Zheng, S. (2017). Predicting short-term survival after liver transplantation on eight score systems: A national report from China Liver Transplant Registry. Sci. Rep., 7.","DOI":"10.1038\/srep42253"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Romano, T.G., Schmidtbauer, I., Silva, F.M.d.Q., Pompilio, C.E., D\u2019Albuquerque, L.A.C., and Macedo, E. (2013). Role of MELD Score and Serum Creatinine as Prognostic Tools for the Development of Acute Kidney Injury after Liver Transplantation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064089"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Al Mana, H., Yassine, H.M., Younes, N.N., Al-Mohannadi, A., Al-Sadeq, D.W., Alhababi, D., Nasser, E.A., and Nasrallah, G.K. (2019). The Current Status of Cytomegalovirus (CMV) Prevalence in the MENA Region: A Systematic Review. Pathogens, 8.","DOI":"10.3390\/pathogens8040213"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e2034","DOI":"10.1002\/rmv.2034","article-title":"Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis","volume":"29","author":"Zuhair","year":"2019","journal-title":"Rev. Med. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Gliga, S., Fiedler, M., Dornieden, T., Achterfeld, A., Paul, A., Horn, P.A., Herzer, K., and Lindemann, M. (2021). Comparison of Three Cellular Assays to Predict the Course of CMV Infection in Liver Transplant Recipients. Vaccines, 9.","DOI":"10.3390\/vaccines9020088"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Pajenda, S., Kapps, S., Gerges, D., Hoermann, G., Wagner, L., Buchtele, N., Geist, B., Strassl, R., Schmidt, A., and Winnicki, W. (2021). Cytomegalovirus in urinary sediment in patients with acute kidney injury. BMC Nephrol., 22.","DOI":"10.1186\/s12882-021-02377-z"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jhep.2014.08.010","article-title":"Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance","volume":"61","author":"Albillos","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Irvine, K.M., Ratnasekera, I., Powell, E.E., and Hume, D.A. (2019). Causes and Consequences of Innate Immune Dysfunction in Cirrhosis. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00293"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/livers3030028","article-title":"Dysfunctions of Circulating Adaptive Immune Cells in End-Stage Liver Disease","volume":"3","author":"Liu","year":"2023","journal-title":"Livers"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/MCG.0000000000001039","article-title":"Impact of Cytomegalovirus Infection on the Outcome of Patients With Cirrhosis: A Preliminary Study","volume":"53","author":"Faivre","year":"2019","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5500\/wjt.v10.i7.183","article-title":"Cytomegalovirus infection after liver transplantation","volume":"10","author":"Rodriguez","year":"2020","journal-title":"World J. Transpl."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jceh.2017.05.011","article-title":"Cytomegalovirus Infection in Liver Transplant Recipients: Current Approach to Diagnosis and Management","volume":"7","author":"Yadav","year":"2017","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/clinids\/22.3.537","article-title":"Cytomegalovirus Infection Following Liver Transplantation: Review of the Literature","volume":"22","author":"Kanj","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Yadav, D.K., Adhikari, V.P., Yadav, R.K., Singh, A., Huang, X., Zhang, Q., Pandit, P., Ling, Q., and Liang, T. (2022). Antiviral prophylaxis or preemptive therapy for cytomegalovirus after liver transplantation?: A systematic review and meta-analysis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.953210"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S766","DOI":"10.1093\/ofid\/ofy229.2195","article-title":"LB21. Preemptive Therapy (PET) vs. Prophylaxis for Prevention of Cytomegalovirus (CMV) Disease in High-Risk Donor Seropositive\/Recipient Seronegative (D+R\u2212) Liver Transplant Recipients (LTR): A NIH-Sponsored, Randomized, Controlled, Multicenter Trial","volume":"5","author":"Singh","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Dobrer, S., Sherwood, K.R., Hirji, I., Lan, J., Gill, J., Matic, N., and Keown, P.A. (2023). Viral load kinetics and the clinical consequences of cytomegalovirus in kidney transplantation. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1302627"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e14196","DOI":"10.1111\/tid.14196","article-title":"Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantation","volume":"26","author":"Kollar","year":"2024","journal-title":"Transpl. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1111\/j.1600-6143.2011.03618.x","article-title":"Association of Cytomegalovirus Infection and Disease With Death and Graft Loss After Liver Transplant in High-Risk Recipients","volume":"11","author":"Bosch","year":"2011","journal-title":"Am. J. Transplant."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1053\/j.ajkd.2013.08.021","article-title":"Cytomegalovirus glomerulopathy and cytomegalovirus interstitial nephritis on sequential transplant kidney biopsies","volume":"63","author":"Vichot","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1034\/j.1600-6143.2002.20717.x","article-title":"Cytomegalovirus&#x2010;Induced Glomerular Vasculopathy in Renal Allografts: A Report of Two Cases","volume":"2","author":"Onuigbo","year":"2002","journal-title":"Am. J. Transplant."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/ckj\/sfs097","article-title":"Cytomegalovirus-induced collapsing focal segmental glomerulosclerosis","volume":"6","author":"Grover","year":"2012","journal-title":"Clin. Kidney J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.7150\/thno.58356","article-title":"Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells","volume":"11","author":"Kirkham","year":"2021","journal-title":"Theranostics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/ki.1986.58","article-title":"Cytomegalovirus glomerulopathy: A controversial lesion","volume":"29","author":"Herrera","year":"1986","journal-title":"Kidney Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.transproceed.2013.12.009","article-title":"Cytomegalovirus Disease After Liver Transplantation: A Nationwide Population-Based Study","volume":"46","author":"Liu","year":"2014","journal-title":"Transplant. Proc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/j.ackd.2019.08.006","article-title":"The Many Faces of Calcineurin Inhibitor Toxicity-What the FK?","volume":"27","author":"Farouk","year":"2020","journal-title":"Adv. Chronic Kidney Dis."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/12\/1830\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:39:30Z","timestamp":1760114370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/12\/1830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":61,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["v16121830"],"URL":"https:\/\/doi.org\/10.3390\/v16121830","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]}}}