{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:38:10Z","timestamp":1760146690119,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia (FAPESB)","award":["1637\/2011","028\/2010","INC0003\/2019","001","9600140","9600141","308167\/2021-0","473667\/2012-6"],"award-info":[{"award-number":["1637\/2011","028\/2010","INC0003\/2019","001","9600140","9600141","308167\/2021-0","473667\/2012-6"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)","award":["1637\/2011","028\/2010","INC0003\/2019","001","9600140","9600141","308167\/2021-0","473667\/2012-6"],"award-info":[{"award-number":["1637\/2011","028\/2010","INC0003\/2019","001","9600140","9600141","308167\/2021-0","473667\/2012-6"]}]},{"name":"the National Foundation for the Development of Private Higher Education (FUNADESP)","award":["1637\/2011","028\/2010","INC0003\/2019","001","9600140","9600141","308167\/2021-0","473667\/2012-6"],"award-info":[{"award-number":["1637\/2011","028\/2010","INC0003\/2019","001","9600140","9600141","308167\/2021-0","473667\/2012-6"]}]},{"name":"CNPq","award":["1637\/2011","028\/2010","INC0003\/2019","001","9600140","9600141","308167\/2021-0","473667\/2012-6"],"award-info":[{"award-number":["1637\/2011","028\/2010","INC0003\/2019","001","9600140","9600141","308167\/2021-0","473667\/2012-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Human T-cell leukemia virus type 1 (HTLV-1) is associated with an increased risk of tuberculosis (TB). This study aimed to evaluate the performance of the QuantiFERON-TB Gold (QFT) test for the diagnosis of Mycobacterium tuberculosis (MTB) infection in HTLV-1-infected individuals. HTLV-1-infected participants were divided into four groups: HTLV-1-infected individuals with a history of tuberculosis (HTLV\/TB), individuals with positive HTLV and tuberculin skin tests (HTLV\/TST+) or negative TST (HTLV\/TST\u2212), and HTLV-1-negative individuals with positive TST results (HN\/TST+). We compared the diagnostic performance of the QFT assay with that of the TST as a reference and evaluated test sensitivity, specificity, accuracy, likelihood ratio, and diagnostic odds ratio. The results showed a higher frequency of positive TST results and induration diameter \u226510 mm in HTLV-1-infected individuals than in the controls. The QFT test was more frequently positive in the HTLV\/TB group than in the other groups, while a combined analysis of HTLV\/TB and HTLV\/TST+ indicated a QFT sensitivity of 57.5%. No significant differences were found in the other diagnostic performance measures, as QFT test results were in agreement with TST results, particularly in TST-negative individuals. Given the low sensitivity of QFT for LTBI in individuals infected with HTLV-1, the TST may be preferable in regions where both infections are endemic.<\/jats:p>","DOI":"10.3390\/v16121873","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T06:58:58Z","timestamp":1733122738000},"page":"1873","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of QuantiFERON-TB Gold for the Diagnosis of Mycobacterium tuberculosis Infection in HTLV-1-Infected Patients"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-3558","authenticated-orcid":false,"given":"Luana Leandro","family":"Gois","sequence":"first","affiliation":[{"name":"Departamento de Biointera\u00e7\u00e3o, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal da Bahia, Salvador 40231-300, Bahia, Brazil"},{"name":"Laborat\u00f3rio Avan\u00e7ado de Sa\u00fade P\u00fablica, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2586-7877","authenticated-orcid":false,"given":"Nat\u00e1lia Barbosa","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Salvador 40110-060, Bahia, Brazil"},{"name":"Laborat\u00f3rio de Bacteriologia e Sa\u00fade, Instituto de Biologia, Universidade Federal da Bahia, Salvador 40170-110, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-0818","authenticated-orcid":false,"given":"Fred Luciano Neves","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Avan\u00e7ado de Sa\u00fade P\u00fablica, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Gustavo","family":"Regis-Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Avan\u00e7ado de Sa\u00fade P\u00fablica, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thain\u00e1 Gon\u00e7alves Tolentino","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador 40290-000, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Galv\u00e3o-Castro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Avan\u00e7ado de Sa\u00fade P\u00fablica, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil"},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador 40290-000, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-8002","authenticated-orcid":false,"given":"Edgar Marcelino","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Salvador 40110-060, Bahia, Brazil"},{"name":"Laborat\u00f3rio de Pesquisa Cl\u00ednica, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-5569","authenticated-orcid":false,"given":"Maria Fernanda Rios","family":"Grassi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Avan\u00e7ado de Sa\u00fade P\u00fablica, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil"},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador 40290-000, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"ref_1","first-page":"205","article-title":"The Prevalence of Human T-Cell Lymphotropic Virus Type 1 in the General Population Is Unknown","volume":"11","author":"Hlela","year":"2009","journal-title":"AIDS Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Gessain, A., and Cassar, O. (2012). Epidemiological Aspects and World Distribution of HTLV-1 Infection. Front. Microbiol., 3.","DOI":"10.3389\/fmicb.2012.00388"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pereira, F.M., de Almeida, M.d.C.C., Santos, F.L.N., Carreiro, R.P., Regis-Silva, C.G., Galv\u00e3o-Castro, B., and Grassi, M.F.R. (2019). Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01002"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1016\/S2666-5247(22)00359-7","article-title":"WHO\u2019s Global Tuberculosis Report 2022","volume":"4","author":"Bagcchi","year":"2023","journal-title":"Lancet Microbe"},{"key":"ref_5","first-page":"959","article-title":"Seroepidemiology of Human T-Cell Lymphotropic Virus Type I\/II in Northeastern Brazil","volume":"6","author":"Moreira","year":"1993","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_6","first-page":"31","article-title":"Co-Infection of Tuberculosis and HIV\/HTLV Retroviruses: Frequency and Prognosis Among Patients Admitted in a Brazilian Hospital","volume":"1","author":"Pedrosa","year":"1997","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_7","first-page":"1519","article-title":"Prevalence of Human T-Cell Lymphotropic Virus Type 1 Infection in Hospitalized Patients with Tuberculosis","volume":"13","author":"Osterbauer","year":"2009","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/01.qai.0000174252.73516.7a","article-title":"Increased Risk of Tuberculosis with Human T-Lymphotropic Virus-1 Infection: A Case-Control Study","volume":"40","author":"Marinho","year":"2005","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Grassi, M.F.R., Dos Santos, N.P., L\u00edrio, M., Kritski, A.L., Chagas Almeida, M.d.C., Santana, L.P., L\u00e1zaro, N., Dias, J., Netto, E.M., and Galv\u00e3o-Castro, B. (2016). Tuberculosis Incidence in a Cohort of Individuals Infected with Human T-Lymphotropic Virus Type 1 (HTLV-1) in Salvador, Brazil. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1428-z"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/CVI.13.5.547-552.2006","article-title":"Peripheral Blood Mononuclear Cells from Individuals Infected with Human T-Cell Lymphotropic Virus Type 1 Have a Reduced Capacity to Respond to Recall Antigens","volume":"13","author":"Mascarenhas","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tube.2017.10.004","article-title":"Impaired TNF, IL-1\u03b2, and IL-17 Production and Increased Susceptibility to Mycobacterium Tuberculosis Infection in HTLV-1 Infected Individuals","volume":"108","author":"Carvalho","year":"2018","journal-title":"Tuberculosis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ijc.2910420605","article-title":"Suppression of Tuberculin Skin Reaction in Healthy HTLV-I Carriers from Japan","volume":"42","author":"Tachibana","year":"1988","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1089\/aid.2006.22.931","article-title":"Proposal for Diagnostic Criteria of Tropical Spastic Paraparesis\/HTLV-I-Associated Myelopathy (TSP\/HAM)","volume":"22","author":"Barreto","year":"2006","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1590\/S1806-37132004000700002","article-title":"II Consenso Brasileiro de Tuberculose: Diretrizes Brasileiras para Tuberculose 2004","volume":"30","author":"Kritski","year":"2004","journal-title":"J. Bras. Pneumol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0166-0934(01)00445-1","article-title":"Quantitation of HTLV-I Proviral Load by a TaqMan Real-Time PCR Assay","volume":"102","author":"Plumelle","year":"2002","journal-title":"J. Virol. Methods"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e012799","DOI":"10.1136\/bmjopen-2016-012799","article-title":"STARD 2015 Guidelines for Reporting Diagnostic Accuracy Studies: Explanation and Elaboration","volume":"6","author":"Cohen","year":"2016","journal-title":"BMJ Open"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S1473-3099(04)01206-X","article-title":"Interferon-Gamma Assays in the Immunodiagnosis of Tuberculosis: A Systematic Review","volume":"4","author":"Pai","year":"2004","journal-title":"Lancet Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1590\/0037-8682-0258-2015","article-title":"Diagnosis of Latent Mycobacterium Tuberculosis Infection: Tuberculin Test versus Interferon-Gamma Release","volume":"48","author":"Ferreira","year":"2015","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1590\/S1806-37132009001000011","article-title":"III Diretrizes para Tuberculose da Sociedade Brasileira de Pneumologia e Tisiologia","volume":"35","author":"Conde","year":"2009","journal-title":"J. Bras. Pneumol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"256148","DOI":"10.1155\/2013\/256148","article-title":"Blood Cells and Interferon-Gamma Levels Correlation in Latent Tuberculosis Infection","volume":"2013","author":"Takenami","year":"2013","journal-title":"ISRN Pulmonol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/ofid\/ofw172.86","article-title":"Interferon Gamma Release Assay and Tuberculin Skin Test Agreement for the Diagnosis of Latent Tuberculosis in Human T- Lymphotropic Virus Subjects","volume":"3","author":"Luhmann","year":"2016","journal-title":"Open Forum Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Umekita, K., Hashiba, Y., Iwao, K., Iwao, C., Kimura, M., Kariya, Y., Kubo, K., Miyauchi, S., Kudou, R., and Rikitake, Y. (2020). Human T-Cell Leukemia Virus Type 1 May Invalidate T-SPOT.TB Assay Results in Rheumatoid Arthritis Patients: A Retrospective Case-Control Observational Study. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0233159"},{"key":"ref_23","first-page":"4862","article-title":"Persistent Clonal Proliferation of Human T-Lymphotropic Virus Type I-Infected Cells in Vivo","volume":"57","author":"Etoh","year":"1997","journal-title":"Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000097259","article-title":"Modulation of T Cell Responses in HTLV-1 Carriers and in Patients with Myelopathy Associated with HTLV-1","volume":"13","author":"Santos","year":"2006","journal-title":"Neuroimmunomodulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-3083.2007.01941.x","article-title":"Patterns of in Vitro Lymphoproliferative Responses among HTLV-1-Infected Subjects: Upregulation by HTLV-1 during HIV-1 Co-Infection","volume":"65","author":"Olah","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Futsch, N., Prates, G., Mahieux, R., Casseb, J., and Dutartre, H. (2018). Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases. Viruses, 10.","DOI":"10.3390\/v10120691"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.biopha.2007.02.006","article-title":"Induction of Pro-Inflammatory Cytokines by Human T-Cell Leukemia Virus Type-1 Tax Protein as Determined by Multiplexed Cytokine Protein Array Analyses of Human Dendritic Cells","volume":"61","author":"Ahuja","year":"2007","journal-title":"Biomed. Pharmacother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/aid.2015.0340","article-title":"Association of Tuberculosis Status with Neurologic Disease and Immune Response in HTLV-1 Infection","volume":"33","author":"Souza","year":"2017","journal-title":"AIDS Res. Hum. Retroviruses"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/12\/1873\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:44:01Z","timestamp":1760114641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/12\/1873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["v16121873"],"URL":"https:\/\/doi.org\/10.3390\/v16121873","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2024,11,30]]}}}