{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:43:19Z","timestamp":1780364599390,"version":"3.54.1"},"reference-count":89,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Council for Scientific and Technological Development (CNPq, acronym in Portuguese) of the Brazilian Ministry of Science, Technology, Innovations, and Communications","award":["426529\/2018-9"],"award-info":[{"award-number":["426529\/2018-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Arthropod-borne viral diseases are acute febrile illnesses, sometimes with chronic effects, that can be debilitating and even fatal worldwide, affecting particularly vulnerable populations. Indigenous communities face not only the burden of these acute febrile illnesses, but also the cardiovascular complications that are worsened by urbanization. A cross-sectional study was conducted in an Indigenous population in the Northeast Region of Brazil to explore the association between arboviral infections (dengue, chikungunya, and Zika) and cardiac biomarkers, including cardiotrophin 1, growth differentiation factor 15, lactate dehydrogenase B, fatty-acid-binding protein 3, myoglobin, N-terminal pro-B-type natriuretic peptide, cardiac troponin I, big endothelin 1, and creatine kinase-MB, along with clinical and anthropometric factors. The study included 174 individuals from the Fulni-\u00f4 community, with a median age of 47 years (interquartile range 39.0 to 56.0). High rates of previous exposure to dengue, chikungunya, and Zika were observed (92.5%, 78.2%, and 95.4% anti-IgG, respectively), while acute exposure (anti-IgM) remained low. The biomarkers were linked to age (especially in the elderly), obesity, chronic kidney disease, and previous or recent exposure to chikungunya. This study pioneers the use of Luminex xMAP technology to reveal the association between cardiac inflammatory biomarkers and exposure to classical arboviruses in an Indigenous population undergoing urbanization.<\/jats:p>","DOI":"10.3390\/v16121902","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T11:17:20Z","timestamp":1733829440000},"page":"1902","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-2414","authenticated-orcid":false,"given":"Jandir Mendon\u00e7a","family":"Nicacio","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"},{"name":"Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University\u2014UNEB, Juazeiro 48904-711, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7995-1893","authenticated-orcid":false,"given":"Carlos Dornels Freire de","family":"Souza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"},{"name":"Postgraduation Program in Epidemiology and Health Problems Control, Oswaldo Cruz Foundation\/Fiocruz, Recife 50670-420, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-7594","authenticated-orcid":false,"given":"Orlando Vieira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"},{"name":"Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University\u2014UNEB, Juazeiro 48904-711, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Vasconcelos","family":"Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Human Pathology, Faculty of Medicine of Bahia, Federal University of Bahia, Salvador 40026-010, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-6995","authenticated-orcid":false,"given":"Jo\u00e3o Augusto Costa","family":"Lima","sequence":"additional","affiliation":[{"name":"Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-6995","authenticated-orcid":false,"given":"Rodrigo Feliciano do","family":"Carmo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 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University of Pernambuco, Serra Talhada 56909-205, PE, Brazil"},{"name":"Agamenon Magalh\u00e3es Hospital, Serra Talhada 50751-530, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-9154","authenticated-orcid":false,"given":"Diego Guerra de Albuquerque","family":"Cabral","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Pernambuco\u2014LACEN, Recife 50050-215, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-4436","authenticated-orcid":false,"given":"Ricardo","family":"Khouri","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation\/Fiocruz, Institute Gon\u00e7alo Moniz, Salvador 40296-710, BA, Brazil"},{"name":"School of Medicine, Federal University of Bahia\u2014UFBA, Salvador 40170-110, BA, Brazil"},{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, 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Socio-Environmental Management, Bahia State University\u2014UNEB, Juazeiro 48904-711, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2024, November 27). 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