{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:37:53Z","timestamp":1762900673778,"version":"build-2065373602"},"reference-count":61,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"IHU OpeRa","doi-asserted-by":"publisher","award":["ANR-10-IBHU-004","19238","ANR 10 LABX 61","075-15-2019-1660"],"award-info":[{"award-number":["ANR-10-IBHU-004","19238","ANR 10 LABX 61","075-15-2019-1660"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"ANRS","doi-asserted-by":"publisher","award":["ANR-10-IBHU-004","19238","ANR 10 LABX 61","075-15-2019-1660"],"award-info":[{"award-number":["ANR-10-IBHU-004","19238","ANR 10 LABX 61","075-15-2019-1660"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French Laboratories of Excellence Network","doi-asserted-by":"publisher","award":["ANR-10-IBHU-004","19238","ANR 10 LABX 61","075-15-2019-1660"],"award-info":[{"award-number":["ANR-10-IBHU-004","19238","ANR 10 LABX 61","075-15-2019-1660"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["ANR-10-IBHU-004","19238","ANR 10 LABX 61","075-15-2019-1660"],"award-info":[{"award-number":["ANR-10-IBHU-004","19238","ANR 10 LABX 61","075-15-2019-1660"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Cyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the context of many viral infections including chronic hepatitis B and C. Cyps are a group of enzymes with peptidyl-prolyl isomerase activity (PPIase), known to be required for replication of diverse viruses including hepatitis B and C viruses (HBV and HCV). Amongst the Cyp family, the molecular mechanisms underlying the antiviral effects of CypA have been investigated in detail, but potential roles of other Cyps are less well studied in the context of viral hepatitis. Furthermore, most studies investigating the role of Cyps in viral hepatitis did not investigate the potential therapeutic effects of their inhibition in already-established infections but have rather been performed in the context of neo-infections. Here, we investigated the effects of genetically silencing Cyps on persistent HCV and HBV infections. We confirm antiviral effects of CypA and CypD knock down and demonstrate novel roles for CypG and CypH in HCV replication. We show, furthermore, that CypA silencing has a modest but reproducible impact on persistent HBV infections in cultured human hepatocytes.<\/jats:p>","DOI":"10.3390\/v17010011","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:19:32Z","timestamp":1735154372000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5447-5253","authenticated-orcid":false,"given":"Jennifer","family":"Molle","sequence":"first","affiliation":[{"name":"INSERM U1052, CNRS UMR5286, Universit\u00e9 Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon Hepatology Institute (IHU Everest), 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3727-2478","authenticated-orcid":false,"given":"Sarah","family":"Duponchel","sequence":"additional","affiliation":[{"name":"INSERM U1052, CNRS UMR5286, Universit\u00e9 Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon Hepatology Institute (IHU Everest), 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rieusset","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, INSERM U1060, INRA U1397, Lyon Hepatology Institute, 69007 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Ovize","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, INSERM U1060, INRA U1397, Lyon Hepatology Institute, 69007 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-9679","authenticated-orcid":false,"given":"Alexander V.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2245-0083","authenticated-orcid":false,"given":"Fabien","family":"Zoulim","sequence":"additional","affiliation":[{"name":"INSERM U1052, CNRS UMR5286, Universit\u00e9 Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon Hepatology Institute (IHU Everest), 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-4660","authenticated-orcid":false,"given":"Birke","family":"Bartosch","sequence":"additional","affiliation":[{"name":"INSERM U1052, CNRS UMR5286, Universit\u00e9 Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon Hepatology Institute (IHU Everest), 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/0962-8924(92)90200-7","article-title":"Cyclophilins: A new family of proteins involved in intracellular folding","volume":"2","author":"Stamnes","year":"1992","journal-title":"Trends Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e888","DOI":"10.1038\/cddis.2013.410","article-title":"Cyclophilin a: A key player for human disease","volume":"4","author":"Nigro","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1242\/jcs.028654","article-title":"Overexpressed cyclophilin b suppresses apoptosis associated with ros and Ca2+ homeostasis after er stress","volume":"121","author":"Kim","year":"2008","journal-title":"J. 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