{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:18:48Z","timestamp":1790792328317,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Technical and Scientific National Council (CONICET), University National of South (UNS), South Chemical Institute (INQUISUR)","award":["PGI N\u00b024\/ZQ09"],"award-info":[{"award-number":["PGI N\u00b024\/ZQ09"]}]},{"name":"Technical and Scientific National Council (CONICET), University National of South (UNS), South Chemical Institute (INQUISUR)","award":["PGI N\u00b024\/ZB95"],"award-info":[{"award-number":["PGI N\u00b024\/ZB95"]}]},{"name":"Technical and Scientific National Council (CONICET), University National of South (UNS), South Chemical Institute (INQUISUR)","award":["PIP 11220200100935CO"],"award-info":[{"award-number":["PIP 11220200100935CO"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Viral infections remain a major concern, as existing treatments often yield inadequate responses or lead to the development of antiviral resistance in some cases. Fucoidan extracted from Undaria pinnatifida (F) is a natural sulphated polysaccharide that exhibits antiviral action. Despite its potential, the biomedical application of F is limited due to its difficult administration through trans-mucosal, skin, or oral ingestion. The most effective way to solve these problems is to propose novel methods of administration aiming to ensure better contact between the biopolymers and pathogens, leading to their inactivation. In this work, the synthesis of films based on chitosan (Ch)-coupled F is reported, aiming to generate a synergic effect between both biopolymers in terms of their antiviral and antioxidant capability. Biocomposites were prepared by a sonochemical method. They were characterized to infer structural properties, functionality, and possible F-Ch interactions by using Zeta potential, FTIR, and XRD techniques. The biocomposites showed excellent film-forming ability. They also exhibited improved antioxidant activity with respect to F and Ch individually and proved to be non-cytotoxic. These results demonstrate, for the first time, the antiviral activity of F:Ch biocomposites against bovine coronavirus and human viruses (adenovirus, poliovirus, herpes simplex, and respiratory syncytial virus), which could be applied in film form to prevent or treat viral infections.<\/jats:p>","DOI":"10.3390\/v17020216","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T05:36:32Z","timestamp":1738560992000},"page":"216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New Insights into Antiviral Natural Formulations: Biopolymeric Films for the Prevention and Treatment of a Wide Gamma of Viral Infections"],"prefix":"10.3390","volume":"17","author":[{"given":"Victoria Bel\u00e9n","family":"Ayala-Pe\u00f1a","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda, Bioqu\u00edmica y Farmacia, Universidad Nacional del Sur, San Juan 670, Bah\u00eda Blanca 8000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Karen","family":"Jaimes","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires 8000, Argentina"},{"name":"INQUISUR, Departamento de Qu\u00edmica, Universidad Nacional del Sur, Av. Alem 1253, Bah\u00eda Blanca 8000, Argentina"},{"name":"Facultad de Ingenier\u00eda, INTEMA, Universidad Nacional de Mar del Plata (UNMdP), Av. Col\u00f3n 10850, Mar del Plata 2695, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luc\u00eda","family":"Conesa","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda, Bioqu\u00edmica y Farmacia, Universidad Nacional del Sur, San Juan 670, Bah\u00eda Blanca 8000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-7176","authenticated-orcid":false,"given":"Cybele Carina","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires 8000, Argentina"},{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Av. Int. 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G\u00fciraldes 2610, Buenos Aires 1053, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Gaspar","family":"Dellatorre","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires 8000, Argentina"},{"name":"Facultad Regional Chubut, Grupo de Investigaci\u00f3n y Desarrollo Tecnol\u00f3gico en Acuicultura y Pesca (GIDTAP), Universidad Tecnol\u00f3gica Nacional, Av. del Trabajo 1536, Puerto Madryn 3000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Latour","sequence":"additional","affiliation":[{"name":"Facultad Regional Chubut, Grupo de Investigaci\u00f3n y Desarrollo Tecnol\u00f3gico en Acuicultura y Pesca (GIDTAP), Universidad Tecnol\u00f3gica Nacional, Av. del Trabajo 1536, Puerto Madryn 3000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora Marta Andrea","family":"Ponce","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires 8000, Argentina"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales and Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR-UBA), Universidad de Buenos Aires, Intendente G\u00fciraldes 2160, Buenos Aires 1053, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4909-4592","authenticated-orcid":false,"given":"Vera Alejandra","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires 8000, Argentina"},{"name":"Facultad de Ingenier\u00eda, INTEMA, Universidad Nacional de Mar del Plata (UNMdP), Av. 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