{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:33:21Z","timestamp":1781825601711,"version":"3.54.5"},"reference-count":25,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Carlos Chagas Filho Foundation","award":["E-26\/211.865\/2016"],"award-info":[{"award-number":["E-26\/211.865\/2016"]}]},{"name":"Carlos Chagas Filho Foundation","award":["E-26\/211.849\/2016"],"award-info":[{"award-number":["E-26\/211.849\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>This study aims to describe neurological, visual, and auditory findings in children whose mothers had confirmed Zika virus (ZIKV) infection during pregnancy, with most of these children not presenting congenital microcephaly; Methods: an observational, longitudinal, and prospective study was conducted in Rio de Janeiro, Brazil, from March 2015 to January 2017, involving children with in utero exposure to Zika virus, following from birth up to 30 months of age. Results: Of the 2882 pregnant women admitted, 116 had a suspected ZIKV infection, of whom 33 had laboratory confirmation. Only one child presented with congenital microcephaly. Despite this, neurodevelopment delay was observed in 36.4% of children evaluated, radiological abnormalities in 29.1%, auditory abnormalities in 8.3%, and ophthalmological abnormalities in 10%. Conclusions: Newborns of mothers with confirmed ZIKV infection during pregnancy may present with varying degrees of visual, auditory, and neurological impairment, despite the presence of congenital microcephaly.<\/jats:p>","DOI":"10.3390\/v17020238","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T05:53:22Z","timestamp":1739166802000},"page":"238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus"],"prefix":"10.3390","volume":"17","author":[{"given":"Marlos Melo","family":"Martins","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology, Martag\u00e3o Gesteira Institute of Childcare and Pediatrics (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-912, RJ, Brazil"},{"name":"Neonatal Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Bittencourt","family":"Guastavino","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"},{"name":"Postgraduate Program, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara","family":"de Magalh\u00e3es-Barbosa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Helena","family":"de Magalh\u00e3es-Barbosa","sequence":"additional","affiliation":[{"name":"Phonoaudiology Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8201-3918","authenticated-orcid":false,"given":"Cristiane Fregonesi Dutra","family":"Garcia","sequence":"additional","affiliation":[{"name":"Phonoaudiology Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"},{"name":"Department of Phonoaudiology, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21044-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Karine Gonet","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria Ciminelli","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gaffree and Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro 20270-004, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina Cidrini","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1483-9029","authenticated-orcid":false,"given":"Jaqueline Rodrigues","family":"Robaina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-8205","authenticated-orcid":false,"given":"Mariana Barros Genuino","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Freire","family":"Tovar-Moll","sequence":"additional","affiliation":[{"name":"Department of Radiology, D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-3930","authenticated-orcid":false,"given":"Roberto","family":"de Andrade Medronho","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21044-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Jos\u00e9 Ledo Alves","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil"},{"name":"Department of Pediatrics, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21044-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Joffre","family":"Amim","sequence":"additional","affiliation":[{"name":"Postgraduate Program, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"},{"name":"Department of Gynecology and Obstetrics, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21044-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-9782","authenticated-orcid":false,"given":"Arnaldo","family":"Prata-Barbosa","sequence":"additional","affiliation":[{"name":"Postgraduate Program, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil"},{"name":"Department of Pediatrics, D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika Virus and Birth Defects\u2014Reviewing the Evidence for Causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N. 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