{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:15:13Z","timestamp":1787030113333,"version":"build-2736575974"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research (ICMR)","doi-asserted-by":"publisher","award":["VIR\/5\/2019\/ECD-1"],"award-info":[{"award-number":["VIR\/5\/2019\/ECD-1"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Indian Council of Medical Research-National Institute for Research in Bacterial Infections (ICMR-NIRBI, formerly ICMR-NICED)","award":["VIR\/5\/2019\/ECD-1"],"award-info":[{"award-number":["VIR\/5\/2019\/ECD-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hepatitis C virus (HCV) is a global public health problem, but advancements in HCV treatment have improved the cure rate. This study evaluated the effectiveness of direct-acting antivirals (DAAs) in HCV-infected patients from May 2021 to April 2023 in collaboration with tertiary care hospitals in West Bengal. The HCV viral load was monitored via qRT-PCR. Sanger sequencing was performed to determine the HCV genotypes. The clinicians prescribed the patient treatment regime. The maximum number of patients in the study population (N = 398) were compensated cirrhosis patients (46.28%). The overall SVR rate of the study population was 94.47%. The decompensated cirrhosis patients experienced the lowest SVR rate (88.89%). The maximum number of patients were prescribed sofosbuvir\/daclatasvir (63.77%), and the lowest SVR rate (93.23%) was observed with this treatment regime. In the study population, GT-3 was the predominant (67.43%) circulating genotype, followed by GT-1 and -4. Among 398 patients, 22 (5.53%) were non-responsive to DAA treatment. Out of these 22 non-responder patients, 77.27% (n = 17) were GT-3-infected (3a:10; 3b:07), followed by GT-1 (1c: 04; 1b: 01). Thus, increasing numbers of DAA non-responsive cases among HCV GT-3-infected and decompensated cirrhosis patients may pose serious threats in the future.<\/jats:p>","DOI":"10.3390\/v17020269","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T04:40:25Z","timestamp":1739767225000},"page":"269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Different Combinations of Direct-Acting Antivirals Against Different Hepatitis C Virus-Infected Population Groups: An Experience in Tertiary Care Hospitals in West Bengal, India"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-2052","authenticated-orcid":false,"given":"Sagnik","family":"Bakshi","sequence":"first","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8720-8799","authenticated-orcid":false,"given":"Partha","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"College of Medicine & Sagore Dutta Hospital, 578 B.T Road, Kolkata 700058, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahiuddin","family":"Ahammed","sequence":"additional","affiliation":[{"name":"IPGME&R and SSKM Hospital, SSKM Hospital Rd, Bhowanipore, Kolkata 700020, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-5526","authenticated-orcid":false,"given":"Raina","family":"Das","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moumita","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-5146","authenticated-orcid":false,"given":"Supradip","family":"Dutta","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9537-2346","authenticated-orcid":false,"given":"Shreyasi","family":"Nath","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwesha","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttaran","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6363-886X","authenticated-orcid":false,"given":"Upasana","family":"Baskey","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Provash Chandra","family":"Sadhukhan","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections P-33, Scheme XM, CIT Road, Beliaghata, Kolkata 700010, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.4254\/wjh.v7.i10.1377","article-title":"Hepatitis C virus: Virology, diagnosis and treatment","volume":"7","author":"Li","year":"2015","journal-title":"World J. 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