{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:25:53Z","timestamp":1782444353796,"version":"3.54.5"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["AI147992"],"award-info":[{"award-number":["AI147992"]}]},{"name":"National Institutes of Health","award":["1R01AI173333"],"award-info":[{"award-number":["1R01AI173333"]}]},{"name":"National Institutes of Health","award":["R01AI177673"],"award-info":[{"award-number":["R01AI177673"]}]},{"name":"National Institutes of Health","award":["HD100170"],"award-info":[{"award-number":["HD100170"]}]},{"name":"National Institutes of Health","award":["UM1AI068632-15"],"award-info":[{"award-number":["UM1AI068632-15"]}]},{"name":"National Institutes of Health","award":["UM1AI068616-15"],"award-info":[{"award-number":["UM1AI068616-15"]}]},{"name":"National Institutes of Health","award":["UM1AI106716-15"],"award-info":[{"award-number":["UM1AI106716-15"]}]},{"name":"National Institutes of Health","award":["HHSN275201800001I"],"award-info":[{"award-number":["HHSN275201800001I"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH)","award":["AI147992"],"award-info":[{"award-number":["AI147992"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH)","award":["1R01AI173333"],"award-info":[{"award-number":["1R01AI173333"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH)","award":["R01AI177673"],"award-info":[{"award-number":["R01AI177673"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH)","award":["HD100170"],"award-info":[{"award-number":["HD100170"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH)","award":["UM1AI068632-15"],"award-info":[{"award-number":["UM1AI068632-15"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH)","award":["UM1AI068616-15"],"award-info":[{"award-number":["UM1AI068616-15"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH)","award":["UM1AI106716-15"],"award-info":[{"award-number":["UM1AI106716-15"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH)","award":["HHSN275201800001I"],"award-info":[{"award-number":["HHSN275201800001I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Congenital cytomegalovirus (cCMV) is the most common infectious cause of birth defects worldwide, affecting approximately 1 in every 200 live-born infants globally. Recent work has identified potential immune correlates of protection against cCMV transmission including maternal and placentally transferred antibody levels and their function, which may inform the development of maternal active (vaccine) and passive (mono\/polyclonal antibody) immunizations. However, these correlates need to also be assessed in diverse cohorts, including women living with HIV who have increased risk of cCMV transmission. Using a case\u2013control design, we investigated whether the magnitude, specificity, function and placental transfer of maternal IgG responses are associated with protection against and\/or risk of cCMV transmission in HIV\/HCMV co-infection. Within 3 historical cohorts of pregnant women with HIV\/HCMV co-infection, we identified 16 cCMV transmitting cases that were matched to 29 cCMV non-transmitting controls. Using a systems serology approach, we found that normalized HCMV-specific IgG binding to Fc\u03b3R1\u03b1 was higher in non-transmitting dyads, whereas HCMV-neutralizing antibody responses were higher in transmitting dyads. These findings suggest that engagement of Fc\u03b3R1\u03b1 by HCMV-specific IgG may help confer protection against cCMV transmission. Building upon previous research, our study reinforces the critical role of validating maternal humoral immune correlates of cCMV transmission risk across diverse seropositive cohorts, providing essential insights to inform and accelerate the development of effective HCMV vaccines.<\/jats:p>","DOI":"10.3390\/v17030325","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:15:33Z","timestamp":1740550533000},"page":"325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Distinct Maternal Cytomegalovirus-Specific Neutralizing and Fc Receptor-Binding Responses on Congenital Cytomegalovirus Transmission in HIV-Exposed Neonates"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9199-8985","authenticated-orcid":false,"given":"Itzayana G.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-122X","authenticated-orcid":false,"given":"Aakash Mahant","family":"Mahant","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Jenks","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University, Durham, NC 27710, USA"},{"name":"Medical Scientist Training Program, Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor C.","family":"Semmes","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University, Durham, NC 27710, USA"},{"name":"Medical Scientist Training Program, Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rochat","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah L.","family":"Herbek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Andy","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Weill Cornell Medicine, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Pollara","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University, Durham, NC 27710, USA"},{"name":"Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-3338","authenticated-orcid":false,"given":"Linda M.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Weill Cornell Medicine, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-0786","authenticated-orcid":false,"given":"Betsy C.","family":"Herold","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Department of Pediatrics, Children\u2019s Hospital at Montefiore, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sallie R.","family":"Permar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s40746-022-00261-y","article-title":"Perinatal Cytomegalovirus Infection","volume":"8","author":"Carmona","year":"2022","journal-title":"Curr. Treat. Options Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chiopris, G., Veronese, P., Cusenza, F., Procaccianti, M., Perrone, S., Dacc\u00f2, V., Colombo, C., and Esposito, S. (2020). Congenital Cytomegalovirus Infection: Update on Diagnosis and Treatment. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101516"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e00030-18","DOI":"10.1128\/JVI.00030-18","article-title":"Advancing Our Understanding of Protective Maternal Immunity as a Guide for Development of Vaccines To Reduce Congenital Cytomegalovirus Infections","volume":"92","author":"Permar","year":"2018","journal-title":"J. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1016\/S2214-109X(16)30362-X","article-title":"First estimates of the global and regional incidence of neonatal herpes infection","volume":"5","author":"Looker","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2120736","DOI":"10.1001\/jamanetworkopen.2021.20736","article-title":"Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening: A Systematic Review and Meta-analysis","volume":"4","author":"Ssentongo","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1128\/CMR.00062-12","article-title":"The \u201csilent\u201d global burden of congenital cytomegalovirus","volume":"26","author":"Manicklal","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e2021055896","DOI":"10.1542\/peds.2021-055896","article-title":"Emerging Concepts in Congenital Cytomegalovirus","volume":"150","author":"Pesch","year":"2022","journal-title":"Pediatrics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13052-022-01387-3","article-title":"Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection","volume":"48","author":"Novelli","year":"2022","journal-title":"Ital. J. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/rmv.535","article-title":"Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection","volume":"17","author":"Kenneson","year":"2007","journal-title":"Rev. Med. Virol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jama.289.8.1008","article-title":"Maternal immunity and prevention of congenital cytomegalovirus infection","volume":"289","author":"Fowler","year":"2003","journal-title":"Jama"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.vaccine.2015.11.056","article-title":"Safety and efficacy of a cytomegalovirus glycoprotein B (gB) vaccine in adolescent girls: A randomized clinical trial","volume":"34","author":"Bernstein","year":"2016","journal-title":"Vaccine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1056\/NEJMoa0804749","article-title":"Vaccine prevention of maternal cytomegalovirus infection","volume":"360","author":"Pass","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"eabb3611","DOI":"10.1126\/scitranslmed.abb3611","article-title":"Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB\/MF59 vaccine in humans","volume":"12","author":"Jenks","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_14","unstructured":"Merck Sharp & Dohme LLC (2025, February 11). V160 2-Dose and 3-Dose Regimens in Healthy Cytomegalovirus (CMV) Seronegative Females (V160-002), Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03486834."},{"key":"ref_15","unstructured":"(2025, February 18). GlaxoSmithKline. A Study of Safety and Immune Response to Different Doses of a Cytomegalovirus Vaccine in Healthy Adults, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05089630."},{"key":"ref_16","unstructured":"ModernaTX, Inc. (2025, February 18). A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05085366."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Huang, Y., Tang, J., Wang, H., Yu, H., Song, Q., Guo, X., Li, C., Wang, J., Liang, C., and Li, S. (2022). Pre-existing maternal IgG antibodies as a protective factor against congenital cytomegalovirus infection: A mother-child prospective cohort study. EBioMedicine, 77.","DOI":"10.1016\/j.ebiom.2022.103885"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e156827","DOI":"10.1172\/JCI156827","article-title":"Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection","volume":"132","author":"Semmes","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e167768","DOI":"10.1172\/jci.insight.167768","article-title":"ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus infection","volume":"8","author":"Semmes","year":"2023","journal-title":"JCI Insight"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1093\/infdis\/jiw487","article-title":"Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants","volume":"214","author":"Bialas","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Amin, O., Powers, J., Bricker, K.M., and Chahroudi, A. (2021). Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.757400"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/imr.12067","article-title":"Insights into B cells and HIV-specific B-cell responses in HIV-infected individuals","volume":"254","author":"Moir","year":"2013","journal-title":"Immunol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/jmv.24420","article-title":"Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy","volume":"88","author":"Gantt","year":"2016","journal-title":"J. Med. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nprot.2006.236","article-title":"Quantification of mRNA using real-time RT-PCR","volume":"1","author":"Nolan","year":"2006","journal-title":"Nat. Protoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/cid\/ciab627","article-title":"Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia","volume":"74","author":"Semmes","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/infdis\/jiac341","article-title":"Characterization of Plasma Immunoglobulin G Responses in Elite Neutralizers of Human Cytomegalovirus","volume":"226","author":"Harnois","year":"2022","journal-title":"J. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/jama.288.2.189","article-title":"Two-dose intrapartum\/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: A randomized trial","volume":"288","author":"Dorenbaum","year":"2002","journal-title":"Jama"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/INF.0b013e318235c7aa","article-title":"Prevalence of congenital anomalies in infants with in utero exposure to antiretrovirals","volume":"31","author":"Knapp","year":"2012","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/ije\/dyn239","article-title":"Cohort Profile: NICHD International Site Development Initiative (NISDI): A prospective, observational study of HIV-exposed and HIV-infected children at clinical sites in Latin American and Caribbean countries","volume":"38","author":"Hazra","year":"2009","journal-title":"Int. J. Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/ije\/dyr024","article-title":"The NICHD International Site Development Initiative perinatal cohorts (2002\u201309)","volume":"41","author":"Read","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/cid\/cix337","article-title":"Risk Factors for Congenital Cytomegalovirus Infection Following Primary and Nonprimary Maternal Infection: A Prospective Neonatal Screening Study Using Polymerase Chain Reaction in Saliva","volume":"65","author":"Magny","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e286","DOI":"10.1542\/peds.2005-1142","article-title":"Risk factors for congenital cytomegalovirus infection in the offspring of young women: Exposure to young children and recent onset of sexual activity","volume":"118","author":"Fowler","year":"2006","journal-title":"Pediatrics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/jech.40.3.205","article-title":"Congenital cytomegalovirus infection: Predisposing maternal factors","volume":"40","author":"Preece","year":"1986","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Tanimura, K., Uchida, A., Imafuku, H., Tairaku, S., Fujioka, K., Morioka, I., and Yamada, H. (2021). The Current Challenges in Developing Biological and Clinical Predictors of Congenital Cytomegalovirus Infection. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413487"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1172\/JCI64314","article-title":"Expansion of HIV-specific T follicular helper cells in chronic HIV infection","volume":"122","author":"Lindqvist","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1172\/JCI63039","article-title":"CD4 T follicular helper cell dynamics during SIV infection","volume":"122","author":"Petrovas","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1006\/clim.2001.5054","article-title":"Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis","volume":"100","author":"Nagase","year":"2001","journal-title":"Clin. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107648","DOI":"10.1016\/j.isci.2023.107648","article-title":"Antibody attributes, Fc receptor expression, gestation and maternal SARS-CoV-2 infection modulate HSV IgG placental transfer","volume":"26","author":"Mahant","year":"2023","journal-title":"iScience"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e01606-20","DOI":"10.1128\/JVI.01606-20","article-title":"Subclinical Genital Herpes Shedding in HIV\/Herpes Simplex Virus 2-Coinfected Women during Antiretroviral Therapy Is Associated with an Increase in HIV Tissue Reservoirs and Potentially Promotes HIV Evolution","volume":"95","author":"Stinn","year":"2020","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e0003122","DOI":"10.1128\/jvi.00031-22","article-title":"Rescue of Pentamer-Null Strains of Human Cytomegalovirus in Epithelial Cells by Use of Histone Deacetylase Inhibitors Reveals an Additional Postentry Function for the Pentamer Complex","volume":"96","author":"Beucler","year":"2022","journal-title":"J. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kim, Y., Lee, S., Kim, S., Kim, D., Ahn, J.H., and Ahn, K. (2012). Human cytomegalovirus clinical strain-specific microRNA miR-UL148D targets the human chemokine RANTES during infection. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002577"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wilcox, C.R., Holder, B., and Jones, C.E. (2017). Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01294"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kayatani, A.K.K., Leke, R.G.F., Leke, R.I.J., Fogako, J., and Taylor, D.W. (2022). Transplacental transfer of total immunoglobulin G and antibodies to Plasmodium falciparum antigens between the 24th week of gestation and term. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-21908-8"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/infdis\/jiac222","article-title":"HIV-Associated Alterations of the Biophysical Features of Maternal Antibodies Correlate with Their Reduced Transfer Across the Placenta","volume":"226","author":"Taylor","year":"2022","journal-title":"J. Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1086\/519845","article-title":"Maternal HIV infection and placental malaria reduce transplacental antibody transfer and tetanus antibody levels in newborns in Kenya","volume":"196","author":"Cumberland","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Choi, K.Y., and McGregor, A. (2021). A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary. Viruses, 13.","DOI":"10.3390\/v13081467"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ebiom.2019.11.005","article-title":"Seronegative patients vaccinated with cytomegalovirus gB-MF59 vaccine have evidence of neutralising antibody responses against gB early post-transplantation","volume":"50","author":"Baraniak","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Reuter, N., Kropff, B., Britt, W.J., Mach, M., and Thomas, M. (2022). Neutralizing Antibodies Limit Cell-Associated Spread of Human Cytomegalovirus in Epithelial Cells and Fibroblasts. Viruses, 14.","DOI":"10.3390\/v14020284"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.4049\/jimmunol.182.2.1202","article-title":"Rapid degranulation of NK cells following activation by HIV-specific antibodies","volume":"182","author":"Chung","year":"2009","journal-title":"J. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jviromet.2017.06.007","article-title":"Antibody-dependent NK cell degranulation as a marker for assessing antibody-dependent cytotoxicity against pandemic 2009 influenza A(H1N1) infection in human plasma and influenza-vaccinated transchromosomic bovine intravenous immunoglobulin therapy","volume":"248","author":"Morrison","year":"2017","journal-title":"J. Virol. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jim.2016.11.005","article-title":"NK cell degranulation as a marker for measuring antibody-dependent cytotoxicity in neutralizing and non-neutralizing human sera from dengue patients","volume":"441","author":"Sun","year":"2017","journal-title":"J. Immunol. Methods"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Kumar, A., Giorgi, E.E., Tu, J.J., Martinez, D.R., Eudailey, J., Mengual, M., Honnayakanahalli Marichannegowda, M., Van Dyke, R., Gao, F., and Permar, S.R. (2021). Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers. PLoS Pathog., 17.","DOI":"10.1101\/2021.01.07.21249396"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"10540","DOI":"10.1128\/JVI.00518-12","article-title":"The breadth and titer of maternal HIV-1-specific heterologous neutralizing antibodies are not associated with a lower rate of mother-to-child transmission of HIV-1","volume":"86","author":"Chaillon","year":"2012","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/QAI.0b013e31829f6e41","article-title":"Evidence for efficient vertical transfer of maternal HIV-1 envelope-specific neutralizing antibodies but no association of such antibodies with reduced infant infection","volume":"64","author":"Omenda","year":"2013","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1172\/JCI65708","article-title":"Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity","volume":"123","author":"Ackerman","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e29105","DOI":"10.1002\/jmv.29105","article-title":"Correlates of postnatal human cytomegalovirus transmission in term babies in the first year","volume":"95","author":"Zelini","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1369-5274(02)00334-X","article-title":"Human cytomegalovirus persistence and latency in endothelial cells and macrophages","volume":"5","author":"Jarvis","year":"2002","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cell.2019.05.046","article-title":"Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women","volume":"178","author":"Martinez","year":"2019","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"eabm3151","DOI":"10.1126\/scitranslmed.abm3151","article-title":"Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection","volume":"14","author":"Dias","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"104088","DOI":"10.1016\/j.isci.2022.104088","article-title":"Functional and structural modifications of influenza antibodies during pregnancy","volume":"25","author":"Jennewein","year":"2022","journal-title":"iScience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"105083","DOI":"10.1016\/j.antiviral.2021.105083","article-title":"Clinical outcome and the role of antivirals in congenital cytomegalovirus infection","volume":"191","author":"Ross","year":"2021","journal-title":"Antivir. 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