{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:13:42Z","timestamp":1787030022499,"version":"build-2736575974"},"reference-count":276,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Food and Drug Safety","award":["23202MFDS144"],"award-info":[{"award-number":["23202MFDS144"]}]},{"name":"Ministry of Food and Drug Safety","award":["RS-2024-00331833"],"award-info":[{"award-number":["RS-2024-00331833"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Zoonotic viruses have significant pandemic potential, as evidenced by the coronavirus pandemic, which underscores that zoonotic infections have historically caused numerous outbreaks and millions of deaths over centuries. Zoonotic viruses induce numerous types of illnesses in their natural hosts. These viruses are transmitted to humans via biological vectors, direct contact with infected animals or their bites, and aerosols. Zoonotic viruses continuously evolve and adapt to human hosts, resulting in devastating consequences. It is very important to understand pathogenesis pathways associated with zoonotic viral infections across various hosts and develop countermeasure strategies accordingly. In this review, we briefly discuss advancements in diagnostics and therapeutics for zoonotic viral infections. It provides insight into recent outbreaks, viral dynamics, licensed vaccines, as well as vaccine candidates progressing to clinical investigations. Despite advancements, challenges persist in combating zoonotic viruses due to immune evasion, unpredicted outbreaks, and the complexity of the immune responses. Most of these viruses lack effective treatments and vaccines, relying entirely on supportive care and preventive measures. Exposure to animal reservoirs, limited vaccine access, and insufficient coverage further pose challenges to preventive efforts. This review highlights the critical need for ongoing interdisciplinary research and collaboration to strengthen preparedness and response strategies against emerging infectious threats.<\/jats:p>","DOI":"10.3390\/v17030352","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T10:12:33Z","timestamp":1740737553000},"page":"352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Advancements and Challenges in Addressing Zoonotic Viral Infections with Epidemic and Pandemic Threats"],"prefix":"10.3390","volume":"17","author":[{"given":"Munazza","family":"Fatima","sequence":"first","affiliation":[{"name":"Department of Microbiology, Gachon University College of Medicine, Incheon 21936, Republic of Korea"},{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"An","sequence":"additional","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-3439","authenticated-orcid":false,"given":"Pil-Gu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Gachon University College of Medicine, Incheon 21936, Republic of Korea"},{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-7014","authenticated-orcid":false,"given":"Kee-Jong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Gachon University College of Medicine, Incheon 21936, Republic of Korea"},{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea"},{"name":"Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea"},{"name":"Korea mRNA Vaccine Initiative, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Grzybek, M., Tolkacz, K., Sironen, T., Maki, S., Alsarraf, M., Behnke-Borowczyk, J., Biernat, B., Nowicka, J., Vaheri, A., and Henttonen, H. (2020). Zoonotic Viruses in Three Species of Voles from Poland. Animals, 10.","DOI":"10.1101\/2020.08.22.259309"},{"key":"ref_2","first-page":"461","article-title":"Hantaviruses as zoonotic pathogens in Germany","volume":"110","author":"Kruger","year":"2013","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Skowron, K., Bauza-Kaszewska, J., Grudlewska-Buda, K., Wiktorczyk-Kapischke, N., Zacharski, M., Bernaciak, Z., and Gospodarek-Komkowska, E. (2021). Nipah Virus-Another Threat From the World of Zoonotic Viruses. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.811157"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhang, D., Zheng, M., Zhang, Y., Feng, G., Peng, C., Li, C., Li, Y., Zhang, H., Li, N., and Xiao, P. (2022). Multiple Novel Mosquito-Borne Zoonotic Viruses Revealed in Pangolin Virome. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.874003"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Weidinger, P., Kolodziejek, J., Khafaga, T., Loney, T., Howarth, B., Sher Shah, M., Abou Tayoun, A., Alsheikh-Ali, A., Camp, J.V., and Nowotny, N. (2023). Potentially Zoonotic Viruses in Wild Rodents, United Arab Emirates, 2019-A Pilot Study. Viruses, 15.","DOI":"10.3390\/v15030695"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Abdelwhab, E.M., and Mettenleiter, T.C. (2023). Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts. Viruses, 15.","DOI":"10.3390\/v15040980"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Guo, Z., Jin, Q., Li, P., Xing, G., Lu, Q., and Zhang, G. (2023). Potential cross-species transmission risks of emerging swine enteric coronavirus to human beings. J. Med. Virol., 95.","DOI":"10.1002\/jmv.28919"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/1751-7915.14269","article-title":"Viral infections at the animal-human interface-Learning lessons from the SARS-CoV-2 pandemic","volume":"16","author":"Brussow","year":"2023","journal-title":"Microb. Biotechnol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Begeman, L., van Riel, D., Koopmans, M.P.G., and Kuiken, T. (2023). The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1151524"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bankar, N.J., Tidake, A.A., Bandre, G.R., Ambad, R., Makade, J.G., and Hawale, D.V. (2022). Emerging and Re-Emerging Viral Infections: An Indian Perspective. Cureus, 14.","DOI":"10.7759\/cureus.30062"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Majiwa, H., Bukachi, S.A., Omia, D., and Fevre, E.M. (2023). Knowledge, perceptions, and practices around zoonotic diseases among actors in the livestock trade in the Lake Victoria crescent ecosystem in East Africa. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1199664"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1016\/j.vaccine.2017.07.110","article-title":"Breaking the chain of zoonoses through biosecurity in livestock","volume":"35","author":"Layton","year":"2017","journal-title":"Vaccine"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mackenzie, J.S., and Jeggo, M. (2019). The One Health Approach-Why Is It So Important?. Trop. Med. Infect. Dis., 4.","DOI":"10.3390\/tropicalmed4020088"},{"key":"ref_14","first-page":"035","article-title":"The first isolation of chikungunya virus from nonhuman primates in Malaysia","volume":"1","author":"Apandi","year":"2009","journal-title":"J. Gen. Mol. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41467-018-03332-7","article-title":"Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal","volume":"9","author":"Althouse","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lounibos, L.P., and Kramer, L.D. (2016). Invasiveness of Aedes aegypti and Aedes albopictus and Vectorial Capacity for Chikungunya Virus. J. Infect. Dis., 214.","DOI":"10.1093\/infdis\/jiw285"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3201\/eid1312.071115","article-title":"Studies of reservoir hosts for Marburg virus","volume":"13","author":"Swanepoel","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Monath, T.P. (1999). Ecology of Marburg and Ebola viruses: Speculations and directions for future research. J. Infect. Dis., 179.","DOI":"10.1086\/514281"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1071\/MA17005","article-title":"Filoviruses and bats","volume":"38","author":"Schuh","year":"2017","journal-title":"Microbiol. Aust."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Towner, J.S., Pourrut, X., Albarino, C.G., Nkogue, C.N., Bird, B.H., Grard, G., Ksiazek, T.G., Gonzalez, J.P., Nichol, S.T., and Leroy, E.M. (2007). Marburg virus infection detected in a common African bat. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000764"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1017\/S0030605303000802","article-title":"Ebola and the decline of gorilla Gorilla gorilla and chimpanzee Pan troglodytes populations in Minkebe Forest, north-eastern Gabon","volume":"37","author":"Huijbregts","year":"2003","journal-title":"Oryx"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/pgmj.49.574.542","article-title":"Marburg virus disease","volume":"49","author":"Martini","year":"1973","journal-title":"Postgrad. Med. J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Childs, M.L., Nova, N., Colvin, J., and Mordecai, E.A. (2019). Mosquito and primate ecology predict human risk of yellow fever virus spillover in Brazil. Philos. Trans. R. Soc. Lond. B Biol. Sci., 374.","DOI":"10.1101\/523704"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2307\/1641","article-title":"The night-resting habits of monkeys in a small area on the edge of the semliki forest, uganda. a study in relation to the epidemiology of sylvan yellow fever","volume":"20","author":"Lumsden","year":"1951","journal-title":"J. Anim. Ecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1473-3099(01)00016-0","article-title":"Yellow fever: An update","volume":"1","author":"Monath","year":"2001","journal-title":"Lancet Infect. Dis."},{"key":"ref_26","first-page":"277","article-title":"Smallpox and monkeypox in non-human primates","volume":"39","author":"Arita","year":"1968","journal-title":"Bull. World Health Organ."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/br.37.1.1-18.1973","article-title":"Monkey Pox","volume":"37","author":"Cho","year":"1973","journal-title":"Bacteriol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1473-3099(03)00856-9","article-title":"Human monkeypox: An emerging zoonosis","volume":"4","author":"Eckburg","year":"2004","journal-title":"Lancet Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0140-6736(86)90748-8","article-title":"Isolation of Monkeypox virus from wild squirrel infected in nature","volume":"327","author":"Khodakevich","year":"1986","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4269\/ajtmh.15-0168","article-title":"Introduction of Monkeypox into a Community and Household: Risk Factors and Zoonotic Reservoirs in the Democratic Republic of the Congo","volume":"93","author":"Nolen","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"29190","DOI":"10.1073\/pnas.2000429117","article-title":"Nipah virus dynamics in bats and implications for spillover to humans","volume":"117","author":"Epstein","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1286-4579(01)01522-2","article-title":"Isolation of Nipah virus from Malaysian Island flying-foxes","volume":"4","author":"Chua","year":"2002","journal-title":"Microbes Infect."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Bedi, J.S., Vijay, D., and Dhaka, P. (2022). Nipah. Textbook of Zoonoses, John Wiley & Sons.","DOI":"10.1002\/9781119809548"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Faus-Cotino, J., Reina, G., and Pueyo, J. (2024). Nipah Virus: A Multidimensional Update. Viruses, 16.","DOI":"10.3390\/v16020179"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.3201\/eid1012.040452","article-title":"Isolation and molecular identification of Nipah virus from pigs","volume":"10","author":"AbuBakar","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1056\/NEJMoa1805376","article-title":"Transmission of Nipah Virus\u201414 Years of Investigations in Bangladesh","volume":"380","author":"Nikolay","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Karan, L.S., Makenov, M.T., Korneev, M.G., Sacko, N., Boumbaly, S., Bayandin, R.B., Gladysheva, A.V., Kourouma, K., Toure, A.H., and Kartashov, M. (2019). Lassa virus in the host rodent mastomys natalensis within urban areas of N\u2019zerekore, guinea. bioRxiv.","DOI":"10.1101\/616466"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/14772000.2017.1358220","article-title":"Small mammal diversity and dynamics within Nigeria, with emphasis on reservoirs of the lassa virus","volume":"16","author":"Olayemi","year":"2017","journal-title":"Syst. Biodivers."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/22221751.2020.1766381","article-title":"Households as hotspots of Lassa fever? Assessing the spatial distribution of Lassa virus-infected rodents in rural villages of Guinea","volume":"9","author":"Marien","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_40","first-page":"1","article-title":"Lassa fever in West African sub-region: An overview","volume":"44","author":"Ogbu","year":"2007","journal-title":"J. Vector Borne Dis."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Roger, M., Beral, M., Licciardi, S., Soule, M., Faharoudine, A., Foray, C., Olive, M.M., Maquart, M., Soulaimane, A., and Madi Kassim, A. (2014). Evidence for circulation of the rift valley fever virus among livestock in the union of Comoros. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003045"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1017\/S0022172400065207","article-title":"Preliminary survey of domestic animals of the Sudan for precipitating antibodies to Rift Valley fever virus","volume":"93","author":"Eisa","year":"1984","journal-title":"J. Hyg."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Rodrigue Simonet, P.N., Alexandre Michel, N.N., Abel, W., Albert, E., Martin Hermann, G., and Franziska, S. (2020). Diversity and Abundance of Potential Vectors of Rift Valley Fever Virus in the North Region of Cameroon. Insects, 11.","DOI":"10.3390\/insects11110814"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Nicolas, G., Chevalier, V., Tantely, L.M., Fontenille, D., and Durand, B. (2014). A spatially explicit metapopulation model and cattle trade analysis suggests key determinants for the recurrent circulation of rift valley Fever virus in a pilot area of madagascar highlands. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003346"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1017\/S0022172400062434","article-title":"Rift Valley fever virus (family Bunyaviridae, genus Phlebovirus). Isolations from Diptera collected during an inter-epizootic period in Kenya","volume":"95","author":"Linthicum","year":"1985","journal-title":"J. Hyg."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Mohapatra, R.K., Kutikuppala, L.V.S., Kandi, V., Mishra, S., Rabaan, A.A., Costa, S., Al-Qaim, Z.H., Padhi, B.K., and Sah, R. (2023). Rift valley fever (RVF) viral zoonotic disease steadily circulates in the Mauritanian animals and humans: A narrative review. Health Sci. Rep., 6.","DOI":"10.1002\/hsr2.1384"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Michelitsch, A., Wernike, K., Klaus, C., Dobler, G., and Beer, M. (2019). Exploring the Reservoir Hosts of Tick-Borne Encephalitis Virus. Viruses, 11.","DOI":"10.3390\/v11070669"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1099\/vir.0.011437-0","article-title":"Tick-borne encephalitis virus\u2014A review of an emerging zoonosis","volume":"90","author":"Mansfield","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Pustijanac, E., Bursic, M., Talapko, J., Skrlec, I., Mestrovic, T., and Lisnjic, D. (2023). Tick-Borne Encephalitis Virus: A Comprehensive Review of Transmission, Pathogenesis, Epidemiology, Clinical Manifestations, Diagnosis, and Prevention. Microorganisms, 11.","DOI":"10.3390\/microorganisms11071634"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Hameed, M., Wahaab, A., Nawaz, M., Khan, S., Nazir, J., Liu, K., Wei, J., and Ma, Z. (2021). Potential Role of Birds in Japanese Encephalitis Virus Zoonotic Transmission and Genotype Shift. Viruses, 13.","DOI":"10.20944\/preprints202101.0549.v1"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Pegu, S.R., Das, P.J., Sonowal, J., Sengar, G.S., Deb, R., Yadav, A.K., Rajkhowa, S., Choudhury, M., Gulati, B.R., and Gupta, V.K. (2023). Japanese Encephalitis Virus Genotype III Strains Detection and Genome Sequencing from Indian Pig and Mosquito Vector. Vaccines, 11.","DOI":"10.3390\/vaccines11010150"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/ije\/dyac050","article-title":"High-risk landscapes of Japanese encephalitis virus outbreaks in India converge on wetlands, rain-fed agriculture, wild Ardeidae, and domestic pigs and chickens","volume":"51","author":"Walsh","year":"2022","journal-title":"Int. J. Epidemiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"van den Hurk, A.F., Skinner, E., Ritchie, S.A., and Mackenzie, J.S. (2022). The Emergence of Japanese Encephalitis Virus in Australia in 2022: Existing Knowledge of Mosquito Vectors. Viruses, 14.","DOI":"10.3390\/v14061208"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Xu, J., Wahaab, A., Khan, S., Nawaz, M., Anwar, M.N., Liu, K., Wei, J., Hameed, M., and Ma, Z. (2023). Recent Population Dynamics of Japanese Encephalitis Virus. Viruses, 15.","DOI":"10.20944\/preprints202305.0087.v1"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s13071-017-2354-7","article-title":"Meta-analyses of the proportion of Japanese encephalitis virus infection in vectors and vertebrate hosts","volume":"10","author":"Oliveira","year":"2017","journal-title":"Parasit Vectors"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s10393-017-1249-6","article-title":"An Integrative Eco-Epidemiological Analysis of West Nile Virus Transmission","volume":"14","author":"Tran","year":"2017","journal-title":"Ecohealth"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Adelman, J.S., Tokarz, R.E., Euken, A.E., Field, E.N., Russell, M.C., and Smith, R.C. (2022). Relative Influence of Land Use, Mosquito Abundance, and Bird Communities in Defining West Nile Virus Infection Rates in Culex Mosquito Populations. Insects, 13.","DOI":"10.3390\/insects13090758"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3201\/eid1108.050289a","article-title":"Epidemiology and transmission dynamics of West Nile virus disease","volume":"11","author":"Hayes","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"de Freitas Costa, E., Streng, K., Avelino de Souza Santos, M., and Counotte, M.J. (2024). The effect of temperature on the boundary conditions of West Nile virus circulation in Europe. PLoS Negl. Trop. Dis., 18.","DOI":"10.1371\/journal.pntd.0012162"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Warner, B.M., Stein, D.R., Griffin, B.D., Tierney, K., Leung, A., Sloan, A., Kobasa, D., Poliquin, G., Kobinger, G.P., and Safronetz, D. (2019). Development and Characterization of a Sin Nombre Virus Transmission Model in Peromyscus maniculatus. Viruses, 11.","DOI":"10.3390\/v11020183"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/jmv.25390","article-title":"Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe","volume":"91","author":"Ling","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Schlohsarczyk, E.K., Drewes, S., Koteja, P., Rohrs, S., Ulrich, R.G., Teifke, J.P., and Herden, C. (2023). Tropism of Puumala orthohantavirus and Endoparasite Coinfection in the Bank Vole Reservoir. Viruses, 15.","DOI":"10.3390\/v15030612"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12985-020-01477-w","article-title":"Seewis hantavirus in common shrew (Sorex araneus) in Sweden","volume":"17","author":"Lwande","year":"2020","journal-title":"Virol. J."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Gu, S.H., Minarro, M., Feliu, C., Hugot, J.P., Forrester, N.L., Weaver, S.C., and Yanagihara, R. (2023). Multiple Lineages of Hantaviruses Harbored by the Iberian Mole (Talpa occidentalis) in Spain. Viruses, 15.","DOI":"10.3390\/v15061313"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1590\/S1678-91992008000400002","article-title":"Hantaviruses as emergent zoonoses","volume":"14","author":"Ullmann","year":"2008","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/biosci\/biv047","article-title":"Toward a Mechanistic Understanding of Environmentally Forced Zoonotic Disease Emergence: Sin Nombre Hantavirus","volume":"65","author":"Carver","year":"2015","journal-title":"Bioscience"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/infdis\/jiab461","article-title":"Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review","volume":"226","author":"Toledo","year":"2022","journal-title":"J. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Ashique, S., Sandhu, N.K., Das, S., Haque, S.N., and Koley, K. (2022). Global Comprehensive Outlook of Hantavirus Contagion on Humans: A Review. Infect. Disord. Drug Targets, 22.","DOI":"10.2174\/1871526522666220105110819"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.3201\/eid1112.050501","article-title":"Person-to-person transmission of Andes viru","volume":"11","author":"Martinez","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Nurettin, C., Engin, B., Sukru, T., Munir, A., Zati, V., and Aykut, O. (2022). The Seroprevalence of Crimean-Congo Hemorrhagic Fever in Wild and Domestic Animals: An Epidemiological Update for Domestic Animals and First Seroevidence in Wild Animals from Turkiye. Vet. Sci., 9.","DOI":"10.3390\/vetsci9090462"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.antiviral.2017.05.010","article-title":"The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus: A review of published field and laboratory studies","volume":"144","author":"Gargili","year":"2017","journal-title":"Antiviral Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Bernard, C., Holzmuller, P., Bah, M.T., Bastien, M., Combes, B., Jori, F., Grosbois, V., and Vial, L. (2022). Systematic Review on Crimean-Congo Hemorrhagic Fever Enzootic Cycle and Factors Favoring Virus Transmission: Special Focus on France, an Apparently Free-Disease Area in Europe. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.932304"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1473-3099(06)70435-2","article-title":"Crimean-Congo haemorrhagic fever","volume":"6","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4269\/ajtmh.21-0685","article-title":"Clinical and Molecular Epidemiology of Crimean-Congo Hemorrhagic Fever in Humans in Uganda, 2013\u20132019","volume":"106","author":"Balinandi","year":"2021","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jhin.2019.12.001","article-title":"Nosocomial infections caused by Crimean-Congo haemorrhagic fever virus","volume":"105","author":"Tsergouli","year":"2020","journal-title":"J. Hosp. Infect."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Osako, H., Xu, Q., Nabeshima, T., Balingit, J.C., Nwe, K.M., Yu, F., Inoue, S., Hayasaka, D., Ngwe Tun, M.M., and Morita, K. (2024). Clinical Factors Associated with SFTS Diagnosis and Severity in Cats. Viruses, 16.","DOI":"10.1101\/2024.03.06.583784"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Saga, Y., Yoshida, T., Yoshida, R., Yazawa, S., Shimada, T., Inasaki, N., Itamochi, M., Yamazaki, E., Oishi, K., and Tani, H. (2023). Long-Term Detection and Isolation of Severe Fever with Thrombocytopenia Syndrome (SFTS) Virus in Dog Urine. Viruses, 15.","DOI":"10.3390\/v15112228"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1089\/vbz.2024.0008","article-title":"Prevalence, Isolation, and Molecular Characterization of Severe Fever with Thrombocytopenia Syndrome Virus in Cattle from the Republic of Korea","volume":"24","author":"Chae","year":"2024","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12985-024-02387-x","article-title":"Direct transmission of severe fever with thrombocytopenia syndrome virus from farm-raised fur animals to workers in Weihai, China","volume":"21","author":"Li","year":"2024","journal-title":"Virol. J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijid.2018.11.017","article-title":"Animals as amplification hosts in the spread of severe fever with thrombocytopenia syndrome virus: A systematic review and meta-analysis","volume":"79","author":"Chen","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.3201\/eid2008.131857","article-title":"Severe fever with thrombocytopenia syndrome virus in ticks collected from humans, South Korea, 2013","volume":"20","author":"Yun","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in China","volume":"364","author":"Yu","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3201\/eid2802.211532","article-title":"Rapid Spread of Severe Fever with Thrombocytopenia Syndrome Virus by Parthenogenetic Asian Longhorned Ticks","volume":"28","author":"Zhang","year":"2022","journal-title":"Emerg. Infect. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"423","DOI":"10.7883\/yoken.JJID.2021.796","article-title":"A Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected from a Sick Dog with SFTS Virus Infection","volume":"75","author":"Oshima","year":"2022","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1089\/vbz.2011.0758","article-title":"Person-to-Person Transmission of Severe Fever with Thrombocytopenia Syndrome Virus","volume":"12","author":"Liu","year":"2012","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Wen, Y., Fang, Y., Cao, F., Zhang, G., Cheng, S., Yu, Y., Huang, R., Ni, Z., and Li, J. (2024). A person-to-person transmission cluster of severe fever with thrombocytopenia syndrome characterized by mixed viral infections with familial and nosocomial clustering. Heliyon, 10.","DOI":"10.1016\/j.heliyon.2024.e24502"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Munster, V.J., Baas, C., Lexmond, P., Waldenstr\u00f6m, J., Wallensten, A., Fransson, T., Rimmelzwaan, G.F., Beyer, W.E., Schutten, M., and Olsen, B. (2007). Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds. PLoS Pathog., 3.","DOI":"10.1371\/journal.ppat.0030061"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/mr.56.1.152-179.1992","article-title":"Evolution and ecology of influenza A viruses","volume":"56","author":"Webster","year":"1992","journal-title":"Microbiol. Rev."},{"key":"ref_89","first-page":"55","article-title":"Development and Application of Treatment for Chikungunya Fever","volume":"13","author":"Millsapps","year":"2022","journal-title":"Res. Rep. Trop. Med."},{"key":"ref_90","unstructured":"U. S. Food & Drug Administration (2024, December 27). FDA Approves First Vaccine to Prevent Disease Caused by Chikungunya Virus, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-vaccine-prevent-disease-caused-chikungunya-virus."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Taki, E., Ghanavati, R., Navidifar, T., Dashtbin, S., Heidary, M., and Moghadamnia, M. (2023). Ebanga\u2122: The most recent FDA-approved drug for treating Ebola. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1083429"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1358\/dot.2021.57.8.3280599","article-title":"Atoltivimab\/maftivimab\/odesivimab (Inmazeb) combination to treat infection caused by Zaire ebolavirus","volume":"57","author":"Saxena","year":"2021","journal-title":"Drugs Today"},{"key":"ref_93","unstructured":"U. S. Food & Drug Administration (2024, December 10). First FDA-Approved Vaccine for the Prevention of Ebola Virus Disease, Marking a Critical Milestone in Public Health Preparedness and Response, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/first-fda-approved-vaccine-prevention-ebola-virus-disease-marking-critical-milestone-public-health."},{"key":"ref_94","unstructured":"U. S. Food & Drug Administration (2024, December 10). YF-Vax, Available online: https:\/\/www.fda.gov\/vaccines-blood-biologics\/vaccines\/yf-vax."},{"key":"ref_95","unstructured":"U. S. Centers for Disease Control and Prevention (2025, February 20). Tecovirimat (TPOXX) for Treatment of Mpox, Available online: https:\/\/www.cdc.gov\/mpox\/hcp\/clinical-care\/tecovirimat.html."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Garcia-Atutxa, I., Mondragon-Teran, P., Huerta-Saquero, A., and Villanueva-Flores, F. (2024). Advancements in monkeypox vaccines development: A critical review of emerging technologies. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1456060"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/ana.1062","article-title":"Treatment of acute Nipah encephalitis with ribavirin","volume":"49","author":"Chong","year":"2001","journal-title":"Ann. Neurol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1473-3099(19)30634-6","article-title":"Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: A first-in-human, randomised, controlled, phase 1 study","volume":"20","author":"Playford","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zeitlin, L., Cross, R.W., Woolsey, C., West, B.R., Borisevich, V., Agans, K.N., Prasad, A.N., Deer, D.J., Stuart, L., and McCavitt-Malvido, M. (2024). Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates. Sci. Transl. Med., 16.","DOI":"10.1126\/scitranslmed.adl2055"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/tmi.13876","article-title":"Lassa fever vaccine candidates: A scoping review of vaccine clinical trials","volume":"28","author":"Sulis","year":"2023","journal-title":"Trop. Med. Int. Health"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41541-023-00769-w","article-title":"Advancements in Rift Valley fever vaccines: A historical overview and prospects for next generation candidates","volume":"8","author":"Alkan","year":"2023","journal-title":"Npj Vaccines"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7205a1","article-title":"Tick-Borne Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2023","volume":"72","author":"Hills","year":"2023","journal-title":"MMWR Recomm. Rep."},{"key":"ref_103","unstructured":"World Health Organization (2015). Japanese Encephalitis Vaccines: WHO position paper. Wkly. Epidemiol. Rec., 90, 69\u201388."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/infdis\/jiq003","article-title":"Phase II, randomized, double-blind, placebo-controlled, multicenter study to investigate the immunogenicity and safety of a West Nile virus vaccine in healthy adults","volume":"203","author":"Biedenbender","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1016\/j.vaccine.2018.12.026","article-title":"An observer blinded, randomized, placebo-controlled, phase I dose escalation trial to evaluate the safety and immunogenicity of an inactivated West Nile virus Vaccine, HydroVax-001, in healthy adults","volume":"37","author":"Woods","year":"2019","journal-title":"Vaccine"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1016\/j.vaccine.2013.07.064","article-title":"The live attenuated chimeric vaccine rWN\/DEN4\u039430 is well-tolerated and immunogenic in healthy flavivirus-na\u00efve adult volunteers","volume":"31","author":"Durbin","year":"2013","journal-title":"Vaccine"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Liu, R., Ma, H., Shu, J., Zhang, Q., Han, M., Liu, Z., Jin, X., Zhang, F., and Wu, X. (2019). Vaccines and Therapeutics Against Hantaviruses. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02989"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Yuan, Y., Lu, Q.B., Yao, W.S., Zhao, J., Zhang, X.A., Cui, N., Yuan, C., Yang, T., Peng, X.F., and Lv, S.M. (2021). Clinical efficacy and safety evaluation of favipiravir in treating patients with severe fever with thrombocytopenia syndrome. EBioMedicine, 72.","DOI":"10.1016\/j.ebiom.2021.103591"},{"key":"ref_109","unstructured":"U. S. Food & Drug Administration (2025, February 21). Influenza (Flu) Antiviral Drugs and Related Information, Available online: https:\/\/www.fda.gov\/drugs\/information-drug-class\/influenza-flu-antiviral-drugs-and-related-information."},{"key":"ref_110","unstructured":"U. S. Food & Drug Administration (2025, February 21). Vaccines Licensed for Use in the United States, Available online: https:\/\/www.fda.gov\/vaccines-blood-biologics\/vaccines\/vaccines-licensed-use-united-states?utm_source=chatgpt.com."},{"key":"ref_111","unstructured":"(2025, February 21). U. S. Centers for Disease Control and Prevention Influenza (Flu) Vaccine Safety, Available online: https:\/\/www.cdc.gov\/vaccine-safety\/vaccines\/flu.html?utm_source=chatgpt.com."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Bettis, A.A., L\u2019Azou Jackson, M., Yoon, I.K., Breugelmans, J.G., Goios, A., Gubler, D.J., and Powers, A.M. (2022). The global epidemiology of chikungunya from 1999 to 2020: A systematic literature review to inform the development and introduction of vaccines. PLoS Negl. Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0010069"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Rama, K., de Roo, A.M., Louwsma, T., Hofstra, H.S., Gurgel do Amaral, G.S., Vondeling, G.T., Postma, M.J., and Freriks, R.D. (2024). Clinical outcomes of chikungunya: A systematic literature review and meta-analysis. PLoS Negl. Trop. Dis., 18.","DOI":"10.1371\/journal.pntd.0012254"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"de Lima Cavalcanti, T.Y.V., Pereira, M.R., de Paula, S.O., and Franca, R.F.O. (2022). A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development. Viruses, 14.","DOI":"10.3390\/v14050969"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Barker, D., Han, X., Wang, E., Dagley, A., Anderson, D.M., Jha, A., Weaver, S.C., Julander, J., Nykiforuk, C., and Kodihalli, S. (2023). Equine Polyclonal Antibodies Prevent Acute Chikungunya Virus Infection in Mice. Viruses, 15.","DOI":"10.3390\/v15071479"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Guo, M., Du, S., Lai, L., Wu, W., Huang, X., Li, A., Li, H., Li, C., Wang, Q., and Sun, L. (2022). Development and evaluation of recombinant E2 protein based IgM capture enzyme-linked immunosorbent assay (ELISA) and double antigen sandwich ELISA for detection of antibodies to Chikungunya virus. PLoS Negl. Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0010829"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0140-6736(23)00641-4","article-title":"Safety and immunogenicity of a single-shot live-attenuated chikungunya vaccine: A double-blind, multicentre, randomised, placebo-controlled, phase 3 trial","volume":"401","author":"Schneider","year":"2023","journal-title":"Lancet"},{"key":"ref_118","unstructured":"Valneva (2025, February 21). Valneva Reports High Sustained Immune Response in Adolescents One Year After Single Vaccination with Its Chikungunya Vaccine. Available online: https:\/\/valneva.com\/press-release\/valneva-reports-high-sustained-immune-response-in-adolescents-one-year-after-single-vaccination-with-its-chikungunya-vaccine\/."},{"key":"ref_119","unstructured":"Valneva (2025, February 21). Valneva Reports Positive Phase 2 Results in Children for its Chikungunya Vaccine and Announces Phase 3 Dose Decision. Available online: https:\/\/valneva.com\/press-release\/valneva-reports-positive-phase-2-results-in-children-for-its-chikungunya-vaccine-and-announces-phase-3-dose-decision\/."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Roques, P., Fritzer, A., Dereuddre-Bosquet, N., Wressnigg, N., Hochreiter, R., Bossevot, L., Pascal, Q., Guehenneux, F., Bitzer, A., and Corbic Ramljak, I. (2022). Effectiveness of CHIKV vaccine VLA1553 demonstrated by passive transfer of human sera. JCI Insight, 7.","DOI":"10.1172\/jci.insight.160173"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.2147\/DDDT.S366112","article-title":"Chikungunya Vaccine Candidates: Current Landscape and Future Prospects","volume":"16","author":"Schmidt","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1001\/jama.2020.2477","article-title":"Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial","volume":"323","author":"Chen","year":"2020","journal-title":"JAMA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1016\/j.vaccine.2023.04.064","article-title":"A phase 1, randomized, placebo-controlled, dose-ranging study to evaluate the safety and immunogenicity of an mRNA-based chikungunya virus vaccine in healthy adults","volume":"41","author":"Shaw","year":"2023","journal-title":"Vaccine"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Varikkodan, M.M., Kunnathodi, F., Azmi, S., and Wu, T.Y. (2023). An Overview of Indian Biomedical Research on the Chikungunya Virus with Particular Reference to Its Vaccine, an Unmet Medical Need. Vaccines, 11.","DOI":"10.3390\/vaccines11061102"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1038\/s41467-024-48587-5","article-title":"Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea","volume":"15","author":"Timothy","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Makenov, M.T., Boumbaly, S., Tolno, F.R., Sacko, N., N\u2019Fatoma, L.T., Mansare, O., Kolie, B., Stukolova, O.A., Morozkin, E.S., and Kholodilov, I.S. (2023). Marburg virus in Egyptian Rousettus bats in Guinea: Investigation of Marburg virus outbreak origin in 2021. PLoS Negl. Trop. Dis., 17.","DOI":"10.1371\/journal.pntd.0011279"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Jayaprakash, A.D., Ronk, A.J., Prasad, A.N., Covington, M.F., Stein, K.R., Schwarz, T.M., Hekmaty, S., Fenton, K.A., Geisbert, T.W., and Basler, C.F. (2023). Marburg and Ebola Virus Infections Elicit a Complex, Muted Inflammatory State in Bats. Viruses, 15.","DOI":"10.3390\/v15020350"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"6599","DOI":"10.1016\/j.vaccine.2022.09.037","article-title":"Immunogenicity of rVSVDeltaG-ZEBOV-GP Ebola vaccine (ERVEBO(R)) in African clinical trial participants by age, sex, and baseline GP-ELISA titer: A post hoc analysis of three Phase 2\/3 trials","volume":"40","author":"Simon","year":"2022","journal-title":"Vaccine"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/cid\/ciad693","article-title":"Immunogenicity and Vaccine Shedding After 1 or 2 Doses of rVSVDeltaG-ZEBOV-GP Ebola Vaccine (ERVEBO(R)): Results From a Phase 2, Randomized, Placebo-controlled Trial in Children and Adults","volume":"78","author":"Lee","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Woolsey, C., Cross, R.W., Agans, K.N., Borisevich, V., Deer, D.J., Geisbert, J.B., Gerardi, C., Latham, T.E., Fenton, K.A., and Egan, M.A. (2022). A highly attenuated Vesiculovax vaccine rapidly protects nonhuman primates against lethal Marburg virus challenge. PLoS Negl. Trop. Dis., 16.","DOI":"10.1101\/2022.01.22.477345"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Zhu, W., Liu, G., Cao, W., He, S., Leung, A., Stroher, U., Fairchild, M.J., Nichols, R., Crowell, J., and Fusco, J. (2022). A Cloned Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine, PHV01, Protects Guinea Pigs from Lethal Marburg Virus Disease. Vaccines, 10.","DOI":"10.3390\/vaccines10071004"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Flaxman, A., Sebastian, S., Appelberg, S., Cha, K.M., Ulaszewska, M., Purushotham, J., Gilbride, C., Sharpe, H., Spencer, A.J., and Bibi, S. (2024). Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse. PLoS Pathog., 20.","DOI":"10.1371\/journal.ppat.1012262"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Cross, R.W., Longini, I.M., Becker, S., Bok, K., Boucher, D., Carroll, M.W., Diaz, J.V., Dowling, W.E., Draghia-Akli, R., and Duworko, J.T. (2022). An introduction to the Marburg virus vaccine consortium, MARVAC. PLoS Pathog., 18.","DOI":"10.1371\/journal.ppat.1010805"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Parish, L.A., Stavale, E.J., Houchens, C.R., and Wolfe, D.N. (2023). Developing Vaccines to Improve Preparedness for Filovirus Outbreaks: The Perspective of the USA Biomedical Advanced Research and Development Authority (BARDA). Vaccines, 11.","DOI":"10.3390\/vaccines11061120"},{"key":"ref_135","unstructured":"(2025, February 21). Remaining Patients Discharged in Uganda\u2019s Ebola Sudan Outbreak. Available online: https:\/\/www.cidrap.umn.edu\/ebola\/remaining-patients-discharged-ugandas-ebola-sudan-outbreak."},{"key":"ref_136","unstructured":"(2025, February 21). Tests Under Way in Suspected Ebola Outbreak in DR Congo. Available online: https:\/\/www.cidrap.umn.edu\/ebola\/tests-under-way-suspected-ebola-outbreak-dr-congo."},{"key":"ref_137","unstructured":"(2025, February 21). Rwanda Declares End of Marburg Virus Disease Outbreak, Available online: https:\/\/www.moh.gov.rw\/news-detail\/article-9."},{"key":"ref_138","unstructured":"World Health Organization (2025, February 21). Marburg Virus Disease\u2013United Republic of Tanzania, Available online: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2025-DON554."},{"key":"ref_139","unstructured":"(2025, February 21). 100% Marburg Case Fatality Rate in Tanzania\u2014Vax-Before-Travel. Available online: https:\/\/www.vax-before-travel.com\/100-marburg-case-fatality-rate-tanzania-2025-02-14."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Gruber, M.F., Rubin, S., and Krause, P.R. (2023). Approaches to demonstrating the effectiveness of filovirus vaccines: Lessons from Ebola and COVID-19. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1109486"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Malik, S., Kishore, S., Nag, S., Dhasmana, A., Preetam, S., Mitra, O., Leon-Figueroa, D.A., Mohanty, A., Chattu, V.K., and Assefi, M. (2023). Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges. Vaccines, 11.","DOI":"10.3390\/vaccines11020268"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Silva, N.I.O., Albery, G.F., Arruda, M.S., Oliveira, G.F.G., Costa, T.A., de Mello, \u00c9.M., Moreira, G.D., Reis, E.V., Silva, S.A.D., and Silva, M.C. (2023). Ecological drivers of sustained enzootic yellow fever virus transmission in Brazil, 2017\u20132021. PLoS Negl. Trop. Dis., 17.","DOI":"10.1371\/journal.pntd.0011407"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3390\/v15030757","article-title":"Yellow Fever Virus Maintained by Sabethes Mosquitoes during the Dry Season in Cerrado, a Semiarid Region of Brazil, in 2021","volume":"15","author":"Andrade","year":"2023","journal-title":"Viruses"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Ribeiro, I.P., Delatorre, E., de Abreu, F.V.S., Dos Santos, A.A.C., Furtado, N.D., Ferreira-de-Brito, A., de Pina-Costa, A., Neves, M., de Castro, M.G., and Motta, M.A. (2023). Ecological, Genetic, and Phylogenetic Aspects of YFV 2017\u20132019 Spread in Rio de Janeiro State. Viruses, 15.","DOI":"10.3390\/v15020437"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Ferreira, M.S., Sousa, J.R., Bezerra Junior, P.S., Cerqueira, V.D., Oliveira Junior, C.A., Rivero, G.R.C., Castro, P.H.G., Silva, G.A., Muniz, J., and da Silva, E.V.P. (2023). Experimental Yellow Fever in Squirrel Monkey: Characterization of Liver In Situ Immune Response. Viruses, 15.","DOI":"10.3390\/v15020551"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Furtado, N.D., de Mello, I.S., de Godoy, A.S., Noske, G.D., Oliva, G., Canard, B., Decroly, E., and Bonaldo, M.C. (2023). Amino Acid Polymorphisms on the Brazilian Strain of Yellow Fever Virus Methyltransferase Are Related to the Host\u2019s Immune Evasion Mediated by Type I Interferon. Viruses, 15.","DOI":"10.3390\/v15010191"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Lin, K., Good, S.S., Julander, J.G., Weight, A.E., Moussa, A., and Sommadossi, J.P. (2022). AT-752, a double prodrug of a guanosine nucleotide analog, inhibits yellow fever virus in a hamster model. PLoS Negl. Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0009937"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"de Freitas, C.S., Higa, L.M., Sacramento, C.Q., Ferreira, A.C., Reis, P.A., Delvecchio, R., Monteiro, F.L., Barbosa-Lima, G., James Westgarth, H., and Vieira, Y.R. (2019). Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007072"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Doyle, M.P., Genualdi, J.R., Bailey, A.L., Kose, N., Gainza, C., Rodriguez, J., Reeder, K.M., Nelson, C.A., Jethva, P.N., and Sutton, R.E. (2022). solation of a potently neutralizing and protective human monoclonal antibody targeting Yellow fever virus. mBio, 13.","DOI":"10.1128\/mbio.00512-22"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Hansen, C.A., and Barrett, A.D.T. (2021). The Present and Future of Yellow Fever Vaccines. Pharmaceuticals, 14.","DOI":"10.3390\/ph14090891"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Juan-Giner, A., and Hombach, J. (2024). The life-long protective immunity of yellow fever vaccination: Time to review?. Lancet Glob. Health, 12.","DOI":"10.1016\/S2214-109X(23)00594-6"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1895644","DOI":"10.1080\/21645515.2021.1895644","article-title":"Re-thinking yellow fever vaccines: Fighting old foes with new generation vaccines","volume":"18","author":"Rollier","year":"2022","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41541-022-00595-6","article-title":"A phase I clinical study to assess safety and immunogenicity of yellow fever vaccine","volume":"7","author":"Desai","year":"2022","journal-title":"NPJ Vaccines"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Sandberg, J.T., Lofling, M., Varnaite, R., Emgard, J., Al-Tawil, N., Lindquist, L., Gredmark-Russ, S., Klingstrom, J., Lore, K., and Blom, K. (2023). Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. PLoS Negl. Trop. Dis., 17.","DOI":"10.1371\/journal.pntd.0010616"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Yu, C., Zuo, L., Miao, J., Mao, L., Selekon, B., Gonofio, E., Nakoune, E., Berthet, N., and Wong, G. (2022). Development of a Novel Loop-Mediated Isothermal Amplification Method for the Rapid Detection of Monkeypox Virus Infections. Viruses, 15.","DOI":"10.3390\/v15010084"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Gong, L., Chen, X., Wang, Y., Liang, J., Liu, X., and Wang, Y. (2023). Rapid, sensitive, and highly specific detection of monkeypox virus by CRISPR-based diagnostic platform. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1137968"},{"key":"ref_157","unstructured":"World Health Organization (2024, November 27). Mpox, Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/mpox."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"049","DOI":"10.1055\/s-0044-1786684","article-title":"Global Re-emergence of Monkeypox: A Synoptic Review","volume":"16","author":"Memariani","year":"2024","journal-title":"Ibnosina J. Med. Biomed. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Rabaan, A.A., Alasiri, N.A., Aljeldah, M., Alshukairiis, A.N., AlMusa, Z., Alfouzan, W.A., Abuzaid, A.A., Alamri, A.A., Al-Afghani, H.M., and Al-Baghli, N. (2023). An Updated Review on Monkeypox Viral Disease: Emphasis on Genomic Diversity. Biomedicines, 11.","DOI":"10.3390\/biomedicines11071832"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Anwar, F., Haider, F., Khan, S., Ahmad, I., Ahmed, N., Imran, M., Rashid, S., Ren, Z.-G., Khattak, S., and Ji, X.-Y. (2023). Clinical Manifestation, Transmission, Pathogenesis, and Diagnosis of Monkeypox Virus: A Comprehensive Review. Life, 13.","DOI":"10.3390\/life13020522"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1111\/1751-7915.14294","article-title":"Pandemic potential of poxviruses: From an ancient killer causing smallpox to the surge of monkeypox","volume":"16","year":"2023","journal-title":"Microb. Biotechnol."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Almehmadi, M., Allahyani, M., Alsaiari, A.A., Alshammari, M.K., Alharbi, A.S., Hussain, K.H., Alsubaihi, L.I., Kamal, M., Alotaibi, S.S., and Alotaibi, A.N. (2022). A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak. Viruses, 14.","DOI":"10.3390\/v14091870"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Ajmal, A., Mahmood, A., Hayat, C., Hakami, M.A., Alotaibi, B.S., Umair, M., Abdalla, A.N., Li, P., He, P., and Wadood, A. (2023). Computer-assisted drug repurposing for thymidylate kinase drug target in monkeypox virus. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1159389"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s11030-023-10636-4","article-title":"Identification of FDA-approved drugs with triple targeting mode of action for the treatment of monkeypox: A high throughput virtual screening study","volume":"28","author":"Srivastava","year":"2024","journal-title":"Mol. Divers."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S1473-3099(23)00345-6","article-title":"Modified vaccinia Ankara-Bavarian Nordic vaccine against mpox in children","volume":"23","author":"Turtle","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"ref_166","first-page":"819","article-title":"FDA Authorizes Intradermal Vaccine, Streamlines Rules to Increase Monkeypox Treatment Access","volume":"328","author":"Larkin","year":"2022","journal-title":"JAMA"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"109994","DOI":"10.1016\/j.virol.2024.109994","article-title":"Monkeypox: Can we count on the current smallpox immunization?","volume":"592","author":"Zhang","year":"2024","journal-title":"Virology"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Zuiani, A., Dulberger, C.L., De Silva, N.S., Marquette, M., Lu, Y.-J., Palowitch, G.M., Dokic, A., Sanchez-Velazquez, R., Schlatterer, K., and Sarkar, S. (2024). A multivalent mRNA monkeypox virus vaccine (BNT166) protects mice and macaques from orthopoxvirus disease. Cell, 187.","DOI":"10.1016\/j.cell.2024.01.017"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Harapan, H., Ophinni, Y., Megawati, D., Frediansyah, A., Mamada, S.S., Salampe, M., Bin Emran, T., Winardi, W., Fathima, R., and Sirinam, S. (2022). Monkeypox: A Comprehensive Review. Viruses, 14.","DOI":"10.3390\/v14102155"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12519-022-00624-3","article-title":"Diagnosis, treatment, and prevention of monkeypox in children: An experts\u2019 consensus statement","volume":"19","author":"Jiang","year":"2023","journal-title":"World J. Pediatr."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Becker, N., and Maisner, A. (2023). Nipah Virus Impairs Autocrine IFN Signaling by Sequestering STAT1 and STAT2 into Inclusion Bodies. Viruses, 15.","DOI":"10.3390\/v15020554"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Pollak, N.M., Olsson, M., Marsh, G.A., Macdonald, J., and McMillan, D. (2022). Evaluation of three rapid low-resource molecular tests for Nipah virus. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1101914"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Kirichenko, A., Bryushkova, E., Dedkov, V., and Dolgova, A. (2023). A Novel DNAzyme-Based Fluorescent Biosensor for Detection of RNA-Containing Nipah Henipavirus. Biosensors, 13.","DOI":"10.3390\/bios13020252"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1038\/s41467-024-48601-w","article-title":"A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer","volume":"15","author":"Fan","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1038\/s41467-024-47213-8","article-title":"Potent human neutralizing antibodies against Nipah virus derived from two ancestral antibody heavy chains","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Woolsey, C., Borisevich, V., Fears, A.C., Agans, K.N., Deer, D.J., Prasad, A.N., O\u2019Toole, R., Foster, S.L., Dobias, N.S., and Geisbert, J.B. (2023). Recombinant vesicular stomatitis virus-vectored vaccine induces long-lasting immunity against Nipah virus disease. J. Clin. Investig., 133.","DOI":"10.1172\/JCI164946"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Monath, T.P., Nichols, R., Feldmann, F., Griffin, A., Haddock, E., Callison, J., Meade-White, K., Okumura, A., Lovaglio, J., and Hanley, P.W. (2023). Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1216225"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Tan, F.H., Sukri, A., Idris, N., Ong, K.C., Schee, J.P., Tan, C.T., Tan, S.H., Wong, K.T., Wong, L.P., and Tee, K.K. (2024). A systematic review on Nipah virus: Global molecular epidemiology and medical countermeasures development. Virus Evol., 10.","DOI":"10.1093\/ve\/veae048"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jobb.2023.04.002","article-title":"Outbreak of an emerging zoonotic Nipah virus: An emerging concern","volume":"5","author":"Paul","year":"2023","journal-title":"J. Biosaf. Biosecur."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Moore, K.A., Mehr, A.J., Ostrowsky, J.T., Ulrich, A.K., Moua, N.M., Fay, P.C., Hart, P.J., Golding, J.P., Benassi, V., and Preziosi, M.P. (2024). Measures to prevent and treat Nipah virus disease: Research priorities for 2024\u20132029. Lancet Infect. Dis., 24.","DOI":"10.1016\/S1473-3099(24)00262-7"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Luo, X.L., Zhang, X.D., Li, B.J., Qin, T., Cao, Z.J., Fan, Q.J., Yang, J., Jin, D., Lu, S., and Zheng, Y.Y. (2023). Comparative evaluation of standard RT-PCR assays and commercial Real-Time RT-PCR kits for detection of Lassa Virus. Microbiol. Spectr., 11.","DOI":"10.1128\/spectrum.05011-22"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Deschambault, Y., Soule, G., Klassen, L., Sloan, A., Audet, J., Azaransky, K., Musa, A.S., Ahmad, A., Akinpelu, A.M., and Mba, N. (2023). An Outbred Guinea Pig Disease Model for Lassa Fever Using a Host-Adapted Clade III Nigerian Lassa Virus. Viruses, 15.","DOI":"10.3390\/v15030769"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41541-024-00930-z","article-title":"Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease","volume":"9","author":"Scher","year":"2024","journal-title":"npj Vaccines"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/s41467-023-37050-6","article-title":"Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys","volume":"14","author":"Mateo","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Ugwu, C., Olumade, T., Nwakpakpa, E., Onyia, V., Odeh, E., Duruiheoma, R.O., Ojide, C.K., Eke, M.A., Nwafor, I.E., and Chika-Igwenyi, N. (2022). Humoral and cellular immune responses to Lassa fever virus in Lassa fever survivors and their exposed contacts in Southern Nigeria. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-26045-w"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Hou, Y., Liu, Y., Jia, X., Zhou, M., Mao, W., Dong, S., Zhang, Y., Xiao, G., and Wang, W. (2022). Screening and Identification of Lassa Virus Entry Inhibitors from a Fragment-Based Drug Discovery Library. Viruses, 14.","DOI":"10.3390\/v14122649"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Aloke, C., Obasi, N.A., Aja, P.M., Emelike, C.U., Egwu, C.O., Jeje, O., Edeogu, C.O., Onisuru, O.O., Orji, O.U., and Achilonu, I. (2023). Combating Lassa Fever in West African Sub-Region: Progress, Challenges, and Future Perspectives. Viruses, 15.","DOI":"10.3390\/v15010146"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Berm\u00fadez-M\u00e9ndez, E., Angelino, P., Keulen, L., Water, S., Rockx, B., Pijlman, G.P., Ciuffi, A., Kortekaas, J., and Schreur, P.J.W. (2023). Transcriptomic profiling reveals intense host-pathogen dispute compromising homeostasis during acute Rift Valley fever virus infection. J. Virol., 97.","DOI":"10.1128\/jvi.00415-23"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Wang, X., Yuan, Y., Liu, Y., and Zhang, L. (2022). Arm race between Rift Valley fever virus and host. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1084230"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Michaely, L.M., Rissmann, M., Armando, F., von Arnim, F., Keller, M., Eiden, M., Konig, R., Gutjahr, B., Baumgartner, W., and Groschup, M.H. (2022). Rift Valley Fever Virus Non-Structural Protein S Is Associated with Nuclear Translocation of Active Caspase-3 and Inclusion Body Formation. Viruses, 14.","DOI":"10.3390\/v14112487"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"995","DOI":"10.4269\/ajtmh.22-0410","article-title":"Detection of Sporadic Outbreaks of Rift Valley Fever in Uganda through the National Viral Hemorrhagic Fever Surveillance System, 2017\u20132020","volume":"108","author":"Nyakarahuka","year":"2023","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Juma, J., Konongoi, S.L., Nsengimana, I., Mwangi, R., Akoko, J., Nyamota, R., Muli, C., Dobi, P.O., Kiritu, E., and Osiany, S. (2023). Using Multiplex Amplicon PCR Technology to Efficiently and Timely Generate Rift Valley Fever Virus Sequence Data for Genomic Surveillance. Viruses, 15.","DOI":"10.3390\/v15020477"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Hao, M., Bian, T., Fu, G., Chen, Y., Fang, T., Zhao, C., Liu, S., Yu, C., Li, J., and Chen, W. (2023). An adenovirus-vectored RVF vaccine confers complete protection against lethal RVFV challenge in A129 mice. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1114226"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Bian, T., Wang, B., Fu, G., Hao, M., Chen, Y., Fang, T., Liu, S., Yu, C., Li, J., and Chen, W. (2022). Single-dose of a replication-competent adenovirus-vectored vaccine provides sterilizing protection against Rift Valley fever virus challenge. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.907675"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Lacote, S., Tamietti, C., Chabert, M., Confort, M.P., Conquet, L., Pulido, C., Aurine, N., Baquerre, C., Thiesson, A., and Pain, B. (2022). Intranasal Exposure to Rift Valley Fever Virus Live-Attenuated Strains Leads to High Mortality Rate in Immunocompetent Mice. Viruses, 14.","DOI":"10.3390\/v14112470"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Saegerman, C., Humblet, M.F., Leandri, M., Gonzalez, G., Heyman, P., Sprong, H., L\u2019Hostis, M., Moutailler, S., Bonnet, S.I., and Haddad, N. (2023). First Expert Elicitation of Knowledge on Possible Drivers of Observed Increasing Human Cases of Tick-Borne Encephalitis in Europe. Viruses, 15.","DOI":"10.3390\/v15030791"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Beicht, J., Kubinski, M., Zdora, I., Puff, C., Biermann, J., Gerlach, T., Baumgartner, W., Sutter, G., Osterhaus, A., and Prajeeth, C.K. (2023). Induction of humoral and cell-mediated immunity to the NS1 protein of TBEV with recombinant Influenza virus and MVA affords partial protection against lethal TBEV infection in mice. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1177324"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Bestehorn-Willmann, M., Girl, P., Greiner, F., Mackenstedt, U., Dobler, G., and Lang, D. (2023). Increased Vaccination Diversity Leads to Higher and Less-Variable Neutralization of TBE Viruses of the European Subtype. Vaccines, 11.","DOI":"10.3390\/vaccines11061044"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Kubinski, M., Beicht, J., Zdora, I., Biermann, J., Puff, C., Gerlach, T., Tscherne, A., Baumgartner, W., Osterhaus, A., and Sutter, G. (2023). A recombinant Modified Vaccinia virus Ankara expressing prME of tick-borne encephalitis virus affords mice full protection against TBEV infection. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1182963"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Matveev, A., Khlusevich, Y., Kozlova, I., Matveev, L., Emelyanova, L., Tikunov, A., Baykov, I., and Tikunova, N. (2023). New Neutralizing Epitope Exposed on the Domain II of Tick-Borne Encephalitis Virus Envelope Glycoprotein E. Viruses, 15.","DOI":"10.3390\/v15061256"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Stone, E.T., and Pinto, A.K. (2023). T Cells in Tick-Borne Flavivirus Encephalitis: A Review of Current Paradigms in Protection and Disease Pathology. Viruses, 15.","DOI":"10.3390\/v15040958"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Hoornweg, T.E., Godeke, G.J., Hoogerwerf, M.N., van Kasteren, P.B., de Vries, A., Sprong, H., Verjans, G., van Riel, D., Reimerink, J.H.J., and Rockx, B. (2023). Rescue and in vitro characterization of a divergent TBEV-Eu strain from the Netherlands. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-29075-0"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Mackenzie, J.S., Williams, D.T., van den Hurk, A.F., Smith, D.W., and Currie, B.J. (2022). Japanese Encephalitis Virus: The Emergence of Genotype IV in Australia and Its Potential Endemicity. Viruses, 14.","DOI":"10.3390\/v14112480"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.pathol.2023.02.006","article-title":"A real-time PCR assay for Japanese encephalitis virus (JEV) genotype IV as a public health laboratory response to an emerging outbreak in Australia","volume":"55","author":"Martin","year":"2023","journal-title":"Pathology"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Yang, H., Wang, X., Wang, Z., Wang, G., Fu, S., Li, F., Yang, L., Yuan, Y., Shen, K., and Wang, H. (2023). Peripheral nerve injury induced by Japanese Encephalitis virus in C57BL\/6 mouse. J. Virol., 97.","DOI":"10.1128\/jvi.01658-22"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Yadav, P., Chakraborty, P., Jha, N.K., Dewanjee, S., Jha, A.K., Panda, S.P., Mishra, P.C., Dey, A., and Jha, S.K. (2022). Molecular Mechanism and Role of Japanese Encephalitis Virus Infection in Central Nervous System-Mediated Diseases. Viruses, 14.","DOI":"10.3390\/v14122686"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Zhao, G., Gao, Y., Zhang, J., Zhang, H., Xie, C., Nan, F., Feng, S., Ha, Z., Li, C., and Zhu, X. (2022). Toll-like receptor 2 signaling pathway activation contributes to a highly efficient inflammatory response in Japanese encephalitis virus-infected mouse microglial cells by proteomics. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.989183"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12985-023-01966-8","article-title":"Exaggerated levels of some specific TLRs, cytokines and chemokines in Japanese encephalitis infected BV2 and neuro 2A cell lines associated with worst outcome","volume":"20","author":"Shukla","year":"2023","journal-title":"Virol. J."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Kakoti, G., Dutta, P., Ram Das, B., Borah, J., and Mahanta, J. (2013). Clinical profile and outcome of Japanese encephalitis in children admitted with acute encephalitis syndrome. Biomed. Res. Int., 2013.","DOI":"10.1155\/2013\/152656"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1086\/505121","article-title":"Clinical Features in Children Hospitalized during the 2005 Epidemic of Japanese Encephalitis in Uttar Pradesh, India","volume":"43","author":"Kumar","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4236\/health.2012.41002","article-title":"Influence of socio-economic status and environmental factors on serologically diagnosed Japanese encephalitis cases in the state of West Bengal, India during 2005\u20132010","volume":"4","author":"Sarkar","year":"2012","journal-title":"Health"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1651-2227.2004.tb02967.x","article-title":"Serosurveillance for Japanese encephalitis in children in several districts of West Bengal, India","volume":"93","author":"Chatterjee","year":"2004","journal-title":"Acta Paediatr."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Srivastava, N., Deval, H., Mittal, M., Deoshatwar, A., Bondre, V.P., Kant, R., and Yadav, R. (2022). Extent of disability among paediatric Japanese encephalitis survivors and predictors of poor outcome: A retrospective cohort study in North India. BMJ Open, 12.","DOI":"10.1136\/bmjopen-2022-060795"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Qi, Z., Zhao, J., Li, Y., Zhang, B., Hu, S., Chen, Y., Ma, J., Shu, Y., Wang, Y., and Cheng, P. (2023). Live-attenuated Japanese encephalitis virus inhibits glioblastoma growth and elicits potent antitumor immunity. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.982180"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Ndione, M.H.D., Ndiaye, E.H., Faye, M., Diagne, M.M., Diallo, D., Diallo, A., Sall, A.A., Loucoubar, C., Faye, O., and Diallo, M. (2022). Re-Introduction of West Nile Virus Lineage 1 in Senegal from Europe and Subsequent Circulation in Human and Mosquito Populations between 2012 and 2021. Viruses, 14.","DOI":"10.3390\/v14122720"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Ruiz-L\u00f3pez, M.J., Aguilera-Sep\u00falveda, P., Cebri\u00e1n-Camis\u00f3n, S., Figuerola, J., Magallanes, S., Varona, S., Cuesta, I., Cano-G\u00f3mez, C., S\u00e1nchez-Mora, P., and Camacho, J. (2023). Re-Emergence of a West Nile Virus (WNV) Variant in South Spain with Rapid Spread Capacity. Viruses, 15.","DOI":"10.3390\/v15122372"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Reemtsma, H., Holicki, C.M., Fast, C., Bergmann, F., Eiden, M., Groschup, M.H., and Ziegler, U. (2022). Pathogenesis of West Nile Virus Lineage 2 in Domestic Geese after Experimental Infection. Viruses, 14.","DOI":"10.3390\/v14061319"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Benzarti, E., Murray, K.O., and Ronca, S.E. (2023). Interleukins, Chemokines, and Tumor Necrosis Factor Superfamily Ligands in the Pathogenesis of West Nile Virus Infection. Viruses, 15.","DOI":"10.3390\/v15030806"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Hruskovicova, J., Bhide, K., Petrouskova, P., Tkacova, Z., Mochnacova, E., Curlik, J., Bhide, M., and Kulkarni, A. (2022). Engineering the Single Domain Antibodies Targeting Receptor Binding Motifs Within the Domain III of West Nile Virus Envelope Glycoprotein. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.801466"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2437244","DOI":"10.1080\/22221751.2024.2437244","article-title":"West Nile Virus in a changing climate: Epidemiology, pathology, advances in diagnosis and treatment, vaccine designing and control strategies, emerging public health challenges\u2014A comprehensive review","volume":"14","author":"Singh","year":"2025","journal-title":"Emerg. Microbes Infect."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Kaiser, J.A., and Barrett, A.D.T. (2019). Twenty Years of Progress Toward West Nile Virus Vaccine Development. Viruses, 11.","DOI":"10.3390\/v11090823"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1080\/21645515.2019.1621149","article-title":"West Nile virus vaccines\u2014Current situation and future directions","volume":"15","author":"Ulbert","year":"2019","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Wei\u00df, R., Issmail, L., Rockstroh, A., Grunwald, T., Fertey, J., and Ulbert, S. (2023). Immunization with different recombinant West Nile virus envelope proteins induces varying levels of serological cross-reactivity and protection from infection. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1279147"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Sun, H., Acharya, D., Paul, A.M., Lai, H., He, J., Bai, F., and Chen, Q. (2023). Antibody-Dependent Enhancement Activity of a Plant-Made Vaccine against West Nile Virus. Vaccines, 11.","DOI":"10.3390\/vaccines11020197"},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Pattnaik, A., Sahoo, B.R., Struble, L.R., Borgstahl, G.E.O., Zhou, Y., Franco, R., Barletta, R.G., Osorio, F.A., Petro, T.M., and Pattnaik, A.K. (2023). A Ferritin Nanoparticle-Based Zika Virus Vaccine Candidate Induces Robust Humoral and Cellular Immune Responses and Protects Mice from Lethal Virus Challenge. Vaccines, 11.","DOI":"10.3390\/vaccines11040821"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41541-023-00650-w","article-title":"An effective live-attenuated Zika vaccine candidate with a modified 5\u2019 untranslated region","volume":"8","author":"Nazneen","year":"2023","journal-title":"NPJ Vaccines"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/s41564-023-01413-y","article-title":"Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody","volume":"8","author":"Stass","year":"2023","journal-title":"Nat. Microbiol."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Aviziniene, A., Kucinskaite-Kodze, I., Petraityte-Burneikiene, R., Zvirbliene, A., Mertens, M.L., Schmidt, S., Schlegel, M., Lattwein, E., Koellner, B., and Ulrich, R.G. (2023). Characterization of a Panel of Cross-Reactive Hantavirus Nucleocapsid Protein-Specific Monoclonal Antibodies. Viruses, 15.","DOI":"10.3390\/v15020532"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Hooper, J., Paolino, K.M., Mills, K., Kwilas, S., Josleyn, M., Cohen, M., Somerville, B., Wisniewski, M., Norris, S., and Hill, B. (2020). A Phase 2a Randomized, Double-Blind, Dose-Optimizing Study to Evaluate the Immunogenicity and Safety of a Bivalent DNA Vaccine for Hemorrhagic Fever with Renal Syndrome Delivered by Intramuscular Electroporation. Vaccines, 8.","DOI":"10.3390\/vaccines8030377"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Noor, F., Ashfaq, U.A., Asif, M., Adeel, M.M., Alshammari, A., and Alharbi, M. (2022). Comprehensive computational analysis reveals YXXPhi[I\/L\/M\/F\/V] motif and YXXPhi-like tetrapeptides across HFRS causing Hantaviruses and their association with viral pathogenesis and host immune regulation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1031608"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"105161","DOI":"10.1016\/j.micpath.2021.105161","article-title":"HantavirusesDB: Vaccinomics and RNA-based therapeutics database for the potentially emerging human respiratory pandemic agents","volume":"160","author":"Khan","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Mocanu, A., Cajvan, A.M., Lazaruc, T.I., Lupu, V.V., Florescu, L., Lupu, A., Bogos, R.A., Ioniuc, I., Scurtu, G., and Dragan, F. (2023). Hantavirus Infection in Children-A Pilot Study of Single Regional Center. Viruses, 15.","DOI":"10.3390\/v15040872"},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Zhang, H., Wang, Y., Ma, Y., Tang, K., Zhang, C., Wang, M., Zhang, X., Xue, M., Jia, X., and Hu, H. (2022). Increased CD4+CD8+ Double Positive T Cells during Hantaan Virus Infection. Viruses, 14.","DOI":"10.3390\/v14102243"},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Glass, G.E. (2023). Forecasting Outbreaks of Hantaviral Disease: Future Directions in Geospatial Modeling. Viruses, 15.","DOI":"10.3390\/v15071461"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.antiviral.2004.08.001","article-title":"Crimean\u2013Congo hemorrhagic fever","volume":"64","author":"Whitehouse","year":"2004","journal-title":"Antivir. Res."},{"key":"ref_236","first-page":"854","article-title":"Crimean-Congo Hemorrhagic Fever Virus for Clinicians-Epidemiology, Clinical Manifestations, and Prevention","volume":"30","author":"Frank","year":"2024","journal-title":"Emerg. Infect. Dis."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13071-022-05588-x","article-title":"Prevalence of Crimean-Congo haemorrhagic fever in livestock following a confirmed human case in Lyantonde district, Uganda","volume":"16","author":"Atim","year":"2023","journal-title":"Parasit Vectors"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Febrer-Sendra, B., Fernandez-Soto, P., Garcia-Bernalt Diego, J., Crego-Vicente, B., Negredo, A., Munor-Bellido, J.L., Belhassen-Garcia, M., Sanchez-Seco, M.P., and Muro, A. (2023). A Novel RT-LAMP for the Detection of Different Genotypes of Crimean-Congo Haemorrhagic Fever Virus in Patients from Spain. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076411"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Hoste, A.C.R., Djadjovski, I., Jim\u00e9nez-Clavero, M.\u00c1., Rueda, P., Barr, J.N., and Sastre, P. (2023). Multiplex assay for simultaneous detection of antibodies against Crimean-Congo Hemorrhagic fever virus nucleocapsid protein and glycoproteins in ruminants. Microbiol. Spectr., 11.","DOI":"10.1128\/spectrum.02600-22"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Saunders, J.E., Gilbride, C., Dowall, S., Morris, S., Ulaszewska, M., Spencer, A.J., Rayner, E., Graham, V.A., Kennedy, E., and Thomas, K. (2023). Adenoviral vectored vaccination protects against Crimean-Congo Haemorrhagic Fever disease in a lethal challenge model. EBioMedicine, 90.","DOI":"10.1016\/j.ebiom.2023.104523"},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Zhang, G., Wang, P., Jiang, L., Wang, S., Zhang, S., and Li, Y. (2023). Evaluation of the immunogenicity of vaccine candidates developed using a baculovirus surface display system for Crimean-Congo hemorrhagic fever virus in mice. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1107874"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41541-024-00931-y","article-title":"Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 subunit vaccine combination prevents morbidity in mice","volume":"9","author":"Karaaslan","year":"2024","journal-title":"npj Vaccines"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41541-024-00887-z","article-title":"A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever","volume":"9","author":"Hawman","year":"2024","journal-title":"npj Vaccines"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Alam, R., Samad, A., Ahammad, F., Nur, S.M., Alsaiari, A.A., Imon, R.R., Talukder, M.E.K., Nain, Z., Rahman, M.M., and Mohammad, F. (2023). In silico formulation of a next-generation multiepitope vaccine for use as a prophylactic candidate against Crimean-Congo hemorrhagic fever. BMC Med., 21.","DOI":"10.1186\/s12916-023-02750-9"},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Shah, S.Z., Jabbar, B., Mirza, M.U., Waqas, M., Aziz, S., Halim, S.A., Ali, A., Rafique, S., Idrees, M., and Khalid, A. (2022). An Immunoinformatics Approach to Design a Potent Multi-Epitope Vaccine against Asia-1 Genotype of Crimean-Congo Haemorrhagic Fever Virus Using the Structural Glycoproteins as a Target. Vaccines, 11.","DOI":"10.3390\/vaccines11010061"},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Igan, H., and Hanci, H. (2024). The six-year prevalence of Crimean-Congo Hemorrhagic Fever (CCHF) in Erzurum, Turkey. J. Vector Borne Dis.","DOI":"10.4103\/JVBD.JVBD_143_21"},{"key":"ref_247","first-page":"650","article-title":"Crimean-Congo Haemorrhagic Fever Virus: From Genomic Insights to Control Strategies","volume":"14","year":"2024","journal-title":"J. Inst. Sci. Technol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"106799","DOI":"10.1016\/j.isci.2023.106799","article-title":"SFTSV infection is associated with transient overproliferation of monoclonal lambda-type plasma cells","volume":"26","author":"Quan","year":"2023","journal-title":"iScience"},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Dai, Y., Pu, Q., Hu, N., Zhu, J., Han, Y., Shi, P., Li, J., and Jin, K. (2023). The dose-response relationship between smoking and the risk factor for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1209705"},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Yoshikawa, R., Kawakami, M., and Yasuda, J. (2023). The NSs protein of severe fever with thrombocytopenia syndrome virus differentially inhibits the type 1 interferon response among animal species. J. Biol. Chem., 299.","DOI":"10.1016\/j.jbc.2023.104819"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Li, Y.H., Huang, W.W., He, W.Q., He, X.Y., Wang, X.H., Lin, Y.L., Zhao, Z.J., Zheng, Y.T., and Pang, W. (2023). Longitudinal analysis of immunocyte responses and inflammatory cytokine profiles in SFTSV-infected rhesus macaques. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1143796"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bsheal.2021.12.008","article-title":"Immunogenicity and protective efficacy of an inactivated SFTS vaccine candidate in mice","volume":"4","author":"Li","year":"2022","journal-title":"Biosaf. Health"},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Hu, Q., Zhang, Y., Jiang, J., and Zheng, A. (2023). Two Point Mutations in the Glycoprotein of SFTSV Enhance the Propagation Recombinant Vesicular Stomatitis Virus Vectors at Assembly Step. Viruses, 15.","DOI":"10.3390\/v15030800"},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Kim, J.Y., Jeon, K., Hong, J.J., Park, S.I., Cho, H., Park, H.J., Kwak, H.W., Park, H.J., Bang, Y.J., and Lee, Y.S. (2023). Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-35328-9"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Park, J.Y., Hewawaduge, C., Sivasankar, C., Lloren, K.K.S., Oh, B., So, M.Y., and Lee, J.H. (2023). An mRNA-Based Multiple Antigenic Gene Expression System Delivered by Engineered Salmonella for Severe Fever with Thrombocytopenia Syndrome and Assessment of Its Immunogenicity and Protection Using a Human DC-SIGN-Transduced Mouse Model. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15051339"},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Raza, M.A., Ashraf, M.A., Amjad, M.N., Din, G.U., Shen, B., and Hu, Y. (2024). The peculiar characteristics and advancement in diagnostic methodologies of influenza A virus. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1435384"},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Fu, X., Wang, Q., Ma, B., Zhang, B., Sun, K., Yu, X., Ye, Z., and Zhang, M. (2023). Advances in Detection Techniques for the H5N1 Avian Influenza Virus. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417157"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/QCO.0000000000000910","article-title":"Antiviral therapies for influenza","volume":"36","author":"Chan","year":"2023","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"936","DOI":"10.62754\/joe.v3i8.4785","article-title":"Emerging Strategies and Therapeutic Advances in Influenza Treatment: A Comprehensive Review","volume":"3","author":"Alrizg","year":"2024","journal-title":"J. Ecohumanism"},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Ghosh, S., Chowdhury, S.R., Rahaman, M., Basu, B., and Prajapati, B. (2024). Revolutionizing Influenza Treatment: A Deep Dive into Targeted Drug Delivery Systems. Curr. Pharm. Biotechnol.","DOI":"10.2174\/0113892010326373241012061547"},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Raviglione, M.C.B., Tediosi, F., Villa, S., Casamitjana, N., and Plas\u00e8ncia, A. (2023). Influenza. Global Health Essentials, Springer International Publishing.","DOI":"10.1007\/978-3-031-33851-9"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41591-020-1118-7","article-title":"A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial","volume":"27","author":"Nachbagauer","year":"2021","journal-title":"Nat. Med."},{"key":"ref_263","first-page":"1421","article-title":"NIH Launches Phase 1 Trial of Broader \u201cUniversal\u201d Flu Vaccine","volume":"330","author":"Harris","year":"2023","journal-title":"JAMA"},{"key":"ref_264","unstructured":"Widge, A., Hofstetter, A., Houser, K., Awan, S., Chen, G., Florez, M., Berkowitz, N., Mendoza, F., Hendel, C., and Holman, L. (2023). An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults. Sci. Transl. Med., 15."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Uno, N., and Ross, T.M. (2024). Multivalent next generation influenza virus vaccines protect against seasonal and pre-pandemic viruses. Sci. Rep., 14.","DOI":"10.1038\/s41598-023-51024-0"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"110424","DOI":"10.1016\/j.clim.2024.110424","article-title":"Clinical advancements in mRNA vaccines against viral infections","volume":"271","author":"Fatima","year":"2025","journal-title":"Clin. Immunol."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Cheng, Z., Ma, J., and Zhao, C. (2024). Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza. Vaccines, 12.","DOI":"10.3390\/vaccines12121382"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"van de Ven, K., Lanfermeijer, J., van Dijken, H., Muramatsu, H., Vilas Boas de Melo, C., Lenz, S., Peters, F., Beattie, M.B., Lin, P.J.C., and Ferreira, J.A. (2022). A universal influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus disease in ferrets. Sci. Adv., 8.","DOI":"10.1126\/sciadv.adc9937"},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Ananworanich, J., Lee, I.T., Ensz, D., Carmona, L., Schaefers, K., Avanesov, A., Stadlbauer, D., Choi, A., Pucci, A., and McGrath, S. (2025). Safety and Immunogenicity of mRNA-1010, an Investigational Seasonal Influenza Vaccine, in Healthy Adults: Final Results From a Phase 1\/2 Randomized Trial. J. Infect. Dis., 231.","DOI":"10.1093\/infdis\/jiae329"},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Gupta, D., and Mohan, S. (2023). Influenza vaccine: A review on current scenario and future prospects. J. Genet. Eng. Biotechnol., 21.","DOI":"10.1186\/s43141-023-00581-y"},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Viboud, C., Gostic, K., Nelson, M.I., Price, G.E., Perofsky, A., Sun, K., Sequeira Trovao, N., Cowling, B.J., Epstein, S.L., and Spiro, D.J. (2020). Beyond clinical trials: Evolutionary and epidemiological considerations for development of a universal influenza vaccine. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008583"},{"key":"ref_272","unstructured":"World Health Organiztion (2025, February 23). Zoonotic Disease: Emerging Public Health Threats in the Region, Available online: https:\/\/www.emro.who.int\/about-who\/rc61\/zoonotic-diseases.html."},{"key":"ref_273","unstructured":"(2024, December 27). Protecting People and Animals from Disease Threats. Available online: https:\/\/openknowledge.fao.org\/server\/api\/core\/bitstreams\/078e6cc3-60d9-412d-9a88-a4444a2dc037\/content."},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Berger, K., and Garbuglia, A.R. (2022). Editorial: Diagnosis of zoonoses: Relevance of BSL3 and BSL4 facilities. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1052082"},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Al-Eitan, L., Khair, I., Shakhatreh, Z., Almahdawi, D., and Alahmad, S. (2024). Epidemiology, biosafety, and biosecurity of Avian Influenza: Insights from the East Mediterranean region. Rev. Med. Virol., 34.","DOI":"10.1002\/rmv.2559"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jobb.2024.10.002","article-title":"A targeted vaccination strategy: Integrating vaccines into biosafety, biosecurity, and one health initiatives","volume":"7","author":"Khiarah","year":"2025","journal-title":"J. Biosaf. Biosecurity"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/3\/352\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:44:44Z","timestamp":1760028284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/3\/352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":276,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["v17030352"],"URL":"https:\/\/doi.org\/10.3390\/v17030352","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]}}}