{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:55:32Z","timestamp":1793778932114,"version":"4.6.1"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Agency for Science and Technology Promotion","award":["PIDC 2018 051"],"award-info":[{"award-number":["PIDC 2018 051"]}]},{"name":"National Agency for Science and Technology Promotion","award":["CONICET PUE 0058"],"award-info":[{"award-number":["CONICET PUE 0058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Social distancing, hand hygiene, mask wearing, surface decontamination, travel restrictions, and school closures have been implemented worldwide to control coronavirus disease 2019 (COVID-19). It was reported that the number of EBV infections as well as the age characteristics of infected persons before and after the COVID-19 pandemic significantly decreased in children from China. Since no studies have explored the changes in EBV-associated lymphomas so far, our aim was to explore EBV infection and viral-associated Hodgkin lymphoma (HL) in a pediatric cohort from a single center. A decrease in EBV+ children by serology was proved, in particular, in those undergoing primary infection, along with a significant increase in the mean age of healthy carriers. Furthermore, a decrease in EBV-associated pediatric cHL was observed post-pandemic, particularly in the NS subtype, with a marked decrease in cases diagnosed from 2022 onward. Even though the underlying reasons for the change in incidence rates seen in this study still remain speculative, it could be hypothesized that, after the pandemic, older children have a better ability to control the EBV-mediated lymphomagenesis, based on the fact that the age of infected patients increased.<\/jats:p>","DOI":"10.3390\/v17030375","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T06:02:13Z","timestamp":1741240933000},"page":"375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pandemic-Driven Shifts in Epstein-Barr Virus (EBV) Epidemiology: Single Center Study"],"prefix":"10.3390","volume":"17","author":[{"given":"Maria Eugenia","family":"Amarillo","sequence":"first","affiliation":[{"name":"Molecular Biology Laboratory, Pathology Division, Multidisciplinary Institute for Investigation in Pediatric Pathologies (IMIPP), CONICET-GCBA, Ricardo Gutierrez Children\u2019s Hospital, Ciudad Aut\u00f3noma de Buenos Aires C1425EFD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lindl","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Pathology Division, Multidisciplinary Institute for Investigation in Pediatric Pathologies (IMIPP), CONICET-GCBA, Ricardo Gutierrez Children\u2019s Hospital, Ciudad Aut\u00f3noma de Buenos Aires C1425EFD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Garc\u00eda Lombardi","sequence":"additional","affiliation":[{"name":"Oncology Division, Ricardo Gutierrez Children \u2019s Hospital, Ciudad Aut\u00f3noma de Buenos Aires C1425EFD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-0698","authenticated-orcid":false,"given":"Maria Victoria","family":"Preciado","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Pathology Division, Multidisciplinary Institute for Investigation in Pediatric Pathologies (IMIPP), CONICET-GCBA, Ricardo Gutierrez Children\u2019s Hospital, Ciudad Aut\u00f3noma de Buenos Aires C1425EFD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"De Matteo","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Pathology Division, Multidisciplinary Institute for Investigation in Pediatric Pathologies (IMIPP), CONICET-GCBA, Ricardo Gutierrez Children\u2019s Hospital, Ciudad Aut\u00f3noma de Buenos Aires C1425EFD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Chabay","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Pathology Division, Multidisciplinary Institute for Investigation in Pediatric Pathologies (IMIPP), CONICET-GCBA, Ricardo Gutierrez Children\u2019s Hospital, Ciudad Aut\u00f3noma de Buenos Aires C1425EFD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Geris, J.M., Duval, L.M., and Balfour, H.H. 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