{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:48:32Z","timestamp":1791996512118,"version":"4.4.0"},"reference-count":170,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FACEPE"},{"name":"CNPq"},{"name":"Fiocruz-Inova"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Arboviruses represent a contemporary global challenge, prompting coordinated efforts from health organizations and governments worldwide. Dengue, chikungunya, and Zika viruses have become endemic in the tropics, resulting in the so-called \u201ctriple arbovirus epidemic\u201d. These viruses are transmitted typically through the bites of infected mosquitoes, especially A. aegypti and A. albopictus. These mosquito species are distributed across all continents and exhibit a high adaptive capacity in diverse environments. When combined with unplanned urbanization, uncontrolled population growth, and international travel\u2014the so-called \u201ctriad of the modern world\u201d\u2014the maintenance and spread of these pathogens to new areas are favored. This review provides updated information on vaccine candidates targeting dengue, chikungunya, and Zika viruses. Additionally, we discuss the challenges, perspectives, and issues associated with their successful production, testing, and deployment within the context of public health.<\/jats:p>","DOI":"10.3390\/v17030382","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T09:59:17Z","timestamp":1741255157000},"page":"382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vaccines Against Urban Epidemic Arboviruses: The State of the Art"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-0716","authenticated-orcid":false,"given":"Cl\u00e1udio Ant\u00f4nio de Moura","family":"Pereira","sequence":"first","affiliation":[{"name":"Laboratory of Virology and Experimental Therapy (Lavite), Department of Virology, Aggeu Magalh\u00e3es Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), 50670-420 Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Pess\u00f4a Germano","family":"Mendes","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Experimental Therapy (Lavite), Department of Virology, Aggeu Magalh\u00e3es Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), 50670-420 Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-2754","authenticated-orcid":false,"given":"Poliana Gomes da","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Experimental Therapy (Lavite), Department of Virology, Aggeu Magalh\u00e3es Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), 50670-420 Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8573-2216","authenticated-orcid":false,"given":"Elton Jos\u00e9 Ferreira","family":"Chaves","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Experimental Therapy (Lavite), Department of Virology, Aggeu Magalh\u00e3es Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), 50670-420 Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-5699","authenticated-orcid":false,"given":"Lindomar Jos\u00e9","family":"Pena","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Experimental Therapy (Lavite), Department of Virology, Aggeu Magalh\u00e3es Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), 50670-420 Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/S1473-3099(16)30518-7","article-title":"Epidemic arboviral diseases: Priorities for research and public health","volume":"17","author":"Gubler","year":"2017","journal-title":"Lancet Infect. 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