{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:15:57Z","timestamp":1790766957062,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Institute of Science and Technology for Emerging and Reemerging Viruses","doi-asserted-by":"publisher","award":["406360\/2022-7"],"award-info":[{"award-number":["406360\/2022-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Institute of Science and Technology for Emerging and Reemerging Viruses","doi-asserted-by":"publisher","award":["TED 98\/2023"],"award-info":[{"award-number":["TED 98\/2023"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brazilian Ministry of Health","award":["406360\/2022-7"],"award-info":[{"award-number":["406360\/2022-7"]}]},{"name":"Brazilian Ministry of Health","award":["TED 98\/2023"],"award-info":[{"award-number":["TED 98\/2023"]}]},{"name":"CAPES and CNPQ","award":["406360\/2022-7"],"award-info":[{"award-number":["406360\/2022-7"]}]},{"name":"CAPES and CNPQ","award":["TED 98\/2023"],"award-info":[{"award-number":["TED 98\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Oropouche fever is caused by the Oropouche virus (OROV; Bunyaviridae, Orthobunyavirus), one of the most frequent arboviruses that infect humans in the Brazilian Amazon. This year, an OROV outbreak was identified in Brazil, and its vertical transmission was reported, which was associated with fetal death and microcephaly. We describe the clinical manifestations identified in three cases of congenital OROV infection with confirmed serology (OROV-IgM) in the mother-newborn binomial. One of the newborns died, and post-mortem molecular analysis using real-time RT-qPCR identified the OROV genome in several tissues. All three newborns were born in the Amazon region in Brazil, and the mothers reported fever, rash, headache, myalgia, and\/or retro-orbital pain during pregnancy. The newborns presented with severe microcephaly secondary to brain damage and arthrogryposis, suggestive of an embryo\/fetal disruptive process at birth. Brain and spinal images identified overlapping sutures, cerebral atrophy, brain cysts, thinning of the spinal cord, corpus callosum, and posterior fossa abnormalities. Fundoscopic findings included macular chorioretinal scars, focal pigment mottling, and vascular attenuation. The clinical presentation of vertical OROV infection resembled congenital Zika syndrome to some extent but presents some distinctive features on brain imaging and in several aspects of its neurological presentation. A recognizable syndrome with severe brain damage, neurological alterations, arthrogryposis, and fundoscopic abnormalities can be associated with in utero OROV infection.<\/jats:p>","DOI":"10.3390\/v17030397","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:59:52Z","timestamp":1741683592000},"page":"397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Congenital Oropouche in Humans: Clinical Characterization of a Possible New Teratogenic Syndrome"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5864-611X","authenticated-orcid":false,"given":"Beth\u00e2nia de Freitas Rodrigues","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Secretaria de Estado de Sa\u00fade do Acre (SESACRE), Rio Branco 69900-376, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6017-1528","authenticated-orcid":false,"given":"Andr\u00e9 Rodrigues Fa\u00e7anha","family":"Barreto","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Walter Cant\u00eddio (HUWC), Radiology Department and Universidade Federal do Cear\u00e1 (UFC), Fortaleza 60020-181, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-5373","authenticated-orcid":false,"given":"Andr\u00e9","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Hospital Infantil Albert Sabin, Universidade Federal do Cear\u00e1 (UFC), Fortaleza 60020-181, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-9976","authenticated-orcid":false,"given":"Raimunda do Socorro da Silva","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Section on Arbovirology and Hemorrhagic Fever, Instituto Evandro Chagas\/SVSA\/MS, Ananindeua 67030-000, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via de Freitas","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio de Bras\u00edlia (UnB), Bras\u00edlia 70330-750, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8342-3011","authenticated-orcid":false,"given":"Bruna da Cruz Beyruth","family":"Borges","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Sa\u00fade do Acre (SESACRE), Rio Branco 69900-376, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-5026","authenticated-orcid":false,"given":"Nat\u00e1lia Pimentel Moreno","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Sa\u00fade do Acre (SESACRE), Rio Branco 69900-376, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-7915","authenticated-orcid":false,"given":"Davi Dantas","family":"Muniz","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia e Neurofisiologia, Universidade Federal de S\u00e3o Paulo (Unifesp), S\u00e3o Paulo 04021-001, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6667-2796","authenticated-orcid":false,"given":"Jannifer Oliveira","family":"Chiang","sequence":"additional","affiliation":[{"name":"Section on Arbovirology and Hemorrhagic Fever, Instituto Evandro Chagas\/SVSA\/MS, Ananindeua 67030-000, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2555-8313","authenticated-orcid":false,"given":"Lucas Rosa","family":"Fraga","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, RS, Brazil"},{"name":"Brazilian Teratogen Information System, SIAT, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, RS, Brazil"},{"name":"Graduate Program in Health Sciences: Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040-060, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-4869","authenticated-orcid":false,"given":"Fernanda Sales Luiz","family":"Vianna","sequence":"additional","affiliation":[{"name":"Brazilian Teratogen Information System, SIAT, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, RS, Brazil"},{"name":"Graduate Program in Health Sciences: Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040-060, RS, Brazil"},{"name":"Graduate-Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa Vieira","family":"Sanseverino","sequence":"additional","affiliation":[{"name":"Brazilian Teratogen Information System, SIAT, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, RS, Brazil"},{"name":"Graduate-Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, RS, Brazil"},{"name":"Department of Pediatrics, School of Medicine, Pontificia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilith Schuler","family":"Faccini","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences: Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040-060, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Eduarda das Neves","family":"Martins","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Virology, Instituto Evandro Chagas\/SVSA\/MS, Ananindeua 67030-000, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael da Silva","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Hospital Geral de Bel\u00e9m, Bel\u00e9m 66050-450, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-2036","authenticated-orcid":false,"given":"L\u00edvia Car\u00edcio","family":"Martins","sequence":"additional","affiliation":[{"name":"Section on Arbovirology and Hemorrhagic Fever, Instituto Evandro Chagas\/SVSA\/MS, Ananindeua 67030-000, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-9984","authenticated-orcid":false,"given":"Livia Medeiros 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Sim\u00f5es","family":"Quaresma","sequence":"additional","affiliation":[{"name":"Tropical Medicine Center, Universidade Federal do Par\u00e1, Bel\u00e9m 66050-540, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-9689","authenticated-orcid":false,"given":"Alberto Mantovani","family":"Abeche","sequence":"additional","affiliation":[{"name":"Brazilian Teratogen Information System, SIAT, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, RS, Brazil"},{"name":"Department of Ginecology and Obstetrics, Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040-060, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania de Mesquita Gadelha","family":"Prazeres","sequence":"additional","affiliation":[{"name":"Graduate-Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, RS, Brazil"},{"name":"Department of Maternal and Fetal Health, School of Medicine, Universidade Federal do Amazonas, Manaus 69020-160, AM, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Andreia Nunes de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Graduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone de Menezes","family":"Karam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidade Federal de Rio Grande (FURG), Pelotas 96090-790, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Radin","sequence":"additional","affiliation":[{"name":"Brazilian Teratogen Information System, SIAT, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Del Campo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-4684","authenticated-orcid":false,"given":"Camila V.","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Altino Ventura Foundation (FAV), Recife 50731-490, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-0460","authenticated-orcid":false,"given":"Lavinia","family":"Schuler-Faccini","sequence":"additional","affiliation":[{"name":"Brazilian Teratogen Information System, SIAT, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, RS, Brazil"},{"name":"Graduate-Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, RS, Brazil"},{"name":"Graduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, RS, Brazil"},{"name":"Medical Genetics Service\u2014Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ramiro Barcelos, 2350, Porto Alegre 91035-903, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4269\/ajtmh.1961.10.574","article-title":"Oropouche virus: A new human disease agent from Trinidad, West Indies","volume":"10","author":"Anderson","year":"1961","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Azevedo, E.d.A.N., da Silva, A.F., da Silva, V.G., Machado, L.C., de Lima, G.B., Ishigami, B.I.M., Silva, K.M.P.e., Costa, M.M.d.O.M.d., Falc\u00e3o, D.A., and Vasconcelos, A.P. (2024). Genomic and phenotypic characterization of the Oropouche virus strain implicated in the 2022\u201324 large-scale outbreak in Brazil. J. Med. 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