{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:39:49Z","timestamp":1794037189917,"version":"4.8.0"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Mpox (formerly known as monkeypox), the major public health concern of 2022, has elicited much attention globally. In addition to the usual symptoms observed in smallpox virus infections, infected mothers were found to hold a possible risk of transmission to newborns during delivery. This review aimed to summarize recent clinical trials that involved antiviral therapy, vaccines, immunoglobulin therapy, and other pharmacological interventions specifically for treating infected pregnant women. A comprehensive search was performed using databases such as PubMed, Google Scholar, and Medline to find appropriate disease management strategies. Amongst the vaccines and antivirals being used for treatment, vaccines such as Modified Vaccinia Ankara (MVA\/MVA-BN) and Lister clone 16-medium pocket size-8 (LC16m8), while prophylactically effective, have been deemed unsafe for pregnant and lactating females. Antivirals like Tecovirimat, on the other hand, are considered to be a better alternative, but they are not without risks that may outweigh the potential benefits. Additionally, efforts to reduce maternal and fetal complications include administering the MVA-BN vaccine and awareness campaigns regarding herd immunity. Therefore, necessary precautions, prophylactic vaccinations in high-risk outbreak regions, and symptomatic treatment in pregnant and lactating females currently appear to be more feasible approaches against the mpox virus.<\/jats:p>","DOI":"10.3390\/v17040456","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T13:48:20Z","timestamp":1742824100000},"page":"456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vaccines and Antiviral Therapies for Mpox Virus in Pregnant and Breastfeeding Women: Efficacy and Maternal\u2013Child Outcomes"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5145-7651","authenticated-orcid":false,"given":"Maryum","family":"Imran","sequence":"first","affiliation":[{"name":"Department of Medicine, Dow University of Health Sciences, Karachi 74200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3515-8691","authenticated-orcid":false,"given":"Myra","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ziauddin Medical College, Karachi 75000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3465-9842","authenticated-orcid":false,"given":"Javeria","family":"Kamran","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dow University of Health Sciences, Karachi 74200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3003-2243","authenticated-orcid":false,"given":"Syeda Qaima","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University, Karachi 75510, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Azeem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bahria University Health Sciences, Karachi 75500, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2739-9535","authenticated-orcid":false,"given":"Emmanuel","family":"Korir","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nairobi, Nairobi P.O. Box 30197-00100, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"ref_1","unstructured":"(2025, January 24). Mpox: Background Information, Available online: https:\/\/www.gov.uk\/guidance\/monkeypox."},{"key":"ref_2","unstructured":"(2025, January 24). Mpox. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/mpox."},{"key":"ref_3","unstructured":"CDC (2025, March 16). Ongoing Clade II Mpox Global Outbreak. Mpox, Available online: https:\/\/www.cdc.gov\/mpox\/outbreaks\/2022\/index-1.html."},{"key":"ref_4","unstructured":"(2025, March 16). Global Mpox Trends. 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