{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:39:10Z","timestamp":1762900750262,"version":"build-2065373602"},"reference-count":66,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Province Science and Technology Planning Program","award":["2021ZDZX0010","2024NSFSC0374","SCCXTD-2024-26"],"award-info":[{"award-number":["2021ZDZX0010","2024NSFSC0374","SCCXTD-2024-26"]}]},{"name":"the Natural Science Foundation of Sichuan Province","award":["2021ZDZX0010","2024NSFSC0374","SCCXTD-2024-26"],"award-info":[{"award-number":["2021ZDZX0010","2024NSFSC0374","SCCXTD-2024-26"]}]},{"name":"the Sichuan Innovation Team Project of National Modern Agricultural Industry Technology System","award":["2021ZDZX0010","2024NSFSC0374","SCCXTD-2024-26"],"award-info":[{"award-number":["2021ZDZX0010","2024NSFSC0374","SCCXTD-2024-26"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Pseudorabies virus (PRV) is a pathogen that causes severe neurological dysfunction in the host, leading to extensive neuronal damage and inflammation. Despite extensive research on the neuropathogenesis of \u03b1-herpesvirus infections, many scientific questions remain unresolved, such as the largely unknown functions of long non-coding RNAs (lncRNAs) in herpesvirus-infected nervous systems. To address these questions, we used RNA sequencing (RNA-seq) to investigate the expression profiles of lncRNAs and mRNAs in the brains of mice infected with PRV. Through bioinformatic analysis, we identified 316 differentially expressed lncRNAs and 886 differentially expressed mRNAs. We predicted the biological functions of these differentially expressed lncRNAs and mRNAs using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases, and the results showed that the differentially expressed transcripts were mainly involved in the innate immune response. Finally, we validated the differential expression trends of lncRNAs and mRNAs using quantitative real-time PCR (q-PCR), which were consistent with the sequencing data. To our knowledge, this is the first report analyzing the lncRNA expression profile in the central nervous system (CNS) of mice infected with PRV. Our findings provide new insights into the roles of lncRNAs and mRNAs during PRV infection of the host CNS.<\/jats:p>","DOI":"10.3390\/v17040580","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T20:50:46Z","timestamp":1744923046000},"page":"580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expression Profiles of lncRNAs and mRNAs in the Mouse Brain Infected with Pseudorabies Virus: A Bioinformatic Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8355-036X","authenticated-orcid":false,"given":"Yanwei","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Diseases and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Tu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Diseases and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Diseases and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueping","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Diseases and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Diseases and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Diseases and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zheng, H.H., Fu, P.F., Chen, H.Y., and Wang, Z.Y. (2022). Pseudorabies Virus: From Pathogenesis to Prevention Strategies. Viruses, 14.","DOI":"10.3390\/v14081638"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Papageorgiou, K., Stoikou, A., Papadopoulos, D.K., Tsapouri-Kanoula, E., Giantsis, I.A., Papadopoulos, D., Stamelou, E., Sofia, M., Billinis, C., and Karapetsiou, C. (2024). Pseudorabies Virus Prevalence in Lung Samples of Hunted Wild Boars in Northwestern Greece. Pathogens, 13.","DOI":"10.3390\/pathogens13110929"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chen, J., Li, G., Wan, C., Li, Y., Peng, L., Fang, R., Peng, Y., and Ye, C. (2022). A Comparison of Pseudorabies Virus Latency to Other alpha-Herpesvirinae Subfamily Members. Viruses, 14.","DOI":"10.3390\/v14071386"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1128\/JVI.02589-05","article-title":"Influence of pseudorabies virus proteins on neuroinvasion and neurovirulence in mice","volume":"80","author":"Klopfleisch","year":"2006","journal-title":"J. Virol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/MMBR.69.3.462-500.2005","article-title":"Molecular biology of pseudorabies virus: Impact on neurovirology and veterinary medicine","volume":"69","author":"Pomeranz","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12951","DOI":"10.1128\/JVI.78.23.12951-12963.2004","article-title":"Two modes of pseudorabies virus neuroinvasion and lethality in mice","volume":"78","author":"Brittle","year":"2004","journal-title":"J. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e3690","DOI":"10.1093\/cid\/ciaa987","article-title":"A Novel Human Acute Encephalitis Caused by Pseudorabies Virus Variant Strain","volume":"73","author":"Liu","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Yang, H., Han, H., Wang, H., Cui, Y., Liu, H., and Ding, S. (2019). A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.00534"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijid.2019.09.019","article-title":"Human encephalitis complicated with bilateral acute retinal necrosis associated with pseudorabies virus infection: A case report","volume":"89","author":"Wang","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12985-025-02640-x","article-title":"Advances in bioinformatics and multi-omics integration: Transforming viral infectious disease research in veterinary medicine","volume":"22","author":"Elrashedy","year":"2025","journal-title":"Virol. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.it.2019.04.001","article-title":"Long Noncoding RNAs in Host-Pathogen Interactions","volume":"40","author":"Agliano","year":"2019","journal-title":"Trends Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13567-021-00922-0","article-title":"Long non-coding RNA LNC_000641 regulates pseudorabies virus replication","volume":"52","author":"Fang","year":"2021","journal-title":"Vet. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e2210321119","DOI":"10.1073\/pnas.2210321119","article-title":"Long noncoding RNA CHROMR regulates antiviral immunity in humans","volume":"119","author":"Cyr","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"113262","DOI":"10.1016\/j.celrep.2023.113262","article-title":"Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape","volume":"42","author":"Cao","year":"2023","journal-title":"Cell Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9623","DOI":"10.7150\/thno.64880","article-title":"A novel lncRNA linc-AhRA negatively regulates innate antiviral response in murine microglia upon neurotropic herpesvirus infection","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sui, B., Chen, D., Liu, W., Wu, Q., Tian, B., Li, Y., Hou, J., Liu, S., Xie, J., and Jiang, H. (2020). A novel antiviral lncRNA, EDAL, shields a T309 O-GlcNAcylation site to promote EZH2 lysosomal degradation. Genome Biol., 21.","DOI":"10.1186\/s13059-020-02150-9"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1016\/j.molcel.2022.08.030","article-title":"The lncRNA ALPHA specifically targets chikungunya virus to control infection","volume":"82","author":"Basavappa","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Nie, Z., Zhu, S., Wu, L., Sun, R., Shu, J., He, Y., and Feng, H. (2023). Progress on innate immune evasion and live attenuated vaccine of pseudorabies virus. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1138016"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Bo, Z., and Li, X. (2022). A Review of Pseudorabies Virus Variants: Genomics, Vaccination, Transmission, and Zoonotic Potential. Viruses, 14.","DOI":"10.3390\/v14051003"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sehl, J., Holper, J.E., Klupp, B.G., Baumbach, C., Teifke, J.P., and Mettenleiter, T.C. (2020). An improved animal model for herpesvirus encephalitis in humans. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008445"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e95727","DOI":"10.7554\/eLife.95727","article-title":"An atlas of brain-bone sympathetic neural circuits in mice","volume":"13","author":"Ryu","year":"2024","journal-title":"eLife"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.coi.2015.06.011","article-title":"Innate immune interactions within the central nervous system modulate pathogenesis of viral infections","volume":"36","author":"Nair","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2013.04.005","article-title":"Innate immunity in the CNS: Redefining the relationship between the CNS and Its environment","volume":"78","author":"Lampron","year":"2013","journal-title":"Neuron"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.coviro.2011.10.008","article-title":"Interferon-stimulated genes and their antiviral effector functions","volume":"1","author":"Schoggins","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-virology-092818-015756","article-title":"Interferon-Stimulated Genes: What Do They All Do?","volume":"6","author":"Schoggins","year":"2019","journal-title":"Annu. Rev. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41583-018-0070-8","article-title":"CNS infection and immune privilege","volume":"19","author":"Forrester","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/infdis\/jis653","article-title":"Type I interferon signaling protects mice from lethal henipavirus infection","volume":"207","author":"Dhondt","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12344","DOI":"10.1128\/JVI.00931-10","article-title":"Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells","volume":"84","author":"Kochs","year":"2010","journal-title":"J. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1172\/JCI59259","article-title":"Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency","volume":"121","author":"Lorenzo","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.immuni.2010.08.014","article-title":"Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis","volume":"33","author":"Lorenzo","year":"2010","journal-title":"Immunity"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1084\/jem.20111316","article-title":"Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood","volume":"209","author":"Herman","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1126\/science.1128346","article-title":"Herpes simplex virus encephalitis in human UNC-93B deficiency","volume":"314","author":"Casrouge","year":"2006","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e01901-17","DOI":"10.1128\/JVI.01901-17","article-title":"Alpha\/Beta Interferon (IFN-alpha\/beta) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-gamma-Dependent Responses","volume":"92","author":"Hwang","year":"2018","journal-title":"J. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1128\/JVI.02979-15","article-title":"Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain","volume":"90","author":"Pfefferkorn","year":"2016","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11223","DOI":"10.1128\/JVI.01093-12","article-title":"Visualizing production of beta interferon by astrocytes and microglia in brain of La Crosse virus-infected mice","volume":"86","author":"Kallfass","year":"2012","journal-title":"J. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Telikani, Z., Monson, E.A., Hofer, M.J., and Helbig, K.J. (2022). Antiviral response within different cell types of the CNS. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1044721"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41579-018-0020-5","article-title":"ISG15 in antiviral immunity and beyond","volume":"16","author":"Perng","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"198036","DOI":"10.1016\/j.virusres.2020.198036","article-title":"How ISG15 combats viral infection","volume":"286","author":"Freitas","year":"2020","journal-title":"Virus Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Liu, H., Li, C., He, W., Chen, J., Yang, G., Chen, L., and Chang, H. (2022). Free ISG15 inhibits Pseudorabies virus infection by positively regulating type I IFN signaling. PLoS Pathog., 18.","DOI":"10.1371\/journal.ppat.1010921"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Das Sarma, J., Burrows, A., Rayman, P., Hwang, M.H., Kundu, S., Sharma, N., Bergmann, C., and Sen, G.C. (2020). Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1009034"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.it.2013.10.012","article-title":"Innate antiviral signalling in the central nervous system","volume":"35","author":"Carty","year":"2014","journal-title":"Trends Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.coi.2021.07.004","article-title":"Neuron-intrinsic immunity to viruses in mice and humans","volume":"72","author":"Zhang","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1084\/jem.20101568","article-title":"Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity","volume":"208","author":"Guo","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12974-025-03354-1","article-title":"Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain","volume":"22","author":"Berankova","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Lim, S.M., van den Ham, H.J., Oduber, M., Martina, E., Zaaraoui-Boutahar, F., Roose, J.M., van Ijcken, W.F.J., Osterhaus, A., Andeweg, A.C., and Koraka, P. (2017). Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.01556"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e00902","DOI":"10.1128\/mBio.00902-14","article-title":"Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases","volume":"5","author":"Clarke","year":"2014","journal-title":"mBio"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12972","DOI":"10.1128\/JVI.06032-11","article-title":"Functional genomics reveals an essential and specific role for Stat1 in protection of the central nervous system following herpes simplex virus corneal infection","volume":"85","author":"Pasieka","year":"2011","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Appolinario, C.M., Daly, J.M., Emes, R.D., Marchi, F.A., Ribeiro, B.L.D., and Megid, J. (2022). Gene Expression Profile Induced by Two Different Variants of Street Rabies Virus in Mice. Viruses, 14.","DOI":"10.3390\/v14040692"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF: A road to inflammation","volume":"23","author":"Bertrand","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.virol.2008.08.023","article-title":"TNF-alpha mediates pseudorabies virus-induced apoptosis via the activation of p38 MAPK and JNK\/SAPK signaling","volume":"381","author":"Yeh","year":"2008","journal-title":"Virology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/s41564-023-01405-y","article-title":"Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids","volume":"8","author":"Wyler","year":"2023","journal-title":"Nat. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Xu, L., Zhang, Y., Tao, Q., Xu, T., Lee, F.-q., Deng, L.-s., Jian, Z., Zhao, J., Yang, Y., and Lai, S. (2024). Transcriptome and metabolome analysis reveals PRV XJ delgE\/gI\/TK protects intracranially infected mice from death by regulating the inflammation. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1374646"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molmed.2007.12.008","article-title":"The alpha-herpesviruses: Molecular pathfinders in nervous system circuits","volume":"14","author":"Ekstrand","year":"2008","journal-title":"Trends Mol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ghafouri-Fard, S., Hussen, B.M., Jamal, H.H., Taheri, M., and Sharifi, G. (2022). The Emerging Role of Non-Coding RNAs in the Regulation of Virus Replication and Resultant Cellular Pathologies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020815"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e01823-19","DOI":"10.1128\/JVI.01823-19","article-title":"Modulation of Voltage-Gated Sodium Channel Activity in Human Dorsal Root Ganglion Neurons by Herpesvirus Quiescent Infection","volume":"94","author":"Zhang","year":"2020","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"65769","DOI":"10.1007\/s11356-021-15567-x","article-title":"Bioinformatic analyses suggest augmented interleukin-17 signaling as the mechanism of COVID-19-associated herpes zoster","volume":"28","author":"Yu","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13567-024-01416-5","article-title":"Nucleotide-binding oligomerization domain 1 (NOD1) regulates microglial activation in pseudorabies virus infection","volume":"55","author":"Sun","year":"2024","journal-title":"Vet. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tig.2017.11.005","article-title":"Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression","volume":"34","author":"Sun","year":"2018","journal-title":"Trends Genet."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jin, Y., Zhang, K., Huang, W., Tang, W., Li, H., Dong, W., Gu, J., and Zhou, J. (2020). Identification of functional lncRNAs in pseudorabies virus type II infected cells. Vet. Microbiol., 242.","DOI":"10.1016\/j.vetmic.2019.108564"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.7150\/ijbs.72318","article-title":"Interplay of LncRNAs NEAT1 and TUG1 in Incidence of Cytokine Storm in Appraisal of COVID-19 Infection","volume":"18","author":"Tayel","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e02250-16","DOI":"10.1128\/JVI.02250-16","article-title":"The Long Noncoding RNA NEAT1 Exerts Antihantaviral Effects by Acting as Positive Feedback for RIG-I Signaling","volume":"91","author":"Ma","year":"2017","journal-title":"J. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.molcel.2017.06.020","article-title":"HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response","volume":"67","author":"Morchikh","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00018-016-2398-4","article-title":"NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription","volume":"74","author":"Wang","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e0020722","DOI":"10.1128\/jvi.00207-22","article-title":"The Role of Long Noncoding RNA BST2-2 in the Innate Immune Response to Viral Infection","volume":"96","author":"Chen","year":"2022","journal-title":"J. Virol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e0118323","DOI":"10.1128\/jvi.01183-23","article-title":"An RBM10 and NF-\u03baB interacting host lncRNA promotes JEV replication and neuronal cell death","volume":"97","author":"Tripathi","year":"2023","journal-title":"J. Virol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/4\/580\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:16:35Z","timestamp":1760030195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/4\/580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":66,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["v17040580"],"URL":"https:\/\/doi.org\/10.3390\/v17040580","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2025,4,17]]}}}