{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:14:19Z","timestamp":1787771659015,"version":"build-2784847793"},"reference-count":177,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Endometrial cancer (EC) is the fourth-most frequent cancer among the female population and a leading cause of death. Multiple factors are susceptible to causing tumorigenesis, including obesity, lack of physical activity, diabetes mellitus, high concentration of estrogen during menopause, unopposed exposure to estrogen, duration of menses, nulliparity and infertility. Human papillomavirus (HPV) is a double-stranded DNA virus, with certain genotypes exclusively human. HPV plays a major role in some cancers (cervical cancer, head and neck cancer, lung cancer, and anogenital cancers). Given the intricate correlation between HPV and cervical cancer, the scientific community conjectured that HPV may be implicated in the carcinogenesis of the endometrium. In this review, we will direct our interest towards previous studies that focused on the expression of HPV on EC samples and cover how both conditions might connect to each other.<\/jats:p>","DOI":"10.3390\/v17050607","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:08:41Z","timestamp":1745482121000},"page":"607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Sibylline Relationship Between Human Papillomavirus and Endometrial Cancer: Scarcity of Strong Evidence Linking Both Conditions"],"prefix":"10.3390","volume":"17","author":[{"given":"Khadija","family":"Bichri","sequence":"first","affiliation":[{"name":"Immunopathology-Immunomonitoring-Immunotherapy Laboratory (3Is), Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca 82403, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"El Ghanmi","sequence":"additional","affiliation":[{"name":"Immunopathology-Immunomonitoring-Immunotherapy Laboratory (3Is), Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca 82403, Morocco"},{"name":"Department of Gynecology and Obstetrics, Mohammed VI International University Hospital, Bouskoura 27182, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-5143","authenticated-orcid":false,"given":"Fadila","family":"Kouhen","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences and Oncogenetics, Neurooncology and Oncogenetic Team, Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca 82403, Morocco"},{"name":"Department of Radiotherapy, International University Hospital Cheikh Khalifa, Casablanca 82403, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salsabil","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Virology and Public Health Laboratory, Institut Pasteur du Maroc, Casablanca 20360, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Fichtali","sequence":"additional","affiliation":[{"name":"Immunopathology-Immunomonitoring-Immunotherapy Laboratory (3Is), Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca 82403, Morocco"},{"name":"Department of Gynecology and Obstetrics, Mohammed VI International University Hospital, Bouskoura 27182, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadoua","family":"El Mansouri","sequence":"additional","affiliation":[{"name":"Immunopathology-Immunomonitoring-Immunotherapy Laboratory (3Is), Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca 82403, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-3369","authenticated-orcid":false,"given":"Jalila","family":"El Bakkouri","sequence":"additional","affiliation":[{"name":"Immunopathology-Immunomonitoring-Immunotherapy Laboratory (3Is), Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca 82403, Morocco"},{"name":"Clinical Immunology, Inflammation and Allergy Laboratory (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca 20250, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouchra","family":"Ghazi","sequence":"additional","affiliation":[{"name":"Immunopathology-Immunomonitoring-Immunotherapy Laboratory (3Is), Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca 82403, Morocco"},{"name":"Department of Gynecology and Obstetrics, Mohammed VI International University Hospital, Bouskoura 27182, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sahoo, S.S., Zhang, X.D., Hondermarck, H., and Tanwar, P.S. (2018). The Emerging Role of the Microenvironment in Endometrial Cancer. Cancers, 10.","DOI":"10.3390\/cancers10110408"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jri.2014.12.006","article-title":"The immune system in the normal endometrium and implications for endometrial cancer development","volume":"109","author":"Vanderstraeten","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_5","unstructured":"Endometrial Cancer Statistics (2024, July 11). World Cancer Research Fund International. WCRF International. Available online: https:\/\/www.wcrf.org\/cancer-trends\/endometrial-cancer-statistics\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s40615-016-0292-2","article-title":"Endometrial Cancer Trends by Race and Histology in the USA: Projecting the Number of New Cases from 2015 to 2040","volume":"4","author":"Gaber","year":"2016","journal-title":"J. Racial Ethn. Health Disparit."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/cncr.11484","article-title":"Analysis of racial differences in incidence, survival, and mortality for malignant tumors of the uterine corpus","volume":"98","author":"Sherman","year":"2003","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.2105\/AJPH.94.12.2104","article-title":"Endometrial cancer: Socioeconomic status and racial\/ethnic differences in stage at diagnosis, treatment, and survival","volume":"94","author":"Madison","year":"2004","journal-title":"Am. J. Public Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-3-319-42542-9_7","article-title":"Obesity and Endometrial Cancer","volume":"Volume 208","author":"Pischon","year":"2016","journal-title":"Obesity and Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101848","DOI":"10.1016\/j.smrv.2023.101848","article-title":"Night shift work, sleep duration and endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2)","volume":"72","author":"Alemany","year":"2023","journal-title":"Sleep Med. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jiph.2023.02.014","article-title":"Human papillomavirus in cancer: Infection, disease transmission, and progress in vaccines","volume":"16","author":"Oyouni","year":"2023","journal-title":"J. Infect. Public Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.biopha.2018.06.149","article-title":"The human papillomavirus (HPV)-related cancer biology: An overview","volume":"106","author":"Araldi","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_13","unstructured":"(2024, July 11). Obesity: Preventing and Managing the Global Epidemic: Report of a WHO Consultation; WHO Consultation on Obesity (1999: Geneva, Switzerland) & World Health Organization. Available online: https:\/\/iris.who.int\/handle\/10665\/42330."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.5301\/JBM.5000047","article-title":"Overweight, Obesity and Endometrial Cancer Risk: Results from a Systematic Review and Meta-Analysis","volume":"29","author":"Zhang","year":"2014","journal-title":"Int. J. Biol. Markers"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ygyno.2009.03.039","article-title":"Endometrial cancer and obesity: Epidemiology, biomarkers, prevention and survivorship","volume":"114","author":"Fader","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4065\/83.1.97","article-title":"Current Issues in the Management of Endometrial Cancer","volume":"83","author":"Laack","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ygyno.2012.03.032","article-title":"Insulin resistance: A significant risk factor of endometrial cancer","volume":"125","author":"Mu","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Sa\u011fn\u0131\u00e7, S. (2021). Obesity and Endometrial Cancer. Role of Obesity in Human Health and Disease, IntechOpen.","DOI":"10.5772\/intechopen.99827"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e30299","DOI":"10.1097\/MD.0000000000030299","article-title":"Diabetes mellitus and endometrial carcinoma: Risk factors and etiological links","volume":"101","author":"Wang","year":"2022","journal-title":"Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(20)32374-6","article-title":"The Lancet Commission on diabetes: Using data to transform diabetes care and patient lives","volume":"396","author":"Chan","year":"2020","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ygyno.2009.12.029","article-title":"The association between metabolic abnormality and endometrial cancer: A large case-control study in China","volume":"117","author":"Zhang","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Byrne, F.L., Martin, A.R., Kosasih, M., Caruana, B.T., and Farrell, R. (2020). The Role of Hyperglycemia in Endometrial Cancer Pathogenesis. Cancers, 12.","DOI":"10.3390\/cancers12051191"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"17298","DOI":"10.1073\/pnas.1012548107","article-title":"Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium","volume":"107","author":"Memarzadeh","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/CCO.0b013e328354e585","article-title":"Molecular targets and targeted therapeutics in endometrial cancer","volume":"24","author":"Weigelt","year":"2012","journal-title":"Curr. Opin. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nrc.2016.77","article-title":"Reprogramming glucose metabolism in cancer: Can it be exploited for cancer therapy?","volume":"16","author":"Nissim","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yasin, H.K., Taylor, A.H., and Ayakannu, T. (2021). A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer. Cancers, 13.","DOI":"10.3390\/cancers13092149"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrc2325","article-title":"Mechanisms linking physical activity with cancer","volume":"8","author":"McTiernan","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0378-5122(85)90021-0","article-title":"Post-menopausal estrogen replacement: The prevention of osteoporosis and systemic effects","volume":"7","author":"Lafferty","year":"1985","journal-title":"Maturitas"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1056\/NEJM197606032942303","article-title":"Increasing Incidence of Endometrial Cancer in the United States","volume":"294","author":"Weiss","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/bjc.1988.44","article-title":"The dose-effect relationship between \u2018unopposed\u2019 oestrogens and endometrial mitotic rate: Its central role in explaining and predicting endometrial cancer risk","volume":"57","author":"Key","year":"1988","journal-title":"Br. J. Cancer"},{"key":"ref_31","first-page":"1531","article-title":"Obesity, endogenous hormones, and endometrial cancer risk: A synthetic review","volume":"11","author":"Kaaks","year":"2002","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/humupd\/dmu012","article-title":"Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: A systematic review and meta-analysis","volume":"20","author":"Barry","year":"2014","journal-title":"Hum. Reprod. Updat."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/humrep\/dei420","article-title":"The association between polycystic ovaries and endometrial cancer","volume":"21","author":"Pillay","year":"2005","journal-title":"Hum. Reprod."},{"key":"ref_34","first-page":"e30351","article-title":"Insulin Resistance in Polycystic Ovarian Syndrome","volume":"14","author":"Purwar","year":"2022","journal-title":"Cureus"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ijc.11529","article-title":"Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women","volume":"108","author":"Lukanova","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/00016348609155179","article-title":"Menstruation Span\u2014A Time-Limited Risk Factor for Endometrial Carcinoma","volume":"65","author":"Pettersson","year":"1986","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/bjc.2013.2","article-title":"The etiology of uterine sarcomas: A pooled analysis of the epidemiology of endometrial cancer consortium","volume":"108","author":"Felix","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wu, Y., Sun, W., Liu, H., and Zhang, D. (2019). Age at Menopause and Risk of Developing Endometrial Cancer: A Meta-Analysis. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/8584130"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.7150\/jca.12736","article-title":"Parity Correlates with the Timing of Developing Endometrial Cancer, But Not Subtype of Endometrial Cancer","volume":"6","author":"Chen","year":"2015","journal-title":"J. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s10552-009-9370-7","article-title":"Timing of births and endometrial cancer risk in Swedish women","volume":"20","author":"Pfeiffer","year":"2009","journal-title":"Cancer Causes Control"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/bjc.2015.24","article-title":"Infertility and incident endometrial cancer risk: A pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)","volume":"112","author":"Yang","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/IGC.0000000000000075","article-title":"Reproductive Factors and the Risk of Endometrial Cancer","volume":"24","author":"Ali","year":"2014","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0090-8258(83)90111-7","article-title":"Two pathogenetic types of endometrial carcinoma","volume":"15","author":"Bokhman","year":"1983","journal-title":"Gynecol. Oncol."},{"key":"ref_44","unstructured":"Herrington, S. (2000). WHO classification of tumours editorial board female genital tumours. Int. Agency Res. Cancer, 5."},{"key":"ref_45","unstructured":"WHO Classification of Tumours of Female Reproductive Organs (2024, October 10). WHO Classification of Tumours, 4th Edition, Volume 6. Available online: https:\/\/publications.iarc.fr\/Book-And-Report-Series\/Who-Classification-Of-Tumours\/WHO-Classification-Of-Tumours-Of-Female-Reproductive-Organs-2014."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41572-021-00324-8","article-title":"Endometrial cancer","volume":"7","author":"Makker","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network, Kandoth, C., Schultz, N., Cherniack, A.D., Akbani, R., Liu, Y., Shen, H., Robertson, A.G., Pashtan, I., and Shen, R. (2013). Integrated genomic characterization of endometrial carcinoma. Nature, 497, 67\u201373.","DOI":"10.1038\/nature12113"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"210","DOI":"10.6004\/jnccn.2022.7096","article-title":"Molecular Profiling of Endometrial Cancer from TCGA to Clinical Practice","volume":"21","author":"Jamieson","year":"2023","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/annonc\/mdy058","article-title":"Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series","volume":"29","author":"Kommoss","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/cncr.30496","article-title":"Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer","volume":"123","author":"Talhouk","year":"2017","journal-title":"Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/ijgo.14969","article-title":"Molecular subtypes of endometrial cancer: Implications for adjuvant treatment strategies","volume":"164","author":"Yang","year":"2023","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00073","article-title":"Landscape of microsatellite instability across 39 cancer types","volume":"1","author":"Bonneville","year":"2017","journal-title":"JCO Precis. Oncol."},{"key":"ref_53","first-page":"323","article-title":"Interpretation of somatic POLE mutations in endometrial carcinoma","volume":"250","author":"Britton","year":"2019","journal-title":"J. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ygyno.2019.03.126","article-title":"Clinical outcomes of patients with pole mutated endometrioid endometrial cancer","volume":"153","author":"Tunnage","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1158\/1078-0432.CCR-16-1820","article-title":"Immunotherapy in Endometrial Cancer: In the Nick of Time","volume":"22","author":"Piulats","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1158\/1078-0432.CCR-15-2878","article-title":"Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer\u2014Combined Analysis of the PORTEC Cohorts","volume":"22","author":"Stelloo","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_57","unstructured":"Mahdy, H., Casey, M.J., and Crotzer, D. (2023). Endometrial Cancer, StatPearls Publishing. Available online: http:\/\/europepmc.org\/books\/NBK525981."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e34461","DOI":"10.2196\/34461","article-title":"Molecular Classification of Endometrial Carcinoma: Protocol for a Cohort Study","volume":"11","author":"Moreira","year":"2022","journal-title":"JMIR Res. Protoc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/PGP.0000000000000583","article-title":"Clinicopathologic and Immunohistochemical Correlates of CTNNB1 Mutated Endometrial Endometrioid Carcinoma","volume":"39","author":"Costigan","year":"2020","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ijgo.14923","article-title":"FIGO staging of endometrial cancer: 2023","volume":"162","author":"Berek","year":"2023","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.ejca.2015.05.015","article-title":"Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer\u2014A pooled analysis of PORTEC 1 and 2 trials","volume":"51","author":"Bosse","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ogunmuyiwa, J., and Williams, V. (2024). Emerging Advances in Endometrial Cancer: Integration of Molecular Classification into Staging for Enhanced Prognostic Accuracy and Implications for Racial Disparities. Cancers, 16.","DOI":"10.3390\/cancers16061172"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/PAP.0000000000000182","article-title":"Pathologic Staging of Endometrial Carcinomas: Selected Areas of Difficulty","volume":"25","author":"McCluggage","year":"2018","journal-title":"Adv. Anat. Pathol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Zheng, W. (2023). Molecular Classification of Endometrial Cancer and the 2023 FIGO Staging: Exploring the Challenges and Opportunities for Pathologists. Cancers, 15.","DOI":"10.3390\/cancers15164101"},{"key":"ref_65","unstructured":"(2024, July 16). Female Genital Tumours. WHO Classification of Tumours, 5th Edition, Volume 4. WHO Classification of Tumours Editorial Board. Available online: https:\/\/publications.iarc.fr\/Book-And-Report-Series\/Who-Classification-Of-Tumours\/Female-Genital-Tumours-2020."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1097\/IGC.0b013e3182954da8","article-title":"Pathologic Ultrastaging Improves Micrometastasis Detection in Sentinel Lymph Nodes During Endometrial Cancer Staging","volume":"23","author":"Kim","year":"2013","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_67","unstructured":"WHO (2024, July 17). Human Papillomavirus and Cancer. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/human-papilloma-virus-and-cancer."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","article-title":"Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis","volume":"8","author":"Georges","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.virol.2013.04.023","article-title":"Cross-roads in the classification of papillomaviruses","volume":"445","year":"2013","journal-title":"Virology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.16.1.1-17.2003","article-title":"Human Papillomavirus and Cervical Cancer","volume":"16","author":"Burd","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"864","DOI":"10.20892\/j.issn.2095-3941.2020.0370","article-title":"Biological and clinical aspects of HPV-related cancers","volume":"17","author":"Szymonowicz","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000355959","article-title":"The Biology of Human Papillomaviruses","volume":"Volume 45","author":"Khan","year":"2014","journal-title":"Current Problems in Dermatology"},{"key":"ref_73","first-page":"1391","article-title":"Transmission of HPV","volume":"168","author":"Giles","year":"2003","journal-title":"CMAJ Can. Med. Assoc. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/scbi.1999.0141","article-title":"Human papillomavirus life cycle: Active and latent phases","volume":"9","author":"Stubenraucha","year":"1999","journal-title":"Semin. Cancer Biol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Pyeon, D., Pearce, S.M., Lank, S.M., Ahlquist, P., and Lambert, P.F. (2009). Establishment of Human Papillomavirus Infection Requires Cell Cycle Progression. PLOS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000318"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.2537532","article-title":"The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product","volume":"243","author":"Dyson","year":"1989","journal-title":"Science"},{"key":"ref_77","first-page":"363","article-title":"Analysis of E7\/Rb associations","volume":"119","author":"Caldeira","year":"2005","journal-title":"Methods Mol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Jensen, J.E., Becker, G.L., Jackson, J.B., and Rysavy, M.B. (2024). Human Papillomavirus and Associated Cancers: A Review. Viruses, 16.","DOI":"10.3390\/v16050680"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1016\/j.vaccine.2012.06.083","article-title":"The Biology and Life-Cycle of Human Papillomaviruses","volume":"30","author":"Doorbar","year":"2012","journal-title":"Vaccine"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/jmv.20245","article-title":"Heparan sulfate proteoglycans interact exclusively with conformationally intact HPV L1 assemblies: Basis for a virus-like particle ELISA","volume":"75","author":"Rommel","year":"2004","journal-title":"J. Med. Virol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0074-7696(01)07004-8","article-title":"Syndecans and cell adhesion","volume":"207","author":"Couchman","year":"2001","journal-title":"Int. Rev. Cytol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13125","DOI":"10.1128\/JVI.77.24.13125-13135.2003","article-title":"Different Heparan Sulfate Proteoglycans Serve asCellular Receptors for HumanPapillomaviruses","volume":"77","author":"Handisurya","year":"2003","journal-title":"J. Virol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1182\/blood.V100.2.610","article-title":"Soluble syndecan-1 promotes growth of myeloma tumors in vivo","volume":"100","author":"Yang","year":"2002","journal-title":"Blood"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1038\/onc.2013.151","article-title":"Irradiation-induced angiogenesis is associated with an MMP-9-miR-494-syndecan-1 regulatory loop in medulloblastoma cells","volume":"33","author":"Asuthkar","year":"2013","journal-title":"Oncogene"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/IGC.0b013e3181e02faa","article-title":"Syndecan-1 Overexpression Promotes Tumor Growth and Angiogenesis in an Endometrial Cancer Xenograft Model","volume":"20","author":"Oh","year":"2010","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"E884","DOI":"10.1002\/ijc.27629","article-title":"Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism","volume":"131","author":"Ibrahim","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Szatm\u00e1ri, T., Mundt, F., Kumar-Singh, A., M\u00f6bus, L., \u00d6tv\u00f6s, R., Hjerpe, A., and Dobra, K. (2017). Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1. BMC Cell Biol., 18.","DOI":"10.1186\/s12860-017-0150-z"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Ibrahim, S.A., Hassan, H., Vilardo, L., Kumar, S.K., Kumar, A.V., Kelsch, R., Schneider, C., Kiesel, L., Eich, H.T., and Zucchi, I. (2013). Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0085737"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/rmv.1822","article-title":"Human papillomavirus molecular biology and disease association","volume":"25","author":"Doorbar","year":"2015","journal-title":"Rev. Med. Virol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1074\/jbc.274.9.5810","article-title":"The L1 Major Capsid Protein of Human Papillomavirus Type 11 Recombinant Virus-like Particles Interacts with Heparin and Cell-surface Glycosaminoglycans on Human Keratinocytes","volume":"274","author":"Joyce","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"20458","DOI":"10.1073\/pnas.0908502106","article-title":"The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding","volume":"106","author":"Kines","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.virol.2014.04.024","article-title":"The nuclear retention signal of HPV16 L2 protein is essential for incoming viral genome to transverse the trans-Golgi network","volume":"458\u2013459","author":"DiGiuseppe","year":"2014","journal-title":"Virology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.virol.2013.06.006","article-title":"The papillomavirus E2 proteins","volume":"445","author":"McBride","year":"2013","journal-title":"Virology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.20558","article-title":"E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I","volume":"113","author":"Ashrafi","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"11614","DOI":"10.1128\/JVI.01053-10","article-title":"CD1d, a Sentinel Molecule Bridging Innate and Adaptive Immunity, Is Downregulated by the Human Papillomavirus (HPV) E5 Protein: A Possible Mechanism for Immune Evasion by HPV","volume":"84","author":"Miura","year":"2010","journal-title":"J. Virol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0042-6822(03)00103-X","article-title":"The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-\u03b3","volume":"310","author":"Zhang","year":"2003","journal-title":"Virology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e01582-19","DOI":"10.1128\/JVI.01582-19","article-title":"Human Papillomavirus 16 E5 Inhibits Interferon Signaling and Supports Episomal Viral Maintenance","volume":"94","author":"Scott","year":"2020","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/carcin\/bgp318","article-title":"Human papillomavirus type 16 E5 protein inhibits hydrogen peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells","volume":"31","author":"Oh","year":"2009","journal-title":"Carcinog."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000076642","article-title":"The HPV-16 E5 Protein Inhibits TRAIL- and FasL-Mediated Apoptosis in Human Keratinocyte Raft Cultures","volume":"47","author":"Kabsch","year":"2004","journal-title":"Intervirology"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Drews, C.M., Case, S., and Pol, S.B.V. (2019). E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt\/\u03b2-catenin pathway through E6AP-dependent degradation of NHERF1. PLOS Pathog., 15.","DOI":"10.1101\/518282"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4161\/cc.11.2.18995","article-title":"Fine-tuning of the intracellular canonical Notch signaling pathway","volume":"11","author":"Borggrefe","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: A simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_103","first-page":"1","article-title":"Notch signaling pathway in cancer: From mechanistic insights to targeted therapies","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1101\/gad.988902","article-title":"Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6\/E7 expression and late steps of malignant transformation","volume":"16","author":"Talora","year":"2002","journal-title":"Genes Dev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/viro.2001.0867","article-title":"Activated Notch1 Signaling Cooperates with Papillomavirus Oncogenes in Transformation and Generates Resistance to Apoptosis on Matrix Withdrawal through PKB\/Akt","volume":"286","author":"Rangarajan","year":"2001","journal-title":"Virology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1158\/1078-0432.CCR-17-3535","article-title":"Loss of Function of Canonical Notch Signaling Drives Head and Neck Carcinogenesis","volume":"24","author":"Nyman","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.2174\/092986712801661130","article-title":"Homeostasis and the Importance for a Balance Between AKT\/mTOR Activity and Intracellular Signaling","volume":"19","author":"Altomare","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1158\/1078-0432.CCR-05-1084","article-title":"Phosphatidylinositol 3-Kinase Inhibition by LY294002 Radiosensitizes Human Cervical Cancer Cell Lines","volume":"12","author":"Lee","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1002\/cncr.25224","article-title":"Up-regulation of interleukin-17 expression by human papillomavirus type 16 E6 in nonsmall cell lung cancer","volume":"116","author":"Chang","year":"2010","journal-title":"Cancer"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"11636","DOI":"10.1128\/JVI.74.24.11636-11641.2000","article-title":"The Ubiquity and Impressive Genomic Diversity of Human Skin Papillomaviruses Suggest a Commensalic Nature of These Viruses","volume":"74","author":"Antonsson","year":"2000","journal-title":"J. Virol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.radonc.2013.06.004","article-title":"Human papillomaviruses and cancer","volume":"108","author":"Haedicke","year":"2013","journal-title":"Radiother. Oncol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Ding, Y.-Q., Yu, J., Wang, R.-Q., and Sang, L. (2023). Clinical and epidemiological features of high-risk human papillomavirus infection in patients with cervical intraepithelial lesions. BMC Women\u2019s Health, 23.","DOI":"10.1186\/s12905-023-02583-x"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1177\/0194599814533494","article-title":"Occult Primary Head and Neck Squamous Cell Carcinoma: Utility of Discovering Primary Lesions","volume":"151","author":"Davis","year":"2014","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/ijc.2910510527","article-title":"Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6-E7 anti-sense RNA","volume":"51","author":"Hausen","year":"1992","journal-title":"Int. J. Cancer"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Veldhuijzen, N.J., Braunstein, S.L., Vyankandondera, J., Ingabire, C., Ntirushwa, J., Kestelyn, E., Tuijn, C., Wit, F.W., Umutoni, A., and Uwineza, M. (2011). The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda. BMC Infect. Dis., 11.","DOI":"10.1186\/1471-2334-11-333"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.semnephrol.2016.05.016","article-title":"Human Papillomavirus in Kidney Transplant Recipients","volume":"36","year":"2016","journal-title":"Semin. Nephrol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Bienkowska-Haba, M., Patel, H.D., and Sapp, M. (2009). Target Cell Cyclophilins Facilitate Human Papillomavirus Type 16 Infection. PLOS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000524"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ijc.31027","article-title":"Immune evasion mechanisms of human papillomavirus: An update","volume":"142","author":"Steinbach","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.virusres.2016.11.004","article-title":"Manipulation of the innate immune response by human papillomaviruses","volume":"231","author":"Hong","year":"2017","journal-title":"Virus Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.semradonc.2021.02.006","article-title":"Biology of HPV Mediated Carcinogenesis and Tumor Progression","volume":"31","author":"Cosper","year":"2021","journal-title":"Semin. Radiat. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.imlet.2018.06.009","article-title":"Taking the lead\u2014How keratinocytes orchestrate skin T cell immunity","volume":"200","author":"Klicznik","year":"2018","journal-title":"Immunol. Lett."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.3390\/v7052485","article-title":"High-Risk Human Papillomavirus Targets Crossroads in Immune Signaling","volume":"7","author":"Tummers","year":"2015","journal-title":"Viruses"},{"key":"ref_123","first-page":"1","article-title":"Salivary and serum IL-10, TNF-\u03b1, TGF-\u03b2, VEGF levels in oropharyngeal squamous cell carcinoma and correlation with HPV and EBV infections","volume":"11","author":"Stec","year":"2016","journal-title":"Infect. Agents Cancer"},{"key":"ref_124","first-page":"369","article-title":"IL-10 expression is regulated by HPV E2 protein in cervical cancer cells","volume":"4","author":"Moreno","year":"2011","journal-title":"Mol. Med. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Dai, W., Gui, L., Du, H., Li, S., and Wu, R. (2022). The association of cervicovaginal Langerhans cells with clearance of human papillomavirus. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.918190"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00262-008-0584-4","article-title":"High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells","volume":"58","author":"Herfs","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/mi.2008.33","article-title":"Evolving immunosuppressive microenvironment during human cervical carcinogenesis","volume":"1","author":"Kobayashi","year":"2008","journal-title":"Mucosal immunology"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Liu, Y., Li, L., Li, Y., and Zhao, X. (2020). Research Progress on Tumor-Associated Macrophages and Inflammation in Cervical Cancer. BioMed Res. Int., 2020.","DOI":"10.1155\/2020\/6842963"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.oraloncology.2012.09.012","article-title":"Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma","volume":"49","author":"Costa","year":"2012","journal-title":"Oral Oncol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00262-022-03226-0","article-title":"Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF\/BAFF-R pathway to promote immunosuppression in cervical cancer","volume":"72","author":"Jianyi","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4049\/jimmunol.167.1.497","article-title":"Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-\u03b3 Production in Human Peripheral Blood Mononuclear and NK Cells","volume":"167","author":"Lee","year":"2001","journal-title":"J. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/cncr.30570","article-title":"TRAF3\/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma","volume":"123","author":"Hajek","year":"2017","journal-title":"Cancer"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pvr.2016.01.002","article-title":"T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation","volume":"2","author":"Woodham","year":"2016","journal-title":"Papillomavirus Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/jid.2009.266","article-title":"Loss of Epidermal Langerhans Cells Occurs in Human Papillomavirus \u03b1, \u03b3, and \u03bc but Not \u03b2 Genus Infections","volume":"130","author":"Leong","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Wang, H.-F., Wang, S.-S., Tang, Y.-J., Chen, Y., Zheng, M., Tang, Y.-L., and Liang, X.-H. (2019). The Double-Edged Sword\u2014How Human Papillomaviruses Interact with Immunity in Head and Neck Cancer. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00653"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1016\/0304-419X(96)00020-0","article-title":"Papillomavirus infections\u2014A major cause of human cancers","volume":"1288","year":"1996","journal-title":"Biochim. Biophys. Acta (BBA) Rev. Cancer"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","article-title":"Human papillomavirus and cervical cancer","volume":"40","author":"Okunade","year":"2020","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ijc.30716","article-title":"Worldwide burden of cancer attributable to HPV by site, country and HPV type","volume":"141","author":"Plummer","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1007\/s00432-021-03738-9","article-title":"Human papillomavirus (HPV) types 16 and 18 infection and esophageal squamous cell carcinoma: A systematic review and meta-analysis","volume":"147","author":"Petrelli","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/carcin\/bgu038","article-title":"HPV-associated lung cancers: An international pooled analysis","volume":"35","author":"Ragin","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz, J.P., Gonz\u00e1lez, C., Parra, B., Corval\u00e1n, A.H., Tornesello, M.L., Eizuru, Y., and Aguayo, F. (2012). Functional Interaction between Human Papillomavirus Type 16 E6 and E7 Oncoproteins and Cigarette Smoke Components in Lung Epithelial Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038178"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3122\/jabfm.2021.04.200588","article-title":"Human Papillomavirus-Associated Head and Neck Cancer","volume":"34","author":"Nogues","year":"2021","journal-title":"J. Am. Board Fam. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1016\/j.vaccine.2012.07.055","article-title":"Global Burden of Human Papillomavirus and Related Diseases","volume":"30","author":"Forman","year":"2012","journal-title":"Vaccine"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nri3819","article-title":"The role of sex hormones in immune protection of the female reproductive tract","volume":"15","author":"Wira","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/humupd\/dmu065","article-title":"Antimicrobial peptides in the female reproductive tract: A critical component of the mucosal immune barrier with physiological and clinical implications","volume":"21","author":"Yarbrough","year":"2014","journal-title":"Hum. Reprod. Updat."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1095\/biolreprod.110.090423","article-title":"Structure and Function of Intercellular Junctions in Human Cervical and Vaginal Mucosal Epithelia","volume":"85","author":"Blaskewicz","year":"2011","journal-title":"Biol. Reprod."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0028-2243(80)90056-8","article-title":"Cervical mucus: Its structure and possible biological functions","volume":"10","author":"Daunter","year":"1980","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1128\/iai.61.11.4569-4574.1993","article-title":"Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry","volume":"61","author":"Eckmann","year":"1993","journal-title":"Infect. Immun."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/humrep\/deh806","article-title":"Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract","volume":"20","author":"Fahey","year":"2005","journal-title":"Hum. Reprod."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Zhao, C., Yan, S., Song, Y., and Xia, X. (2022). Roles of Antimicrobial Peptides in Gynecological Cancers. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231710104"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1152\/physrev.00031.2019","article-title":"Physiology of the Endometrium and Regulation of Menstruation","volume":"100","author":"Critchley","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"King, A.E., Critchley, H.O., and Kelly, R.W. (2003). Innate immune defences in the human endometrium. Reprod. Biol. Endocrinol., 1.","DOI":"10.1186\/1477-7827-1-116"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jri.2006.11.004","article-title":"Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle","volume":"74","author":"Hirata","year":"2007","journal-title":"J. Reprod. Immunol."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Perez-Mu\u00f1oz, M.E., Arrieta, M.-C., Ramer-Tait, A.E., and Walter, J. (2017). A critical assessment of the \u201csterile womb\u201d and \u201cin utero colonization\u201d hypotheses: Implications for research on the pioneer infant microbiome. Microbiome, 5.","DOI":"10.1186\/s40168-017-0268-4"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41467-017-00901-0","article-title":"The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/PGP.0b013e318199943b","article-title":"Does Human Papillomavirus Play a Role in Endometrial Carcinogenesis?","volume":"28","author":"Fedrizzi","year":"2009","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"E9076","DOI":"10.1073\/pnas.1712018114","article-title":"Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen","volume":"114","author":"Spurgeon","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_158","first-page":"383","article-title":"Search for human papillomaviruses in normal, hyperplastic, and neoplastic endometria","volume":"72","author":"Bergeron","year":"1988","journal-title":"Obstet. Gynecol."},{"key":"ref_159","first-page":"3818","article-title":"Detection of Human Papilloma Virus in Endometrial Cancers among Moroccan Women","volume":"45","author":"Bouziyane","year":"2022","journal-title":"Teikyo Med. J."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s12032-013-0597-5","article-title":"Association between human papillomavirus and endometrial adenocarcinoma","volume":"30","author":"Karadayi","year":"2013","journal-title":"Med. Oncol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ygyno.2014.02.040","article-title":"Prevalence of Human Papillomavirus in endometrial cancer: A systematic review and meta-analysis","volume":"134","author":"Olesen","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1699-0463.1997.tb00575.x","article-title":"Adenocarcinoma of the cervix and adenocarcinoma of the endometrium: Distinction with PCR-mediated detection of HPV DNA","volume":"105","author":"Hording","year":"1997","journal-title":"APMIS"},{"key":"ref_163","first-page":"490","article-title":"Relation of Human Papilloma Virus Infection with Pre Malignant and Malignant Endometrial Lesions","volume":"21","author":"Mahmoud","year":"2021","journal-title":"Medico-Legal Updat."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Grabarek, B.O., Ossowski, P., Czarniecka, J., O\u017c\u00f3g, M., Prucnal, J., Dziuba, I., Ostenda, A., Dziobek, K., Boro\u0144, D., and Peszek, W. (2023). Detection and Genotyping of Human Papillomavirus (HPV16\/18), Epstein\u2013Barr Virus (EBV), and Human Cytomegalovirus (HCMV) in Endometrial Endometroid and Ovarian Cancers. Pathogens, 12.","DOI":"10.3390\/pathogens12030397"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"60549","DOI":"10.1155\/2007\/60549","article-title":"Human Papillomavirus in Endometrial Adenocarcinomas: Infectious Agent or a Mere \u201cPassenger\u201d?","volume":"2007","author":"Giatromanolaki","year":"2007","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"91","DOI":"10.17650\/1994-4098-2020-16-4-91-99","article-title":"Human papillomavirus and endometrial cancer (review of literature and meta-analysis)","volume":"16","author":"Ibragimova","year":"2021","journal-title":"Tumors Female Reprod. Syst."},{"key":"ref_167","first-page":"613","article-title":"Human papillomavirus as an independent risk factor of invasive cervical and endometrial carcinomas in Jordan","volume":"13","author":"Jarajreh","year":"2019","journal-title":"J. Infect. Public Health"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Wu, P.-J., Tsai, S.C.-S., Huang, J.-Y., Lee, M.-S., Wang, P.-H., and Lin, F.C.-F. (2023). From Infection to Malignancy: Tracing the Impact of Human Papillomavirus on Uterine Endometrial Cancer in a Nationwide Population-Based Cohort Study. Viruses, 15.","DOI":"10.3390\/v15122314"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/0046-8177(95)90171-X","article-title":"Association of human papillomavirus with malignant and premalignant lesions of the uterine endometrium","volume":"26","author":"Fujita","year":"1995","journal-title":"Hum. Pathol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e222530","DOI":"10.1001\/jamanetworkopen.2022.2530","article-title":"Trends in Human Papillomavirus\u2013Associated Cancers, Demographic Characteristics, and Vaccinations in the US, 2001-2017","volume":"5","author":"Liao","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12105-012-0372-5","article-title":"HPV Detection Methods in Head and Neck Cancer","volume":"6","author":"Venuti","year":"2012","journal-title":"Head Neck Pathol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Nguyen, H.V., Hwang, S., Lee, S.W., Jin, E., and Lee, M.-H. (2024). Detection of HPV 16 and 18 L1 genes by a nucleic acid amplification-free electrochemical biosensor powered by CRISPR\/Cas9. Bioelectrochemistry, 162.","DOI":"10.1016\/j.bioelechem.2024.108861"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12672-024-01213-8","article-title":"Hepatitis B virus infection and the risk of gynecologic cancers: A systematic review and meta-analysis","volume":"15","author":"Peng","year":"2024","journal-title":"Discov. Oncol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e18747","DOI":"10.7717\/peerj.18747","article-title":"Incidence and risk factors of hepatitis E virus infection in women with gynecological tumors in Eastern China","volume":"12","author":"Bai","year":"2024","journal-title":"PeerJ"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejogrb.2009.08.008","article-title":"Evidence of measles virus antigens and RNA in endometrial cancer","volume":"147","author":"Benharroch","year":"2009","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e27879","DOI":"10.1016\/j.heliyon.2024.e27879","article-title":"Exploring prognostic microbiota markers in patients with endometrial carcinoma: Intratumoral insights","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Semertzidou, A., Whelan, E., Smith, A., Ng, S., Roberts, L., Brosens, J.J., Marchesi, J.R., Bennett, P.R., MacIntyre, D.A., and Kyrgiou, M. (2024). Microbial signatures and continuum in endometrial cancer and benign patients. 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