{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:54:21Z","timestamp":1790484861887,"version":"4.1.0"},"reference-count":116,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"nova FIOCRUZ (PROEP-IAM)","award":["2024\/02373-3"],"award-info":[{"award-number":["2024\/02373-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The Zika virus (ZIKV) gained prominence as a significant global pathogen after the 2015\u20132016 outbreaks associated it with an increase in neurological complications in adults and congenital malformations. Different mechanisms have been proposed by which ZIKV may cross the blood\u2013brain barrier and reach the central nervous system to cause neuroinflammation. Although ZIKV infection triggers a robust immune response, the virus has developed different strategies to escape it. Furthermore, although the virus is present in areas with cocirculation of other pathogenic agents, few studies have evaluated the cross-immune reactions and coinfection of ZIKV. Coinfections of ZIKV with other viruses, parasites, and bacteria are described. Such interactions can worsen infections and alter the immune response, imposing new therapeutic challenges and highlighting the need for more studies in the field. In this review, we discuss various aspects of ZIKV biology, focusing on the impacts of coinfections.<\/jats:p>","DOI":"10.3390\/v17050637","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:35:13Z","timestamp":1746185713000},"page":"637","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Zika Virus: A Review of Biology, Clinical Impacts, and Coinfections"],"prefix":"10.3390","volume":"17","author":[{"given":"Lucas Matheus Barreto","family":"Santana","sequence":"first","affiliation":[{"name":"Department of Virology and Experimental Therapy, Funda\u00e7\u00e3o Oswaldo Cruz\/Fiocruz, Recife 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0715-8674","authenticated-orcid":false,"given":"Ingrid Andr\u00eassa","family":"de Moura","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Studies and Experimental Therapy\u2014LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8386-9904","authenticated-orcid":false,"given":"Yuri","family":"Mouzinho Ramos Tanaka","sequence":"additional","affiliation":[{"name":"Department of Entomology, Funda\u00e7\u00e3o Oswaldo Cruz\/Fiocruz, Recife 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-6007","authenticated-orcid":false,"given":"Rafael Freitas de Oliveira","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Plataforma de Pesquisa em Medicina Translacional, Funda\u00e7\u00e3o Oswaldo Cruz\u2013Fiocruz S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Souza, A.D., Abreu, M.C., and Oliveira-J\u00fanior, J.F. 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