{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:57:36Z","timestamp":1794020256394,"version":"4.8.0"},"reference-count":69,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Head and neck squamous-cell carcinoma (HNSCC) has long been associated with tobacco and alcohol use. In the last two decades, however, human papillomavirus (HPV) infection has emerged as an important driver of these cancers, particularly in the oropharynx. The eighth edition of the American Joint Committee on Cancer (AJCC) staging system now defines HPV+ and HPV\u2212 OPSCC as separate entities. Although our understanding of HPV+ HNSCC continues to improve, it can be challenging to keep up to date with the growing body of evidence. In this context, the present narrative review was carried out to provide an overview of HPV-driven head and neck cancer, with an emphasis on Europe. We review the latest evidence on epidemiology, diagnosis, and treatment, including recent trends towards treatment de-intensification and future directions.<\/jats:p>","DOI":"10.3390\/v17050662","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:35:13Z","timestamp":1746185713000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["HPV-Driven Head and Neck Cancer: The European Perspective"],"prefix":"10.3390","volume":"17","author":[{"given":"Wojciech","family":"Golusi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, University of Medical Sciences, 61-701 Poznan, Poland"},{"name":"The Greater Poland Cancer Centre, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-2670","authenticated-orcid":false,"given":"Ewelina","family":"Golusi\u0144ska-Kardach","sequence":"additional","affiliation":[{"name":"Department and Clinic of Dental Surgery, Periodontal Diseases and Oral Mucosa, Poznan University of Medical Sciences, 60-812 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Machczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, University of Medical Sciences, 61-701 Poznan, Poland"},{"name":"The Greater Poland Cancer Centre, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-5369","authenticated-orcid":false,"given":"Mateusz","family":"Szewczyk","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, University of Medical Sciences, 61-701 Poznan, Poland"},{"name":"The Greater Poland Cancer Centre, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Augustin, J.G., Lepine, C., Morini, A., Brunet, A., Veyer, D., Brochard, C., Mirghani, H., P\u00e9r\u00e9, H., and Badoual, C. 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