{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:25:39Z","timestamp":1782347139018,"version":"3.54.5"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Direction G\u00e9n\u00e9rale de l\u2019Offre de Soins Plan Hospitalier de Recherche Clinique","award":["DGOS PHRC 2006"],"award-info":[{"award-number":["DGOS PHRC 2006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>In this cohort study, we evaluated the cognitive and learning difficulties of school-age children perinatally infected with Chikungunya virus (CHIKV) on Reunion Island using the Evaluation of Cognitive Functions and Learning in Children (EDA) battery screening test compared to the healthy children cohort used for EDA development. Of the 19 infected children, 11 (57.9%) exhibited subnormal or abnormal scores, of whom 3 were classified as high risk, and 8 were classified as at risk for cognitive and learning difficulties. Children who had encephalopathy were at higher risk for displaying at least one difficulty than non-encephalopathic children (relative risk 2.13; 95% CI 1.05\u20134.33). The difficulties observed affected verbal functions, non-verbal functions, and learning abilities, such as phonology, lexical evocation and comprehension, graphism, selective visual attention, planning, visual\u2013spatial reasoning, dictation and mathematics, as well as core executive functions, such as inhibitory control, shifting, and working memory. Neurocognitive dysfunctions could be linked to severe brain damage, as evidenced by severe white matter reduction mainly in the frontal lobes and corpus callosum and potentially in all functional networks involved in difficulties. These results should motivate further investigation of intellectual and adaptive functioning to diagnose intellectual deficiency and severe maladaptive behaviour in children perinatally infected with Chikungunya virus.<\/jats:p>","DOI":"10.3390\/v17050704","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:27:41Z","timestamp":1747218461000},"page":"704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Perinatal Mother-to-Child Chikungunya Virus Infection: Screening of Cognitive and Learning Difficulties in a Follow-Up Study of the Chimere Cohort on Reunion Island"],"prefix":"10.3390","volume":"17","author":[{"given":"Rapha\u00eblle","family":"Sarton","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97410 Saint Pierre, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Carbonnier","sequence":"additional","affiliation":[{"name":"Centre d\u2019Action M\u00e9dico-Sociale Pr\u00e9coce Isautier, Fondation P\u00e8re Favron, 97450 Saint Louis, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Robin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97400 Saint Denis, Reunion, France"},{"name":"Centre Ressources TSAF (Troubles du Spectre de l\u2019Alcoolisation F\u0153tale), Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97400 Saint Denis, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duksha","family":"Ramful","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97400 Saint Denis, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Samp\u00e9riz","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97400 Saint Denis, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97410 Saint Pierre, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bintner","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97410 Saint Pierre, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahim","family":"Boumahni","sequence":"additional","affiliation":[{"name":"Neonatalogy Unit, Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97410 Saint Pierre, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3276-5919","authenticated-orcid":false,"given":"Patrick","family":"G\u00e9rardin","sequence":"additional","affiliation":[{"name":"Centre for Clinical Investigation Clinical Epidemiology (INSERM CIC 1410), Centre Hospitalier Universitaire (CHU) de La R\u00e9union, 97410 Saint Pierre, Reunion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMra1406035","article-title":"Chikungunya virus and the global spread of a mosquito-borne disease","volume":"372","author":"Weaver","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.antiviral.2012.04.002","article-title":"Alphaviruses: Population genetics and determinants of emergence","volume":"94","author":"Weaver","year":"2012","journal-title":"Antivir. Res."},{"key":"ref_3","first-page":"314","article-title":"Virological investigation of cases with neurological complications during the outbreak of haemorrhagic fever in Calcutta","volume":"45","author":"Chatterjee","year":"1965","journal-title":"J. Indian Med. Assoc."},{"key":"ref_4","first-page":"764","article-title":"Chikungunya disease in infants and children in Vellore: A report of clinical and haematological features of virologically proved cases","volume":"53","author":"Jadhav","year":"1965","journal-title":"Indian J. Med. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.antiviral.2015.04.016","article-title":"Chikungunya: Evolutionary history and recent epidemic spread","volume":"120","author":"Weaver","year":"2015","journal-title":"Antivir. Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"G\u00e9rardin, P., Guernier, V., Perrau, J., Fianu, A., Le Roux, K., Grivard, P., Michault, A., de Lamballerie, X., Flahault, A., and Favier, A. (2008). Estimating Chikungunya prevalence in La R\u00e9union Island outbreak by serosurveys: Two methods for two critical times of the epidemic. BMC Infect. Dis., 8.","DOI":"10.1186\/1471-2334-8-99"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4269\/ajtmh.2008.78.212","article-title":"Case report: Chikungunya virus\u2013induced myopericarditis: Toward an increase of dilated cardiomyopathy in countries with epidemics?","volume":"78","author":"Simon","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1212\/01.wnl.0000277267.07220.88","article-title":"Guillain-Barr\u00e9 syndrome complicating a Chikungunya virus infection","volume":"69","author":"Wielaneck","year":"2007","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1212\/WNL.0000000000002234","article-title":"Chikungunya virus-associated encephalitis: A cohort study on La R\u00e9union Island, 2005\u20132009","volume":"86","author":"Couderc","year":"2016","journal-title":"Neurology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1017\/S0950268808001167","article-title":"Atypical Chikungunya virus infections: Clinical manifestations, mortality and risk factors for severe disease during the 2005\u20132006 outbreak on R\u00e9union","volume":"137","author":"Economopoulou","year":"2009","journal-title":"Epidemiol. Infect."},{"key":"ref_11","first-page":"171","article-title":"Transmission dynamics and disease severity in children infected with the East Central South African (ECSA) or ECSA-diverged clades of Chikungunya virus","volume":"68","author":"Freitas","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/INF.0b013e3180616d4f","article-title":"Mother-to-child transmission of Chikungunya virus infection","volume":"26","author":"Ramful","year":"2007","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"G\u00e9rardin, P., Barau, G., Michault, A., Bintner, M., Randrianaivo, H., Choker, G., Lenglet, Y., Touret, Y., Bouveret, A., and Grivard, P. (2008). Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La R\u00e9union. PLoS Med., 5.","DOI":"10.1371\/journal.pmed.0050060"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3201\/eid1604.091403","article-title":"Chikungunya virus infection during pregnancy, R\u00e9union, France, 2006","volume":"16","author":"Fritel","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ferreira, F.C.P.A.D.M., da Silva, A.S.V., Recht, J., Guaraldo, L., Moreira, M.E.L., de Siqueira, A.M., G\u00e9rardin, P., and Brasil, P. (2021). Vertical transmission of Chikungunya virus: A systematic review. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0249166"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"G\u00e9rardin, P., Samp\u00e9riz, S., Ramful, D., Boumahni, B., Bintner, M., Alessandri, J.L., Carbonnier, M., Tiran-Rajaoefera, I., Beullier, G., and Boya, I. (2014). Neurocognitive outcome of children exposed to perinatal mother-to-child chikungunya virus infection: The CHIMERE cohort study on Reunion island. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002996"},{"key":"ref_17","first-page":"2013","article-title":"Un nouvel outil d\u2019\u00e9valuation des fonctions cognitives et des apprentissages pour le p\u00e9diatre: De la th\u00e9orie \u00e0 la pratique","volume":"257","author":"Willig","year":"2013","journal-title":"Pediatre"},{"key":"ref_18","unstructured":"Cavin, M., and Cuisset, M. (2014). Validation de l\u2019EDA comme outil de d\u00e9pistage et crit\u00e8res d\u2019indication orthophonique. Sciences Cognitives, HAL Open Science. dumas-01077468."},{"key":"ref_19","first-page":"61","article-title":"Mise au point et recherche de validation d\u2019un outil de rep\u00e9rage des troubles de l\u2019apprentissage en classe de CE1","volume":"1617","author":"Sorreau","year":"2013","journal-title":"D\u00e9veloppements"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mercier, C., Deforge, H., and Hasco\u00ebt, J.M. (2022). Neurodevelopment at seven years and parents\u2019 feelings of prematurely born children. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.1004785"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1207\/s15326942dn2601_3","article-title":"Executive Function in preschool children: Examination through everyday behavior","volume":"26","author":"Isquith","year":"2004","journal-title":"Dev. Neuropsychol."},{"key":"ref_22","unstructured":"Reitan, R.M., and Wolfson, D. (1985). The Halstead\u2013Reitan Neuropsycholgical Test Battery: Therapy and Clinical Interpretation, Neuropsychological Press."},{"key":"ref_23","unstructured":"Korkman, M., Kirk, U., and Kemp, S. (1998). Manual for the NEPSY: A Developmental Neuropsychological Assessment, Psychological Testing Corporation."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1076\/chin.6.3.235.3152","article-title":"The Behavior Rating Inventory of Executive Function","volume":"6","author":"Gioia","year":"2000","journal-title":"Child. Neuropsychol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12028-017-0413-8","article-title":"The range of neurological complications in Chikungunya fever","volume":"27","author":"Cerny","year":"2017","journal-title":"Neurocrit. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e1978","DOI":"10.1002\/rmv.1978","article-title":"The neurological complications of chikungunya virus: A systematic review","volume":"28","author":"Mehta","year":"2018","journal-title":"Rev. Med. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Devaraju, M., Li, A., Ha, S., Li, M., Shivakumar, M., Nishigushi, E.P., G\u00e9rardin, P., Waldorf, K.A., and Al-Haddad, B.J.S. (2023). Beyond TORCH: A narrative review of the impact of antenatal and perinatal infections on the risk of disability. Neurosci. Biobehav. Rev., 153.","DOI":"10.1016\/j.neubiorev.2023.105390"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/ije\/dyy087","article-title":"The impact of multidimensional disadvantage over childhood on developmental outcomes in Australia","volume":"47","author":"Goldfeld","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1469-7580.2006.00615.x","article-title":"Functional anatomy of interhemispheric cortical connections in the human brain","volume":"209","author":"Zarei","year":"2006","journal-title":"J. Anat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00381-002-0604-1","article-title":"Functional anatomy of thalamus and basal ganglia","volume":"18","author":"Herrero","year":"2002","journal-title":"Child\u2019s Nerv. Syst."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/brain\/awad308","article-title":"White matter tracts and executive functions: A review of causal and correlation evidence","volume":"147","author":"Ribeiro","year":"2024","journal-title":"Brain"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1002\/hbm.24274","article-title":"Neural specialization of phonological and semantic processing in young children","volume":"39","author":"Weiss","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e79667","DOI":"10.7554\/eLife.79667","article-title":"Right inferior frontal gyrus damage is associated with impaired initiation","volume":"11","author":"Choo","year":"2022","journal-title":"eLife"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/hbm.23118","article-title":"Contribution of writing to reading: Dissociation between cognitive and motor process in the left dorsal premotor","volume":"37","author":"Pattamadilok","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/cercor\/bhz180","article-title":"The cortical organization of syntax","volume":"30","author":"Matchin","year":"2020","journal-title":"Cereb. Cortex"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Tsai, Y.P., Hung, S.H., Huang, T.R., Sullivan, W.C., Tang, S.A., and Chang, C.Y. (2021). What part of the brain is involved in graphic design thinking in landscape architecture?. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0258413"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-psych-122414-033400","article-title":"Neural mechanisms of selective visual attention","volume":"68","author":"Moore","year":"2017","journal-title":"Annu. Rev. Psychol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"fcad131","DOI":"10.1093\/braincomms\/fcad131","article-title":"Oscillatory dynamics serving visual attention during a Simon task","volume":"5","author":"Son","year":"2023","journal-title":"Brain Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/s41593-024-01675-7","article-title":"A recurrent network model of planning explains hippocampal replay and human behavior","volume":"27","author":"Jensen","year":"2024","journal-title":"Nat. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1038\/s41467-023-38571-w","article-title":"Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuropsychologia.2017.10.005","article-title":"Bilateral parietal activations for complex visual-spatial functions: Evidence form a visual-spatial construction task","volume":"106","author":"Ferrara","year":"2017","journal-title":"Neuropsychologia"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cortex.2013.09.012","article-title":"The neural basis for writing from dictation in the temporoparietal cortex","volume":"50","author":"Roux","year":"2014","journal-title":"Cortex"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cortex.2018.10.009","article-title":"The brain-structural correlates of mathematical expertise","volume":"114","author":"Popescu","year":"2019","journal-title":"Cortex"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"100987","DOI":"10.1016\/j.dcn.2021.100987","article-title":"Development of brain white matter and math computation ability in children born very preterm and full-term","volume":"51","author":"Collins","year":"2021","journal-title":"Dev. Cogn. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Beaulieu, C., Yip, E., Low, P.B., M\u00e4dler, B., Lebel, C.A., Siegel, L., Mackay, A.L., and Laule, C. (2020). Myelin water imaging demonstrates lower brain myelination in children and adolescents with poor reading ability. Front. Hum. Neurosci., 14.","DOI":"10.3389\/fnhum.2020.568395"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10802-015-0117-5","article-title":"Social influences on executive functions development in children and adolescents: Steps toward a social neuroscience of predictive adaptive responses","volume":"44","author":"Dishion","year":"2016","journal-title":"J. Abnorm. Child. Psychol."},{"key":"ref_47","unstructured":"Gathercole, S.E., and Alloway, T.P. (2008). Working Memory & Learning: A Practical Guide for Teachers, Sage Publications."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tics.2010.01.004","article-title":"The multi-demand (MD) system of the primate brain: Mental program form intelligent behaviour","volume":"14","author":"Duncan","year":"2010","journal-title":"Trends Cogn. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"120878","DOI":"10.1016\/j.neuroimage.2024.120878","article-title":"Oscillatory activity in bilateral prefrontal cortices is altered by distractor strength during working memory processing","volume":"301","author":"Hall","year":"2024","journal-title":"Neuroimage"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Salomao, N., Rabelo, K., Avvad-Portari, E., Basilio-de-Oliveira, R., Ferreira, F., Ferreira, L., de Souza, T.M., Nunes, P., Lima, M., and Sales, A.P. (2022). Histopathological and immunological characteristics of placentas infected with chikungunya virus. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1055536"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.chom.2024.02.011","article-title":"Pathophysiology of chikungunya virus infection associated with fatal outcomes","volume":"32","author":"Fumagalli","year":"2024","journal-title":"Cell Host Microbe"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Kelly, C.E., Shaul, M.E., Thompson, D.K., Mainzer, R.M., Yang, J.Y.M., Dhollander, T., Cheong, J.L.Y., Inder, T.E., Doyle, L.W., and Anderson, P.J. (2023). Long-lasting effects of very preterm birth on brain structure in adulthood: A systematic review and meta-analysis. Neurosci. Biobehav. Rev., 147.","DOI":"10.1016\/j.neubiorev.2023.105082"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bandc.2007.02.009","article-title":"Fetal alcohol syndrome and the developing socio-emotional brain","volume":"65","author":"Niccols","year":"2007","journal-title":"Brain Cogn."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Perez-Garcia, J.M., Suarez-Suarez, S., Doallo, S., and Cadaveira, F. (2022). Effects of binge drinking during adolescence and emerging adulthood on the brain: A systematic review of neuroimaging studies. Neurosci. Biobehav. Rev., 137.","DOI":"10.1016\/j.neubiorev.2022.104637"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Schuler-Faccini, L., Del Campo, M., Garc\u00eda-Alix, A., Ventura, L.O., Boquett, J.A., van der Linden, V., Pessoa, A., van der Linden Junior, H., Ventura, C.V., and Leal, M.C. (2022). Neurodevelopment in children exposed to Zika in utero: Clinical and molecular aspects. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.758715"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm.4485","article-title":"Congenital Zika virus infection as a silent pathology with loss of neurogenic output in fetal brain","volume":"24","author":"Nelson","year":"2018","journal-title":"Nat. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/j.pedhc.2020.05.007","article-title":"Umbrella review of school age outcomes of preterm survivors","volume":"34","author":"Kelly","year":"2020","journal-title":"J. Pediatr. Health Care"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1080\/09638288.2023.2207043","article-title":"Effectiveness of interventions for school-aged children and adolescents with fetal alcohol spectrum disorder: A systematic review and meta-analysis","volume":"46","author":"Hilly","year":"2023","journal-title":"Dis. Rehab."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Lei, T., Liao, X., Liang, X., Sun, L., Xia, M., Xia, Y., Zhao, T., Chen, X., Men, W., and Wang, Y. (2024). Functional network modules overlap and are linked to interindividual connectome differences during human brain development. PLoS Biol., 22.","DOI":"10.1371\/journal.pbio.3002653"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Sarton, R., Mery, M.O., Carbonnier, M., Renouil, M., Morice, C., Medjane, S., Bintner, M., Boumahni, B., and G\u00e9rardin, P. (2025). Long-term neurodevelopmental outcomes of children perinatally-infected with chikungunya: The CHIK13+ matched cohort study on Reunion Island. SSRN Prepr.","DOI":"10.2139\/ssrn.5024401"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/5\/704\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:32:38Z","timestamp":1760031158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/5\/704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["v17050704"],"URL":"https:\/\/doi.org\/10.3390\/v17050704","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]}}}