{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:10:11Z","timestamp":1787767811109,"version":"build-2784847793"},"reference-count":69,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Canine distemper virus (CDV) is a highly contagious pathogen and causes a fatal systemic disease in domestic dogs and wild carnivores worldwide. Despite CDV infections being monitored globally, studies on CDV in Vietnam seem to be limited. This study, therefore, investigated the epidemiological, clinical, and molecular characteristics of CDV in the Mekong Delta (MD) region of Vietnam. A total of 6687 ocular\/nasal swabs were collected from CDV-suspected dogs across seven cities\/provinces. CDV infection was detected in 6.19% (414 dogs) of suspected dogs using a commercially available rapid kit, with infection associated with age, roaming status, and vaccination status. Hematological and blood biochemical analysis of CDV-infected dogs revealed anemia, leukopenia, neutrophilia, thrombocytopenia, a slight increase in aspartate aminotransferase (AST) levels, and a significant increase in blood urea nitrogen (BUN) levels. Molecular characterization of partial hemagglutinin (H) and fusion (F) genes exhibited high nucleotide and amino acid homology with the Asia-1 genotype. Phylogenetic analysis confirmed that the field sequences were clustered into the Asia-1 genotype together with the neighboring countries. These findings provide important insights into the current epidemiological, clinical, and molecular features of CDV circulating in Vietnam.<\/jats:p>","DOI":"10.3390\/v17060781","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T08:07:58Z","timestamp":1748592478000},"page":"781","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epidemiological, Clinical, and Molecular Insights into Canine Distemper Virus in the Mekong Delta Region of Vietnam"],"prefix":"10.3390","volume":"17","author":[{"given":"Tien My","family":"Van","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Can Tho University, Can Tho City 94000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Thi Anh","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Can Tho University, Can Tho City 94000, Vietnam"},{"name":"Faculty of Applied Biological Sciences, Vinh Long University of Technology and Education, Vinh Long 85000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien Tran Phuoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Can Tho University, Can Tho City 94000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0923-986X","authenticated-orcid":false,"given":"Giang Truong","family":"Huynh","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Can Tho University, Can Tho City 94000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mong Thi Nhu","family":"Luu","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Can Tho University, Can Tho City 94000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8785-5199","authenticated-orcid":false,"given":"Trung Quang","family":"Le","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Can Tho University, Can Tho City 94000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-1408","authenticated-orcid":false,"given":"Bich Ngoc","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Can Tho University, Can Tho City 94000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/viro.1993.1103","article-title":"Canine distemper terminal and intergenic non-protein coding nucleotide sequences: Completion of the entire CDV genome sequence","volume":"193","author":"Sidhu","year":"1993","journal-title":"Virology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12985-019-1136-6","article-title":"Tropism and molecular pathogenesis of canine distemper virus","volume":"16","author":"Canal","year":"2019","journal-title":"Virol. 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