{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:18:38Z","timestamp":1791469118610,"version":"4.3.4"},"reference-count":210,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R21AI129369"],"award-info":[{"award-number":["R21AI129369"]}]},{"name":"NIH","award":["R21AI175931"],"award-info":[{"award-number":["R21AI175931"]}]},{"name":"U.S. Department of Veterans Affairs","award":["I01BX004652"],"award-info":[{"award-number":["I01BX004652"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Zika virus (ZIKV) was first discovered in Uganda\u2019s Zika Forest in 1947. The early African viruses posed little or no health risk to humans. Since then, ZIKV has undergone extensive genetic evolution and adapted to humans, and it now causes a range of human diseases, including neurologically related diseases in adults and congenital malformations such as microcephaly in newborns. This raises a critical question as to why ZIKV has become pathogenic to humans, and what virological changes have taken place and enabled it to cause these diseases? This review aims to address these questions. Specifically, we focus on the ZIKV envelope (E) protein, which is essential for initiating infection and plays a crucial role in viral entry. We compare various virologic attributes of E protein between the ancestral African strains, which presumably did not cause human diseases, with epidemic strains responsible for current human pathogenesis. First, we review the role of the ZIKV E protein in viral entry and endocytosis during the viral life cycle. We will then examine how the E protein interacts with host immune responses and evades host antiviral responses. Additionally, we will analyze key differences in the sequence, structure, and post-translational modifications between African and Asian lineages, and discuss their potential impacts on viral infection and pathogenesis. Finally, we will evaluate neutralizing antibodies, small molecule inhibitors, and natural compounds that target the E protein. This will provide insights into the development of potential vaccines and antiviral therapies to prevent or treat ZIKV infections and associated diseases.<\/jats:p>","DOI":"10.3390\/v17060817","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T03:52:28Z","timestamp":1749181948000},"page":"817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Evolving Role of Zika Virus Envelope Protein in Viral Entry and Pathogenesis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2686-5171","authenticated-orcid":false,"given":"Ashkan","family":"Roozitalab","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-9743","authenticated-orcid":false,"given":"Jiantao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-2356","authenticated-orcid":false,"given":"Qiyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-2852","authenticated-orcid":false,"given":"Richard Y.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"},{"name":"Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"},{"name":"Institute of Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA"},{"name":"Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"},{"name":"Research and Development Service, VA Maryland Heath Care System, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lee, I., Bos, S., Li, G., Wang, S., Gadea, G., Despres, P., and Zhao, R.Y. (2018). Probing Molecular Insights into Zika Virus-Host Interactions. Viruses, 10.","DOI":"10.20944\/preprints201804.0063.v1"},{"key":"ref_2","first-page":"735","article-title":"Zika Virus: A New Virus Isolated from Aedes mosquitoes in Uganda","volume":"229","author":"Dick","year":"1952","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF01249709","article-title":"Zika virus infection of the central nervous system of mice","volume":"35","author":"Bell","year":"1971","journal-title":"Arch. Gesamte Virusforsch."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0035-9203(52)90043-6","article-title":"Zika virus. II. Pathogenicity and physical properties","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3201\/eid1509.090442","article-title":"Zika virus outside Africa","volume":"15","author":"Hayes","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3201\/eid1705.101939","article-title":"Probable non-vector-borne transmission of Zika virus, Colorado, USA","volume":"17","author":"Foy","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/QCO.0000000000000414","article-title":"Zika virus as a sexually transmitted pathogen","volume":"31","author":"Mead","year":"2018","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"20761","DOI":"10.2807\/1560-7917.ES2014.19.14.20761","article-title":"Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014","volume":"19","author":"Musso","year":"2014","journal-title":"Euro. Surveill."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0035-9203(54)90006-1","article-title":"Zika virus: A report on three cases of human infection during an epidemic of jaundice in Nigeria","volume":"48","author":"Macnamara","year":"1954","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4269\/ajtmh.1969.18.411","article-title":"Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia","volume":"18","author":"Marchette","year":"1969","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0035-9203(81)90100-0","article-title":"Zika virus, a cause of fever in Central Java, Indonesia","volume":"75","author":"Olson","year":"1981","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0035-9203(83)90106-2","article-title":"A sero-epidemiological survey for certain arboviruses (Togaviridae) in Pakistan","volume":"77","author":"Darwish","year":"1983","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus outbreak on Yap Island, Federated States of Micronesia","volume":"360","author":"Duffy","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"i657","DOI":"10.1136\/bmj.i657","article-title":"Zika virus is a global public health emergency, declares WHO","volume":"352","author":"Gulland","year":"2016","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3855\/jidc.8217","article-title":"Zika virus outbreak in Brazil","volume":"10","author":"Heukelbach","year":"2016","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1002\/jmv.27638","article-title":"Detection of Zika virus disease in Thiruvananthapuram, Kerala, India 2021 during the second wave of COVID-19 pandemic","volume":"94","author":"Yadav","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yu, X., and Cheng, G. (2022). Adaptive Evolution as a Driving Force of the Emergence and Re-Emergence of Mosquito-Borne Viral Diseases. Viruses, 14.","DOI":"10.3390\/v14020435"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","article-title":"Flavivirus genome organization, expression, and replication","volume":"44","author":"Chambers","year":"1990","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.aaf5316","article-title":"The 3.8 A resolution cryo-EM structure of Zika virus","volume":"352","author":"Sirohi","year":"2016","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/0470058005.ch3","article-title":"Molecular biology of flaviviruses","volume":"277","author":"Harris","year":"2006","journal-title":"Novartis Found. Symp."},{"key":"ref_22","first-page":"E376","article-title":"Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aam7120","article-title":"A single mutation in the prM protein of Zika virus contributes to fetal microcephaly","volume":"358","author":"Yuan","year":"2017","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Nambala, P., and Su, W.-C.J.F.i.m. (2018). Role of Zika virus prM protein in viral pathogenicity and use in vaccine development. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01797"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1128\/jvi.68.6.3794-3802.1994","article-title":"NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: In vitro and in vivo studies","volume":"68","author":"Amberg","year":"1994","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.virol.2010.02.008","article-title":"A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis","volume":"401","author":"Lobigs","year":"2010","journal-title":"Virology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Li, G., Bos, S., Tsetsarkin, K.A., Pletnev, A.G., Despres, P., Gadea, G., and Zhao, R.Y. (2019). The Roles of prM-E Proteins in Historical and Epidemic Zika Virus-mediated Infection and Neurocytotoxicity. Viruses, 11.","DOI":"10.3390\/v11020157"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1128\/jvi.71.11.8475-8481.1997","article-title":"Proteolytic activation of tick-borne encephalitis virus by furin","volume":"71","author":"Stadler","year":"1997","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1099\/vir.0.18723-0","article-title":"Cleavage of protein prM is necessary for infection of BHK-21 cells by tick-borne encephalitis virus","volume":"84","author":"Elshuber","year":"2003","journal-title":"J. Gen. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s44298-023-00004-2","article-title":"Zika virus M protein latches and locks the E protein from transitioning to an immature state after prM cleavage","volume":"1","author":"Majowicz","year":"2023","journal-title":"NPJ Viruses"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Faye, O., Freire, C.C., Iamarino, A., Faye, O., de Oliveira, J.V., Diallo, M., Zanotto, P.M., and Sall, A.A. (2014). Molecular evolution of Zika virus during its emergence in the 20(th) century. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002636"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11262-022-01898-5","article-title":"A review on structural genomics approach applied for drug discovery against three vector-borne viral diseases: Dengue, Chikungunya and Zika","volume":"58","author":"Sundar","year":"2022","journal-title":"Virus Genes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.aag2419","article-title":"Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor","volume":"353","author":"Lei","year":"2016","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s11427-020-1818-4","article-title":"ZIKV viral proteins and their roles in virus-host interactions","volume":"64","author":"Guo","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.celrep.2017.02.014","article-title":"Ultrastructural characterization of Zika virus replication factories","volume":"18","author":"Cortese","year":"2017","journal-title":"Cell Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chom.2016.07.002","article-title":"Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission","volume":"20","author":"Tabata","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jamaophthalmol.2016.0267","article-title":"Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil","volume":"134","author":"Prazeres","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sager, G., Gabaglio, S., Sztul, E., and Belov, G.A.J.V. (2018). Role of host cell secretory machinery in Zika virus life cycle. Viruses, 10.","DOI":"10.3390\/v10100559"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrmicro1067","article-title":"A structural perspective of the flavivirus life cycle","volume":"3","author":"Mukhopadhyay","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zhang, X., Jia, R., Shen, H., Wang, M., Yin, Z., and Cheng, A. (2017). Structures and functions of the envelope glycoprotein in flavivirus infections. Viruses, 9.","DOI":"10.3390\/v9110338"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.tibs.2017.02.009","article-title":"Structural biology of the Zika virus","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1021\/acs.chemrev.7b00719","article-title":"Biochemistry and molecular biology of flaviviruses","volume":"118","author":"Barrows","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Frumence, E., Haddad, J.G., Vanwalscappel, B., Andries, J., Decotter, J., Viranaicken, W., Gadea, G., and Despr\u00e8s, P. (2020). Immune Reactivity of a 20-mer Peptide Representing the Zika E Glycan Loop Involves the Antigenic Determinants E-152\/156\/158. Viruses, 12.","DOI":"10.3390\/v12111258"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.chom.2016.04.013","article-title":"Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody","volume":"19","author":"Dai","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Routhu, N.K., Lehoux, S.D., Rouse, E.A., Bidokhti, M.R.M., Giron, L.B., Anzurez, A., Reid, S.P., Abdel-Mohsen, M., Cummings, R.D., and Byrareddy, S.N. (2019). Glycosylation of Zika Virus is Important in Host-Virus Interaction and Pathogenic Potential. Int. J. Mol. Sci., 20.","DOI":"10.1101\/564542"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12985-021-01611-2","article-title":"The key amino acids of E protein involved in early flavivirus infection: Viral entry","volume":"18","author":"Hu","year":"2021","journal-title":"Virol. J."},{"key":"ref_47","first-page":"1150","article-title":"Computational analysis of perturbations in the post-fusion Dengue virus envelope protein highlights known epitopes and conserved residues in the Zika virus","volume":"5","author":"Chakraborty","year":"2016","journal-title":"F1000Research"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/sj.emboj.7600064","article-title":"Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation","volume":"23","author":"Bressanelli","year":"2004","journal-title":"EMBO J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1074\/jbc.M506614200","article-title":"Quantifying the specific binding between West Nile virus envelope domain III protein and the cellular receptor \u03b1V\u03b23 integrin","volume":"281","author":"Lee","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.meegid.2019.01.018","article-title":"ZIKA virus entry mechanisms in human cells","volume":"69","author":"Agrelli","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.antiviral.2018.04.010","article-title":"Insect cell-produced recombinant protein subunit vaccines protect against Zika virus infection","volume":"154","author":"Qu","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s41182-022-00485-6","article-title":"Vaccination with a Zika virus envelope domain III protein induces neutralizing antibodies and partial protection against Asian genotype in immunocompetent mice","volume":"50","author":"Shin","year":"2022","journal-title":"Trop. Med. Health"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/infdis\/jix473","article-title":"CD-loop Extension in Zika Virus Envelope Protein Key for Stability and Pathogenesis","volume":"216","author":"Gallichotte","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JVI.00104-20","article-title":"Flavivirus envelope protein glycosylation: Impacts on viral infection and pathogenesis","volume":"94","author":"Carbaugh","year":"2020","journal-title":"J. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1080\/21505594.2022.2060464","article-title":"Glycosylation of viral proteins: Implication in virus\u2013host interaction and virulence","volume":"13","author":"Feng","year":"2022","journal-title":"Virulence"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e00113-19","DOI":"10.1128\/JVI.00113-19","article-title":"Envelope Protein Glycosylation Mediates Zika Virus Pathogenesis","volume":"93","author":"Carbaugh","year":"2019","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Bos, S., Viranaicken, W., Frumence, E., Li, G., Despres, P., Zhao, R.Y., and Gadea, G. (2019). The Envelope Residues E152\/156\/158 of Zika Virus Influence the Early Stages of Virus Infection in Human Cells. Cells, 8.","DOI":"10.3390\/cells8111444"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Lei, Y., Yu, H., Dong, Y., Yang, J., Ye, W., Wang, Y., Chen, W., Jia, Z., Xu, Z., and Li, Z.J.P.O. (2015). Characterization of N-glycan structures on the surface of mature dengue 2 virus derived from insect cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132122"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Pralow, A., Nikolay, A., Leon, A., Genzel, Y., Rapp, E., and Reichl, U.J.S.R. (2021). Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-84682-z"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.isci.2018.02.005","article-title":"High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells","volume":"1","author":"Gong","year":"2018","journal-title":"iScience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jmgm.2017.04.009","article-title":"Study of the mechanism of protonated histidine-induced conformational changes in the Zika virus dimeric envelope protein using accelerated molecular dynamic simulations","volume":"74","author":"Sun","year":"2017","journal-title":"J. Mol. Graph. Model."},{"key":"ref_62","first-page":"565","article-title":"Phosphatidylserine receptors: Enhancers of enveloped virus entry and infection","volume":"468\u2013470","author":"Maury","year":"2014","journal-title":"Virology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virol.2021.04.013","article-title":"Development of a blocker of the universal phosphatidylserine- and phosphatidylethanolamine-dependent viral entry pathways","volume":"560","author":"Song","year":"2021","journal-title":"Virology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.str.2015.12.011","article-title":"The Role of the Membrane in the Structure and Biophysical Robustness of the Dengue Virion Envelope","volume":"24","author":"Reddy","year":"2016","journal-title":"Structure"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/bs.ircmb.2020.09.003","article-title":"TAM receptors: A phosphatidylserine receptor family and its implications in viral infections","volume":"357","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Tang, D., Wang, Y., Dong, X., Yuan, Y., Kang, F., Tian, W., Wang, K., Li, H., and Qi, S. (2022). Scramblases and virus infection. BioEssays, 44.","DOI":"10.1002\/bies.202100261"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12964-019-0452-1","article-title":"Roles of phosphatidylserine exposed on the viral envelope and cell membrane in HIV-1 replication","volume":"17","author":"Chua","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Berneck, B.S., Rockstroh, A., Fertey, J., Grunwald, T., and Ulbert, S.J.V. (2020). A recombinant Zika virus envelope protein with mutations in the conserved fusion loop leads to reduced antibody cross-reactivity upon vaccination. Vaccines, 8.","DOI":"10.3390\/vaccines8040603"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e0141423","DOI":"10.1128\/jvi.01414-23","article-title":"The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies","volume":"97","author":"Kikawa","year":"2023","journal-title":"J. Virol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1080\/22221751.2022.2082888","article-title":"Identification and characterization of key residues in Zika virus envelope protein for virus assembly and entry","volume":"11","author":"Ma","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JVI.01291-19","article-title":"Deep mutational scanning comprehensively maps how Zika envelope protein mutations affect viral growth and antibody escape","volume":"93","author":"Sourisseau","year":"2019","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e00640-19","DOI":"10.1128\/JVI.00640-19","article-title":"Comparative Analysis of African and Asian Lineage-Derived Zika Virus Strains Reveals Differences in Activation of and Sensitivity to Antiviral Innate Immunity","volume":"93","author":"Aarreberg","year":"2019","journal-title":"J. Virol."},{"key":"ref_73","first-page":"4114","article-title":"The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and dengue virus","volume":"144","author":"Shao","year":"2017","journal-title":"Development"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e00292-17","DOI":"10.1128\/mSphere.00292-17","article-title":"Phenotypic Differences between Asian and African Lineage Zika Viruses in Human Neural Progenitor Cells","volume":"2","author":"Anfasa","year":"2017","journal-title":"mSphere"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature22365","article-title":"Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes","volume":"545","author":"Liu","year":"2017","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Sievers, F., Wilm, A., Dineen, D., Gibson, T.J., Karplus, K., Li, W., Lopez, R., McWilliam, H., Remmert, M., and Soding, J. (2011). Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol. Syst. Biol., 7.","DOI":"10.1038\/msb.2011.75"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e10873","DOI":"10.1002\/ece3.10873","article-title":"TreeViewer: Flexible, modular software to visualise and manipulate phylogenetic trees","volume":"14","author":"Bianchini","year":"2024","journal-title":"Ecol. Evol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1126\/science.aaf5036","article-title":"Zika virus in the Americas: Early epidemiological and genetic findings","volume":"352","author":"Faria","year":"2016","journal-title":"Science"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Haddow, A.D., Schuh, A.J., Yasuda, C.Y., Kasper, M.R., Heang, V., Huy, R., Guzman, H., Tesh, R.B., and Weaver, S.C. (2012). Genetic characterization of Zika virus strains: Geographic expansion of the Asian lineage. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001477"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Beaver, J.T., Lelutiu, N., Habib, R., and Skountzou, I. (2018). Evolution of Two Major Zika Virus Lineages: Implications for Pathology, Immune Response, and Vaccine Development. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01640"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.virol.2017.12.003","article-title":"The structural proteins of epidemic and historical strains of Zika virus differ in their ability to initiate viral infection in human host cells","volume":"516","author":"Bos","year":"2018","journal-title":"Virology"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Frumence, E., Viranaicken, W., Bos, S., Alvarez-Martinez, M.T., Roche, M., Arnaud, J.D., Gadea, G., and Despres, P. (2019). A Chimeric Zika Virus between Viral Strains MR766 and BeH819015 Highlights a Role for E-glycan Loop in Antibody-mediated Virus Neutralization. Vaccines, 7.","DOI":"10.3390\/vaccines7020055"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.meegid.2017.03.012","article-title":"Comparative analysis of protein evolution in the genome of pre-epidemic and epidemic Zika virus","volume":"51","author":"Ramaiah","year":"2017","journal-title":"Infect. Genet. Evol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.virol.2017.12.032","article-title":"The Zika virus envelope protein glycan loop regulates virion antigenicity","volume":"515","author":"Goo","year":"2018","journal-title":"Virology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e01348-17","DOI":"10.1128\/JVI.01348-17","article-title":"Zika Virus Encoding Non-Glycosylated Envelope Protein is Attenuated and Defective in Neuroinvasion","volume":"91","author":"Annamalai","year":"2017","journal-title":"J. Virol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.virusres.2017.08.018","article-title":"Taking the defensive: Immune control of Zika virus infection","volume":"254","author":"Bowen","year":"2018","journal-title":"Virus Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/hmg\/ddx382","article-title":"Modeling neuro-immune interactions during Zika virus infection","volume":"27","author":"Mesci","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"E1587","DOI":"10.1073\/pnas.1616097114","article-title":"Vulnerability of primitive human placental trophoblast to Zika virus","volume":"114","author":"Sheridan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.stem.2016.10.017","article-title":"Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stem.2016.03.012","article-title":"Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells","volume":"18","author":"Nowakowski","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.celrep.2016.12.045","article-title":"Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses","volume":"18","author":"Meertens","year":"2017","journal-title":"Cell Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.omto.2021.11.001","article-title":"AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines","volume":"23","author":"Zwernik","year":"2021","journal-title":"Mol. Ther. Oncolytics"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Al Kafri, N., Ahnstr\u00f6m, J., Teraz-Orosz, A., Chaput, L., Singh, N., Villoutreix, B.O., and Hafizi, S. (2022). The first laminin G-like domain of protein S is essential for binding and activation of Tyro3 receptor and intracellular signalling. Biochem. Biophys. Rep., 30.","DOI":"10.1016\/j.bbrep.2022.101263"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1749-6632.2010.05744.x","article-title":"TAM receptors and the clearance of apoptotic cells","volume":"1209","author":"Lemke","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Espino, A., Gouilly, J., Chen, Q., Colin, P., Guerby, P., Izopet, J., Amara, A., Tabiasco, J., Al-Daccak, R., and El Costa, H. (2022). The mechanisms underlying the immune control of zika virus infection at the maternal-fetal interface. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1000861"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Komarasamy, T.V., Adnan, N.A.A., James, W., and Balasubramaniam, V. (2022). Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.773191"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika virus infection in human skin cells","volume":"89","author":"Hamel","year":"2015","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1073\/pnas.1620558114","article-title":"AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses","volume":"114","author":"Richard","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"8327","DOI":"10.1128\/JVI.01025-13","article-title":"Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry","volume":"87","author":"Kondratowicz","year":"2013","journal-title":"J. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Estevez-Herrera, J., Perez-Yanes, S., Cabrera-Rodriguez, R., Marquez-Arce, D., Trujillo-Gonzalez, R., Machado, J.D., Madrid, R., and Valenzuela-Fernandez, A. (2021). Zika Virus Pathogenesis: A Battle for Immune Evasion. Vaccines, 9.","DOI":"10.3390\/vaccines9030294"},{"key":"ref_101","first-page":"1125565","article-title":"Transmission of Zika virus by dendritic cell subsets in skin and vaginal mucosa","volume":"14","author":"Eder","year":"2023","journal-title":"Cell"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Jaimipuk, T., Sachdev, S., Yoksan, S., and Thepparit, C. (2022). A Small-Plaque Isolate of the Zika Virus with Envelope Domain III Mutations Affect Viral Entry and Replication in Mammalian but Not Mosquito Cells. Viruses, 14.","DOI":"10.3390\/v14030480"},{"key":"ref_103","first-page":"1150","article-title":"MEPPitope: Spatial, electrostatic and secondary structure perturbations in the post-fusion Dengue virus envelope protein highlights known epitopes and conserved residues in the Zika virus","volume":"5","author":"Chakraborty","year":"2016","journal-title":"F1000Research"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"S935","DOI":"10.1093\/infdis\/jix515","article-title":"Zika virus structure, maturation, and receptors","volume":"216","author":"Sirohi","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.celrep.2017.10.016","article-title":"Functional analysis of glycosylation of Zika virus envelope protein","volume":"21","author":"Shan","year":"2017","journal-title":"Cell Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bbrc.2017.01.022","article-title":"Role of N-glycosylation on Zika virus E protein secretion, viral assembly and infectivity","volume":"492","author":"Mossenta","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1128\/JVI.03287-13","article-title":"Role of phosphatidylserine receptors in enveloped virus infection","volume":"88","author":"Morizono","year":"2014","journal-title":"J. Virol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/v6010069","article-title":"Flavivirus entry receptors: An update","volume":"6","author":"Meertens","year":"2013","journal-title":"Viruses"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Li, M., Zhang, D., Li, C., Zheng, Z., Fu, M., Ni, F., Liu, Y., Du, T., Wang, H., and Griffin, G.E.J.F.I.M. (2020). Characterization of Zika virus endocytic pathways in human glioblastoma cells. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00242"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12964-019-0349-z","article-title":"Zika virus: Mapping and reprogramming the entry","volume":"17","author":"Owczarek","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.virol.2019.04.008","article-title":"Comparative analysis of viral entry for Asian and African lineages of Zika virus","volume":"533","author":"Rinkenberger","year":"2019","journal-title":"Virology"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.bbrc.2015.01.017","article-title":"Inhibition of Mer and Axl receptor tyrosine kinases leads to increased apoptosis and improved chemosensitivity in human neuroblastoma","volume":"457","author":"Li","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00430-015-0445-7","article-title":"Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase","volume":"205","author":"Tappe","year":"2016","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"ofw203","DOI":"10.1093\/ofid\/ofw203","article-title":"Zika Virus Causing Encephalomyelitis Associated With Immunoactivation","volume":"3","author":"Galliez","year":"2016","journal-title":"Open Forum Infect. Dis."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s10995-020-03053-8","article-title":"Parental Stress in Primary Caregivers of Children with Evidence of Congenital Zika Virus Infection in Northeastern Brazil","volume":"25","author":"Santelli","year":"2021","journal-title":"Matern. Child Health J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1038\/s41467-019-11866-7","article-title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice","volume":"10","author":"Figueiredo","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/pbi.12796","article-title":"Plant-produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice","volume":"16","author":"Yang","year":"2018","journal-title":"Plant. Biotechnol. J."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Shin, M., Kim, K., Lee, H.J., Lee, R., Jung, Y.J., Park, J., and Hahn, T.W. (2022). Zika virus baculovirus-expressed envelope protein elicited humoral and cellular immunity in immunocompetent mice. Sci. Rep., 12.","DOI":"10.1038\/s41598-021-04713-7"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Lunardelli, V.A.S., de Souza Apostolico, J., Souza, H.F.S., Coirada, F.C., Martinho, J.A., Astray, R.M., Boscardin, S.B., and Rosa, D.S. (2022). ZIKV-envelope proteins induce specific humoral and cellular immunity in distinct mice strains. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-20183-x"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.7150\/ijbs.83056","article-title":"Targeting Type I Interferon Induction and Signaling: How Zika Virus Escapes from Host Innate Immunity","volume":"19","author":"Hu","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Anglero-Rodriguez, Y.I., MacLeod, H.J., Kang, S., Carlson, J.S., Jupatanakul, N., and Dimopoulos, G. (2017). Aedes aegypti Molecular Responses to Zika Virus: Modulation of Infection by the Toll and Jak\/Stat Immune Pathways and Virus Host Factors. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.02050"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e01372-19","DOI":"10.1128\/mBio.01372-19","article-title":"Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells","volume":"10","author":"Strange","year":"2019","journal-title":"mBio"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"155343","DOI":"10.1016\/j.phymed.2024.155343","article-title":"Atranorin inhibits Zika virus infection in human glioblastoma cell line SNB-19 via targeting Zika virus envelope protein","volume":"125","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Mellors, J., Tipton, T., Longet, S., and Carroll, M. (2020). Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01450"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Malekshahi, Z., Schiela, B., Bernklau, S., Banki, Z., Wurzner, R., and Stoiber, H. (2020). Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.569549"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e00046-18","DOI":"10.1128\/mBio.00046-18","article-title":"N-glycosylation of viral E protein is the determinant for vector midgut invasion by flaviviruses","volume":"9","author":"Wen","year":"2018","journal-title":"mBio"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Dussupt, V., Modjarrad, K., and Krebs, S.J. (2021). Landscape of monoclonal antibodies targeting zika and dengue: Therapeutic solutions and critical insights for vaccine development. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.621043"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"206","DOI":"10.15252\/embr.201745302","article-title":"The bright and the dark side of human antibody responses to flaviviruses: Lessons for vaccine design","volume":"19","author":"Rey","year":"2018","journal-title":"EMBO Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e01485-19","DOI":"10.1128\/mBio.01485-19","article-title":"Role of Zika Virus Envelope Protein Domain III as a Target of Human Neutralizing Antibodies","volume":"10","author":"Gallichotte","year":"2019","journal-title":"mBio"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s12250-019-00093-5","article-title":"Development of Neutralizing Antibodies against Zika Virus Based on Its Envelope Protein Structure","volume":"34","author":"Yang","year":"2019","journal-title":"Virol. Sin."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e20191792","DOI":"10.1084\/jem.20191792","article-title":"Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge","volume":"217","author":"Zhao","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2016.07.020","article-title":"Structural basis of Zika virus-specific antibody protection","volume":"166","author":"Zhao","year":"2016","journal-title":"Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1073\/pnas.2000414117","article-title":"A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques","volume":"117","author":"Coffey","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2017.04.024","article-title":"Recurrent potent human neutralizing antibodies to Zika virus in Brazil and Mexico","volume":"169","author":"Robbiani","year":"2017","journal-title":"Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbrc.2021.01.075","article-title":"Neutralization of Zika virus by E protein domain III-Specific human monoclonal antibody","volume":"545","author":"Kim","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e02423-20","DOI":"10.1128\/JVI.02423-20","article-title":"A Novel Antigenic Site Spanning Domains I and III of the Zika Virus Envelope Glycoprotein Is the Target of Strongly Neutralizing Human Monoclonal Antibodies","volume":"95","author":"Graham","year":"2021","journal-title":"J. Virol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"Stettler","year":"2016","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41591-019-0746-2","article-title":"Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor","volume":"26","author":"Dussupt","year":"2020","journal-title":"Nat. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature18938","article-title":"Structural basis of potent Zika-dengue virus antibody cross-neutralization","volume":"536","author":"Dejnirattisai","year":"2016","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2017.09.002","article-title":"A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential","volume":"171","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Deng, Y.-Q., Dai, J.-X., Ji, G.-H., Jiang, T., Wang, H.-J., Yang, H.-o., Tan, W.-L., Liu, R., Yu, M., and Ge, B.-X. (2011). A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E protein. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016059"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Fran\u00e7a, R., Silva, J.M., Rodrigues, L.S., Sokolowskei, D., Brigido, M.M., and Maranh\u00e3o, A.Q. (2022). New Anti-Flavivirus Fusion Loop Human Antibodies with Zika Virus-Neutralizing Potential. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147805"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41421-019-0140-8","article-title":"A new class of broadly neutralizing antibodies that target the glycan loop of Zika virus envelope protein","volume":"6","author":"Qu","year":"2020","journal-title":"Cell Discov."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/vim.2023.0153","article-title":"Characterization of Two Highly Specific Monoclonal Antibodies Targeting the Glycan Loop of the Zika Virus Envelope Protein","volume":"37","author":"McLaury","year":"2024","journal-title":"Viral Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"369ra179","DOI":"10.1126\/scitranslmed.aai8336","article-title":"Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus","volume":"8","author":"Wang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"112942","DOI":"10.1016\/j.celrep.2023.112942","article-title":"Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes","volume":"42","author":"Sankhala","year":"2023","journal-title":"Cell Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"13679","DOI":"10.1038\/ncomms13679","article-title":"Neutralization mechanism of a highly potent antibody against Zika virus","volume":"7","author":"Zhang","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ni.3849","article-title":"Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection","volume":"18","author":"Fernandez","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature20564","article-title":"Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice","volume":"540","author":"Sapparapu","year":"2016","journal-title":"Nature"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"14722","DOI":"10.1038\/ncomms14722","article-title":"A human antibody against Zika virus crosslinks the E protein to prevent infection","volume":"8","author":"Hasan","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tim.2017.10.004","article-title":"A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?","volume":"26","author":"Sariol","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Langerak, T., Mumtaz, N., Tolk, V.I., van Gorp, E.C.M., Martina, B.E., Rockx, B., and Koopmans, M.P.G. (2019). The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007640"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e190098","DOI":"10.1590\/0074-02760190098","article-title":"Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses","volume":"114","author":"Oliveira","year":"2019","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"aaf8160","DOI":"10.1126\/science.aaf8160","article-title":"Assessing the global threat from Zika virus","volume":"353","author":"Lessler","year":"2016","journal-title":"Science"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Castanha, P.M.S., and Marques, E.T.A. (2020). A glimmer of hope: Recent updates and future challenges in Zika vaccine development. Viruses, 12.","DOI":"10.3390\/v12121371"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Malafa, S., Medits, I., Aberle, J.H., Aberle, S.W., Haslwanter, D., Tsouchnikas, G., Wolfel, S., Huber, K.L., Percivalle, E., and Cherpillod, P. (2020). Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008034"},{"key":"ref_157","first-page":"7239347","article-title":"Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population","volume":"2019","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ijid.2020.01.031","article-title":"An epidemiological survey of the current status of Zika and the immune interaction between dengue and Zika infection in Southern Taiwan","volume":"93","author":"Wang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Bonheur, A.N., Thomas, S., Soshnick, S.H., McGibbon, E., Dupuis, A.P., Hull, R., Slavinski, S., Del Rosso, P.E., Weiss, D., and Hunt, D.T. (2021). A fatal case report of antibody-dependent enhancement of dengue virus type 1 following remote Zika virus infection. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06482-0"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aal4365","article-title":"Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity","volume":"356","author":"Bardina","year":"2017","journal-title":"Science"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Crooks, C.M., Weiler, A.M., Rybarczyk, S.L., Bliss, M.I., Jaeger, A.S., Murphy, M.E., Simmons, H.A., Mejia, A., Fritsch, M.K., and Hayes, J.M. (2021). Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009641"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-981-10-8727-1_6","article-title":"Structures of Zika Virus E & NS1: Relations with Virus Infection and Host Immune Responses","volume":"1062","author":"Shi","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_163","unstructured":"Wolford, R.W., and Schaefer, T.J. (2024). Zika Virus. StatPearls, StatPearls Publishing."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S1286-4579(00)01320-4","article-title":"The Brazilian flaviviruses","volume":"2","author":"Figueiredo","year":"2000","journal-title":"Microbes Infect."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Anez, G., and Rios, M. (2013). Dengue in the United States of America: A worsening scenario?. BioMed Res. Int., 2013.","DOI":"10.1155\/2013\/678645"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2471\/BLT.16.182105","article-title":"Systematic analysis of protein identity between Zika virus and other arthropod-borne viruses","volume":"95","author":"Chang","year":"2017","journal-title":"Bull. World Health Organ."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Sekaran, S.D., Ismail, A.A., Thergarajan, G., Chandramathi, S., Rahman, S.K.H., Mani, R.R., Jusof, F.F., Lim, Y.A.L., and Manikam, R. (2022). Host immune response against DENV and ZIKV infections. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.975222"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus","volume":"17","author":"Dejnirattisai","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Kribs, C., and Greenhalgh, D.J.J.o.M.B. (2023). Impact of tetravalent dengue vaccination with screening, ADE, and altered infectivity on single-serotype dengue and Zika transmission. J. Math. Biol., 86.","DOI":"10.1007\/s00285-023-01915-7"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41541-016-0003-3","article-title":"A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus","volume":"2","author":"Xu","year":"2017","journal-title":"NPJ Vaccines"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"e92428","DOI":"10.1172\/jci.insight.92428","article-title":"Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections","volume":"2","author":"Kam","year":"2017","journal-title":"JCI Insight"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Sun, H., Yang, M., Lai, H., Neupane, B., Teh, A.Y., Jugler, C., Ma, J.K., Steinkellner, H., Bai, F., and Chen, Q. (2023). A Dual-Approach Strategy to Optimize the Safety and Efficacy of Anti-Zika Virus Monoclonal Antibody Therapeutics. Viruses, 15.","DOI":"10.3390\/v15051156"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Khandia, R., Munjal, A., Dhama, K., Karthik, K., Tiwari, R., Malik, Y.S., Singh, R.K., and Chaicumpa, W. (2018). Modulation of Dengue\/Zika Virus Pathogenicity by Antibody-Dependent Enhancement and Strategies to Protect Against Enhancement in Zika Virus Infection. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00597"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.virol.2010.12.020","article-title":"Antibody-mediated neutralization of flaviviruses: A reductionist view","volume":"411","author":"Dowd","year":"2011","journal-title":"Virology"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"104876","DOI":"10.1016\/j.antiviral.2020.104876","article-title":"Small molecule inhibitors possibly targeting the rearrangement of Zika virus envelope protein","volume":"182","author":"Sharma","year":"2020","journal-title":"Antivir. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chembiol.2022.10.003","article-title":"Bortezomib inhibits ZIKV\/DENV by interfering with viral polyprotein cleavage via the ERAD pathway","volume":"30","author":"Ci","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Gao, Y., Tai, W., Wang, N., Li, X., Jiang, S., Debnath, A.K., Du, L., and Chen, S. (2019). Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors. Viruses, 11.","DOI":"10.3390\/v11111019"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.virol.2016.06.012","article-title":"The green tea molecule EGCG inhibits Zika virus entry","volume":"496","author":"Carneiro","year":"2016","journal-title":"Virology"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.antiviral.2017.09.006","article-title":"Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry","volume":"147","author":"Behrendt","year":"2017","journal-title":"Antivir. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1080\/07391102.2020.1797538","article-title":"Polysaccharides like pentagalloylglucose, parishin a and stevioside inhibits the viral entry by binding the Zika virus envelope protein","volume":"39","author":"Sharma","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"104540","DOI":"10.1016\/j.micpath.2020.104540","article-title":"Molecular docking and antiviral activities of plant derived compounds against zika virus","volume":"149","author":"Sangeetha","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00705-018-4083-4","article-title":"Baicalein and baicalin as Zika virus inhibitors","volume":"164","author":"Oo","year":"2019","journal-title":"Arch. Virol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.bbrc.2019.08.120","article-title":"Palmatine inhibits Zika virus infection by disrupting virus binding, entry, and stability","volume":"518","author":"Ho","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Lai, Z.-Z., Ho, Y.-J., and Lu, J.-W. (2020). Harringtonine inhibits Zika virus infection through multiple mechanisms. Molecules, 25.","DOI":"10.3390\/molecules25184082"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/CIRCRESAHA.116.309866","article-title":"AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus","volume":"119","author":"Liu","year":"2016","journal-title":"Circ. Res."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Zhang, B., Yu, J., Zhu, G., Huang, Y., Zhang, K., Xiao, X., He, W., Yuan, J., and Gao, X. (2023). Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro. Molecules, 28.","DOI":"10.3390\/molecules28248142"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s12033-016-9979-1","article-title":"An Approach for Zika Virus Inhibition Using Homology Structure of the Envelope Protein","volume":"58","author":"Fernando","year":"2016","journal-title":"Mol. Biotechnol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2017.03.014","article-title":"Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding","volume":"142","author":"Mounce","year":"2017","journal-title":"Antivir. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"174144","DOI":"10.1016\/j.ejphar.2021.174144","article-title":"Therapeutic targets and biological mechanisms of action of curcumin against Zika virus: In silico and in vitro analyses","volume":"904","author":"Kim","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.antiviral.2019.02.008","article-title":"Identification of small molecule inhibitors targeting the Zika virus envelope protein","volume":"164","author":"Pitts","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1074\/jbc.RA118.005015","article-title":"A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles","volume":"294","author":"Li","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1167\/iovs.17-22585","article-title":"Atovaquone impairs growth of Aspergillus and Fusarium keratitis isolates by modulating mitochondrial function and zinc homeostasis","volume":"59","author":"Clark","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/jac\/dks504","article-title":"Antimalarial pharmacology and therapeutics of atovaquone","volume":"68","author":"Nixon","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Yamamoto, M., Ichinohe, T., Watanabe, A., Kobayashi, A., Zhang, R., Song, J., Kawaguchi, Y., Matsuda, Z., and Inoue, J.-i. (2020). The antimalarial compound atovaquone inhibits Zika and dengue virus infection by blocking E protein-mediated membrane fusion. Viruses, 12.","DOI":"10.3390\/v12121475"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Wang, L., Liang, R., Gao, Y., Li, Y., Deng, X., Xiang, R., Zhang, Y., Ying, T., Jiang, S., and Yu, F. (2019). Development of Small-Molecule Inhibitors Against Zika Virus Infection. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02725"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"15672","DOI":"10.1038\/ncomms15672","article-title":"A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses","volume":"8","author":"Yu","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.antiviral.2017.02.009","article-title":"Antiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses","volume":"141","author":"Chen","year":"2017","journal-title":"Antivir. Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1080\/21505594.2021.1948261","article-title":"LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination","volume":"12","author":"Hu","year":"2021","journal-title":"Virulence"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Ling, J., Morente, S.F., Lundkvist, \u00c5., and Li, J. (2025). Heparanase attenuates Zika virus infection by destabilizing the viral envelope protein. bioRxiv.","DOI":"10.1101\/2025.03.16.643511"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Van der Hoek, K.H., Eyre, N.S., Shue, B., Khantisitthiporn, O., Glab-Ampi, K., Carr, J.M., Gartner, M.J., Jolly, L.A., Thomas, P.Q., and Adikusuma, F. (2017). Viperin is an important host restriction factor in control of Zika virus infection. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-04138-1"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, Q., Hu, D., Gao, D., Wang, W., Wu, K., and Wu, J. (2021). USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination. Viruses, 13.","DOI":"10.20944\/preprints202107.0634.v1"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.chom.2016.05.004","article-title":"An infectious cDNA clone of Zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors","volume":"19","author":"Shan","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Annamalai, A.S., Pattnaik, A., Sahoo, B.R., Guinn, Z.P., Bullard, B.L., Weaver, E.A., Steffen, D., Natarajan, S.K., Petro, T.M., and Pattnaik, A.K. (2019). An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model. Vaccines, 7.","DOI":"10.3390\/vaccines7030112"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Zhong, Z., Portela Catani, J.P., Mc Cafferty, S., Couck, L., Van Den Broeck, W., Gorl\u00e9, N., Vandenbroucke, R.E., Devriendt, B., Ulbert, S., and Cnops, L. (2019). Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine. Vaccines, 7.","DOI":"10.3390\/vaccines7030096"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Contreras, M., Stuart, J.B., Levoir, L.M., Belmont, L., and Goo, L. (2024). Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies. mBio, 15.","DOI":"10.1128\/mbio.03048-23"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Feng, Y.J.F.i.P. (2024). Recent advances in the study of zika virus structure, drug targets, and inhibitors. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1418516"},{"key":"ref_207","first-page":"474","article-title":"The 2021 Zika outbreak in Uttar Pradesh state of India: Tackling the emerging public health threat","volume":"52","author":"Khan","year":"2022","journal-title":"Trop. Dr."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"110655","DOI":"10.1016\/j.celrep.2022.110655","article-title":"A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity","volume":"39","author":"Wang","year":"2022","journal-title":"Cell Rep."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Chan, K.W.K., Bifani, A.M., Watanabe, S., Choy, M.M., Ooi, E.E., and Vasudevan, S.G. (2023). Tissue-specific expansion of Zika virus isogenic variants drive disease pathogenesis. eBioMedicine, 91.","DOI":"10.1016\/j.ebiom.2023.104570"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-pathmechdis-031521-034739","article-title":"Pathogenesis of Zika Virus Infection","volume":"18","author":"Giraldo","year":"2023","journal-title":"Annu. Rev. Pathol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/6\/817\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:47:23Z","timestamp":1760032043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/6\/817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":210,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["v17060817"],"URL":"https:\/\/doi.org\/10.3390\/v17060817","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,6]]}}}