{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:31:48Z","timestamp":1760059908403,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the United States Centers for Disease Control and Prevention (CDC) through the National Center for Emerging and Zoonotic Infectious Disease","award":["RFA-CK-13-001"],"award-info":[{"award-number":["RFA-CK-13-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>In Africa, Rift Valley Fever poses a substantial risk to animal health, and human cases occur after contact with infected animals or their tissues. RVF has re-emerged in Uganda after nearly five decades, with multiple outbreaks recorded since 2016. We investigated a unique RVF outbreak associated with an animal abortion storm of 30 events and human cases on a dairy farm in Mbarara District, Western Uganda, in February 2023. Genomic analysis was performed, comparing animal and human RVF viruses (RVFV) circulating in the region. A cluster of thirteen human RVF cases and nine PCR-positive animals could directly be linked with the abortion storm. Overall, during the year 2023, we confirmed 61 human RVFV cases across Uganda, 88.5% of which were reported to have had direct contact with livestock, and a high case fatality rate of 31%. We recommend implementing extensive health education programs in affected communities and using sustainable mosquito control strategies to limit transmission in livestock, coupled with initiating animal vaccination trials in Uganda.<\/jats:p>","DOI":"10.3390\/v17071015","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:56:14Z","timestamp":1753084574000},"page":"1015","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rift Valley Fever Outbreak Investigation Associated with a Dairy Farm Abortion Storm, Mbarara District, Western Uganda, 2023"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2944-9157","authenticated-orcid":false,"given":"Luke","family":"Nyakarahuka","sequence":"first","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"},{"name":"Department of Biosecurity, Ecosystems and Veterinary Public Health, Makerere University, Kampala P.O. Box 7062, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Whitmer","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Mulei","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanita","family":"Mutesi","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy","family":"Baluku","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson","family":"Kyondo","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Whitesell","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carson","family":"Telford","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Tumusiime","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin Richie","family":"Torach","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianah","family":"Namanya","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Nambuya","sequence":"additional","affiliation":[{"name":"Ministry of Health of Uganda, Kampala P.O. Box 7272, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Muhereza","sequence":"additional","affiliation":[{"name":"Mbarara Regional Referral Hospital, Mbarara P.O. Box 40, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3416-4111","authenticated-orcid":false,"given":"Zainah","family":"Kabami","sequence":"additional","affiliation":[{"name":"Public Health Fellowship Program, Uganda National Institute of Public Health, Kampala P.O. Box 7272, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annet","family":"Nankya","sequence":"additional","affiliation":[{"name":"Public Health Fellowship Program, Uganda National Institute of Public Health, Kampala P.O. Box 7272, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Muwanguzi","sequence":"additional","affiliation":[{"name":"Ministry of Health of Uganda, Kampala P.O. Box 7272, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Mugabi","sequence":"additional","affiliation":[{"name":"Mbarara Regional Referral Hospital, Mbarara P.O. Box 40, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Wandera","sequence":"additional","affiliation":[{"name":"Mbarara Regional Referral Hospital, Mbarara P.O. Box 40, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Muhindo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara P.O. Box 1410, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius J.","family":"Lutwama","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen Karabyo","family":"Balinandi","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-6193","authenticated-orcid":false,"given":"John D.","family":"Klena","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor R.","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4269\/ajtmh.18-0732","article-title":"First Laboratory-Confirmed Outbreak of Human and Animal Rift Valley Fever Virus in Uganda in 48 Years","volume":"100","author":"Shoemaker","year":"2019","journal-title":"Am. J. Trop. Med. 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