{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:41:51Z","timestamp":1791618111899,"version":"4.3.4"},"reference-count":73,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CSIR\u2014Central Drug Research Institute (CDRI)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Kyasanur Forest disease virus (KFDV), a tick-borne Orthoflavivirus endemic to the Indian subcontinent, is a public health threat due to its recurrent outbreaks and expanding geographic range. This review provides a comprehensive overview of KFDV, encompassing its epidemiological trends, transmission dynamics, and ecological determinants that influence its spread. We delve into the current understanding of KFDV pathogenesis, highlighting key viral and host factors that drive infection and disease progression. Despite the absence of targeted antiviral therapies, recent advances have spurred the development of candidate therapeutics, including broad-spectrum antivirals and immunomodulators. We also discuss progress in vaccine development, with an emphasis on the limitations of the existing formalin-inactivated vaccine and the promise of next-generation platforms. Furthermore, we explore recent innovations in diagnostics, including molecular and serological tools, that aim to improve early detection and surveillance. A multidisciplinary approach integrating virology, immunology, ecology, and public health is essential for the effective management and eventual control of KFDV outbreaks.<\/jats:p>","DOI":"10.3390\/v17081022","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:45:18Z","timestamp":1753173918000},"page":"1022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Kyasanur Forest Disease Virus: Epidemiological Insights, Pathogenesis, Therapeutic Strategies, and Advances in Vaccines and Diagnostics"],"prefix":"10.3390","volume":"17","author":[{"given":"Babita","family":"Bohra","sequence":"first","affiliation":[{"name":"Division of Virus Research and Therapeutics, CSIR-Central Drug Research Institute, Lucknow 226031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0971-737X","authenticated-orcid":false,"given":"Kumar Saurabh","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Division of Virus Research and Therapeutics, CSIR-Central Drug Research Institute, Lucknow 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3671-429X","authenticated-orcid":false,"given":"Ayush","family":"Raj","sequence":"additional","affiliation":[{"name":"Division of Virus Research and Therapeutics, CSIR-Central Drug Research Institute, Lucknow 226031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabanita","family":"Pal","sequence":"additional","affiliation":[{"name":"Division of Virus Research and Therapeutics, CSIR-Central Drug Research Institute, Lucknow 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-9512","authenticated-orcid":false,"given":"Rahul","family":"Shukla","sequence":"additional","affiliation":[{"name":"Division of Virus Research and Therapeutics, CSIR-Central Drug Research Institute, Lucknow 226031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"ref_1","first-page":"619","article-title":"Kyasanur forest disease III. 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