{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:34:56Z","timestamp":1768271696468,"version":"3.49.0"},"reference-count":49,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Background: Cytomegalovirus (CMV) colitis is commonly seen in patients who are immunodeficient or have inflammatory bowel disease. Among the gastrointestinal sites affected by CMV, the colon is the most frequently affected, though rectal involvement is relatively rare. Reactivated CMV proctitis primarily occurs in elderly patients with comorbidities and is quite uncommon in immunocompetent individuals. Patients with reactivated CMV typically present with symptoms such as diarrhea, hematochezia, or tenesmus. Case presentation: We report a case of a female patient with uncontrolled diabetes who presented to the clinic complaining of perianal pain. She had no history of diarrhea or rectal bleeding. Lower GI endoscopy reported a small, localized, approximately 0.5 cm swelling in the proximal anal canal in addition to sigmoid diverticulosis. The biopsy revealed a small ulcer at the anorectal junction caused by CMV and confirmed by immunohistochemistry. Unfortunately, the patient was lost to follow-up before antiviral therapy could be initiated. Conclusions: This case highlights an uncommon presentation of reactivated CMV proctitis in an older diabetic patient presenting solely with perianal pain. Clinicians should maintain a high index of suspicion for CMV infection in elderly patients with comorbidities, even when classical colitis symptoms are absent, to avoid delayed diagnosis and management.<\/jats:p>","DOI":"10.3390\/v17081023","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:45:18Z","timestamp":1753173918000},"page":"1023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reactivated CMV Proctitis\/Anitis Presenting as a Localized Proximal Anal Swelling and Anal Pain in a Diabetic Patient: Case Report and Literature Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-7853","authenticated-orcid":false,"given":"Dua","family":"Abuquteish","sequence":"first","affiliation":[{"name":"Department of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan"},{"name":"Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman 11941, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1069-0071","authenticated-orcid":false,"given":"Ayat","family":"Al Oqaily","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Abdullah University Hospital (KAUH), Jordan University of Science and Technology (JUST), Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lama","family":"Bataineh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Abdullah University Hospital (KAUH), Jordan University of Science and Technology (JUST), Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-1886","authenticated-orcid":false,"given":"Bashar","family":"Khater","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11908-019-0664-y","article-title":"Diagnosis and Management of CMV Colitis","volume":"21","author":"Padlipsky","year":"2019","journal-title":"Curr. Infect. Dis. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Shang, Z., and Li, X. (2024). Human cytomegalovirus: Pathogenesis, prevention, and treatment. Mol. Biomed., 5.","DOI":"10.1186\/s43556-024-00226-7"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1038\/s41467-021-24820-3","article-title":"Structural basis for genome packaging, retention, and ejection in human cytomegalovirus","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1743-422X-5-47","article-title":"Severe cytomegalovirus infection in apparently immunocompetent patients: A systematic review","volume":"5","author":"Rafailidis","year":"2008","journal-title":"Virol. J."},{"key":"ref_5","unstructured":"Azer, S.A., and Limaiem, F. (2025, July 07). Cytomegalovirus Colitis [Updated 1 May 2022], StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542231."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10140-020-01750-z","article-title":"Clinical, imaging, endoscopic findings, and management of patients with CMV colitis: A single- institute experience","volume":"27","author":"Shieh","year":"2020","journal-title":"Emerg. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1121.e1","DOI":"10.1016\/j.cmi.2015.05.016","article-title":"Symptomatic cytomegalovirus gastrointestinal infection with positive quantitative real-time PCR findings in apparently immunocompetent patients: A case series","volume":"21","author":"Bernard","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1093\/cid\/ciu969","article-title":"Clinical presentation and risk factors for Cytomegalovirus colitis in immunocompetent adult patients","volume":"60","author":"Ko","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1097\/MEG.0000000000000716","article-title":"Cytomegalovirus disease in inflammatory bowel disease: Epidemiology and disease characteristics in a large single-centre experience","volume":"28","author":"Zeitz","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"do Carmo, A.M., Santos, F.M., Ortiz-Agostinho, C.L., Nishitokukado, I., Frota, C.S., Gomes, F.U., Leite, A.Z.d.A., Pannuti, C.S., Boas, L.S.V., and Teixeira, M.G. (2014). Cytomegalovirus infection in inflammatory bowel disease is not associated with worsening of intestinal inflammatory activity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111574"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Subbarao, S., O\u2019Sullivan, A., Adesina, T., Gwozdz, A.M., Rees, J., and Satta, G. (2014). Cytomegalovirus proctitis mimicking rectal cancer in an immunocompetent elderly patient: A case report. BMC Res. Notes, 7.","DOI":"10.1186\/1756-0500-7-799"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/jde.JDE_45_16","article-title":"Cytomegalovirus colitis presenting as a rectal mass","volume":"8","author":"Cohen","year":"2017","journal-title":"J. Dig. Endosc."},{"key":"ref_13","unstructured":"Nadella, D., Tandon, A., and Dara, P. (2020). A Case of Cytomegalovirus Infection Mimicking Rectal Malignancy in an Immunocompetent Patient. J. Hosp. Med., Available online: https:\/\/shmabstracts.org\/abstract\/a-case-of-cytomegalovirus-infection-mimicking-rectal-malignancy-in-an-immunocompetent-patient\/."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4253\/wjge.v8.i6.301","article-title":"Characteristic endoscopic findings and riskfactors for cytomegalovirus-associated colitis in patients with active ulcerative colitis","volume":"8","author":"Hirayama","year":"2016","journal-title":"World J. Gastrointest Endosc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/PAS.0b013e31827fcc33","article-title":"A comparison of CMV detection in gastrointestinal mucosal biopsies using immunohistochemistryand PCR performed on formalin-fixed, paraffinembedded tissue","volume":"37","author":"Mills","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/MIB.0000000000001095","article-title":"The association between CMV viremia or endoscopic features and histopathological characteristics of CMV colitis in patients with underlying ulcerative colitis","volume":"23","author":"Yang","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.3748\/wjg.v21.i12.3750","article-title":"Cytomegalovirus colitis followed by ischemic colitis in a nonimmunocompromised adult: A case report","volume":"21","author":"Hasegawa","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/0377-4929.151195","article-title":"Cytomegalovirus colitis masquerading asrectal malignancy in an immunocompetent patient","volume":"58","author":"Jacob","year":"2015","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3109\/00365521.2010.499962","article-title":"Cytomegalovirus colitis in patients without inflammatory bowel disease: A single center study","volume":"45","author":"Kim","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/00365549850161098","article-title":"Cytomegalovirus colitis in the immuncompetent host: An overview","volume":"30","author":"Klauber","year":"1998","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/OLQ.0b013e31821a5a90","article-title":"Cytomegalovirus proctitis: A rare and disregarded sexually transmitted disease","volume":"38","author":"Studemeister","year":"2011","journal-title":"Sex. Transm. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.58600\/eurjther2148","article-title":"Factors Associated with Cytomegalovirus (CMV) Procto-Colitis in Immunocompetent Adults: A Systematic Review","volume":"30","author":"Bromley","year":"2024","journal-title":"Eur. J. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lee, C.-Y., Chen, Y.-H., and Lu, P.-L. (2017). Reactivated cytomegalovirus proctitis in an immunocompetent patient presenting as nosocomial diarrhea: A case report and literature review. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2218-y"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1023\/A:1026604529393","article-title":"Cytomegalovirus colitis in individuals without apparent cause of immunodeficiency","volume":"44","author":"Ng","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.humpath.2013.07.040","article-title":"qPCR increases sensitivity to detect cytomegalovirus in formalinfixed, paraffin-embedded tissue of gastrointestinal biopsies","volume":"45","author":"McCoy","year":"2014","journal-title":"Hum. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1386-6532(02)00091-4","article-title":"Diagnosis and Treatment Approaches to CMV Infections in Adult Patients","volume":"25","author":"Stephens","year":"2002","journal-title":"J. Clin. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1099\/jmm.0.45629-0","article-title":"Infection with Cytomegalovirus in Patients with Inflammatory Bowel Disease: Prevalence, Clinical Significance and Outcome","volume":"53","author":"Kishore","year":"2004","journal-title":"J. Med. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Maresca, R., Varca, S., Di Vincenzo, F., Ainora, M.E., Mignini, I., Papa, A., Scaldaferri, F., Gasbarrini, A., Giustiniani, M.C., and Zocco, M.A. (2024). Cytomegalovirus Infection: An Underrated Target in Inflammatory Bowel Disease Treatment. J. Clin. Med., 13.","DOI":"10.3390\/jcm13010130"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3748\/wjg.v19.i1.17","article-title":"Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease","volume":"19","author":"Garrido","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cgh.2012.12.034","article-title":"Combined endoscopy, aspiration, andbiopsy analysis for identifying infectious colitis in patients with ileocecal ulcers","volume":"11","author":"Nagata","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.3748\/wjg.15.4327","article-title":"Cytomegalovirus enteritis mimicking Crohn\u2019s disease in a lupus nephritis patient: A case report","volume":"15","author":"Khan","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s10350-003-0117-3","article-title":"Prevalence of cytomegalovirus infection ininflammatory bowel disease patients","volume":"47","author":"Takahashi","year":"2004","journal-title":"Dis. Colon. Rectum"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/000313480707300113","article-title":"CMV colitis mimicking recurrent inflammatory bowel disease: Report of three cases","volume":"73","author":"Rezania","year":"2007","journal-title":"Am. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/infdis\/158.2.449","article-title":"Cytomegalovirus infection in patients with AIDS","volume":"158","author":"Drew","year":"1988","journal-title":"J. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10620-005-2544-6","article-title":"Meta-analysis of outcome of cytomegalovirus colitis in immunocompetent hosts","volume":"50","author":"Galiatsatos","year":"2005","journal-title":"Dig. Dis. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/IJGM.S63771","article-title":"Case of cytomegalovirus colitis in an immunocompetent patient: A rare cause of abdominal pain and diarrhea in the elderly","volume":"3","author":"Harano","year":"2015","journal-title":"Int. J. Gen. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.4103\/2230-8210.94253","article-title":"Infections in patients with diabetes mellitus: A review of pathogenesis","volume":"16","author":"Casqueiro","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2337\/diacare.24.2.371","article-title":"Relationships of upper gastrointestinal motor and sensory function with glycemic control","volume":"24","author":"Rayner","year":"2001","journal-title":"Diabetes Care"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1464-5491.2008.02637.x","article-title":"Antiplatelet therapy, Helicobacter pylori infection and complicated peptic ulcer disease in diabetes: The fremantle diabetes study","volume":"26","author":"Schimke","year":"2009","journal-title":"Diabet. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.3748\/wjg.15.2701","article-title":"Helicobacter pylori infection and endocrine disorders: Is there a link?","volume":"15","author":"Papamichael","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1523-5378.2009.00705.x","article-title":"Helicobacter pylori infection significantly increases insulin resistance in the asymptomatic Japanese population","volume":"14","author":"Gunji","year":"2009","journal-title":"Helicobacter"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/1743-422X-8-367","article-title":"Association of UVV with diabetes mellitus: An Egyptian case-control study","volume":"8","author":"Elhawary","year":"2011","journal-title":"Virol. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0168-8278(01)00143-X","article-title":"Risk factors for diabetes mellitus and insulin resistance in chronic hepatitis C","volume":"35","author":"Petit","year":"2001","journal-title":"J. Hepatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/MEG.0b013e3282f55e1e","article-title":"The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients","volume":"20","author":"Demir","year":"2008","journal-title":"Eu. J. Gastroenterol. Hepatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/193229680900300208","article-title":"Eliminating the blood: Ongoing outbreaks of hepatitis B virus infection and the need for innovative glucose monitoring technologies","volume":"3","author":"Thomson","year":"2009","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Yeh, P.-J., Wu, R.-C., Chen, C.-L., Chiu, C.-T., Lai, M.-W., Chen, C.-C., Chiu, C.-H., Pan, Y.-B., Lin, W.-R., and Le, P.-H. (2024). Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review. Viruses, 16.","DOI":"10.3390\/v16030346"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/ibd\/izy045","article-title":"CMV Disease in IBD: Comparison of Diagnostic Tests and Correlation with Disease Outcome","volume":"24","author":"Johnson","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/ibd.21275","article-title":"Cytomegalovirus in inflammatory bowel disease: Pathogen or innocent bystander?","volume":"16","author":"Lawlor","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_49","first-page":"132","article-title":"Lymphocyte proliferation: Dichotomy of effect of related anaesthetic agents","volume":"58","author":"Platt","year":"1986","journal-title":"Br. J. Anaesth."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/8\/1023\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:13:40Z","timestamp":1760033620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/8\/1023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":49,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["v17081023"],"URL":"https:\/\/doi.org\/10.3390\/v17081023","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]}}}