{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:36:05Z","timestamp":1760060165395,"version":"build-2065373602"},"reference-count":243,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"USDA NIFA","award":["2016-67015-24948","2019-67015-29831"],"award-info":[{"award-number":["2016-67015-24948","2019-67015-29831"]}]},{"name":"Jorgensen Foundation","award":["2016-67015-24948","2019-67015-29831"],"award-info":[{"award-number":["2016-67015-24948","2019-67015-29831"]}]},{"name":"MAES program at the University of Maryland","award":["2016-67015-24948","2019-67015-29831"],"award-info":[{"award-number":["2016-67015-24948","2019-67015-29831"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Influenza viruses are major threats to global health, with potential to cause widespread disease in both humans and animals. Cattle, once considered resistant, are susceptible hosts for multiple influenza viruses, including influenza A, C and D, while no evidence currently supports infection with influenza B virus. Cattle serve not only as natural reservoirs for influenza D virus but also as emerging spillover hosts for highly pathogenic avian influenza A strains like H5N1. Their role in sustaining viral circulation, facilitating interspecies transmission, and potentially contributing to viral evolution raises significant concerns about future global outbreaks. As host immunity controls viral clearance and spread, understanding how cattle respond to influenza is essential. While most research has focused on antibody-mediated immunity, T cells play indispensable roles in controlling influenza infections by regulating antibody response, clearing infected cells, and providing long-term protection. However, bovine T cell responses to influenza remain poorly characterized. Given that most research has focused on mice and humans, this review outlines current knowledge of bovine T cell responses to influenza viruses in comparison to these well-characterized models. Cross-species comparative studies are essential to identify species-specific immunity, guide cattle vaccine development, and build predictive models to evaluate future pandemic potential.<\/jats:p>","DOI":"10.3390\/v17081116","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T14:51:46Z","timestamp":1755183106000},"page":"1116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T Cell Responses to Influenza Infections in Cattle"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-5515","authenticated-orcid":false,"given":"Akanksha","family":"Hada","sequence":"first","affiliation":[{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengguo","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sreenivasan, C.C., Thomas, M., Kaushik, R.S., Wang, D., and Li, F. (2019). Influenza A in Bovine Species: A Narrative Literature Review. Viruses, 11.","DOI":"10.3390\/v11060561"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/s41564-025-01998-6","article-title":"Dairy cows develop protective immunity against reinfection with bovine H5N1 influenza virus","volume":"10","author":"Facciuolo","year":"2025","journal-title":"Nat. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.3201\/eid2410.180589","article-title":"Influenza C Virus in Cattle with Respiratory Disease, United States, 2016\u20132018","volume":"24","author":"Zhang","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhang, H., Porter, E.P., Lohman, M., Lu, N., Peddireddi, L., Hanzlicek, G., Marthaler, D., Liu, X., and Bai, J. (2018). Complete Genome Sequence of an Influenza C Virus Strain Identified from a Sick Calf in the United States. Microbiol. Resour. Announc., 7.","DOI":"10.1128\/MRA.00828-18"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/tbed.13172","article-title":"Respiratory viruses identified in western Canadian beef cattle by metagenomic sequencing and their association with bovine respiratory disease","volume":"66","author":"Zhang","year":"2019","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.virol.2020.08.014","article-title":"Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD","volume":"551","author":"Nissly","year":"2020","journal-title":"Virology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1128\/JVI.03122-15","article-title":"Pathogenesis of Influenza D Virus in Cattle","volume":"90","author":"Ferguson","year":"2016","journal-title":"J. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"185318","DOI":"10.1128\/JVI.01853-18","article-title":"Pathogenesis, Host Innate Immune Response, and Aerosol Transmission of Influenza D Virus in Cattle","volume":"93","author":"Salem","year":"2019","journal-title":"J. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1073\/pnas.87.12.4485","article-title":"Bovine and mouse serum beta inhibitors of influenza A viruses are mannose-binding lectins","volume":"87","author":"Anders","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1128\/jvi.66.7.4358-4363.1992","article-title":"Two distinct serum mannose-binding lectins function as beta inhibitors of influenza virus: Identification of bovine serum beta inhibitor as conglutinin","volume":"66","author":"Hartley","year":"1992","journal-title":"J. Virol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kuchipudi, S.V., and Nissly, R.H. (2018). Novel Flu Viruses in Bats and Cattle: \u201cPushing the Envelope\u201d of Influenza Infection. Vet. Sci., 5.","DOI":"10.3390\/vetsci5030071"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Superti, F., Agamennone, M., Pietrantoni, A., and Ammendolia, M.G. (2019). Bovine Lactoferrin Prevents Influenza A Virus Infection by Interfering with the Fusogenic Function of Viral Hemagglutinin. Viruses, 11.","DOI":"10.3390\/v11010051"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"L90","DOI":"10.1152\/ajplung.2000.278.1.L90","article-title":"Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein","volume":"278","author":"Hartshorn","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0042-6822(88)90407-2","article-title":"The action of recombinant bovine interferons on influenza virus replication correlates with the induction of two Mx-related proteins in bovine cells","volume":"162","author":"Horisberger","year":"1988","journal-title":"Virology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1111\/tbed.13943","article-title":"Virus strain influenced the interspecies transmission of influenza D virus between calves and pigs","volume":"68","author":"Kaplan","year":"2021","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/rmv.666","article-title":"Structure of influenza virus ribonucleoprotein complexes and their packaging into virions","volume":"20","author":"Noda","year":"2010","journal-title":"Rev. Med. Virol."},{"key":"ref_17","unstructured":"(1980). A revision of the system of nomenclature for influenza viruses: A WHO memorandum. Bull. World Health Organ., 58, 585\u2013591."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1128\/jvi.35.1.24-30.1980","article-title":"Antigenic variation of influenza A virus nucleoprotein detected with monoclonal antibodies","volume":"35","author":"Hinshaw","year":"1980","journal-title":"J. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.4049\/jimmunol.144.7.2730","article-title":"A dominant Th epitope in influenza nucleoprotein. Analysis of the fine specificity and functional repertoire of T cells recognizing a single determinant","volume":"144","author":"Gao","year":"1990","journal-title":"J. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/CVI.00091-15","article-title":"Protective Efficacy of the Conserved NP, PB1, and M1 Proteins as Immunogens in DNA- and Vaccinia Virus-Based Universal Influenza A Virus Vaccines in Mice","volume":"22","author":"Wang","year":"2015","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16119","DOI":"10.1128\/JVI.00161-19","article-title":"Deep Mutational Scan of the Highly Conserved Influenza A Virus M1 Matrix Protein Reveals Substantial Intrinsic Mutational Tolerance","volume":"93","author":"Hom","year":"2019","journal-title":"J. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1128\/jvi.63.9.3622-3633.1989","article-title":"M protein (M1) of influenza virus: Antigenic analysis and intracellular localization with monoclonal antibodies","volume":"63","author":"Bucher","year":"1989","journal-title":"J. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.coviro.2020.08.004","article-title":"Influenza D virus","volume":"44","author":"Liu","year":"2020","journal-title":"Curr. Opin. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nrmicro2613","article-title":"Influenza A viruses: New research developments","volume":"9","author":"Medina","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_25","first-page":"1","article-title":"Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes","volume":"2019","author":"Wang","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.tim.2018.05.013","article-title":"Influenza Virus","volume":"26","author":"Hutchinson","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1073\/pnas.1916585116","article-title":"Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity","volume":"117","author":"Virk","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1128\/JCM.02116-09","article-title":"Differentiation of Influenza B Virus Lineages Yamagata and Victoria by Real-Time PCR","volume":"48","author":"Biere","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.virol.2013.07.035","article-title":"Structural basis for the divergent evolution of influenza B virus hemagglutinin","volume":"446","author":"Ni","year":"2013","journal-title":"Virology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e2211616119","DOI":"10.1073\/pnas.2211616119","article-title":"Substitutions near the HA receptor binding site explain the origin and major antigenic change of the B\/Victoria and B\/Yamagata lineages","volume":"119","author":"Rosu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1128\/JVI.77.2.871-881.2003","article-title":"Frequent Reassortment among Influenza C Viruses","volume":"77","author":"Matsuzaki","year":"2003","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/jmv.25589","article-title":"Genetic and antigenic characteristics of a human influenza C virus clinical isolate","volume":"92","author":"Liu","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Hause, B.M., Ducatez, M., Collin, E.A., Ran, Z., Liu, R., Sheng, Z., Armien, A., Kaplan, B., Chakravarty, S., and Hoppe, A.D. (2013). Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003176"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e0190823","DOI":"10.1128\/jvi.01908-23","article-title":"Antigenic commonality and divergence of hemagglutinin-esterase-fusion protein among influenza D virus lineages revealed using epitope mapping","volume":"98","author":"Katayama","year":"2024","journal-title":"J. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.virol.2021.04.003","article-title":"Isolation and development of bovine primary respiratory cells as model to study influenza D virus infection","volume":"559","author":"Uprety","year":"2021","journal-title":"Virology"},{"key":"ref_36","first-page":"474","article-title":"Isolation and identification of the A-Hong Kong (H3N2) virus in respiratory diseases of cattle","volume":"18","author":"Fatkhuddinova","year":"1973","journal-title":"Vopr. Virusol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.2460\/ajvr.1987.48.08.1264","article-title":"Response of calves to exposure with swine influenza virus","volume":"48","author":"Lopez","year":"1987","journal-title":"Am. J. Vet. Res."},{"key":"ref_38","first-page":"153","article-title":"Prevalence of influenza A virus (H1N1) antibodies in bovine sera","volume":"21","author":"Lee","year":"1998","journal-title":"New Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e0213824","DOI":"10.1128\/jvi.02138-24","article-title":"Detection of antibodies against influenza A viruses in cattle","volume":"99","author":"Lang","year":"2025","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3201\/eid1407.071468","article-title":"Experimental Infection of Cattle with Highly Pathogenic Avian Influenza Virus (H5N1)","volume":"14","author":"Kalthoff","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Mostafa, A., Abdelwhab, E.M., Mettenleiter, T.C., and Pleschka, S. (2018). Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview. Viruses, 10.","DOI":"10.3390\/v10090497"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1128\/JVI.80.7.3675-3678.2006","article-title":"Comparison of the Mutation Rates of Human Influenza A and B Viruses","volume":"80","author":"Nobusawa","year":"2006","journal-title":"J. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Sreenivasan, C.C., Li, F., and Wang, D. (2024). Emerging Threats of Highly Pathogenic Avian Influenza A (H5N1) in US Dairy Cattle: Understanding Cross-Species Transmission Dynamics in Mammalian Hosts. Viruses, 16.","DOI":"10.3390\/v16111703"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.virol.2020.02.007","article-title":"Influenza D virus diverges from its related influenza C virus in the recognition of 9-O-acetylated N-acetyl- or N-glycolyl-neuraminic acid-containing glycan receptors","volume":"545","author":"Liu","year":"2020","journal-title":"Virology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"110138","DOI":"10.1016\/j.virol.2024.110138","article-title":"Receptor binding and immunogenic properties of the receptor binding domain of influenza D virus hemagglutinin-esterase-fusion protein expressed from Escherichia coli","volume":"597","author":"Naveed","year":"2024","journal-title":"Virology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/22221751.2021.1910078","article-title":"Emergence of new phylogenetic lineage of Influenza D virus with broad antigenicity in California, United States","volume":"10","author":"Huang","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"001529","DOI":"10.1099\/jgv.0.001529","article-title":"The first decade of research advances in influenza D virus","volume":"102","author":"Yu","year":"2021","journal-title":"J. Gen. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00705-022-05416-8","article-title":"Cattle influenza D virus in Brazil is divergent from established lineages","volume":"167","author":"Mosena","year":"2022","journal-title":"Arch. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ambrose, R.K., Blakebrough-Hall, C., Gravel, J.L., Gonzalez, L.A., and Mahony, T.J. (2023). Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease. Viruses, 15.","DOI":"10.3390\/v15020455"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Brito, B.P., Frost, M.J., Anantanawat, K., Jaya, F., Batterham, T., Djordjevic, S.P., Chang, W.-S., Holmes, E.C., Darling, A.E., and Kirkland, P.D. (2023). Expanding the range of the respiratory infectome in Australian feedlot cattle with and without respiratory disease using metatranscriptomics. Microbiome, 11.","DOI":"10.1186\/s40168-023-01591-1"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2150443","DOI":"10.1080\/21505594.2022.2150443","article-title":"Epidemiological, serological, and genetic evidence of influenza D virus infection in humans: Is it a justifiable cause for concern?","volume":"14","author":"Ly","year":"2023","journal-title":"Virulence"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jcv.2016.05.017","article-title":"Serologic evidence of exposure to influenza D virus among persons with occupational contact with cattle","volume":"81","author":"White","year":"2016","journal-title":"J. Clin. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Limaye, S., Lohar, T., Dube, H., Ramasamy, S., Kale, M., Kulkarni-Kale, U., and Kuchipudi, S.V. (2024). Rapid evolution leads to extensive genetic diversification of cattle flu Influenza D virus. Commun. Biol., 7.","DOI":"10.1038\/s42003-024-06954-4"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Trombetta, C.M., Marchi, S., Manini, I., Kistner, O., Li, F., Piu, P., Manenti, A., Biuso, F., Sreenivasan, C., and Druce, J. (2020). Influenza D Virus: A Potential Threat for Humans?. Proceedings, 50.","DOI":"10.3390\/proceedings2020050036"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ruiz, M., Puig, A., Bassols, M., Fraile, L., and Armengol, R. (2022). Influenza D Virus: A Review and Update of Its Role in Bovine Respiratory Syndrome. Viruses, 14.","DOI":"10.3390\/v14122717"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"109859","DOI":"10.1016\/j.virol.2023.109859","article-title":"Prevalence and characterization of seven-segmented influenza viruses in bovine respiratory disease complex","volume":"587","author":"Uprety","year":"2023","journal-title":"Virology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1099\/jgv.0.000492","article-title":"Metagenomic characterization of the virome associated with bovine respiratory disease in feedlot cattle identified novel viruses and suggests an etiologic role for influenza D virus","volume":"97","author":"Mitra","year":"2016","journal-title":"J. Gen. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nri3665","article-title":"Innate immunity to influenza virus infection","volume":"14","author":"Iwasaki","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Malik, G., and Zhou, Y. (2020). Innate Immune Sensing of Influenza A Virus. Viruses, 12.","DOI":"10.3390\/v12070755"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bj.2018.12.009","article-title":"The dual role of innate immunity during influenza","volume":"42","author":"Biondo","year":"2019","journal-title":"Biomed. J."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kandasamy, M., Suryawanshi, A., Tundup, S., Perez, J.T., Schmolke, M., Manicassamy, S., and Manicassamy, B. (2016). RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005754"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.4049\/jimmunol.179.7.4711","article-title":"Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination","volume":"179","author":"Koyama","year":"2007","journal-title":"J. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"An, W., Lakhina, S., Leong, J., Rawat, K., and Husain, M. (2024). Host Innate Antiviral Response to Influenza A Virus Infection: From Viral Sensing to Antagonism and Escape. Pathogens, 13.","DOI":"10.3390\/pathogens13070561"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Mooney, J.P., Qendro, T., Keith, M., Philbey, A.W., Groves, H.T., Tregoning, J.S., Goodier, M.R., and Riley, E.M. (2020). Natural Killer Cells Dampen the Pathogenic Features of Recall Responses to Influenza Infection. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00135"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Frank, K., and Paust, S. (2020). Dynamic Natural Killer Cell and T Cell Responses to Influenza Infection. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00425"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1073\/pnas.0538056100","article-title":"Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice","volume":"100","author":"Johnson","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.4049\/jimmunol.0902022","article-title":"CXCR3 Directs Antigen-Specific Effector CD4+ T Cell Migration to the Lung During Parainfluenza Virus Infection","volume":"183","author":"Kohlmeier","year":"2009","journal-title":"J. Immunol."},{"key":"ref_68","first-page":"423","article-title":"The effector T cell response to influenza infection","volume":"386","author":"Hufford","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e182615","DOI":"10.1172\/jci.insight.182615","article-title":"Airway-resident memory CD4 T cell activation accelerates antigen presentation and T cell priming in draining lymph nodes","volume":"10","author":"Finn","year":"2025","journal-title":"JCI Insight"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e20230112","DOI":"10.1084\/jem.20230112","article-title":"Allergen exposure functionally alters influenza-specific CD4+ Th1 memory cells in the lung","volume":"220","author":"Hondowicz","year":"2023","journal-title":"J. Exp. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1084\/jem.20140625","article-title":"Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell\u2013dependent inflammation","volume":"211","author":"Wang","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41385-020-00373-4","article-title":"Influenza- and MCMV-induced memory CD8 T cells control respiratory vaccinia virus infection despite residence in distinct anatomical niches","volume":"14","author":"Welten","year":"2021","journal-title":"Mucosal Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.4049\/jimmunol.178.12.7563","article-title":"Persistent Depots of Influenza Antigen Fail To Induce a Cytotoxic CD8 T Cell Response","volume":"178","author":"Dibble","year":"2007","journal-title":"J. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI44675","article-title":"CD8+ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung","volume":"121","author":"Piet","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e20240668","DOI":"10.1084\/jem.20240668","article-title":"Maturation of germinal center B cells after influenza virus vaccination in humans","volume":"221","author":"Mcintire","year":"2024","journal-title":"J. Exp. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-020-2711-0","article-title":"Human germinal centres engage memory and naive B cells after influenza vaccination","volume":"586","author":"Turner","year":"2020","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cvfa.2010.03.001","article-title":"Innate immunology of bovine respiratory disease","volume":"26","author":"Ackermann","year":"2010","journal-title":"Vet. Clin. N. Am. Food Anim. Pract."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Laloli, L., Licheri, M.F., Probst, L., Licheri, M., Gultom, M., Holwerda, M., V\u2019Kovski, P., and Dijkman, R. (2022). Time-resolved characterization of the innate immune response in the respiratory epithelium of human, porcine, and bovine during influenza virus infection. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.970325"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Chen, X., Liu, S., Goraya, M.U., Maarouf, M., Huang, S., and Chen, J.-L. (2018). Host Immune Response to Influenza A Virus Infection. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00320"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Mifsud, E.J., Kuba, M., and Barr, I.G. (2021). Innate Immune Responses to Influenza Virus Infections in the Upper Respiratory Tract. Viruses, 13.","DOI":"10.3390\/v13102090"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Hartshorn, K.L. (2020). Innate Immunity and Influenza A Virus Pathogenesis: Lessons for COVID-19. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.563850"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Pulendran, B., and Maddur, M.S. (2014). Innate Immune Sensing and Response to Influenza. Current Topics in Microbiology and Immunology, Springer International Publishing.","DOI":"10.1007\/82_2014_405"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41392-025-02264-1","article-title":"Pattern recognition receptors: Function, regulation and therapeutic potential","volume":"10","author":"Chen","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kumari, R., Sharma, S.D., Kumar, A., Ende, Z., Mishina, M., Wang, Y., Falls, Z., Samudrala, R., Pohl, J., and Knight, P.R. (2023). Antiviral Approaches against Influenza Virus. Clin. Microbiol. Rev., 36.","DOI":"10.1128\/cmr.00040-22"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3390\/v4091438","article-title":"Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses","volume":"4","author":"Kreijtz","year":"2012","journal-title":"Viruses"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316","article-title":"The Pathology of Influenza Virus Infections","volume":"3","author":"Taubenberger","year":"2008","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"George, S.T., Lai, J., Ma, J., Stacey, H.D., Miller, M.S., and Mullarkey, C.E. (2021). Neutrophils and Influenza: A Thin Line between Helpful and Harmful. Vaccines, 9.","DOI":"10.3390\/vaccines9060597"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/cmi.2017.10","article-title":"Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection","volume":"15","author":"Liu","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"0209018","DOI":"10.1128\/JVI.02090-18","article-title":"Influenza Virus Infection Enhances Antibody-Mediated NK Cell Functions via Type I Interferon-Dependent Pathways","volume":"93","author":"Jegaskanda","year":"2019","journal-title":"J. Virol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.4049\/jimmunol.171.12.6355","article-title":"Homing to Nonlymphoid Tissues Is Not Necessary for Effector Th1 Cell Differentiation","volume":"171","author":"Guerder","year":"2003","journal-title":"J. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.immuni.2012.09.007","article-title":"The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses","volume":"37","author":"Zhu","year":"2012","journal-title":"Immunity"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.4049\/jimmunol.148.12.3943","article-title":"Anti-class II antibodies potentiate IgG2a production by lipopolysaccharide-stimulated B lymphocytes treated with prostaglandin E2 and IFN-gamma","volume":"148","author":"Stein","year":"1992","journal-title":"J. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0008-8749(91)90257-C","article-title":"IFN-gamma enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells: Implications for the role of IFN-gamma in class switching","volume":"135","author":"Bossie","year":"1991","journal-title":"Cell. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00281-017-0636-y","article-title":"New fronts emerge in the influenza cytokine storm","volume":"39","author":"Guo","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Vlasova, A.N., and Saif, L.J. (2021). Bovine Immunology: Implications for Dairy Cattle. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.643206"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e0142322","DOI":"10.1128\/jvi.01423-22","article-title":"The Activation of the RIG-I\/MDA5 Signaling Pathway upon Influenza D Virus Infection Impairs the Pulmonary Proinflammatory Response Triggered by Mycoplasma bovis Superinfection","volume":"97","author":"Gaudino","year":"2023","journal-title":"J. Virol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Da Silva Barcelos, L., Ford, A.K., Fr\u00fchauf, M.I., Botton, N.Y., Fischer, G., and Maggioli, M.F. (2024). Interactions Between Bovine Respiratory Syncytial Virus and Cattle: Aspects of Pathogenesis and Immunity. Viruses, 16.","DOI":"10.3390\/v16111753"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Mendez, J., Sun, D., Tuo, W., and Xiao, Z. (2018). Bovine neutrophils form extracellular traps in response to the gastrointestinal parasite Ostertagia ostertagi. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-36070-3"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Li, L., Si, H., Wu, S.-W., Mendez, J.O., Zarlenga, D., Tuo, W., and Xiao, Z. (2019). Characterization of IL-10-producing neutrophils in cattle infected with Ostertagia ostertagi. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-56824-x"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Xiao, Z., Kandel, A., and Li, L. (2021). Synergistic Activation of Bovine CD4+ T Cells by Neutrophils and IL-12. Pathogens, 10.","DOI":"10.3390\/pathogens10060694"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1172\/JCI60659","article-title":"Cross-presenting CD103+ dendritic cells are protected from influenza virus infection","volume":"122","author":"Helft","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.4049\/jimmunol.1100987","article-title":"Lung CD103+ Dendritic Cells Efficiently Transport Influenza Virus to the Lymph Node and Load Viral Antigen onto MHC Class I for Presentation to CD8 T Cells","volume":"187","author":"Ho","year":"2011","journal-title":"J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.coi.2010.02.013","article-title":"Inflammatory cytokines as a third signal for T cell activation","volume":"22","author":"Curtsinger","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.4049\/jimmunol.2200407","article-title":"STAT1 Controls the Functionality of Influenza-Primed CD4 T Cells but Therapeutic STAT4 Engagement Maximizes Their Antiviral Impact","volume":"210","author":"Finn","year":"2023","journal-title":"J. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.4110\/in.2024.24.e19","article-title":"Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines","volume":"24","author":"Kim","year":"2024","journal-title":"Immune Netw."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Schmidt, M.E., and Varga, S.M. (2018). The CD8 T Cell Response to Respiratory Virus Infections. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00678"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S2666-5247(24)00024-7","article-title":"Assessment of CD8+ T-cell mediated immunity in an influenza A(H3N2) human challenge model in Belgium: A single centre, randomised, double-blind phase 2 study","volume":"5","author":"Evans","year":"2024","journal-title":"Lancet Microbe"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Duan, S., and Thomas, P.G. (2016). Balancing Immune Protection and Immune Pathology by CD8+ T-Cell Responses to Influenza Infection. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00025"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4049\/jimmunol.1300093","article-title":"CD40 Ligand Preferentially Modulates Immune Response and Enhances Protection against Influenza Virus","volume":"193","author":"Hashem","year":"2014","journal-title":"J. Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1172\/JCI96957","article-title":"Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles","volume":"128","author":"Pizzolla","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1164\/rccm.202106-1508ED","article-title":"Lung-Resident Memory CD8+ T Cells in Human Influenza: How Innate Are They?","volume":"204","author":"Nguyen","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Vicosa Bauermann, F., Falkenberg, S., Rudd, J.M., Peter, C.M., Merchioratto, I., Ritchey, J.W., Gilliam, J., Taylor, J., Ma, H., and Maggioli, M.F. (2023). Immune Responses to Influenza D Virus in Calves Previously Infected with Bovine Viral Diarrhea Virus 2. Viruses, 15.","DOI":"10.3390\/v15122442"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41541-025-01063-7","article-title":"Influenza A virus in dairy cattle: Infection biology and potential mammary gland-targeted vaccines","volume":"10","author":"Martins","year":"2025","journal-title":"NPJ Vaccines"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Souza, C.K., Santos, J.J.S., Boggiatto, P., Sterle, H., Arruda, B., Palmer, M.V., Campos, A., Liu, J., Ye, N., and Weissman, D. (2025). H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves. bioRxiv.","DOI":"10.1101\/2025.05.01.651548"},{"key":"ref_115","first-page":"399","article-title":"Memory CD4 T cells in influenza","volume":"386","author":"Zens","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.coi.2018.03.019","article-title":"Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus","volume":"53","author":"Sant","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/imr.12662","article-title":"CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential","volume":"284","author":"Sant","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1016\/j.vaccine.2019.07.033","article-title":"Highly conserved influenza T cell epitopes induce broadly protective immunity","volume":"37","author":"Eickhoff","year":"2019","journal-title":"Vaccine"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/cmi.2016.20","article-title":"Identification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H1N1 influenza virus and its antigen-driven TCR usage signature in BALB\/c mice","volume":"14","author":"Lu","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"eaaw7636","DOI":"10.1126\/sciimmunol.aaw7636","article-title":"Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells","volume":"4","author":"Papillion","year":"2019","journal-title":"Sci. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Hornick, E.E., Zacharias, Z.R., and Legge, K.L. (2019). Kinetics and Phenotype of the CD4 T Cell Response to Influenza Virus Infections. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02351"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.coviro.2013.05.015","article-title":"Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination","volume":"3","author":"Hu","year":"2013","journal-title":"Curr. Opin. Virol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e150888","DOI":"10.1172\/jci.insight.150888","article-title":"IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection","volume":"6","author":"Kvistad","year":"2021","journal-title":"JCI Insight"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"14330","DOI":"10.1073\/pnas.1311998110","article-title":"Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses","volume":"110","author":"Spensieri","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Nelson, S.A., and Sant, A.J. (2019). Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00932"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"6792","DOI":"10.1128\/JVI.07172-11","article-title":"Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection","volume":"86","author":"Brown","year":"2012","journal-title":"J. Virol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Sundararajan, A., Huan, L., Richards, K.A., Marcelin, G., Alam, S., Joo, H., Yang, H., Webby, R.J., Topham, D.J., and Sant, A.J. (2012). Host Differences in Influenza-Specific CD4 T Cell and B Cell Responses Are Modulated by Viral Strain and Route of Immunization. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034377"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.immuni.2021.03.006","article-title":"Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells","volume":"54","author":"Krueger","year":"2021","journal-title":"Immunity"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1128\/jvi.69.10.6359-6366.1995","article-title":"Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected mice","volume":"69","author":"Eichelberger","year":"1995","journal-title":"J. Virol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Moltedo, B., Li, W., Yount, J.S., and Moran, T.M. (2011). Unique Type I Interferon Responses Determine the Functional Fate of Migratory Lung Dendritic Cells during Influenza Virus Infection. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002345"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.1128\/JVI.01069-10","article-title":"Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms","volume":"84","author":"Teijaro","year":"2010","journal-title":"J. Virol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.4049\/jimmunol.170.9.4601","article-title":"Influenza A Virus Infection Inhibits the Efficient Recruitment of Th2 Cells into the Airways and the Development of Airway Eosinophilia","volume":"170","author":"Wohlleben","year":"2003","journal-title":"J. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1086\/314952","article-title":"Th2 Responses to Inactivated Influenza Virus Can Be Converted to Th1 Responses and Facilitate Recovery from Heterosubtypic Virus Infection","volume":"180","author":"Moran","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/jmv.25406","article-title":"Th17 serum cytokines in relation to laboratory-confirmed respiratory viral infection: A pilot study","volume":"91","author":"Antalis","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.4049\/jimmunol.0900995","article-title":"Critical Role of IL-17RA in Immunopathology of Influenza Infection","volume":"183","author":"Crowe","year":"2009","journal-title":"J. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.4049\/jimmunol.1203302","article-title":"Viral Antigen Induces Differentiation of Foxp3+ Natural Regulatory T Cells in Influenza Virus\u2013Infected Mice","volume":"190","author":"Bedoya","year":"2013","journal-title":"J. Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Furuya, Y., Furuya, A.K.M., Roberts, S., Sanfilippo, A.M., Salmon, S.L., and Metzger, D.W. (2015). Prevention of Influenza Virus-Induced Immunopathology by TGF-\u03b2 Produced during Allergic Asthma. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005180"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1128\/JVI.05685-11","article-title":"Influenza A Virus Infection Results in a Robust, Antigen-Responsive, and Widely Disseminated Foxp3+ Regulatory T Cell Response","volume":"86","author":"Betts","year":"2012","journal-title":"J. Virol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1126\/science.1058867","article-title":"Preferential localization of effector memory cells in nonlymphoid tissue","volume":"291","author":"Masopust","year":"2001","journal-title":"Science"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2796.2011.02367.x","article-title":"Hallmarks of CD4 T cell immunity against influenza","volume":"269","author":"McKinstry","year":"2011","journal-title":"J. Intern. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nm.2142","article-title":"Memory CD4+ T cells induce innate responses independently of pathogen","volume":"16","author":"Strutt","year":"2010","journal-title":"Nat. Med."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Hada, A., Li, L., Kandel, A., Jin, Y., and Xiao, Z. (2023). Characterization of Bovine Intraepithelial T Lymphocytes in the Gut. Pathogens, 12.","DOI":"10.3390\/pathogens12091173"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Hada, A., and Xiao, Z. (2025). Ligands for Intestinal Intraepithelial T Lymphocytes in Health and Disease. Pathogens, 14.","DOI":"10.3390\/pathogens14020109"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1038\/s41467-024-48555-z","article-title":"Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus","volume":"15","author":"Furey","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/cimm.1994.1078","article-title":"IFN-gamma stimulates IgG2 production from bovine B cells costimulated with anti-mu and mitogen","volume":"154","author":"Estes","year":"1994","journal-title":"Cell. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.vetimm.2011.08.023","article-title":"Immunoglobulin isotypes of lactating Holstein cows classified as high, average, and low type-1 or -2 immune responders","volume":"144","author":"Heriazon","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-2427(02)00201-5","article-title":"Type 1 and type 2 responses in regulation of Ig isotype expression in cattle","volume":"90","author":"Estes","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Kandel, A., Li, L., Wang, Y., Tuo, W., and Xiao, Z. (2024). Differentiation and Regulation of Bovine Th2 Cells In Vitro. Cells, 13.","DOI":"10.3390\/cells13090738"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/cei.12186","article-title":"Influenza infection results in local expansion of memory CD8+ T cells with antigen non-specific phenotype and function","volume":"175","author":"Sckisel","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1084\/jem.188.2.223","article-title":"Contribution of virus-specific CD8+ cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model","volume":"188","author":"Moskophidis","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"aaa4352","DOI":"10.1126\/science.aaa4352","article-title":"Neutrophil trails guide influenza-specific CD8+ T cells in the airways","volume":"349","author":"Lim","year":"2015","journal-title":"Science"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1084\/jem.20080314","article-title":"Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs","volume":"205","author":"Mcgill","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41590-019-0320-6","article-title":"Human CD8+ T cell cross-reactivity across influenza A, B and C viruses","volume":"20","author":"Koutsakos","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Koutsakos, M., Mcwilliam, H.E.G., Aktepe, T.E., Fritzlar, S., Illing, P.T., Mifsud, N.A., Purcell, A.W., Rockman, S., Reading, P.C., and Vivian, J.P. (2019). Downregulation of MHC Class I Expression by Influenza A and B Viruses. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01158"},{"key":"ref_156","first-page":"0050721","article-title":"Broadly Protective CD8+ T Cell Immunity to Highly Conserved Epitopes Elicited by Heat Shock Protein gp96-Adjuvanted Influenza Monovalent Split Vaccine","volume":"95","author":"Zhang","year":"2021","journal-title":"J. Virol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1164\/rccm.202103-0620OC","article-title":"Innate-like Gene Expression of Lung-Resident Memory CD8+ T Cells during Experimental Human Influenza: A Clinical Study","volume":"204","author":"Paterson","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Lin, X., Lin, F., Liang, T., Ducatez, M.F., Zanin, M., and Wong, S.S. (2021). Antibody Responsiveness to Influenza: What Drives It?. Viruses, 13.","DOI":"10.3390\/v13071400"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.immuni.2022.03.003","article-title":"Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites","volume":"55","author":"Maclean","year":"2022","journal-title":"Immunity"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1073\/pnas.0800003105","article-title":"Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia","volume":"105","author":"Joo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0264-410X(96)00287-3","article-title":"Influenza virus neutralizing antibodies and IgG isotype profiles after immunization of mice with influenza A subunit vaccine using various adjuvants","volume":"15","author":"Benne","year":"1997","journal-title":"Vaccine"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Padilla-Quirarte, H.O., Lopez-Guerrero, D.V., Gutierrez-Xicotencatl, L., and Esquivel-Guadarrama, F. (2019). Protective Antibodies Against Influenza Proteins. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01677"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1002\/eji.1830241222","article-title":"IgG isotype distribution of local and systemic immune responses induced by influenza virus infection","volume":"24","author":"Fazekas","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1128\/CVI.00156-06","article-title":"Distinct Contributions of Vaccine-Induced Immunoglobulin G1 (IgG1) and IgG2a Antibodies to Protective Immunity against Influenza","volume":"13","author":"Huber","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Van Erp, E.A., Luytjes, W., Ferwerda, G., and Van Kasteren, P.B. (2019). Fc-Mediated Antibody Effector Functions During Respiratory Syncytial Virus Infection and Disease. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00548"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Chandler, T.L., Yang, A., Otero, C.E., Permar, S.R., and Caddy, S.L. (2023). Protective mechanisms of nonneutralizing antiviral antibodies. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011670"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Murugaiah, V., Varghese, P.M., Saleh, S.M., Tsolaki, A.G., Alrokayan, S.H., Khan, H.A., Collison, K.S., Sim, R.B., Nal, B., and Al-Mohanna, F.A. (2020). Complement-Independent Modulation of Influenza A Virus Infection by Factor H. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00355"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1128\/JVI.02128-06","article-title":"Natural Antibody and Complement Mediate Neutralization of Influenza Virus in the Absence of Prior Immunity","volume":"81","author":"Jayasekera","year":"2007","journal-title":"J. Virol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4049\/jimmunol.1801208","article-title":"The Multifaceted B Cell Response to Influenza Virus","volume":"202","author":"Lam","year":"2019","journal-title":"J. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Von Holle, T.A., and Moody, M.A. (2019). Influenza and Antibody-Dependent Cellular Cytotoxicity. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01457"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Gao, R., Sheng, Z., Sreenivasan, C.C., Wang, D., and Li, F. (2020). Influenza A Virus Antibodies with Antibody-Dependent Cellular Cytotoxicity Function. Viruses, 12.","DOI":"10.3390\/v12030276"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1093\/infdis\/jiz010","article-title":"Antibody Determinants of Influenza Immunity","volume":"219","author":"Crowe","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1128\/CVI.00374-14","article-title":"Influenza Virus-Specific Neutralizing IgM Antibodies Persist for a Lifetime","volume":"21","author":"Skountzou","year":"2014","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.4049\/jimmunol.1002090","article-title":"Protective B Cell Responses to Flu\u2014No Fluke!","volume":"186","author":"Waffarn","year":"2011","journal-title":"J. Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1038\/s41467-023-39734-5","article-title":"Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses","volume":"14","author":"Lam","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/eji.200939798","article-title":"B-cell fate decisions following influenza virus infection","volume":"40","author":"Rothaeusler","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.4049\/jimmunol.1102808","article-title":"Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens","volume":"188","author":"Bortnick","year":"2012","journal-title":"J. Immunol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.4049\/jimmunol.1300161","article-title":"What Is and What Should Always Have Been: Long-Lived Plasma Cells Induced by T Cell\u2013Independent Antigens","volume":"190","author":"Bortnick","year":"2013","journal-title":"J. Immunol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.immuni.2017.12.009","article-title":"Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires","volume":"48","author":"Mccarthy","year":"2018","journal-title":"Immunity"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Guthmiller, J.J., Utset, H.A., and Wilson, P.C. (2021). B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat. Viruses, 13.","DOI":"10.3390\/v13060965"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e132155","DOI":"10.1172\/jci.insight.132155","article-title":"Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination","volume":"5","author":"Abreu","year":"2020","journal-title":"JCI Insight"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Sicca, F., Sakorafa, E., De Jonge, A., De Vries-Idema, J., Zhou, F., Cox, R.J., and Huckriede, A. (2022). The evolution of humoral immune responses to past and novel influenza virus strains gives evidence for antigenic seniority. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.987984"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s13238-015-0193-x","article-title":"Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus","volume":"7","author":"Wang","year":"2016","journal-title":"Protein Cell"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.3201\/eid2309.170342","article-title":"Serologic Evidence for Influenza C and D Virus among Ruminants and Camelids, Africa, 1991\u20132015","volume":"23","author":"Salem","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Okda, F.A., Griffith, E., Sakr, A., Nelson, E., and Webby, R. (2020). New Diagnostic Assays for Differential Diagnosis Between the Two Distinct Lineages of Bovine Influenza D Viruses and Human Influenza C Viruses. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.605704"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1046\/j.1365-2567.2000.00962.x","article-title":"Activation of bovine B cells via surface immunoglobulin M cross-linking or CD40 ligation results in different B-cell phenotypes","volume":"99","author":"Haas","year":"2000","journal-title":"Immunology"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Frie, M.C., Droscha, C.J., Greenlick, A.E., and Coussens, P.M. (2018). MicroRNAs Encoded by Bovine Leukemia Virus (BLV) Are Associated with Reduced Expression of B Cell Transcriptional Regulators in Dairy Cattle Naturally Infected with BLV. Front. Vet. Sci., 4.","DOI":"10.3389\/fvets.2017.00245"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.coviro.2013.05.001","article-title":"Role of T cell immunity in recovery from influenza virus infection","volume":"3","author":"Sun","year":"2013","journal-title":"Curr. Opin. Virol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","article-title":"Pathogenesis of influenza-induced acute respiratory distress syndrome","volume":"14","author":"Short","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"L650","DOI":"10.1152\/ajplung.00360.2014","article-title":"Inflammatory impact of IFN-\u03b3 in CD8+ T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways","volume":"308","author":"Ramana","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.4049\/jimmunol.1302729","article-title":"Soluble, but Not Transmembrane, TNF-\u03b1 Is Required during Influenza Infection To Limit the Magnitude of Immune Responses and the Extent of Immunopathology","volume":"192","author":"Deberge","year":"2014","journal-title":"J. Immunol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"235.32","DOI":"10.4049\/jimmunol.210.Supp.235.32","article-title":"IFN-\u03b3 mediated epithelial injury during influenza pathogenesis","volume":"210","author":"Navaeiseddighi","year":"2023","journal-title":"J. Immunol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1128\/JVI.02030-09","article-title":"Interleukin-15 Is Critical in the Pathogenesis of Influenza A Virus-Induced Acute Lung Injury","volume":"84","author":"Nakamura","year":"2010","journal-title":"J. Virol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4049\/jimmunol.1002613","article-title":"A Role for IL-15 in the Migration of Effector CD8 T Cells to the Lung Airways following Influenza Infection","volume":"186","author":"Verbist","year":"2011","journal-title":"J. Immunol."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Ma, W.-T., Yao, X.-T., Peng, Q., and Chen, D.-K. (2019). The protective and pathogenic roles of IL-17 in viral infections: Friend or foe?. Open Biol., 9.","DOI":"10.1098\/rsob.190109"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1038\/ncomms4495","article-title":"FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability","volume":"5","author":"Bradley","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Sant, S., Grzelak, L., Wang, Z., Pizzolla, A., Koutsakos, M., Crowe, J., Loudovaris, T., Mannering, S.I., Westall, G.P., and Wakim, L.M. (2018). Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01453"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1182\/blood-2008-05-157016","article-title":"Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines","volume":"112","author":"Yu","year":"2008","journal-title":"Blood"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Lee, J., Wang, L., Palinski, R., Walsh, T., He, D., Li, Y., Wu, R., Lang, Y., Sunwoo, S.-Y., and Richt, J.A. (2019). Comparison of Pathogenicity and Transmissibility of Influenza B and D Viruses in Pigs. Viruses, 11.","DOI":"10.3390\/v11100905"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.molimm.2021.02.028","article-title":"Special features of \u03b3\u03b4 T cells in ruminants","volume":"134","author":"Baldwin","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Kandel, A., Li, L., Hada, A., and Xiao, Z. (2022). Differential Expression of CD45RO and CD45RA in Bovine T Cells. Cells, 11.","DOI":"10.3390\/cells11111844"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s44149-022-00057-5","article-title":"Are CD45RO+ and CD45RA\u2212 genuine markers for bovine memory T cells?","volume":"2","author":"Kandel","year":"2022","journal-title":"Anim. Dis."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"109919","DOI":"10.1016\/j.vetimm.2019.109919","article-title":"WC1+ and WC1neg \u03b3\u03b4 T lymphocytes in intestinal mucosa of healthy and Mycobacterium avium subspecies paratuberculosis-infected calves","volume":"216","author":"Ludwig","year":"2019","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2613.2009.00679.x","article-title":"Gamma\u2013delta T cell subsets are differentially associated with granuloma development and organization in a bovine model of mycobacterial disease","volume":"90","author":"Plattner","year":"2009","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2567.2006.02477.x","article-title":"Workshop cluster 1+\u03b3\u03b4 T-cell receptor+ T cells from calves express high levels of interferon-\u03b3 in response to stimulation with interleukin-12 and -18","volume":"120","author":"Price","year":"2007","journal-title":"Immunology"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Samuel, B.E.R., Diaz, F.E., Maina, T.W., Corbett, R.J., Tuggle, C.K., and Mcgill, J.L. (2024). Evidence of innate training in bovine \u03b3\u03b4 T cells following subcutaneous BCG administration. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1423843"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1038\/s41467-021-22242-9","article-title":"Host-derived lipids orchestrate pulmonary \u03b3\u03b4 T cell response to provide early protection against influenza virus infection","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/eji.201948157","article-title":"Early production of IL-17A by \u03b3\u03b4 T cells in the trachea promotes viral clearance during influenza infection in mice","volume":"50","author":"Latino","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Dong, P., Ju, X., Yan, Y., Zhang, S., Cai, M., Wang, H., Chen, H., Hu, Y., Cui, L., and Zhang, J. (2018). \u03b3\u03b4 T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02812"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4049\/jimmunol.1303398","article-title":"Bovine \u03b3\u03b4 T Cells Are a Major Regulatory T Cell Subset","volume":"193","author":"Guzman","year":"2014","journal-title":"J. Immunol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41579-023-00945-8","article-title":"Co-evolution of immunity and seasonal influenza viruses","volume":"21","author":"Han","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Taylor, K.Y., Agu, I., Jos\u00e9, I., M\u00e4ntynen, S., Campbell, A.J., Mattson, C., Chou, T.-W., Zhou, B., Gresham, D., and Ghedin, E. (2023). Influenza A virus reassortment is strain dependent. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011155"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2009.04.006","article-title":"Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I","volume":"5","author":"Gack","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Rajsbaum, R., Albrecht, R.A., Wang, M.K., Maharaj, N.P., Versteeg, G.A., Nistal-Vill\u00e1n, E., Garc\u00eda-Sastre, A., and Gack, M.U. (2012). Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1003059"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/JVI.01712-07","article-title":"Avian Influenza Virus A\/HK\/483\/97(H5N1) NS1 Protein Induces Apoptosis in Human Airway Epithelial Cells","volume":"82","author":"Lam","year":"2008","journal-title":"J. Virol."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Woltz, R., Schweibenz, B., Tsutakawa, S.E., Zhao, C., Ma, L., Shurina, B., Hura, G.L., John, R., Vorobiev, S., and Swapna, G. (2023). The NS1 protein of influenza B virus binds 5\u2032-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral response. bioRxiv.","DOI":"10.1101\/2023.09.25.559316"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.1128\/JVI.02381-05","article-title":"Influenza Virus Evades Innate and Adaptive Immunity via the NS1 Protein","volume":"80","author":"Marukian","year":"2006","journal-title":"J. Virol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1743-422X-8-48","article-title":"Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling","volume":"8","author":"Pachler","year":"2011","journal-title":"Virol. J."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1128\/JVI.01627-09","article-title":"Influenza C Virus NS1 Protein Upregulates the Splicing of Viral mRNAs","volume":"84","author":"Muraki","year":"2010","journal-title":"J. Virol."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Skelton, R.M., and Huber, V.C. (2022). Comparing Influenza Virus Biology for Understanding Influenza D Virus. Viruses, 14.","DOI":"10.3390\/v14051036"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2022.01.001","article-title":"Influenza D virus Matrix protein 1 restricts the type I interferon response by degrading TRAF6","volume":"568","author":"Chen","year":"2022","journal-title":"Virology"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.coi.2011.07.016","article-title":"The pathogenesis of influenza virus infections: The contributions of virus and host factors","volume":"23","author":"Fukuyama","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Rigby, R.E., Wise, H.M., Smith, N., Digard, P., and Rehwinkel, J. (2019). PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-43632-6"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1126\/science.1222213","article-title":"An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response","volume":"337","author":"Jagger","year":"2012","journal-title":"Science"},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Khaperskyy, D.A., Schmaling, S., Larkins-Ford, J., Mccormick, C., and Gaglia, M.M. (2016). Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005427"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1128\/JVI.00386-15","article-title":"Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins","volume":"89","author":"Khaperskyy","year":"2015","journal-title":"J. Virol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.celrep.2013.03.034","article-title":"Neuraminidase-Mediated, NKp46-Dependent Immune-Evasion Mechanism of Influenza Viruses","volume":"3","author":"Glasner","year":"2013","journal-title":"Cell Rep."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/infdis\/jiu094","article-title":"Influenza Virus Uses Its Neuraminidase Protein to Evade the Recognition of Two Activating NK Cell Receptors","volume":"210","author":"Seidel","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"25417","DOI":"10.1128\/mSphere.00254-17","article-title":"The Hemagglutinin-Esterase Fusion Glycoprotein Is a Primary Determinant of the Exceptional Thermal and Acid Stability of Influenza D Virus","volume":"2","author":"Yu","year":"2017","journal-title":"mSphere"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Octaviani, C.P., Huang, P., Bi-Hung, P., Gray, G.C., and Tseng, C.-T.K. (2025). Superior replication, pathogenicity, and immune evasion of a Texas dairy cattle H5N1 virus compared to a historical avian isolate. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-93493-5"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Turnbull, M.L., Zakaria, M.K., Upfold, N.S., Bakshi, S., Das, U.R., Magill, C., Mojsiejczuk, L., Herder, V., Dee, K., and Liu, N. (2024). Polygenic Determinants of H5N1 Adaptation to Bovine Cells. bioRxiv.","DOI":"10.1101\/2024.11.29.626120"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Lion, A., Secula, A., Ran\u00e7on, C., Boulesteix, O., Pinard, A., Deslis, A., H\u00e4gglund, S., Salem, E., Cassard, H., and N\u00e4slund, K. (2021). Enhanced Pathogenesis Caused by Influenza D Virus and Mycoplasma bovis Coinfection in Calves: A Disease Severity Linked with Overexpression of IFN-\u03b3 as a Key Player of the Enhanced Innate Immune Response in Lungs. Microbiol. Spectr., 9.","DOI":"10.1128\/spectrum.01690-21"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"e85832","DOI":"10.1172\/jci.insight.85832","article-title":"Vaccine-generated lung tissue\u2013resident memory T cells provide heterosubtypic protection to influenza infection","volume":"1","author":"Zens","year":"2016","journal-title":"JCI Insight"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1016\/j.vaccine.2023.09.007","article-title":"A recombinant chimeric influenza virus vaccine expressing the consensus H3 hemagglutinin elicits broad hemagglutination inhibition antibodies against divergent swine H3N2 influenza viruses","volume":"41","author":"Yu","year":"2023","journal-title":"Vaccine"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/infdis\/jiu654","article-title":"Longevity of B-Cell and T-Cell Responses After Live Attenuated Influenza Vaccination in Children","volume":"211","author":"Mohn","year":"2015","journal-title":"J. Infect. Dis."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/21645515.2017.1377376","article-title":"Immune responses after live attenuated influenza vaccination","volume":"14","author":"Mohn","year":"2018","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Janssens, Y., Joye, J., Waerlop, G., Clement, F., Leroux-Roels, G., and Leroux-Roels, I. (2022). The role of cell-mediated immunity against influenza and its implications for vaccine evaluation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.959379"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"11756","DOI":"10.1128\/JVI.01460-06","article-title":"Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines","volume":"80","author":"He","year":"2006","journal-title":"J. Virol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"e2111064119","DOI":"10.1073\/pnas.2111064119","article-title":"Strong influenza-induced TFH generation requires CD4 effectors to recognize antigen locally and receive signals from continuing infection","volume":"119","author":"Devarajan","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41590-024-01926-6","article-title":"Influenza vaccination stimulates maturation of the human T follicular helper cell response","volume":"25","author":"Schattgen","year":"2024","journal-title":"Nat. Immunol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1038\/s41467-025-59182-7","article-title":"Epitope-optimized vaccine elicits enduring immunity against swine influenza A virus","volume":"16","author":"Madapong","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"eadc9937","DOI":"10.1126\/sciadv.adc9937","article-title":"A universal influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus disease in ferrets","volume":"8","author":"Lanfermeijer","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41467-024-55546-7","article-title":"Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice","volume":"16","author":"Hawman","year":"2025","journal-title":"Nat. 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