{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:30:20Z","timestamp":1774330220235,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Human Papillomavirus (HPV), particularly high-risk strains such as HPV16 and HPV18, is a leading cause of cervical cancer and a significant risk factor for several other epithelial malignancies. While the oncogenic mechanisms of viral proteins E6 and E7 are well characterized, the broader effects of HPV infection on host transcriptional regulation remain less clearly defined. This study explores the hypothesis that conserved genomic motifs within the HPV genome may act as molecular decoys, sequestering human transcription factors (TFs) and thereby disrupting normal gene regulation in host cells. Such interactions could contribute to oncogenesis by altering the transcriptional landscape and promoting malignant transformation.We conducted a computational analysis of the genomes of high-risk HPV types using MEME-ChIP for de novo motif discovery, followed by Tomtom for identifying matching human TFs. Protein\u2013protein interactions among the predicted TFs were examined using STRING, and biological pathway enrichment was performed with Enrichr. The analysis identified conserved viral motifs with the potential to interact with host transcription factors (TFs), notably those from the FOX, HOX, and NFAT families, as well as various zinc finger proteins. Among these, SMARCA1, DUX4, and CDX1 were not previously associated with HPV-driven cell transformation. Pathway enrichment analysis revealed involvement in several key biological processes, including modulation of Wnt signaling pathways, transcriptional misregulation associated with cancer, and chromatin remodeling. These findings highlight the multifaceted strategies by which HPV may influence host cellular functions and contribute to pathogenesis. In this context, the study underscores the power of in silico approaches for elucidating viral\u2013host interactions and reveals promising therapeutic targets in computationally predicted regulatory network changes.<\/jats:p>","DOI":"10.3390\/v17091166","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:49:34Z","timestamp":1756309774000},"page":"1166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["HPV as a Molecular Hacker: Computational Exploration of HPV-Driven Changes in Host Regulatory Networks"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-0604","authenticated-orcid":false,"given":"Massimiliano","family":"Chetta","sequence":"first","affiliation":[{"name":"Azienda Ospedaliera di rilievo nazionale \u201cA. Cardarelli Hospital\u2019s\u201d Laboratory of Medical Genetics and Genomics, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-0857","authenticated-orcid":false,"given":"Alessandra","family":"Rosati","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cSchola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-8987","authenticated-orcid":false,"given":"Nenad","family":"Bukvic","sequence":"additional","affiliation":[{"name":"U.O.C Genetica Medica, Azienda Ospedaliero\u2014Universitaria Consorziale Policlinico di Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","article-title":"Human papillomavirus and cervical cancer","volume":"40","author":"Okunade","year":"2020","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/14737159.2025.2486653","article-title":"Evolution and future of cervical cancer screening: From cytology to primary HPV testing and the impact of vaccination","volume":"25","author":"Franco","year":"2025","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2886","article-title":"Human papillomavirus oncoproteins: Pathways to transformation","volume":"10","author":"Moody","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1128\/JVI.00097-15","article-title":"CCCTC-binding factor recruitment to the early region of the human papillomavirus 18 genome regulates viral oncogene expression","volume":"89","author":"Paris","year":"2015","journal-title":"J. Virol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Pentland, I., Campos-Le\u00f3n, K., Cotic, M., Davies, K.J., Wood, C.D., Groves, I.J., Burley, M., Coleman, N., Stockton, J.D., and Noyvert, B. (2018). Disruption of CTCF-YY1-dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription. PLoS Biol., 16.","DOI":"10.1371\/journal.pbio.2005752"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Litwin, T.R., Clarke, M.A., Dean, M., and Wentzensen, N. (2017). Somatic Host Cell Alterations in HPV Carcinogenesis. Viruses, 9.","DOI":"10.3390\/v9080206"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Morgan, E.L., and Macdonald, A. (2019). Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NF\u03baB-IL-6 signalling axis. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007835"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1038\/s41388-023-02772-w","article-title":"Exploitation of ATP-sensitive potassium ion (KATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK\/AP-1 signalling","volume":"42","author":"Scarth","year":"2023","journal-title":"Oncogene"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ccell.2016.05.005","article-title":"YAP\/TAZ at the Roots of Cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1038\/s41467-024-49965-9","article-title":"The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer","volume":"15","author":"Patterson","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chetta, M., Cammarota, A.L., De Marco, M., Bukvic, N., Marzullo, L., and Rosati, A. (2023). The Continuous Adaptive Challenge Played by Arboviruses: An In Silico Approach to Identify a Possible Interplay between Conserved Viral RNA Sequences and Host RNA Binding Proteins (RBPs). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241311051"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chetta, M., Tarsitano, M., Oro, M., Rivieccio, M., and Bukvic, N. (2022). An in silico pipeline approach uncovers a potentially intricate network involving spike SARS-CoV-2 RNA, RNA vaccines, host RNA-binding proteins (RBPs), and host miRNAs at the cellular level. J. Genet. Eng. Biotechnol., 20.","DOI":"10.1186\/s43141-022-00413-5"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"W39","DOI":"10.1093\/nar\/gkv416","article-title":"The MEME Suite","volume":"43","author":"Bailey","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lin, K., Quan, X., Yin, W., and Zhang, H. (2022). A Contrastive Learning Pre-Training Method for Motif Occupancy Identification. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094699"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chen, E.Y., Tan, C.M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G.V., Clark, N.R., and Ma\u2019ayan, A. (2013). Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform., 14.","DOI":"10.1186\/1471-2105-14-128"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"001540","DOI":"10.1099\/jgv.0.001540","article-title":"The human papillomavirus oncoproteins: A review of the host pathways targeted on the road to transformation","volume":"102","author":"Scarth","year":"2021","journal-title":"J. Gen. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"RP91469","DOI":"10.7554\/eLife.91469","article-title":"Design of the HPV-automated visual evaluation (PAVE) study: Validating a novel cervical screening strategy","volume":"12","author":"Perkins","year":"2024","journal-title":"eLife"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/onc.2008.21","article-title":"The FoxO code","volume":"27","author":"Calnan","year":"2008","journal-title":"Oncogene"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1177\/1758834017742576","article-title":"FOXC1 in cancer development and therapy: Deciphering its emerging and divergent roles","volume":"9","author":"Yang","year":"2017","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1158\/0008-5472.CAN-10-2825","article-title":"Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis","volume":"71","author":"Zhang","year":"2011","journal-title":"Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"200914","DOI":"10.1016\/j.omton.2024.200914","article-title":"FOXJ3, a novel tumor suppressor in neuroblastoma","volume":"33","author":"Challagundla","year":"2024","journal-title":"Mol. Ther. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc2826","article-title":"The Hox genes and their roles in oncogenesis","volume":"10","author":"Shah","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Afzal, Z., and Krumlauf, R. (2022). Transcriptional Regulation and Implications for Controlling Hox Gene Expression. J. Dev. Biol., 10.","DOI":"10.3390\/jdb10010004"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Barahona de Brito, C., and Patra, A.K. (2022). NFAT Factors Are Dispensable for the Development but Are Critical for the Maintenance of Foxp3+ Regulatory T Cells. Cells, 11.","DOI":"10.3390\/cells11091397"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Louren\u00e7o de Freitas, N., Deberaldini, M.G., Gomes, D., Pavan, A.R., Sousa, \u00c2., Dos Santos, J.L., and Soares, C.P. (2021). Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.592868"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lisek, M., Przybyszewski, O., Zylinska, L., Guo, F., and Boczek, T. (2023). The Role of MEF2 Transcription Factor Family in Neuronal Survival and Degeneration. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043120"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrc3278","article-title":"NRF2 and cancer: The good, the bad and the importance of context","volume":"12","author":"Sporn","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Giammona, A., Crivaro, E., and Stecca, B. (2023). Emerging Roles of Hedgehog Signaling in Cancer Immunity. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021321"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9431","DOI":"10.3390\/cimb45120592","article-title":"SRY-Related Transcription Factors in Head and Neck Squamous Cell Carcinomas: In Silico Based Analysis","volume":"45","author":"Kolenda","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s00109-017-1592-7","article-title":"Interplay between circadian clock and viral infection","volume":"95","author":"Zhuang","year":"2017","journal-title":"J. Mol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Pearson, J.A., Voisey, A.C., Boest-Bjerg, K., Wong, F.S., and Wen, L. (2021). Circadian Rhythm Modulation of Microbes During Health and Infection. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.721004"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1158\/1541-7786.MCR-19-1074","article-title":"Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes","volume":"18","author":"Roden","year":"2020","journal-title":"Mol. Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1038\/cddiscovery.2017.71","article-title":"Zinc-finger proteins in health and disease","volume":"3","author":"Cassandri","year":"2017","journal-title":"Cell Death Discov."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)81299-4","article-title":"The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4","volume":"85","author":"Ho","year":"1996","journal-title":"Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7802","DOI":"10.1128\/MCB.02179-06","article-title":"Sox17 and Sox4 differentially regulate beta-catenin\/T-cell factor activity and proliferation of colon carcinoma cells","volume":"27","author":"Sinner","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm820","article-title":"Reciprocal regulation of inflammation and lipid metabolism by liver X receptors","volume":"9","author":"Joseph","year":"2003","journal-title":"Nat. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15872","DOI":"10.1074\/jbc.M411144200","article-title":"Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation","volume":"280","author":"Lengner","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.celrep.2013.08.010","article-title":"Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells","volume":"4","author":"Taylor","year":"2013","journal-title":"Cell Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1158\/0008-5472.CAN-12-2377","article-title":"ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells","volume":"73","author":"Yuan","year":"2013","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ydbio.2011.03.012","article-title":"Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field","volume":"353","author":"Zhou","year":"2011","journal-title":"Dev. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1126\/science.1075958","article-title":"Projection of an immunological self shadow within the thymus by the aire protein","volume":"298","author":"Anderson","year":"2002","journal-title":"Science"},{"key":"ref_43","first-page":"91","article-title":"Expression of the HPV16E7 oncoprotein by thymic epithelium is accompanied by disrupted T cell maturation and a failure of the thymus to involute with age","volume":"10","author":"Malcolm","year":"2003","journal-title":"Clin. Dev. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"30897","DOI":"10.1074\/jbc.R111.309302","article-title":"SWI\/SNF chromatin-remodeling factors: Multiscale analyses and diverse functions","volume":"287","author":"Euskirchen","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.devcel.2011.11.013","article-title":"DUX4 activates germline genes, retroelements, and immune mediators: Implications for facioscapulohumeral dystrophy","volume":"22","author":"Geng","year":"2012","journal-title":"Dev. Cell"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ilie-Petrov, A.C., Cristian, D.A., Grama, F.A., Chitul, A., Blajin, A., Popa, A., Mandi, D.M., Welt, L., Bara, M.A., and Vr\u00eencianu, R. (2024). Evaluation of the Immunohistochemical Scoring System of CDX2 Expression as a Prognostic Biomarker in Colon Cancer. Diagnostics, 14.","DOI":"10.3390\/diagnostics14101023"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: A comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.freeradbiomed.2011.09.037","article-title":"Nitric oxide-cyclic GMP signaling in stem cell differentiation","volume":"51","author":"Mujoo","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Jastrz\u0105b, P., Narejko, K., Car, H., and Wielgat, P. (2023). Cell Membrane Sialome: Sialic Acids as Therapeutic Targets and Regulators of Drug Resistance in Human Cancer Management. Cancers, 15.","DOI":"10.3390\/cancers15205103"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41419-023-06177-1","article-title":"FOXO family isoforms","volume":"14","author":"Santos","year":"2023","journal-title":"Cell Death Dis"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1128\/MCB.25.9.3575-3582.2005","article-title":"Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation","volume":"25","author":"Ma","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1242\/dev.001206","article-title":"Wnt signaling is a key mediator of Cdx1 expression in vivo","volume":"134","author":"Pilon","year":"2007","journal-title":"Development"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Koch, S. (2021). Regulation of Wnt Signaling by FOX Transcription Factors in Cancer. Cancers, 13.","DOI":"10.3390\/cancers13143446"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"148501","DOI":"10.1016\/j.gene.2024.148501","article-title":"Role of HOX genes in cancer progression and their therapeutical aspects","volume":"919","author":"Yadav","year":"2024","journal-title":"Gene"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41420-025-02327-w","article-title":"Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer","volume":"11","author":"Cong","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.semcancer.2019.06.016","article-title":"Transcription factors in SOX family: Potent regulators for cancer initiation and development in the human body","volume":"67","author":"Kumar","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1080\/15548627.2016.1208889","article-title":"Transcription factor NFE2L2\/NRF2 is a regulator of macroautophagy genes","volume":"12","author":"Pajares","year":"2016","journal-title":"Autophagy"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/1873-3468.13057","article-title":"Regulation of cellular senescence via the FOXO4-p53 axis","volume":"592","author":"Bourgeois","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Moody, C. (2017). Mechanisms by which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes. Viruses, 9.","DOI":"10.3390\/v9090261"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.stemcr.2022.06.002","article-title":"Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2","volume":"17","author":"Yoshihara","year":"2022","journal-title":"Stem Cell Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3179421","DOI":"10.1155\/2017\/3179421","article-title":"DNA Oncogenic Virus-Induced Oxidative Stress, Genomic Damage, and Aberrant Epigenetic Alterations","volume":"2017","author":"Kgatle","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41392-025-02340-6","article-title":"Epigenetic regulation of cancer stemness","volume":"10","author":"Galassi","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12964-020-00540-x","article-title":"GLI3: A mediator of genetic diseases, development and cancer","volume":"18","author":"Matissek","year":"2020","journal-title":"Cell Commun. Signal"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Budhwani, M., Lukowski, S.W., Porceddu, S.V., Frazer, I.H., and Chandra, J. (2020). Dysregulation of Stemness Pathways in HPV Mediated Cervical Malignant Transformation Identifies Potential Oncotherapy Targets. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00307"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/his.13980","article-title":"SOX17 expression and its down-regulation by promoter methylation in cervical adenocarcinoma in situ and adenocarcinoma","volume":"76","author":"Hopman","year":"2020","journal-title":"Histopathology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41467-025-55928-5","article-title":"Herpesviruses mimic zygotic genome activation to promote viral replication","volume":"16","author":"Neugebauer","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.molonc.2014.08.016","article-title":"SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer","volume":"9","author":"Rose","year":"2015","journal-title":"Mol. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e18311","DOI":"10.7554\/eLife.18311","article-title":"A systematic view on influenza induced host shutoff","volume":"5","author":"Tai","year":"2016","journal-title":"eLife"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/9\/1166\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:33:47Z","timestamp":1760034827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/9\/1166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":70,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["v17091166"],"URL":"https:\/\/doi.org\/10.3390\/v17091166","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}