{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:27:29Z","timestamp":1760142449597,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Experience with the effect of antiviral therapy on HBsAg seroconversion in acute hepatitis B is limited. We aimed to evaluate the factors affecting HBsAg seroconversion in patients with acute hepatitis B (AHB) receiving antiviral treatment. We performed a retrospective and multicenter study involving 107 adult patients who received antiviral treatment for AHB between January 2018 and December 2023. The median age was 48 (min\u2013max, 18\u201391) years, and 66.3% of the patients were male; 70 patients with 24-week follow-up (15 patients without HBsAg seroconversion versus 55 patients with HBsAg seroconversion) were compared based on HBsAg seroconversion status. Multivariate logistic regression analysis revealed that age was independently associated with HBsAg seroconversion (odds ratio = 0.926; 95% confidence interval (CI) 0.874 to 0.981; p = 0.009). A one-year increase in age was associated with a 0.926-fold decrease in HBsAg seroconversion. In conclusion, age was an independent predictor of HBsAg seroconversion following acute hepatitis B virus infection.<\/jats:p>","DOI":"10.3390\/v17091182","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:25:57Z","timestamp":1756470357000},"page":"1182","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Factors for HBsAg Seroconversion Following Acute Hepatitis B Virus Infection: A Multicenter BUHASDER Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-3101","authenticated-orcid":false,"given":"Ozge","family":"Caydasi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sancaktepe Education and Research Hospital, Health Sciences University, 34785 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sancaktepe Education and Research Hospital, Health Sciences University, 34785 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-1534","authenticated-orcid":false,"given":"\u00d6mer","family":"Kara\u015fahin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Erzurum Education and Research Hospital, Health Sciences University, 25070 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Bat\u0131rel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Kartal Dr. L\u00fctfi K\u0131rdar City Hospital, Health Sciences University, 34865 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman","family":"Dolu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Dokuz Eyl\u00fcl University, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-2727","authenticated-orcid":false,"given":"M\u00fcge","family":"Deniz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Kocaeli University, 41380 Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0131la","family":"Akhan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Kocaeli University, 41380 Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemalettin","family":"\u00d6zden","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Atat\u00fcrk University, 25240 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-9399","authenticated-orcid":false,"given":"Selma","family":"Tosun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Izmir City Hospital, Health Sciences University, 35170 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-1927","authenticated-orcid":false,"given":"Burak","family":"Sar\u0131kaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sultan 2. Abdulhamid Han Education and Research Hospital, Health Sciences University, 34668 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"G\u00f6renek","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sultan 2. Abdulhamid Han Education and Research Hospital, Health Sciences University, 34668 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Aydo\u011fdu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sancaktepe Education and Research Hospital, Health Sciences University, 34785 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-465X","authenticated-orcid":false,"given":"Ey\u00fcp","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sancaktepe Education and Research Hospital, Health Sciences University, 34785 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4657-5291","authenticated-orcid":false,"given":"Fatma","family":"Karada\u011f","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sancaktepe Education and Research Hospital, Health Sciences University, 34785 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil","family":"Erol","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Haydarpa\u015fa Numune Education and Research Hospital, Health Sciences University, 34668 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semiha","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Fatih Sultan Mehmet Education and Research Hospital, Health Sciences University, 34752 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dr Ersin Arslan Education and Research Hospital, Gaziantep Islam Science and Technology University, 27010 Gaziantep, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcge","family":"\u00d6zg\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Elaz\u0131\u011f Fethi Sekin City Hospital, Health Sciences University, 23280 Elazig, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar","family":"Atasoy","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital, Health Sciences University, 06800 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Seyman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Antalya Education and Research Hospital, Health Sciences University, 07100 Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Izmir City Hospital, Health Sciences University, 35170 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6zde","family":"Hakim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Izmir City Hospital, Health Sciences University, 35170 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba","family":"\u00c7ak\u0131rca","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, \u015eanl\u0131urfa Education and Research Hospital, 63300 Sanliurfa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Saral","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Trabzon Kanuni Education and Research Hospital, Health Sciences University, 61040 Trabzon, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-2371","authenticated-orcid":false,"given":"Tu\u011fba","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Pamukkale University, 20070 Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fcrkkan","family":"Kaygusuz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, F\u0131rat University, 23119 Elazig, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-1577","authenticated-orcid":false,"given":"S\u00fcleyman","family":"G\u00fcnay","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u0130zmir Katip \u00c7elebi University, 35620 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckran","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dokuz Eyl\u00fcl University, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0140-6736(09)60207-5","article-title":"Hepatitis B virus 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