{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:42:46Z","timestamp":1760060566887,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["RO1 EY034844","P30 EY031631"],"award-info":[{"award-number":["RO1 EY034844","P30 EY031631"]}]},{"name":"Retinal Research Foundation Pilot Study Grant","award":["RO1 EY034844","P30 EY031631"],"award-info":[{"award-number":["RO1 EY034844","P30 EY031631"]}]},{"name":"NIH","award":["RO1 EY034844","P30 EY031631"],"award-info":[{"award-number":["RO1 EY034844","P30 EY031631"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>(1) Background: Retinal degeneration develops upon caspase-12 activation in aged BALB\/c mice following systemic neonatal infection. (2) Methods: MCMV or medium was injected intraperitoneally (i.p.) into caspase-12\u2212\/\u2212 and caspase-12+\/+ mice (on BALB\/c background) at &lt;3 days after birth. At 8 and 12 months post infection (p.i.), eyes were analyzed by SD-OCT before eyes and extraocular tissues were collected and analyzed by plaque assay, H&amp;E staining, TUNEL assay, Western blot and real-time RT-PCR. (3) Results: Virus DNA, but not replicating virus, was present in eyes and extraocular tissues at 8 and 12 months p.i. Several MCMV genes were expressed in eyes of both MCMV-infected caspase-12\u2212\/\u2212 and caspase-12+\/+ mice, while mean retinal thickness was significantly higher in MCMV latently infected aged caspase-12\u2212\/\u2212 mice compared to age-matched infected caspase-12+\/+ mice. Although similar levels of cleaved caspase-1 were detected in eyes of both infected caspase-12\u2212\/\u2212 and control mice, significantly higher levels of activated NF-\u03baB, cleaved caspase-8, MLKL, p-RIP3 and p53 were observed in eyes of infected caspase-12+\/+ mice compared to eyes of infected caspase-12\u2212\/\u2212 mice. (4) Conclusions: Our results suggest that caspase-12 contributes to retinal degeneration during MCMV ocular latency via multiple pathways including apoptosis and necroptosis.<\/jats:p>","DOI":"10.3390\/v17091206","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:07:32Z","timestamp":1756901252000},"page":"1206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Depletion of Caspase-12 Alleviates Retinal Degeneration in Aged BALB\/c Mice Following Systemic Neonatal Infection by Murine Cytomegalovirus (MCMV)"],"prefix":"10.3390","volume":"17","author":[{"given":"Jinxian","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"},{"name":"James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"},{"name":"James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"},{"name":"James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"},{"name":"James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4012-3932","authenticated-orcid":false,"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"},{"name":"James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/clinids\/13.2.315","article-title":"Infectious Diseases Society of America and Centers for Disease Control. 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