{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:59:11Z","timestamp":1792807151119,"version":"4.5.0"},"reference-count":76,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tertiary Education Trust Fund Nigeria","award":["TETF\/ES\/MEGA\/RG\/2021\/FUHSO\/VOL.1"],"award-info":[{"award-number":["TETF\/ES\/MEGA\/RG\/2021\/FUHSO\/VOL.1"]}],"id":[{"id":"https:\/\/ror.org\/03p8jwd38","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Lassa fever (LF), a severe hemorrhagic disease endemic to West Africa, is primarily transmitted by rodents of the genus Mastomys, particularly Mastomys natalensis, which serve as the main reservoirs of Lassa virus (LASV). There have been reports of high prevalence of LF in Nigeria, and outbreaks tend to be recurrent yet geographically restricted, implying that additional ecological or epidemiological factors influence the distribution of the disease beyond the mere presence of M. natalensis. However, national-scale data on LASV prevalence in rodent populations remain scarce. To address this gap, a targeted small mammal survey was conducted over a four-month period (May to August 2024) in Otukpo Local Government Area (LGA) of Benue State, north-central Nigeria. Rodents and other small mammals were trapped across three purposively selected wards identified as high-risk areas based on prior reports of occurrence of such small mammals in the areas and the informal settlements in which the selected wards were located in in Otukpo LGA. Analysis of the samples revealed no statistically significant variation in LASV prevalence among the study sites, indicating a relatively uniform, low-level exposure risk across the LGA and region. However, a marginally significant difference in LASV detection between plasma and serum samples suggests that sample type and storage conditions may influence serological sensitivity. These findings highlight the importance of refining diagnostic protocols, broadening surveillance to include additional rodent hosts, and integrating ecological data with public health strategies to improve early warning systems and strengthen Lassa fever control efforts.<\/jats:p>","DOI":"10.3390\/v17101368","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:48:21Z","timestamp":1760420901000},"page":"1368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serological Evidence of Lassa Virus Exposure in Non-Mastomys Small Mammals Within a Hyperendemic Region of North-Central Nigeria: A Pilot Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4032-3923","authenticated-orcid":false,"given":"Augustine Ovie","family":"Edegbene","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Federal University of Health Sciences, Otukpo 972261, Nigeria"},{"name":"Institute for Global Health and Health Security, Federal University of Health Sciences, Otukpo 972261, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temidayo Oluwatosin","family":"Omotehinwa","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, Federal University of Health Sciences, Otukpo 972261, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Anejo-Okopi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Federal University of Health Sciences, Otukpo 972261, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-6433","authenticated-orcid":false,"given":"Sara El","family":"Yaagoubi","sequence":"additional","affiliation":[{"name":"LESCB URL-CNRST N\u00b0 18, Faculty of Sciences, Abdelmalek Essa\u00e2di University, T\u00e9touan, 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Vector Borne Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Trovato, M., Sartorius, R., D\u2019Apice, L., Manco, R., and De Berardinis, P. (2020). Viral emerging diseases: Challenges in developing vaccination strategies. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.02130"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"670","DOI":"10.4269\/ajtmh.1970.19.670","article-title":"Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings","volume":"19","author":"Frame","year":"1970","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Salvato, M.S. (1993). Lassa fever. The Arenaviridae, Springer.","DOI":"10.1007\/978-1-4615-3028-2"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jiph.2011.05.002","article-title":"Fever, fever patterns and diseases called \u2018fever\u2019\u2014A review","volume":"4","author":"Ogoina","year":"2011","journal-title":"J. Infect. Public Health"},{"key":"ref_7","unstructured":"Kaslow, R.A., Stanberry, L.R., and Le Duc, J.W. (2014). Arenaviruses: Lassa fever, Lujo hemorrhagic fever, lymphocytic choriomeningitis, and the South American hemorrhagic fevers. Viral Infections of Humans: Epidemiology and Control, Springer."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41564-018-0296-2","article-title":"Tracking virus outbreaks in the twenty-first century","volume":"4","author":"Grubaugh","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fichet-Calvet, E., and Rogers, D.J. (2009). Risk maps of Lassa fever in West Africa. PLoS Negl. Trop. Dis., 3.","DOI":"10.1371\/journal.pntd.0000388"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Olayemi, A., Cadar, D., Magassouba, N., Obadare, A., Kourouma, F., Oyeyiola, A., Fasogbon, S., Igbokwe, J., Rieger, T., and Bockholt, S. (2016). New hosts of the Lassa virus. Sci. Rep., 6.","DOI":"10.1038\/srep25280"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S2222-1808(15)60893-3","article-title":"Epidemiological role of a rodent in Morocco: Case of cutaneous leishmaniasis","volume":"5","author":"Echchakery","year":"2015","journal-title":"Asian Pac. J. Trop. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1098\/rstb.2011.0299","article-title":"Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever","volume":"367","author":"Andersen","year":"2012","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3201\/eid2403.171905","article-title":"New lineage of Lassa virus, Togo, 2016","volume":"24","author":"Whitmer","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41392-024-01917-x","article-title":"Emerging and reemerging infectious diseases: Global trends and new strategies for their prevention and control","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1567-1348(02)00026-6","article-title":"Natural nidality in Bolivian hemorrhagic fever and the systematics of the reservoir species","volume":"1","author":"Dragoo","year":"2002","journal-title":"Infect. Genet. Evol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/10408410902989837","article-title":"Rodent-borne diseases and their risks for public health","volume":"35","author":"Meerburg","year":"2009","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-642-71726-0_3","article-title":"Epidemiology and control of Lassa fever","volume":"Volume 134","author":"Oldstone","year":"1987","journal-title":"Arenaviruses: Biology and Immunotherapy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.3201\/eid1212.060812","article-title":"Mastomys natalensis and Lassa fever, West Africa. Emerg","volume":"12","author":"Lecompte","year":"2006","journal-title":"Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/15303660160025912","article-title":"Lassa fever in Guinea: II. Distribution and prevalence of Lassa virus infection in small mammals","volume":"1","author":"Demby","year":"2001","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_20","first-page":"349","article-title":"Pathologic and virologic study of fatal Lassa fever in man","volume":"107","author":"Walker","year":"1982","journal-title":"Am. J. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/infdis\/155.3.456","article-title":"Clinical virology of Lassa fever in hospitalized patients","volume":"155","author":"Johnson","year":"1987","journal-title":"J. Infect. Dis."},{"key":"ref_22","first-page":"651","article-title":"Lassa virus infection in Mastomys natalensis in Sierra Leone: Gross and microscopic findings in infected and uninfected animals","volume":"52","author":"Demartini","year":"1975","journal-title":"Bull. World Health Organ."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0035-9203(72)90271-4","article-title":"Lassa fever: Epidemiological aspects of the 1970 epidemic, Jos, Nigeria","volume":"66","author":"Carey","year":"1972","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0035-9203(86)90147-1","article-title":"Lassa fever in children in Sierra Leone, West Africa","volume":"80","author":"Webb","year":"1986","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0168-1656(99)00122-4","article-title":"Lassa fever: Implications of T-cell immunity for vaccine development","volume":"73","year":"1999","journal-title":"J. Biotechnol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1863-2378.2012.01469.x","article-title":"Lassa fever in West Africa: Evidence for an expanded region of endemicity","volume":"59","author":"Sogoba","year":"2012","journal-title":"Zoonoses Public Health"},{"key":"ref_27","first-page":"722","article-title":"Lassa Fever: Patients Profile and Treatment Outcomes at Benue State University Teaching Hospital Makurdi, North-Central Nigeria","volume":"13","author":"Mbaave","year":"2023","journal-title":"Adv. Infect. Dis."},{"key":"ref_28","first-page":"577","article-title":"Lassa fever: Review of epidemiology and epizootiology","volume":"52","author":"Monath","year":"1975","journal-title":"Bull. World Health Organ."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1128\/JVI.02081-10","article-title":"Conserved residues in Lassa fever virus Z protein modulate viral infectivity at the level of the ribonucleoprotein","volume":"85","author":"Capul","year":"2011","journal-title":"J. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3390\/v4102031","article-title":"Pathogenesis of Lassa fever","volume":"4","author":"Yun","year":"2012","journal-title":"Viruses"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Grard, G., Fair, J.N., Lee, D., Slikas, E., Steffen, I., Muyembe, J.J., and Leroy, E.M. (2012). A novel rhabdovirus associated with acute hemorrhagic fever in central Africa. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.ppat.1002924"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ijheh.2018.03.005","article-title":"Pathogens transmitted in animal feces in low-and middle-income countries","volume":"221","author":"Delahoy","year":"2018","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0035-9203(79)90218-9","article-title":"Lassa virus antibodies in hospital personnel in western Liberia","volume":"73","author":"Frame","year":"1979","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"661","DOI":"10.4269\/ajtmh.1996.55.661","article-title":"Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea","volume":"55","author":"Lukashevich","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3201\/eid0605.000504","article-title":"Imported Lassa fever in Germany: Molecular characterization of a new Lassa virus strain","volume":"6","author":"Emmerich","year":"2000","journal-title":"Emerg. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0035-9203(85)90242-1","article-title":"Antibodies to Lassa and Lassa-like viruses in man and mammals in the Central African Republic","volume":"79","author":"Georges","year":"1985","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/(SICI)1096-9071(199912)59:4<552::AID-JMV21>3.0.CO;2-A","article-title":"Lassa and Mopeia virus replication in human monocytes\/macrophages and in endothelial cells: Different effects on IL-8 and TNF-alpha gene expression","volume":"59","author":"Lukashevich","year":"1999","journal-title":"J. Med. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3201\/eid1205.050052","article-title":"Historical Lassa fever reports and 30-year clinical update. Emerg","volume":"12","author":"Macher","year":"2006","journal-title":"Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Safronetz, D., Mire, C., Rosenke, K., Feldmann, F., Haddock, E., Geisbert, T., and Feldmann, H. (2015). A recombinant vesicular stomatitis virus-based Lassa fever vaccine protects guinea pigs and macaques against challenge with geographically and genetically distinct Lassa viruses. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003736"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41579-022-00789-8","article-title":"Lassa fever\u2014The road ahead","volume":"21","author":"Garry","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1365-3156.2012.03010.x","article-title":"Hospital--based surveillance for Lassa fever in Edo State, Nigeria, 2005\u20132008","volume":"17","author":"Ehichioya","year":"2012","journal-title":"Trop. Med. Int. Health"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Happi, A.N., Olumade, T.J., Ogunsanya, O.A., Sijuwola, A.E., Ogunleye, S.C., Oguzie, J.U., Nwofoke, C., Ugwu, C.A., Okoro, S.J., and Otuh, P.I. (2022). Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.00366-22"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Mateer, E.J., Huang, C., Shehu, N.Y., and Paessler, S. (2018). Lassa fever\u2013induced sensorineural hearing loss: A neglected public health and social burden. PLoS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006187"},{"key":"ref_44","first-page":"933","article-title":"Lassa fever: Epidemiology, clinical features, diagnosis, management and prevention","volume":"33","author":"Asogun","year":"2019","journal-title":"Infect. Dis. Clin."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/14772000.2017.1358220","article-title":"Small mammal diversity and dynamics within Nigeria, with emphasis on reservoirs of the Lassa virus","volume":"16","author":"Olayemi","year":"2018","journal-title":"Syst. Biodivers."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1038\/s41467-022-33112-3","article-title":"Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades","volume":"13","author":"Klitting","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1038\/s41467-021-25910-y","article-title":"Geographical drivers and climate-linked dynamics of Lassa fever in Nigeria","volume":"12","author":"Redding","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/23570008.2025.2483013","article-title":"Water quality assessment in Benue South, Nigeria: An investigation of physico-chemical and microbial characteristics","volume":"39","author":"Edegbene","year":"2025","journal-title":"Water Sci."},{"key":"ref_49","unstructured":"Daniel, W.W., and Cross, C.L. (2018). Biostatistics: A Foundation for Analysis in the Health Sciences, Wiley. [11th ed.]."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/vbz.2006.0520","article-title":"Fluctuation of abundance and Lassa virus prevalence in Mastomys natalensis in Guinea, West Africa","volume":"7","author":"Lecompte","year":"2007","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_51","first-page":"270","article-title":"Serological evidence of arenavirus circulation in wild rodents fro, central-west, southeast, and south regions or Brazil, 2002-2006","volume":"54","author":"Cunha","year":"2023","journal-title":"Braz. J. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6992","DOI":"10.1128\/JVI.74.15.6992-7004.2000","article-title":"Genetic diversity among Lassa virus strains","volume":"74","author":"Bowen","year":"2000","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cheng, X., Tan, Y., Li, H., Huang, J., Zhao, D., Zhang, Z., Yi, M., Zhu, L., Hui, S., and Yang, J. (2022). Fecal 16S rRNA sequencing and multi-compartment metabolomics revealed gut microbiota and metabolites interactions in APP\/PS1 mice. Comp. Bio. Med., 151.","DOI":"10.1016\/j.compbiomed.2022.106312"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2147\/IDR.S505311","article-title":"Effectiveness of Omadacycline in a Patient with Chlamydia psittaci and KPC-Producing Gram-Negative Bacteria Infection","volume":"18","author":"Yang","year":"2025","journal-title":"Infect. Drug Resist."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Williams, E.S., and Barker, I.K. (2001). Rodent--borne hemorrhagic fever viruses. Infectious Diseases of Wild Mammals, Iowa State University Press.","DOI":"10.1002\/9780470344880"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10393-018-1331-8","article-title":"Movement patterns of small rodents in Lassa fever-endemic villages in Guinea","volume":"15","author":"Kourouma","year":"2018","journal-title":"EcoHealth"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Feng, S., Cao, M., Tang, P., Deng, S., Chen, L., Tang, Y., Zhu, L., Chen, X., Huang, Z., and Shen, M. (2023). Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China. Toxins, 15.","DOI":"10.3390\/toxins15040293"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Davis, N.A., Kenyon, M.A., Ghersi, B.M., Sparks, J.L.D., and Gass, J.D. (2025). Assessing the environmental drivers of Lassa fever in West Africa: A systematic review. Viruses, 17.","DOI":"10.3390\/v17040504"},{"key":"ref_59","unstructured":"Singleton, G.R., Hinds, L.A., Krebs, C.J., and Spratt, D.M. (2003). Evolutionary biology of the genus Rattus: Profile of an archetypal rodent pest. Rats, Mice and People: Rodent Biology and Management, ACIAR Monograph No. 96; Australian Centre for International Agricultural Research."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"108502","DOI":"10.1016\/j.reprotox.2023.108502","article-title":"Combined exposure of beta-cypermethrin and emamectin benzoate interferes with the HPO axis through oxidative stress, causing an imbalance of hormone homeostasis in female rats","volume":"123","author":"Li","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"102733","DOI":"10.1016\/j.jiph.2025.102733","article-title":"Postpartum hemorrhage emerges as a key outcome of maternal SARS-CoV-2 omicron variant infection surge across pregnancy trimesters","volume":"18","author":"Xu","year":"2025","journal-title":"J. Infect. Pub. Health"},{"key":"ref_62","first-page":"71","article-title":"The Burden of Rodent-Borne Diseases in Africa South of the Sahara","volume":"127","author":"Gratz","year":"1997","journal-title":"Belg. J. Zool. Bruss. Belg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1515\/MAMM.2008.025","article-title":"Polyandry and polygyny in an African rodent pest species, Mastomys natalensis","volume":"72","author":"Kennis","year":"2008","journal-title":"Mammalia"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Madueme, P.G.U., and Chirove, F. (2024). A systematic review of mathematical models of Lassa fever. Math. Biosci., 374.","DOI":"10.1016\/j.mbs.2024.109227"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cell.2015.07.020","article-title":"Clinical sequencing uncovers origins and evolution of Lassa virus","volume":"162","author":"Andersen","year":"2015","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.csbj.2022.12.053","article-title":"MNNMDA: Predicting human microbe-disease association via a method to minimize matrix nuclear norm","volume":"21","author":"Liu","year":"2023","journal-title":"Comput. Struct. Biotech. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/15303660160025903","article-title":"Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations","volume":"1","author":"Bausch","year":"2001","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3201\/eid2506.181035","article-title":"Epidemiologic and clinical features of Lassa fever outbreak in Nigeria, January 1\u2013May 6, 2018","volume":"25","author":"Ilori","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10408360490497456","article-title":"Lassa virus","volume":"41","author":"Lenz","year":"2004","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_70","first-page":"212","article-title":"Lassa fever and Marburg virus disease","volume":"28","author":"Monath","year":"1974","journal-title":"WHO Chron."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e2304876120","DOI":"10.1073\/pnas.2304876120","article-title":"A human monoclonal antibody combination rescues nonhuman primates from advanced disease caused by the major lineages of Lassa virus","volume":"120","author":"Cross","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Musa, S.S., Zhao, S., Gao, D., Lin, Q., Chowell, G., and He, D. (2020). Mechanistic modelling of the large-scale Lassa fever epidemics in Nigeria from 2016 to 2019. J. Theor. Biol., 493.","DOI":"10.1016\/j.jtbi.2020.110209"},{"key":"ref_73","first-page":"629","article-title":"The ecology of Praomys (Mastomys) natalensis in southern Africa","volume":"52","year":"1975","journal-title":"Bull. World Health Organ."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1038\/s41467-024-47991-1","article-title":"Reservoir displacement by an invasive rodent reduces Lassa virus zoonotic spillover risk","volume":"15","author":"Eskew","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_75","unstructured":"Saluzzo, J.F., and Dodet, B. (1998). The progression from endemic to epidemic Lassa fever in war-torn West Africa. Emergence and Control of Rodent-Borne Viral Diseases, Elsevier."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1365-3156.2001.00676.x","article-title":"Short communication: Lassa fever in Sierra Leone: UN peacekeepers are at risk","volume":"6","author":"Lenz","year":"2001","journal-title":"Trop. Med. Int. 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