{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T19:42:13Z","timestamp":1773171733223,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnologia (CONAHCYT) now SECIHTI","award":["303081"],"award-info":[{"award-number":["303081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Avian influenza A viruses pose ongoing threats to human and animal health, with H7 subtypes causing outbreaks globally. In Mexico, highly pathogenic H7N3 viruses have circulated in poultry since 2012, causing sporadic human infections. Here we analyzed genetic markers in hemagglutinin sequences from Mexican H7N3 isolates and conducted serological assays on human populations with poultry exposure. Our results show conserved avian-like receptor binding sites, thus limiting human adaptation, alongside antigenic drift and acquisition of glycosylation sites likely driven by vaccination. Serological testing of 1103 individuals revealed no detectable antibodies against H7N3, indicating a na\u00efve population. Phylogenetic analyses revealed multiple virus clades circulating regionally. These findings suggest that while current H7N3 viruses have limited capacity for sustained human transmission, the lack of population immunity underscores the importance of continued surveillance and risk assessment to mitigate potential pandemic threats.<\/jats:p>","DOI":"10.3390\/v17101376","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T06:06:32Z","timestamp":1760508392000},"page":"1376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic and Serological Analysis of H7N3 Avian Influenza Viruses in Mexico for Pandemic Risk Assessment"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2829-6945","authenticated-orcid":false,"given":"Guadalupe","family":"Ayora-Talavera","sequence":"first","affiliation":[{"name":"Laboratorio de Virolog\u00eda, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida 97225, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"L\u00f3pez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos, Mexico City 01480, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Barrera-Badillo","sequence":"additional","affiliation":[{"name":"Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos, Mexico City 01480, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Aparicio-Antonio","sequence":"additional","affiliation":[{"name":"Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos, Mexico City 01480, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7450-3060","authenticated-orcid":false,"given":"Nidia","family":"Ar\u00e9chiga-Ceballos","sequence":"additional","affiliation":[{"name":"Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos, Mexico City 01480, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0374-9404","authenticated-orcid":false,"given":"Anita","family":"Aguirre-Barbosa","sequence":"additional","affiliation":[{"name":"Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos, Mexico City 01480, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3582-5120","authenticated-orcid":false,"given":"Rosa Maria","family":"Wong-Chew","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Canul-Canul","sequence":"additional","affiliation":[{"name":"Laboratorio de Virolog\u00eda, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida 97225, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7285-9396","authenticated-orcid":false,"given":"Mario","family":"Sol\u00eds-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Comisi\u00f3n M\u00e9xico\u2013Estados Unidos para la Prevenci\u00f3n de la Fiebre Aftosa y Otras Enfermedades Ex\u00f3ticas de los Animales (CPA), Servicio Nacional de Sanidad, Inocuidad y Calidad Agroalimentaria (SENASICA), Mexico City 04530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","unstructured":"(2025, August 05). 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