{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:12:46Z","timestamp":1789665166860,"version":"4.0.1"},"reference-count":20,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Infection with oncogenic human papillomavirus (HPV) remains a leading cause of cervical cancer and other HPV-related diseases. This situation persists despite the availability of effective prophylactic vaccines. While global vaccination programs have significantly reduced the incidence of HPV in adolescents and young adults, many women presenting with HPV infection or squamous intraepithelial lesions (SIL) were not covered by primary prevention. This review was performed with the aim of evaluating the impact of administering the 9-valent HPV vaccine in adult women who are HPV-positive or have histologically confirmed cervical precancerous lesions. Following the PRISMA 2020 guidelines, a search was performed in the MEDLINE, Scopus, and Cochrane Library databases. A total of 653 studies were retrieved, of which 7 studies, including 19,414 women, met the inclusion criteria. According to the literature, vaccination was linked to significant reductions in persistent HPV infection, progression of SIL, and recurrence of high-grade lesions after surgical removal. Complete HPV remission was achieved in up to 72.4% of vaccinated women, compared to 45.7% among unvaccinated controls. Vaccination after conization lowered the recurrence risk of CIN2+ lesions by 87%, with benefits seen regardless of timing. The most significant effect was observed when vaccine administration was performed before the surgical procedure. Furthermore, HPV vaccination notably enhanced viral clearance and decreased the likelihood of repeated surgical interventions. Despite differences in study design and follow-up definitions, the overall evidence supports additional vaccination in HPV-positive adult women as an effective measure to reduce recurrence and promote viral remission. These findings emphasize the need for clear guidelines and wider access to HPV vaccination for adult populations.<\/jats:p>","DOI":"10.3390\/v17101377","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:12:29Z","timestamp":1760523149000},"page":"1377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Vaccinating Adult Women Who Are HPV-Positive or with Confirmed Cervical SIL with the 9-Valent Vaccine\u2014A Systematic Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-5731","authenticated-orcid":false,"given":"Dominik","family":"Pruski","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, District Public Hospital, Jurasz\u00f3w 7-19, 60-479 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8291-3879","authenticated-orcid":false,"given":"Sonja","family":"Millert-Kali\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, District Public Hospital, Jurasz\u00f3w 7-19, 60-479 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-763X","authenticated-orcid":false,"given":"Robert","family":"Jach","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Endocrinology, Jagiellonian University Medical College, Kopernika 23, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-0451","authenticated-orcid":false,"given":"Jakub","family":"\u017burawski","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Poznan University of Medical Sciences, 60-512 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-0822","authenticated-orcid":false,"given":"Marcin","family":"Przybylski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, District Public Hospital, Jurasz\u00f3w 7-19, 60-479 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200245","DOI":"10.1016\/j.tvr.2022.200245","article-title":"HPV and head and neck cancers: Towards early diagnosis and prevention","volume":"14","author":"Galati","year":"2022","journal-title":"Tumour Virus Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"724","DOI":"10.15585\/mmwr.mm6833a3","article-title":"Human Papillomavirus-Attributable Cancers\u2014United States, 2012\u20132016","volume":"68","author":"Senkomago","year":"2019","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_3","unstructured":"(2025, October 01). Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240014107."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"f7361","DOI":"10.1136\/bmj.f7361","article-title":"Effect of ageing on cervical or vaginal cancer in Swedish women previously treated for cervical intraepithelial neoplasia grade 3: Population-based cohort study of long te-m incidence and mortality","volume":"348","author":"Strander","year":"2014","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101942","DOI":"10.1016\/j.pmedr.2022.101942","article-title":"Barriers to human papillomavirus (HPV) vaccination among young adults, aged 18-35","volume":"29","author":"Muthukrishnan","year":"2022","journal-title":"Prev. Med. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2362449","DOI":"10.1080\/21645515.2024.2362449","article-title":"Integrative literature review on human papillomavirus vaccination recommendations in national immunization programs in select areas in the Asia-Pacific region","volume":"20","author":"Phongsamart","year":"2024","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/jog.16034","article-title":"The AOFOG recommendations on human papillomavirus vaccination in the Asia-Pacific region","volume":"50","author":"Tse","year":"2024","journal-title":"J. Obs. Gynaecol. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2343552","DOI":"10.1080\/21645515.2024.2343552","article-title":"Reduced risk of CIN2+ recurrence in women immunized with a 9-valent HPV vaccine post-excision: Retrospective cohort study","volume":"20","author":"Pilka","year":"2024","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Palumbo, M., Lavitola, G., Di Filippo, C., Foreste, V., Granata, M., Imperatore, O., Ascione, M., Della Corte, L., and Bifulco, G. (2025). Impact of Human papillomavirus 9-valent vaccine on viral clearance after surgical treatment: A single-center retrospective observational study. Eur. J. Obs. Gynecol. Reprod. Biol., 310.","DOI":"10.1016\/j.ejogrb.2025.113994"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101337","DOI":"10.1016\/j.lanepe.2025.101337","article-title":"Early and long-term effects of prophylactic and post-excision human papillomavirus vaccination on recurrent high-grade cervical intraepithelial neoplasia relative to margin status: A retrospective cohort study in the Czech Republic","volume":"55","author":"Rosina","year":"2025","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"del Pino, M., Mart\u00ed, C., Torras, I., Henere, C., Munmany, M., Marimon, L., Saco, A., Torn\u00e9, A., and Ordi, J. (2020). HPV Vaccination as Adjuvant to Conization in Women with Cervical Intraepithelial Neoplasia: A Study under Real-Life Conditions. Vaccines, 8.","DOI":"10.3390\/vaccines8020245"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"430.e1","DOI":"10.1016\/j.ajog.2023.11.1235","article-title":"Risk of progression of cervical intraepithelial neoplasia grade 2 in human papillomavirus-vaccinated and unvaccinated women: A population-based cohort study","volume":"230","author":"Krog","year":"2024","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Pruski, D., Millert-Kali\u0144ska, S., Jach, R., and Przybylski, M. (2025). Effect of vaccination against HPV in the HPV-positive patients not covered by primary prevention on the disappearance of infection. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-92861-5"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Henere, C., Torn\u00e9, A., Llupi\u00e0, A., Aldea, M., Mart\u00ed, C., Glickman, A., Saco, A., Marimon, L., Manzotti, C., and Rakislova, N. (2022). HPV Vaccination in Women with Cervical Intraepithelial Neoplasia Undergoing Excisional Treatment: Insights into Unsolved Questions. Vaccines, 10.","DOI":"10.3390\/vaccines10060887"},{"key":"ref_16","unstructured":"Wells, G., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2014). Newcastle-Ottawa Quality Assessment Scale Cohort Studies, University of Ottawa."},{"key":"ref_17","first-page":"572","article-title":"Assessment of frequency of regression and progression of mild cervical neoplasia--LGSIL in women with positive high-risk HPV DNA test result","volume":"83","author":"Pruski","year":"2012","journal-title":"Ginekol. Pol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5603\/GP.a2021.0164","article-title":"Remission of HPV infection after LEEP-conization\u2014A retrospective study","volume":"93","author":"Przybylski","year":"2022","journal-title":"Ginekol. Pol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Roncati, L. (2025). Ozone\u2013Oxygen Therapy to Prevent HPV-Related Cancers of the Lower Gynecological Tract in Infected Patients: The Rationale for Further Developments. Cancers, 17.","DOI":"10.3390\/cancers17030543"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.5603\/GP.2019.0011","article-title":"Sensitivity and specificity of HR HPV E6\/E7 mRNA test in detecting cervical squamous intraepithelial lesion and cervical cancer","volume":"90","author":"Pruski","year":"2019","journal-title":"Ginekol. Pol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/10\/1377\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:17:02Z","timestamp":1760523422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/10\/1377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":20,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["v17101377"],"URL":"https:\/\/doi.org\/10.3390\/v17101377","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]}}}