{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:36:02Z","timestamp":1788388562435,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FSO"},{"DOI":"10.13039\/100019533","name":"Moderna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019533","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Respiratory syncytial virus (RSV) is a major cause of respiratory illness, particularly in children, yet its burden in adults\u2014especially in older adults\u2014remains under-recognized. We analyzed RSV-related hospitalizations in Switzerland from 2017 to 2023 using national data from the Federal Statistical Office, including cases with RSV coded as either a primary or secondary diagnosis. Over 35,000 RSV-related hospitalizations were recorded. The highest incidence occurred in children under 10 years (390 per 100,000\/year), with a second peak in adults \u2265 80 years (151 per 100,000\/year). Older adults (\u226560 years) accounted for more than 9700 hospitalizations overall, with an average of over 16,600 total hospital days per year. Average length of stay (LOS) was shortest in young children (4.6 days) and highest in adolescents (13.9 days), while in adults, it increased from 6.8 days (age 20\u201329) to 12.3 (age \u2265 80). Mechanical ventilation rates peaked at 12.6% in 60\u201369 year olds, and in-hospital mortality at 7.1% in those \u226580 years. In adults, RSV was more often recorded as a secondary diagnosis and commonly associated with chronic comorbidities, including chronic obstructive pulmonary disease, heart failure, kidney disease, and diabetes. Frailty-related diagnoses\u2014such as cognitive or motor impairment, delirium, and need for nursing care\u2014were also frequent. These findings highlight the importance of improved adult RSV surveillance and targeted prevention strategies in high-risk populations.<\/jats:p>","DOI":"10.3390\/v17111407","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:14:04Z","timestamp":1761207244000},"page":"1407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Burden and Characteristics of RSV-Associated Hospitalizations in Switzerland: A Nationwide Analysis from 2017 to 2023"],"prefix":"10.3390","volume":"17","author":[{"given":"Elisa D.","family":"Bally-von Passavant","sequence":"first","affiliation":[{"name":"University Institute of Internal Medicine, Kantonsspital Baselland, CH-4410 Liestal, Switzerland"},{"name":"Faculty of Medicine, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetha","family":"Joseph","sequence":"additional","affiliation":[{"name":"University Institute of Internal Medicine, Kantonsspital Baselland, CH-4410 Liestal, Switzerland"},{"name":"Faculty of Medicine, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nike Julia","family":"Kr\u00e4utler","sequence":"additional","affiliation":[{"name":"Moderna Switzerland GmbH, CH-4052 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"McCarthy-Pontier","sequence":"additional","affiliation":[{"name":"Moderna Switzerland GmbH, CH-4052 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-3895","authenticated-orcid":false,"given":"Giorgia","family":"L\u00fcthi-Corridori","sequence":"additional","affiliation":[{"name":"University Institute of Internal Medicine, Kantonsspital Baselland, CH-4410 Liestal, Switzerland"},{"name":"Faculty of Medicine, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-2181","authenticated-orcid":false,"given":"Fabienne","family":"Jaun","sequence":"additional","affiliation":[{"name":"University Institute of Internal Medicine, Kantonsspital Baselland, CH-4410 Liestal, Switzerland"},{"name":"Faculty of Medicine, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-0675","authenticated-orcid":false,"given":"J\u00f6rg D.","family":"Leuppi","sequence":"additional","affiliation":[{"name":"University Institute of Internal Medicine, Kantonsspital Baselland, CH-4410 Liestal, Switzerland"},{"name":"Faculty of Medicine, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-1893","authenticated-orcid":false,"given":"Maria","family":"Boesing","sequence":"additional","affiliation":[{"name":"University Institute of Internal Medicine, Kantonsspital Baselland, CH-4410 Liestal, Switzerland"},{"name":"Faculty of Medicine, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Piralla, A., Chen, Z., and Zaraket, H. 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