{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:31:18Z","timestamp":1772253078086,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The phylum Nematoda is host to a vast and diverse virosphere, yet severe viral diseases are rarely observed. This paradox between pervasive infection and limited pathology suggests the existence of a highly effective host\u2013virus \u201ctruce\u201d. In this review, we argue that this truce is not a result of viral attenuation but is actively arbitrated by a multi-tiered host immune network, whose primary characteristic is not destructive power but exquisite cost\u2013benefit management. We deconstruct this network into two functional tiers. The first, the \u201ceffector layer\u201d, comprises a diverse arsenal of antiviral pathways, including RNA interference (RNAi), the Intracellular Pathogen Response (IPR), and other direct-acting mechanisms. The second, the \u201cregulatory layer\u201d, acts as a command hub, integrating internal physiological states\u2014such as metabolism and aging\u2014with external threat signals to orchestrate a proportional defense, thereby mitigating the high fitness costs of immunity. Understanding this intricate network is critical, as it not only explains the dynamics of infection within nematodes but also has profound implications for a broader medical landscape, particularly through the \u201cTrojan Horse\u201d effect, where nematode-borne viruses might elicit immune responses in their final vertebrate hosts. Together, these insights provide a unified framework for studying nematode\u2013virus interactions and for comparing antiviral strategies across metazoans.<\/jats:p>","DOI":"10.3390\/v17111485","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T08:57:55Z","timestamp":1762765075000},"page":"1485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Pathogenesis: The Nematode Immune Network as the Arbiter of a Host\u2013Virus Truce"],"prefix":"10.3390","volume":"17","author":[{"given":"Emma","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Biosciences, Rice University, 6500 Main Street, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2451-2320","authenticated-orcid":false,"given":"Tan","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, University of Illinois Urbana-Champaign, 1201 W Gregory Dr, Urbana, IL 61801, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanqiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Rice University, 6500 Main Street, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"F\u00e9lix, M.-A., Ashe, A., Piffaretti, J., Wu, G., Nuez, I., B\u00e9licard, T., Jiang, Y., Zhao, G., Franz, C.J., and Goldstein, L.D. 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