{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:16:15Z","timestamp":1763975775165,"version":"3.45.0"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The ability of a virus to adapt is key to its survival, and this is achieved through mutation, which allows the virus to change and adapt to new environments. To capture the full extent of SARS-CoV-2 diversity in Asturias, samples obtained from nasopharyngeal swabs were characterised using whole-genome sequencing. Between 2020 and July 2024, a total of 4001 sequences were analysed and 5302 mutations were identified. An increase in the positivity rate was observed between 2022 and 2024 in children under 1 year of age. During this period, 55 new circulating variants belonging to 41 pangolin lineages were detected: 24 originated throughout the world and 31 in Asturias (10 detected only in the region, 8 in the rest of Spain, and 13 around the world). A total of 31 new non-synonymous mutations were fixed in the viral population 250 \u00b1 46 (93\u2013620) days after their appearance. During seasonal SARS-CoV-2 circulation, surveillance systems developed during the pandemic continue to detect new indigenous and imported variants without indicating an increase in severity.<\/jats:p>","DOI":"10.3390\/v17121531","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:02:07Z","timestamp":1763974927000},"page":"1531","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Circulating Variants of SARS-CoV-2 in Asturias During the Period (2022\u20132024)"],"prefix":"10.3390","volume":"17","author":[{"given":"Jos\u00e9 Mar\u00eda","family":"Gonz\u00e1lez-Alba","sequence":"first","affiliation":[{"name":"Unit of Virology, Microbiology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitario del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulema P\u00e9rez","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unit of Virology, Microbiology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitario del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Rojo-Alba","sequence":"additional","affiliation":[{"name":"Unit of Virology, Microbiology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitario del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Ochoa","family":"Varela","sequence":"additional","affiliation":[{"name":"Unit of Virology, Microbiology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitario del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-4649","authenticated-orcid":false,"given":"Juan G\u00f3mez de","family":"O\u00f1a","sequence":"additional","affiliation":[{"name":"Unit of Virology, Microbiology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Genetic Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes Rodr\u00edguez","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Unit of Virology, Microbiology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitario del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-7902","authenticated-orcid":false,"given":"Santiago Mel\u00f3n","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unit of Virology, Microbiology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitario del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-2620","authenticated-orcid":false,"given":"Marta Elena","family":"\u00c1lvarez-Arg\u00fcelles","sequence":"additional","affiliation":[{"name":"Unit of Virology, Microbiology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitario del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.imj.2021.08.001","article-title":"Global trends in COVID-19","volume":"1","author":"Zhou","year":"2022","journal-title":"Infect. 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