{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:23:41Z","timestamp":1764307421813,"version":"3.46.0"},"reference-count":59,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior, Brasil","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro\/FAPERJ","award":["E-26\/103.285\/2011","E-26\/210.664\/2016","E-26\/210.245\/2018","E-210.127\/2025"],"award-info":[{"award-number":["E-26\/103.285\/2011","E-26\/210.664\/2016","E-26\/210.245\/2018","E-210.127\/2025"]}]},{"name":"Conselho Nacional de Educa\u00e7\u00e3o","award":["E-26\/202.575\/2019"],"award-info":[{"award-number":["E-26\/202.575\/2019"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\/CNPq","award":["485074\/2012-5","439208\/2018-1","313211\/2018-3","442113\/2024-2","303024\/2019-24"],"award-info":[{"award-number":["485074\/2012-5","439208\/2018-1","313211\/2018-3","442113\/2024-2","303024\/2019-24"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["444903\/2024-0"],"award-info":[{"award-number":["444903\/2024-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The lymphocytic choriomeningitis virus (LCMV) is an under-investigated rodent-borne arenavirus primarily associated with its natural reservoir, the cosmopolitan rodent Mus musculus. Although widely distributed in mice worldwide, human cases are rare, likely under-reported, and often misdiagnosed. While typically asymptomatic or self-limiting, infection can progress to neurological disease, severe congenital outcomes, or fatal illness in transplant recipients. Despite its public health relevance, this study provides the first detection and characterization of LCMV in Brazil. We analyzed 236 rodent serum samples and 78 tissue samples from synanthropic rodents (Mus musculus, Rattus rattus, and Rattus norvegicus) collected during seven independent expeditions across the state of Rio de Janeiro, Southeastern Brazil. Using ELISAs, IgG anti-LCMV antibodies were detected in 20% of rodents, including two R. rattus (2\/10), two R. norvegicus (2\/95), and forty-five M. musculus (45\/131). The LCMV\u2019s RNA was amplified and partially sequenced from fourteen M. musculus, and complete S segment sequences were obtained from two mouse samples. Phylogenetic analyses revealed that these Brazilian strains belong to lineage I, which is composed of strains that induce disease in humans. Our results underscore the importance of implementing integrated surveillance for this zoonosis in Brazil.<\/jats:p>","DOI":"10.3390\/v17121544","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:04:57Z","timestamp":1764151497000},"page":"1544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of Lymphocytic Choriomeningitis Virus in House Mouse (Mus musculus) in Brazil"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-5062","authenticated-orcid":false,"given":"Gabriel Rosa","family":"Cavalcanti","sequence":"first","affiliation":[{"name":"Laboratory of Hantaviruses and Rickettsiosis, Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5039-0604","authenticated-orcid":false,"given":"Jorlan","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratory of Hantaviruses and Rickettsiosis, Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando de Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Parasitology of Wild Reservoir Mammals (LABPMR), Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-9492","authenticated-orcid":false,"given":"Bernardo Rodrigues","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Parasitology of Wild Reservoir Mammals (LABPMR), Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8323-1477","authenticated-orcid":false,"given":"Alexandro","family":"Guterres","sequence":"additional","affiliation":[{"name":"Department of Genetics, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014USP, Ribeir\u00e3o Preto 14049-900, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Brignone","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, INEVH-ANLIS, Monteagudo 2510, Pergamino 2700, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Levis","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, INEVH-ANLIS, Monteagudo 2510, Pergamino 2700, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila dos Santos","family":"Lucio","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Parasitology of Wild Reservoir Mammals (LABPMR), Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f3crates Fraga da","family":"Costa-Neto","sequence":"additional","affiliation":[{"name":"Fiocruz Mata Atl\u00e2ntica, Oswaldo Cruz Fundation, Rio de Janeiro 22713-560, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-6448","authenticated-orcid":false,"given":"Vagner","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Exact and Earth Sciences, University of the State of Bahia, Salvador 41150-000, Bahia, Brazil"},{"name":"Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa"},{"name":"Instituto Rene Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Belo Horizonte 30190-002, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-7326","authenticated-orcid":false,"given":"Marta","family":"Giovanetti","sequence":"additional","affiliation":[{"name":"Instituto Rene Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Belo Horizonte 30190-002, Minas Gerais, Brazil"},{"name":"Department of Sciences and Technologies for Sustainable Development and One Health, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-9931","authenticated-orcid":false,"given":"Luiz Carlos Junior","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Instituto Rene Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Belo Horizonte 30190-002, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo S\u00e9rgio","family":"D\u2019Andrea","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Parasitology of Wild Reservoir Mammals (LABPMR), Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elba Regina Sampaio","family":"de Lemos","sequence":"additional","affiliation":[{"name":"Laboratory of Hantaviruses and Rickettsiosis, Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7552-6643","authenticated-orcid":false,"given":"Renata Carvalho de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Hantaviruses and Rickettsiosis, Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hallam, S.J., Koma, T., Maruyama, J., and Paessler, S. 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