{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T05:15:39Z","timestamp":1764738939021,"version":"3.46.0"},"reference-count":29,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Global seroprevalence of SARS-CoV-2 in children and adolescents has risen to an estimated 56.6%. Limited data on children highlights the need for ongoing surveillance as recommended by the WHO. Understanding this need, in this study we carry out a feasibility study of a rapid lateral flow immunoassay test (LFIAT) and determine SARS-CoV-2 seroprevalence in children and adolescents. The method used in the paper included 202 children (1\u201318 years old) who were evaluated for SARS-CoV-2 IgG\/IgM antibodies using the LFIAT. LFIAT provides results in 20 min. Demographic data was collected through questionnaires. As a result, SARS-CoV-2 antibody seroprevalence was 52.0% (n = 105). No gender differences were observed. Adolescents exhibited higher seroprevalence (63.0%) compared to children aged 1\u20135.9 (49.3%) and 6\u201311.9 years old (46.8%), without statistical significance (p &gt; 0.05). The median age of seropositive children was 9 years, and 77.1% had a history of PCR-confirmed infection (p = 0.001). In conclusion, results are consistent with global data. It was observed that the LFIAT can be easily administered to children and parents had a positive outlook on the test. Findings suggest that LFIAT can be used to assess SARS-CoV-2 immunity, while providing the first seroprevalence estimate for SARS-CoV-2 among healthy children and adolescents in Turkey, utilizing the COVID-19 IgG\/IgM Rapid Test-KitA.<\/jats:p>","DOI":"10.3390\/v17121553","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:31:52Z","timestamp":1764261112000},"page":"1553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Feasibility Study of a Rapid Lateral Flow Immunoassay Test for Children and Adolescents to Determine SARS-CoV-2 Seroprevalence"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5077-4843","authenticated-orcid":false,"given":"Rukiye","family":"Sa\u00e7","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ankara Training and Research Hospital, Ankara 06230, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medine Ay\u015fin","family":"Ta\u015far","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency, Ankara Training and Research Hospital, Ankara 06230, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5153-2136","authenticated-orcid":false,"given":"Burcu Ceylan","family":"Cura Yayla","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Ankara Training and Research Hospital, Ankara 06230, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-1000","authenticated-orcid":false,"given":"Ser\u00e7in","family":"Ta\u015far","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ankara Training and Research Hospital, Ankara 06230, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meliha","family":"Sevim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ankara Training and Research Hospital, Ankara 06230, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6zde","family":"Onay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ankara Training and Research Hospital, Ankara 06230, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lknur","family":"Fidanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency, Ankara Training and Research Hospital, Ankara 06230, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2025, January 20). 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