{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T13:18:47Z","timestamp":1764595127061,"version":"3.46.0"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Background: Pediatric SARS-CoV-2 infection is usually mild, but in rare cases may lead to severe complications. Early recognition and comprehensive management are critical for favorable outcomes. Case Presentation: We present the case of a 2-year-old girl, previously healthy and unvaccinated against Streptococcus Pneumoniae (S. pneumoniae), who developed SARS-CoV-2 infection and acute otitis media. Initial laboratory evaluation revealed leukocytosis with neutrophilia and increased inflammatory markers. Antiviral and antibiotic treatment was initiated, but she remained febrile, polypneic, and tachycardic. The diagnosis of MIS-C was excluded; there was no involvement of two organs, and infection with S. pneumoniae serotype 19 F was identified. Given the unfavorable evolution, corticosteroid therapy and immunoglobulin were instituted, and subsequently, following the antibiogram result, antibiotic therapy was escalated to Meropenem and Linezolid. Clinical and laboratory parameters improved, but pericarditis with a small fluid slide and ECG changes were associated. The evolution was favorable with complete cardiac recovery at 30 days. Conclusion: This case highlights the importance of vigilant assessment for secondary bacterial infections and cardiac complications in pediatric COVID-19. Prompt recognition and targeted treatment are essential, and pneumococcal vaccination remains a fundamental preventive measure. Moreover, the scarcity of literature documenting SARS-CoV-2 infections complicated by pericarditis further underscores the uniqueness of this case and its relevance for specialists in the field.<\/jats:p>","DOI":"10.3390\/v17121567","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T13:03:02Z","timestamp":1764594182000},"page":"1567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pericarditis in a Child with COVID-19 Complicated by Streptococcus pneumoniae Sepsis: A Case Report"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8902-2051","authenticated-orcid":false,"given":"M\u0103d\u0103lina Maria","family":"Meri\u0219escu","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Infectious Diseases, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cProf. Dr. Matei Bals\u201d, European HIV\/AIDS and Infectious Diseases Academy, No. 1 Dr. Calistrat Grozovici Street, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-8880","authenticated-orcid":false,"given":"Mihaela","family":"Oro\u0219","sequence":"additional","affiliation":[{"name":"Physiology, Department of Preclinical Sciences, Faculty of Medicine, Titu Maiorescu University, No. 67A, Gheorghe Petra\u0219cu Street, 3rd District, 031593 Bucharest, Romania"},{"name":"Ponderas Academic Hospital, No. 85A, Nicolae G. Caramfil Street, 014142 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-063X","authenticated-orcid":false,"given":"Gheorghi\u021b\u0103","family":"Jugulete","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Infectious Diseases, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cProf. Dr. Matei Bals\u201d, European HIV\/AIDS and Infectious Diseases Academy, No. 1 Dr. Calistrat Grozovici Street, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Borco\u0219","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Infectious Diseases, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cProf. Dr. Matei Bals\u201d, European HIV\/AIDS and Infectious Diseases Academy, No. 1 Dr. Calistrat Grozovici Street, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa Mirela","family":"R\u0103du\u021b","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u201cProf. Dr. Matei Bals\u201d, European HIV\/AIDS and Infectious Diseases Academy, No. 1 Dr. Calistrat Grozovici Street, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Totoianu","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u201cProf. Dr. Matei Bals\u201d, European HIV\/AIDS and Infectious Diseases Academy, No. 1 Dr. Calistrat Grozovici Street, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca Oana","family":"Dragomirescu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Orthodontics and Dentofacial Orthopaedics, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020). 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