{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:20:44Z","timestamp":1792722044233,"version":"4.5.0"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The year 2025 likely marks a turning point in both the perception and the reality of mosquito-borne arboviral diseases in Europe. While chikungunya and dengue viruses have long been regarded as tropical illnesses confined to intertropical regions, West Nile virus has circulated for decades in temperate areas, including southern Europe. Nevertheless, all three mosquito-borne viruses are now increasingly established across the European continent. This evolution reflects a profound transformation of the European epidemiological landscape, where arboviral diseases are increasingly emerging as endemic and seasonal threats. This shift concerns not only the scale but also the dynamics of transmission, with the appearance of newly affected regions, an earlier onset of the transmission season, and a broader diversity of arboviruses involved. Europe is thus entering a new phase in which longer, wider, and more intense transmission of vector-borne diseases is likely to become the new norm requiring strengthened preparedness.<\/jats:p>","DOI":"10.3390\/v17121642","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:45:07Z","timestamp":1766065507000},"page":"1642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Europe Faces Multiple Arboviral Threats in 2025"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3475-1369","authenticated-orcid":false,"given":"Yannick","family":"Simonin","sequence":"first","affiliation":[{"name":"Pathogenesis and Control of Chronic and Emerging Infections, Montpellier University, INSERM, CHU Montpellier, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Simonin, Y. (2024). Circulation of West Nile Virus and Usutu Virus in Europe: Overview and Challenges. Viruses, 16.","DOI":"10.3390\/v16040599"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2001095","DOI":"10.2807\/1560-7917.ES.2021.26.19.2001095","article-title":"Epidemiology of human West Nile virus infections in the European Union and European Union enlargement countries, 2010 to 2018","volume":"26","author":"Young","year":"2021","journal-title":"Eurosurveillance"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sejvar, J.J. (2014). Clinical Manifestations and Outcomes of West Nile Virus Infection. Viruses, 6.","DOI":"10.3390\/v6020606"},{"key":"ref_4","unstructured":"European Centre for Disease Prevention and Control (ECDC) (2025, December 11). Surveillance of West Nile Virus Infections in Humans and Animals in Europe, Monthly Report. Available online: https:\/\/www.ecdc.europa.eu\/en\/west-nile-fever\/surveillance-and-disease-data\/disease-data-ecdc."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Carrasco, L., Utrilla, M.J., Fuentes-Romero, B., Fernandez-Novo, A., and Martin-Maldonado, B. (2024). West Nile Virus: An Update Focusing on Southern Europe. Microorganisms, 12.","DOI":"10.3390\/microorganisms12122623"},{"key":"ref_6","unstructured":"(2025, November 05). Chikungunya, Dengue, Zika et West Nile en France Hexagonale. Bulletin de la Surveillance renforc\u00e9e du 5 Novembre 2025. Available online: https:\/\/www.santepubliquefrance.fr\/maladies-et-traumatismes\/maladies-a-transmission-vectorielle\/chikungunya\/documents\/bulletin-national\/chikungunya-dengue-zika-et-west-nile-en-france-hexagonale.-bulletin-de-la-surveillance-renforcee-du-5-novembre-2025."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"ofaf243","DOI":"10.1093\/ofid\/ofaf243","article-title":"Paradigm Shift Toward \u201cOne Health\u201d Monitoring of Culex-Borne Arbovirus Circulation in France: The 2022 Inaugural Spotlight on West Nile and Usutu Viruses in Nouvelle-Aquitaine","volume":"12","author":"Gonzalez","year":"2025","journal-title":"Open Forum Infect. Dis."},{"key":"ref_8","unstructured":"European Centre for Disease Prevention and Control (ECDC) (2025, December 11). Seasonal Surveillance of Dengue in the EU\/EEA, Weekly Report. Available online: https:\/\/www.ecdc.europa.eu\/en\/dengue\/surveillance-and-updates\/seasonal-surveillance-dengue-eueea-weekly."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.15190\/d.2024.8","article-title":"Complexities of Dengue Fever: Pathogenesis, Clinical Features and Management Strategies","volume":"12","author":"Nasir","year":"2024","journal-title":"Discoveries"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107940","DOI":"10.1016\/j.ijid.2025.107940","article-title":"Global dengue epidemic worsens with record 14 million cases and 9000 deaths reported in 2024","volume":"158","author":"Haider","year":"2025","journal-title":"Int. J. Infect. Dis."},{"key":"ref_11","unstructured":"European Centre for Disease Prevention and Control (ECDC) (2025, December 05). Seasonal Surveillance of Chikungunya Virus Disease in the EU\/EEA, Weekly Report. Available online: https:\/\/www.ecdc.europa.eu\/en\/chikungunya-virus-disease\/surveillance-and-updates\/seasonal-surveillance."},{"key":"ref_12","unstructured":"European Centre for Disease Prevention and Control (ECDC) (2025, November 01). Worsening Spread of Mosquito-Borne Disease Outbreaks in EU\/EEA, According to Latest ECDC Figures. Available online: https:\/\/www.ecdc.europa.eu\/en\/news-events\/worsening-spread-mosquito-borne-disease-outbreaks-eueea-according-latest-ecdc-figures?.com."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"114ra128","DOI":"10.1126\/scitranslmed.3003084","article-title":"Dynamics of Dengue Disease Severity Determined by the Interplay Between Viral Genetics and Serotype-Specific Immunity","volume":"3","author":"OhAinle","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e0033","DOI":"10.5041\/RMMJ.10260","article-title":"Chikungunya Virus Infection: An Update on Joint Manifestations and Management","volume":"7","author":"Krutikov","year":"2016","journal-title":"Rambam Maimonides Med. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2500344","DOI":"10.2807\/1560-7917.ES.2025.30.22.2500344","article-title":"Genomic insights into the re-emergence of chikungunya virus on R\u00e9union Island, France, 2024 to 2025","volume":"30","author":"Frumence","year":"2025","journal-title":"Eurosurveillance"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2400271","DOI":"10.2807\/1560-7917.ES.2024.29.20.2400271","article-title":"Aedes albopictus is a competent vector of five arboviruses affecting human health, greater Paris, France, 2023","volume":"29","author":"Bohers","year":"2024","journal-title":"Eurosurveillance"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1016\/S2542-5196(25)00059-2","article-title":"Impact of climate and Aedes albopictus establishment on dengue and chikungunya outbreaks in Europe: A time-to-event analysis","volume":"9","author":"Farooq","year":"2025","journal-title":"Lancet Planet. Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00436-024-08137-w","article-title":"History of research on Aedes albopictus (Diptera: Culicidae) in Europe: Approaching the world\u2019s most invasive mosquito species from a bibliometric perspective","volume":"123","year":"2024","journal-title":"Parasitol. Res."},{"key":"ref_19","unstructured":"(2025, July 01). ECDC, E.C. for D.P. and C. Aedes Albopictus\u2014Current Known Distribution: June 2025. Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/aedes-albopictus-current-known-distribution-june-2025."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Santos, J.M., Capinha, C., Rocha, J., and Sousa, C.A. (2022). The current and future distribution of the yellow fever mosquito (Aedes aegypti) on Madeira Island. PLoS Negl. Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0010715"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1051\/parasite\/2023043","article-title":"Two invasions at once: Update on the introduction of the invasive species Aedes aegypti and Aedes albopictus in Cyprus\u2014A call for action in Europe","volume":"30","author":"Vasquez","year":"2023","journal-title":"Parasite"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Vega-R\u00faa, A., Louren\u00e7o-De-Oliveira, R., Mousson, L., Vazeille, M., Fuchs, S., Y\u00e9bakima, A., Gustave, J., Girod, R., Dusfour, I., and Leparc-Goffart, I. (2015). Chikungunya virus transmission potential by local Aedes mosquitoes in the Americas and Europe. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003780"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Vazeille, M., Moutailler, S., Coudrier, D., Rousseaux, C., Khun, H., Huerre, M., Thiria, J., Dehecq, J.S., Fontenille, D., and Schuffenecker, I. (2007). Two Chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0001168"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Tsetsarkin, K.A., McGee, C.E., Volk, S.M., Vanlandingham, D.L., Weaver, S.C., and Higgs, S. (2009). Epistatic roles of E2 glycoprotein mutations in adaption of chikungunya virus to Aedes albopictus and Ae. aegypti mosquitoes. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006835"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2113015118","DOI":"10.1073\/pnas.2113015118","article-title":"A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host","volume":"118","author":"Yu","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Daudt-Lemos, M., Ramos-Silva, A., Faustino, R., Noronha, T.G.d., Vianna, R.A.d.O., Cabral-Castro, M.J., Cardoso, C.A.A., Silva, A.A., and Carvalho, F.R. (2025). Rising Incidence and Spatiotemporal Dynamics of Emerging and Reemerging Arboviruses in Brazil. Viruses, 17.","DOI":"10.3390\/v17020158"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"105187","DOI":"10.1016\/j.idnow.2025.105187","article-title":"Tick-borne encephalitis: An ancient pathology, but a current emergence in Europe","volume":"56","author":"Hoellinger","year":"2026","journal-title":"Infect. Dis. Now"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2404271","DOI":"10.1080\/22221751.2024.2404271","article-title":"Epidemiology and global spread of emerging tick-borne Alongshan virus","volume":"13","author":"Lang","year":"2024","journal-title":"Emerg. Microbes Infect."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102806","DOI":"10.1016\/j.tmaid.2025.102806","article-title":"Changes in the epidemiology of Crimean-Congo hemorrhagic fever: Impact of travel and a One Health approach in the European region","volume":"64","author":"Norman","year":"2025","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cadar, D., and Simonin, Y. (2023). Human Usutu Virus Infections in Europe: A New Risk on Horizon?. Viruses, 15.","DOI":"10.3390\/v15010077"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"taad062","DOI":"10.1093\/jtm\/taad062","article-title":"Climate change and vector-borne diseases: A multi-omics approach of temperature-induced changes in the mosquito","volume":"30","author":"Bellone","year":"2023","journal-title":"J. Travel Med."},{"key":"ref_32","first-page":"100017","article-title":"Climate change impacts on vector-borne diseases in Europe: Risks, predictions and actions","volume":"1","author":"Paz","year":"2020","journal-title":"Lancet Reg. Health-Eur."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41558-022-01426-1","article-title":"Over half of known human pathogenic diseases can be aggravated by climate change","volume":"12","author":"Mora","year":"2022","journal-title":"Nat. Clim. Chang."},{"key":"ref_34","unstructured":"(2025, November 01). Copernicus European Summer 2025\u2014Hot in the West and South, Dry in the Southeast. Available online: https:\/\/climate.copernicus.eu\/european-summer-2025-hot-west-and-south-dry-southeast."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1111\/gcb.16406","article-title":"Worldwide impacts of landscape anthropization on mosquito abundance and diversity: A meta-analysis","volume":"28","author":"Perrin","year":"2022","journal-title":"Glob. Change Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"106832","DOI":"10.1016\/j.actatropica.2023.106832","article-title":"Invasive mosquito vectors in Europe: From bioecology to surveillance and management","volume":"239","author":"Giunti","year":"2023","journal-title":"Acta Trop."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13071-022-05413-5","article-title":"A literature review of dispersal pathways of Aedes albopictus across different spatial scales: Implications for vector surveillance","volume":"15","author":"Swan","year":"2022","journal-title":"Parasit. Vectors"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2400515","DOI":"10.2807\/1560-7917.ES.2025.30.15.2400515","article-title":"Description and comparison of national surveillance systems and response measures for Aedes-borne diseases in France, Italy and Portugal: A benchmarking study, 2023","volume":"30","author":"Fotakis","year":"2025","journal-title":"Eurosurveillance"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cmi.2017.12.010","article-title":"Laboratory preparedness and response with a focus on arboviruses in Europe","volume":"24","author":"Reusken","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S1473-3099(24)00654-6","article-title":"Multi-antigen serology and a diagnostic algorithm for the detection of arbovirus infections as novel tools for arbovirus preparedness in southeast Europe (MERMAIDS-ARBO): A prospective observational study","volume":"25","author":"Kasbergen","year":"2025","journal-title":"Lancet Infect. Dis."},{"key":"ref_41","unstructured":"(2025, July 31). European Medicines Agency New Chikungunya Vaccine for Adolescents from 12 and Adults. Available online: https:\/\/www.ema.europa.eu\/en\/news\/new-chikungunya-vaccine-adolescents-12-adults."},{"key":"ref_42","unstructured":"(2024, May 31). European Medicines Agency Ixchiq. Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/ixchiq."},{"key":"ref_43","unstructured":"(2024, May 31). European Medicines Agency First Vaccine to Protect Adults from Chikungunya. Available online: https:\/\/www.ema.europa.eu\/en\/news\/first-vaccine-protect-adults-chikungunya."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa1800820","article-title":"Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy","volume":"379","author":"Sridhar","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Aguiar, M., and Stollenwerk, N. (2020). The Impact of Serotype Cross-Protection on Vaccine Trials: DENVax as a Case Study. Vaccines, 8.","DOI":"10.20944\/preprints202009.0671.v1"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/12\/1642\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:49:40Z","timestamp":1766065780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/17\/12\/1642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["v17121642"],"URL":"https:\/\/doi.org\/10.3390\/v17121642","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}