{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:58:03Z","timestamp":1790132283526,"version":"4.0.1"},"reference-count":138,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hangzhou Science and Technology Bureau and the Scientific Research Foundation of Hangzhou City University","award":["S202513021066"],"award-info":[{"award-number":["S202513021066"]}]},{"name":"Hangzhou Science and Technology Bureau and the Scientific Research Foundation of Hangzhou City University","award":["F-202504"],"award-info":[{"award-number":["F-202504"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus prevalent in more than 110 countries and regions, including Africa, Asia, the Americas, and Europe. It can cause acute fever, rash, and severe joint pain, and some patients may develop chronic arthritis, which significantly impairs quality of life. CHIKV infection can occasionally be fatal, with neurologic disease a particularly severe manifestation. Following its resurgence in 2005, CHIKV has emerged as a major threat to global public health. This review summarizes diagnostic techniques, advances in vaccine development, and the latest drug interventions for CHIKV. We also present an overview of the epidemiology, structure, and invasion mechanisms of epidemic hotspots in 2024\u20132025 and propose evidence-based strategies for effective prevention and control of CHIKV infection.<\/jats:p>","DOI":"10.3390\/v18010100","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:30:34Z","timestamp":1768203034000},"page":"100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chikungunya in 2025: Comprehensive Insights into Virology, Diagnostics, Vaccines, and Antiviral Therapies"],"prefix":"10.3390","volume":"18","author":[{"given":"Zeyong","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Medicine, Hangzhou City University, Hangzhou 310015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Medicine, Hangzhou City University, Hangzhou 310015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3206-1376","authenticated-orcid":false,"given":"Zeping","family":"Shan","sequence":"additional","affiliation":[{"name":"School of Medicine, Hangzhou City University, Hangzhou 310015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangcheng","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Medicine, Hangzhou City University, Hangzhou 310015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Hangzhou City University, Hangzhou 310015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Hangzhou City University, Hangzhou 310015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, People\u2019s Hospital of Anji, 699 Tianmu Road, Anji County, Huzhou 313300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-7135","authenticated-orcid":false,"given":"Shibo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naru","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Hangzhou City University, Hangzhou 310015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tiozzo, G., de Roo, A.M., Gurgel do Amaral, G.S., Hofstra, H., Vondeling, G.T., and Postma, M.J. 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