{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:59:40Z","timestamp":1768586380487,"version":"3.49.0"},"reference-count":25,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Strategic Academic Leadership Program of Kazan Federal University","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"DOI":"10.13039\/100004319","name":"Pfizer Inc.","doi-asserted-by":"publisher","award":["65238411"],"award-info":[{"award-number":["65238411"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Internal grant funding from the Scientific Centre for Family Health and Human Reproduction Problems","award":["121022500179-0"],"award-info":[{"award-number":["121022500179-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe disease of the human central nervous system. Currently, the data on the genetic variants of TBEV in Kyrgyzstan are practically absent. Therefore, the aim of this study was to analyze and describe the genetic diversity of TBEV in this region. The complete genome sequences of seven TBEV strains from the collection of the Scientific Centre for Family Health and Human Reproduction Problems (Irkutsk, Russia) were determined. These strains, isolated from Ixodes persulcatus ticks from Kyrgyzstan, were sequenced using the next generation sequencing approach on a MiSeq high-performance sequencer (Illumina, San Diego, CA, USA). A molecular genetic analysis of the obtained sequences, along with sequences of two previously isolated TBEV strains from Kyrgyzstan available in the GenBank database, demonstrated that the Siberian subtype of three genetic lineages (Zausaev, Vasilchenko and Bosnia) is predominantly distributed in Kyrgyzstan. The Far Eastern subtype of TBEV is also present. To date, this location probably represents the southernmost boundary of these TBEV subtypes\u2019 ranges.<\/jats:p>","DOI":"10.3390\/v18010107","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:52:57Z","timestamp":1768319577000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Diversity of Tick-Borne Encephalitis Virus in Kyrgyzstan"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6292-6560","authenticated-orcid":false,"given":"Leyla H.","family":"Shigapova","sequence":"first","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan 420012, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-8746","authenticated-orcid":false,"given":"Irina V.","family":"Kozlova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction, Irkutsk 664003, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-6958","authenticated-orcid":false,"given":"Galya V.","family":"Klink","sequence":"additional","affiliation":[{"name":"International Laboratory of Statistical and Computational Genomics, National Research University\u2014Higher School of Economics, Moscow 109028, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena K.","family":"Doroshchenko","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction, Irkutsk 664003, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga V.","family":"Suntsova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction, Irkutsk 664003, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana V.","family":"Lisak","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction, Irkutsk 664003, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-261X","authenticated-orcid":false,"given":"Elena I.","family":"Shagimardanova","sequence":"additional","affiliation":[{"name":"Genomics and Bio-imaging Core Facility, Moscow 121205, Russia"},{"name":"Life Improvement by Future Technologies (LIFT) Center, Moscow 121205, Russia"},{"name":"Loginov Moscow Clinical Scientific Center, Moscow 111394, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5410-5113","authenticated-orcid":false,"given":"Yuriy P.","family":"Dzhioev","sequence":"additional","affiliation":[{"name":"Faculty of Preventive Medicine, Irkutsk State Medical University, Irkutsk 664003, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-5113","authenticated-orcid":false,"given":"Vladimir I.","family":"Zlobin","sequence":"additional","affiliation":[{"name":"National Research Center for Epidemiology and Microbiology Named After Honorary Academician Nikolai Fedorovich Gamaleya of the Ministry of Health of the Russian Federation, Moscow 123098, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey E.","family":"Tkachev","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan 420012, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"ref_1","unstructured":"(2025, November 25). 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