{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:08:30Z","timestamp":1785431310324,"version":"3.56.0"},"reference-count":56,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL146201"],"award-info":[{"award-number":["U01HL146201"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"award":["U01HL146201"],"award-info":[{"award-number":["U01HL146201"]}],"id":[{"id":"https:\/\/ror.org\/012pb6c26","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Here, we describe vision health in aging adults living with HIV (PLWH) and comparable people without HIV (PWOH) from the MACS\/WIHS Combined Cohort Study (MWCCS). PLWH and PWOH aged 60 years and older were recruited from Baltimore\/Washington, DC, from September 2021 to September 2023. Exact matching and sample weights were used to create age-balanced comparisons. Visual impairment (VA worse than 20\/40 after refraction or CS worse than 1.50 logCS in the better eye) and the presence of eye pathology were assessed. We studied 74 PLWH (97% virally suppressed) and 65 PWOH, aged 61 to 79 years, 36% Black, and 87% male. For PLWH and PWOH, distance VA impairment was noted in 4% vs. 1%, respectively, and uncorrected refractive error in 15% vs. 5%. More than half had signs of dry eye disease (63% for PLWH and 51% for PWOH). About half of PLWH had developed at least an early stage of cataract, compared to 20% of PWOH. Posterior chamber abnormalities were observed in 4% and 0%, and glaucomatous changes in 19% and 25% of PLWH and PWOH, respectively. The need for eyecare was high among this sample of PLWH with viral suppression and PWOH.<\/jats:p>","DOI":"10.3390\/v18040431","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:26:12Z","timestamp":1775121972000},"page":"431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eye Health and Vision Function in Adults Aging with Well-Controlled HIV"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6863-0565","authenticated-orcid":false,"given":"Alison G.","family":"Abraham","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA"},{"name":"Department of Ophthalmology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-1225","authenticated-orcid":false,"given":"Xinxing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijana","family":"Lawa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-5164","authenticated-orcid":false,"given":"Aleks","family":"Mihailovic","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Plankey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd T.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"},{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Margolick","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Ramulu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-7062","authenticated-orcid":false,"given":"Seema","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"ref_1","first-page":"131","article-title":"Surveillance for Sensory Impairment, Activity Limitation, and Health-Related Quality of Life Among Older Adults\u2014United States, 1993\u20131997","volume":"48","author":"Campbell","year":"1999","journal-title":"Morb. Mortal. Wkly. Rep. Surveill. Summ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1001\/archopht.122.4.477","article-title":"Causes and prevalence of visual impairment among adults in the United States","volume":"122","author":"Congdon","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1001\/jama.295.18.2158","article-title":"Prevalence of visual impairment in the United States","volume":"295","author":"Vitale","year":"2006","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/jamaophthalmol.2016.1284","article-title":"Visual Impairment and Blindness in Adults in the United States: Demographic and Geographic Variations from 2015 to 2050","volume":"134","author":"Varma","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"ref_5","first-page":"772","article-title":"Sensory Impairment and Health-Related Quality of Life","volume":"44","author":"Kwon","year":"2015","journal-title":"Iran. J. Public Health"},{"key":"ref_6","unstructured":"National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Population Health and Public Health Practice, Committee on Public Health Approaches to Reduce Vision Impairment and Promote Eye Health, Teutsch, S.M., McCoy, M.A., Woodbury, R.B., and Welp, A. (2022, March 21). The Impact of Vision Loss, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK402367\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-vision-111815-114550","article-title":"Vision and Aging","volume":"2","author":"Owsley","year":"2016","journal-title":"Annu. Rev. Vis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/09286580600864794","article-title":"Assessment of Vision-Related Quality of Life in an Older Population Subsample: The Blue Mountains Eye Study","volume":"13","author":"Chia","year":"2006","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s13365-011-0073-y","article-title":"Accelerated aging and human immunodeficiency virus infection: Emerging challenges of growing older in the era of successful antiretroviral therapy","volume":"18","author":"Bhatia","year":"2011","journal-title":"J. NeuroVirology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/gerona\/glt168","article-title":"Is HIV a model of accelerated or accentuated aging?","volume":"69","author":"Pathai","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_11","first-page":"118","article-title":"Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy","volume":"17","author":"Deeks","year":"2009","journal-title":"Top. HIV Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(13)61809-7","article-title":"The end of AIDS: HIV infection as a chronic disease","volume":"382","author":"Deeks","year":"2013","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11904-010-0041-9","article-title":"HIV and aging: Time for a new paradigm","volume":"7","author":"Justice","year":"2010","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1089\/apc.2015.0091","article-title":"Neuroretinal Degeneration in HIV Patients Without Opportunistic Ocular Infections in the cART Era","volume":"29","author":"Demirkaya","year":"2015","journal-title":"AIDS Patient Care STDS"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ophtha.2014.11.009","article-title":"Incidence and long-term outcomes of the human immunodef\u0131ciency virus neuroretinal disorder in patients with AIDS","volume":"122","author":"Jabs","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ophtha.2006.07.065","article-title":"Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollment","volume":"114","author":"Jabs","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/j.ophtha.2014.06.014","article-title":"Risk of cataract among subjects with acquired immune deficiency syndrome free of ocular opportunistic infections","volume":"121","author":"Kempen","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ajo.2004.09.039","article-title":"Objective analysis of retinal damage in HIV-positive patients in the HAART era using OCT","volume":"139","author":"Kozak","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ajo.2007.10.013","article-title":"Vision function in HIV-infected individuals without retinitis: Report of the Studies of Ocular Complications of AIDS Research Group","volume":"145","author":"Freeman","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ajo.2020.06.018","article-title":"Prevalence and Consequences of Perceived Vision Difficulty in Aging Adults with HIV Infection","volume":"218","author":"Abraham","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1177\/0145482X0610001S07","article-title":"Double Jeopardy: The Effects of Comorbid Conditions among Older People with Vision Loss","volume":"100","author":"Crews","year":"2006","journal-title":"J. Vis. Impair. Blind."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/09286586.2024.2346894","article-title":"Vision Problems As a Contributor to Lower Engagement in Care Among Aging Men Living with HIV","volume":"32","author":"Abraham","year":"2024","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1177\/1359105320922303","article-title":"Activation in individuals with vision loss","volume":"26","author":"Morse","year":"2021","journal-title":"J. Health Psychol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/09286586.2022.2078495","article-title":"Vision Impairment and Patient Activation among Medicare Beneficiaries","volume":"30","author":"Assi","year":"2023","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_25","unstructured":"Mansfield, J., Legge, G., Luebker, A., and Cunningham, K. (1994). MNRead Acuity Charts, University of Minnesota."},{"key":"ref_26","first-page":"3327","article-title":"Monocular versus binocular visual acuity as measures of vision impairment and predictors of visual disability","volume":"41","author":"Rubin","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000356753","article-title":"Useful field of view test","volume":"60","author":"Wood","year":"2014","journal-title":"Gerontology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.visres.2012.11.014","article-title":"Visual processing speed","volume":"90","author":"Owsley","year":"2013","journal-title":"Vis. Res."},{"key":"ref_29","unstructured":"Palay, D.A., and Krachmer, J.H. (2005). Primary Care Ophthalmology, Elsevier. [2nd ed.]."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1442-9071.1989.tb00492.x","article-title":"The clinical grading of lens opacities","volume":"17","author":"Taylor","year":"1989","journal-title":"Aust. N. Z. J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v042.i08","article-title":"MatchIt: Nonparametric Preprocessing for Parametric Causal Inference","volume":"42","author":"Ho","year":"2011","journal-title":"J. Stat. Softw."},{"key":"ref_32","first-page":"4561","article-title":"Retinal microvascular health and what it tells us about cognitive function: The Eye Determinants of Cognition (EyeDOC) Study","volume":"60","author":"Abraham","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_33","first-page":"809","article-title":"Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features with Visual Function in Older Adults","volume":"140","author":"Dong","year":"2022","journal-title":"JAMA Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/gerona\/glab349","article-title":"Associations of Visual Function with Cognitive Performance in Community-Based Older Adults: The Eye Determinants of Cognition Study","volume":"77","author":"Arsiwala","year":"2022","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_35","unstructured":"Centers for Disease Control and Prevention (2024, October 11). Vision & Eye Health Surveillance System (VEHSS), Available online: https:\/\/www.cdc.gov\/vision-health-data\/index.html."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/09286580802077716","article-title":"Ophthalmic manifestations of HIV infections in India in the era of HAART: Analysis of 100 consecutive patients evaluated at a tertiary eye care center in India","volume":"15","author":"Gharai","year":"2008","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Bekele, S., Gelaw, Y., and Tessema, F. (2013). Ocular manifestation of HIV\/AIDS and correlation with CD4+ cells count among adult HIV\/AIDS patients in Jimma town, Ethiopia: A cross sectional study. BMC Ophthalmol., 13.","DOI":"10.1186\/1471-2415-13-20"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1167\/iovs.14-14633","article-title":"Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration","volume":"55","author":"Mao","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"101201","DOI":"10.1016\/j.redox.2019.101201","article-title":"Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors","volume":"24","author":"Brown","year":"2019","journal-title":"Redox Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4103\/ijmr.IJMR_1037_15","article-title":"Ocular manifestations in patients attending antiretroviral therapy centre at a tertiary care hospital in Himachal Pradesh, India","volume":"147","author":"Sharma","year":"2018","journal-title":"Indian J. Med. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Singalavanija, T., Ausayakhun, S., and Tangmonkongvoragul, C. (2018). Anterior segment and external ocular disorders associated with HIV infections in the era of HAART in Chiang Mai University Hospital, a prospective descriptive cross sectional study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193161"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II Epidemiology Report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_43","first-page":"693","article-title":"Presence of HTLV-III in tears and cells from the eyes of AIDS patients","volume":"3","author":"Ablashi","year":"1987","journal-title":"J. Exp. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0140-6736(85)90464-7","article-title":"Isolation of human T-Lymphotropic virus type III from the tears of a patient with the acquired immunodeficiency syndrome","volume":"326","author":"Fujikawa","year":"1985","journal-title":"Lancet"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/QAD.0b013e328340fe91","article-title":"Intraocular and plasma HIV-1 RNA loads and HIV uveitis","volume":"25","author":"Pathanapitoon","year":"2011","journal-title":"AIDS"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1097\/QAD.0b013e32834b3578","article-title":"Detection of HIV-1 viruses in tears of patients even under long-term HAART","volume":"25","author":"Han","year":"2011","journal-title":"AIDS"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/labinvest.2014.72","article-title":"HIV-1 impairs human retinal pigment epithelial barrier function: Possible association with the pathogenesis of HIV-associated retinopathy","volume":"94","author":"Tan","year":"2014","journal-title":"Lab. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3892\/etm.2014.1521","article-title":"Mechanism of blood-retinal barrier breakdown induced by HIV-1 (Review)","volume":"7","author":"Che","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0161-6420(86)33528-0","article-title":"The autoimmune nature of aqueous tear deficiency","volume":"93","author":"Pflugfelder","year":"1986","journal-title":"Ophthalmology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jtos.2020.02.003","article-title":"Meibomian gland dropout is associated with immunodeficiency at HIV diagnosis: Implications for dry eye disease","volume":"18","author":"Nguyen","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/QAI.0b013e31828ad759","article-title":"Increased ocular lens density in HIV-infected individuals with low nadir CD4 counts in South Africa: Evidence of accelerated aging","volume":"63","author":"Pathai","year":"2013","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1093\/cid\/cir675","article-title":"Risk of cataract surgery in HIV-infected individuals: A Danish Nationwide Population-based cohort study","volume":"53","author":"Rasmussen","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/ICU.0000000000001009","article-title":"Oxidative stress and antioxidants in cataract development","volume":"35","author":"Lee","year":"2024","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_54","first-page":"20","article-title":"Gender Difference in Ocular Diseases, Risk Factors and Management with Specific Reference to Role of Sex Steroid Hormones","volume":"13","author":"Korpole","year":"2022","journal-title":"J. Midlife Health"},{"key":"ref_55","unstructured":"Office of AIDS Research, National Institutes of Health (2024, October 13). HIV and Older People, Available online: https:\/\/hivinfo.nih.gov\/understanding-hiv\/fact-sheets\/hiv-and-older-people#:~:text=Yes%2C%20anyone%20can%20get%20HIV,who%20are%20living%20with%20HIV."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"100646","DOI":"10.1016\/j.eclinm.2020.100646","article-title":"The value and implementation of routine ophthalmic examination in the era of HAART","volume":"31","author":"Li","year":"2021","journal-title":"eClinicalMedicine"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/4\/431\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:30:07Z","timestamp":1775122207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/4\/431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["v18040431"],"URL":"https:\/\/doi.org\/10.3390\/v18040431","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]}}}